BRCA1 Pathway

No Pathway Network information available for BRCA1 Pathway

Pathways in the BRCA1 Pathway SuperPath

#	Name	Source	Genes
1	BRCA1 Pathway	QIAGEN	ARPC3 ATF1 ATM ATR BACH1 BARD1 BLM BRCA1 BRCA2 CHEK1 CHEK2 E2F1 E2F2 E2F3 E2F4 E2F5 FANCA FANCC FANCD2 FANCE FANCF FANCG FANCL GADD45A GADD45B GADD45G HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HELLS HLTF MRE11 MSH2 MSH6 NBN PLK1 POU2F1 RAD50 RAD51 RB1 RBBP8 SMARCA1 SMARCA2 SMARCA4 SMARCA5 SMARCAD1 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCD2 STAT1 TP53 UBB UBC UBD (see all 63) (see less)
2	Fanconi's Anaemia Pathway	QIAGEN	ATM ATR BARD1 BRCA1 BRCA2 FANCA FANCC FANCD2 FANCE FANCF FANCG FANCL MRE11 NBN RAD50 RAD51 UBB UBC UBD (see all 19) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ATM	ATM Serine/Threonine Kinase	Protein Coding	2
2	ATR	ATR Checkpoint Kinase	Protein Coding	2
3	BARD1	BRCA1 Associated RING Domain 1	Protein Coding	2
4	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	2
5	BRCA2	BRCA2 DNA Repair Associated	Protein Coding	2
6	FANCA	FA Complementation Group A	Protein Coding	2
7	FANCC	FA Complementation Group C	Protein Coding	2
8	FANCD2	FA Complementation Group D2	Protein Coding	2
9	FANCE	FA Complementation Group E	Protein Coding	2
10	FANCF	FA Complementation Group F	Protein Coding	2
11	FANCG	FA Complementation Group G	Protein Coding	2
12	FANCL	FA Complementation Group L	Protein Coding	2
13	MRE11	MRE11 Double Strand Break Repair Nuclease	Protein Coding	2
14	NBN	Nibrin	Protein Coding	2
15	RAD50	RAD50 Double Strand Break Repair Protein	Protein Coding	2
16	RAD51	RAD51 Recombinase	Protein Coding	2
17	UBB	Ubiquitin B	Protein Coding	2
18	UBC	Ubiquitin C	Protein Coding	2
19	UBD	Ubiquitin Like Modifier D	Protein Coding	2
20	ARPC3	Actin Related Protein 2/3 Complex Subunit 3	Protein Coding	1
21	ATF1	Activating Transcription Factor 1	Protein Coding	1
22	BACH1	BACH Transcriptional Regulator 1	Protein Coding	1
23	BLM	BLM RecQ Like Helicase	Protein Coding	1
24	CHEK1	Checkpoint Kinase 1	Protein Coding	1
25	CHEK2	Checkpoint Kinase 2	Protein Coding	1
26	E2F1	E2F Transcription Factor 1	Protein Coding	1
27	E2F2	E2F Transcription Factor 2	Protein Coding	1
28	E2F3	E2F Transcription Factor 3	Protein Coding	1
29	E2F4	E2F Transcription Factor 4	Protein Coding	1
30	E2F5	E2F Transcription Factor 5	Protein Coding	1
31	GADD45A	Growth Arrest And DNA Damage Inducible Alpha	Protein Coding	1
32	GADD45B	Growth Arrest And DNA Damage Inducible Beta	Protein Coding	1
33	GADD45G	Growth Arrest And DNA Damage Inducible Gamma	Protein Coding	1
34	HDAC1	Histone Deacetylase 1	Protein Coding	1
35	HDAC10	Histone Deacetylase 10	Protein Coding	1
36	HDAC11	Histone Deacetylase 11	Protein Coding	1
37	HDAC2	Histone Deacetylase 2	Protein Coding	1
38	HDAC3	Histone Deacetylase 3	Protein Coding	1
39	HDAC5	Histone Deacetylase 5	Protein Coding	1
40	HDAC6	Histone Deacetylase 6	Protein Coding	1
41	HDAC7	Histone Deacetylase 7	Protein Coding	1
42	HDAC8	Histone Deacetylase 8	Protein Coding	1
43	HDAC9	Histone Deacetylase 9	Protein Coding	1
44	HELLS	Helicase, Lymphoid Specific	Protein Coding	1
45	MSH2	MutS Homolog 2	Protein Coding	1
46	MSH6	MutS Homolog 6	Protein Coding	1
47	PLK1	Polo Like Kinase 1	Protein Coding	1
48	POU2F1	POU Class 2 Homeobox 1	Protein Coding	1
49	RB1	RB Transcriptional Corepressor 1	Protein Coding	1
50	RBBP8	RB Binding Protein 8, Endonuclease	Protein Coding	1
51	SMARCA1	SNF2 Related Chromatin Remodeling ATPase 1	Protein Coding	1
52	SMARCA2	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit ATPase 2	Protein Coding	1
53	HLTF	Helicase Like Transcription Factor	Protein Coding	1
54	SMARCA4	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit ATPase 4	Protein Coding	1
55	SMARCA5	SNF2 Related Chromatin Remodeling ATPase 5	Protein Coding	1
56	SMARCAD1	SNF2 Related Chromatin Remodeling ATPase With DExD Box 1	Protein Coding	1
57	SMARCB1	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit B1	Protein Coding	1
58	SMARCC1	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit C1	Protein Coding	1
59	SMARCC2	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit C2	Protein Coding	1
60	SMARCD1	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit D1	Protein Coding	1
61	SMARCD2	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit D2	Protein Coding	1
62	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
63	TP53	Tumor Protein P53	Protein Coding	1

Disorders associated with BRCA1 Pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Breast cancer	Enrichment	ATM, BARD1, BLM, BRCA1, BRCA2, CHEK2, FANCC, MRE11, MSH2, MSH6, NBN, RAD50, RAD51, TP53	16.00
2	Ovarian cancer	Enrichment	ATM, BARD1, BRCA1, BRCA2, FANCA, FANCC, FANCD2, FANCE, FANCG, MRE11, NBN, RAD50	16.00
3	Hereditary breast carcinoma	Enrichment	ATM, BARD1, BLM, BRCA1, BRCA2, CHEK2, MSH2, MSH6, NBN, RAD50, RAD51, TP53	13.03
4	Gastric cancer	Enrichment	ATM, BARD1, BRCA1, BRCA2, CHEK2, MSH2, MSH6, NBN, TP53	10.99
5	Inherited cancer-predisposing syndrome	Enrichment	ATM, BARD1, BLM, BRCA1, BRCA2, CHEK2, FANCA, FANCC, MRE11, MSH2, MSH6, NBN, RAD50, RB1, SMARCA4, SMARCB1, TP53	10.96
6	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, BARD1, BRCA1, BRCA2, MRE11, NBN, RAD50, RAD51	10.94
7	Pancreatic cancer	Enrichment	ATM, BRCA1, BRCA2, CHEK2, FANCE, FANCG, NBN, RBBP8, TP53	10.83
8	Uterine corpus cancer	Enrichment	ATM, BRCA1, BRCA2, CHEK2, MSH2, MSH6	10.82
9	Fanconi anemia, complementation group a	Enrichment	BRCA1, BRCA2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCL, RAD51	10.63
10	Breast-ovarian cancer, familial 1	Enrichment	ATM, BRCA1, BRCA2, CHEK2, MSH2, NBN	10.55
11	Endometrial cancer	Enrichment	ATM, BARD1, BLM, BRCA1, BRCA2, CHEK2, MSH2, MSH6	10.53
12	Colorectal cancer	Enrichment	ATM, BLM, BRCA1, BRCA2, CHEK2, FANCC, FANCE, MSH2, MSH6, TP53	10.48
13	Prostate cancer	Enrichment	ATM, BRCA1, BRCA2, CHEK2, MSH6, NBN, TP53	10.20
14	Rhabdomyosarcoma	Enrichment	BRCA1, BRCA2, MSH2, MSH6, TP53	8.11
15	Hepatoblastoma	Enrichment	BARD1, BRCA2, FANCA, MSH2, TP53	7.45
16	Lynch syndrome 1	Enrichment	ATM, CHEK2, MSH2, MSH6	7.06
17	Osteogenic sarcoma	Enrichment	CHEK2, RB1, TP53	7.02
18	Bone osteosarcoma	Enrichment	CHEK2, RB1, TP53	7.02
19	Bladder cancer	Enrichment	ATM, BRCA1, BRCA2, RB1, TP53	6.70
20	Lynch syndrome 4	Enrichment	MSH2, MSH6, RB1	6.42
21	Coffin-siris syndrome 1	Enrichment	SMARCA4, SMARCB1, SMARCC2, SMARCD1	6.26
22	Diffuse large b-cell lymphoma	Enrichment	BRCA2, CHEK2, NBN, TP53	5.81
23	Inflammatory breast carcinoma	Enrichment	BRCA1, BRCA2	5.73
24	Bilateral breast cancer	Enrichment	BRCA1, BRCA2	5.73
25	Colonic benign neoplasm	Enrichment	ATM, CHEK2, MRE11	5.10
26	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA1, BRCA2	4.95
27	Cholangiocarcinoma	Enrichment	BRCA1, BRCA2	4.95
28	Nijmegen breakage syndrome-like disorder	Enrichment	MRE11, RAD50	4.95
29	Familial colorectal cancer type x	Enrichment	ATM, BRCA2, CHEK2	4.81
30	Breast-ovarian cancer, familial 2	Enrichment	BRCA1, BRCA2	4.73
31	Rhabdoid tumor predisposition syndrome	Enrichment	SMARCA4, SMARCB1	4.67
32	Li-fraumeni syndrome 1	Enrichment	CHEK2, TP53	4.67
33	Sarcoma	Enrichment	CHEK2, TP53	4.67
34	Pituitary stalk interruption syndrome	Enrichment	FANCA, FANCG, SMARCA2	4.47
35	Lynch syndrome	Enrichment	CHEK2, MSH2, MSH6	4.38
36	Gliosarcoma	Enrichment	ATM, MSH2, TP53	4.29
37	Myeloma, multiple	Enrichment	ATM, BARD1, BRCA2	4.21
38	Giant cell glioblastoma	Enrichment	ATM, MSH2, TP53	4.21
39	Atypical teratoid rhabdoid tumor	Enrichment	SMARCB1, TP53	4.20
40	Squamous cell carcinoma	Enrichment	RB1, TP53	4.20
41	Adenocarcinoma	Enrichment	ATM, TP53	4.20
42	Small cell cancer of the lung	Enrichment	RB1, TP53	3.90
43	Mismatch repair cancer syndrome 1	Enrichment	MSH2, MSH6	3.90
44	Hepatocellular carcinoma	Enrichment	NBN, RAD50, TP53	3.86
45	Glioblastoma	Enrichment	ATM, MSH2	3.68
46	Li-fraumeni syndrome	Enrichment	CHEK2, TP53	3.50
47	Fanconi anemia, complementation group c	Enrichment	FANCC, HDAC8	3.23
48	Leukemia, chronic lymphocytic	Enrichment	ATM, TP53	3.03
49	Familial colorectal cancer	Enrichment	MSH2, TP53	3.03
50	Atrial heart septal defect	Enrichment	HDAC8, SMARCA4	2.94
51	Interatrial communication	Enrichment	HDAC8, SMARCA4	2.94
52	Lip and oral cavity carcinoma	Enrichment	RB1, TP53	2.87
53	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	2.85
54	Glioma susceptibility 3	Enrichment	BRCA2	2.85
55	Seckel syndrome 1	Enrichment	ATR	2.85
56	Mirror movements 2	Enrichment	RAD51	2.85
57	Fanconi anemia, complementation group g	Enrichment	FANCG	2.85
58	Fanconi anemia, complementation group r	Enrichment	RAD51	2.85
59	Infant-type hemispheric glioma	Enrichment	BRCA1	2.85
60	Pancreatic cancer 2	Enrichment	BRCA2	2.85
61	Ataxia-telangiectasia-like disorder 1	Enrichment	MRE11	2.85
62	Cutaneous telangiectasia and cancer syndrome, familial	Enrichment	ATR	2.85
63	Endometrial serous adenocarcinoma	Enrichment	ATM	2.85
64	Fanconi anemia, complementation group l	Enrichment	FANCL	2.85
65	B-cell non-hodgkin lymphoma	Enrichment	ATM	2.85
66	Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome	Enrichment	ATR	2.85
67	Primary peritoneal carcinoma	Enrichment	BRCA1	2.85
68	Nk-cell enteropathy	Enrichment	CHEK2, SMARCB1	2.80
69	Lung cancer susceptibility 3	Enrichment	RB1, TP53	2.73
70	Seckel syndrome	Enrichment	ATR, RBBP8	2.73
71	Wilms tumor 1	Enrichment	BRCA2, CHEK2	2.67
72	Primary ovarian insufficiency	Enrichment	CHEK2, FANCA, NBN	2.59
73	Vacterl association, x-linked, with or without hydrocephalus	Enrichment	FANCL	2.55
74	Fanconi anemia, complementation group s	Enrichment	BRCA1	2.55
75	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	2.55
76	Pancreatic cancer 4	Enrichment	BRCA1	2.55
77	Fanconi anemia, complementation group e	Enrichment	FANCE	2.55
78	Diffuse midline glioma, h3 k27m-mutant	Enrichment	BRCA2	2.55
79	High grade glioma	Enrichment	ATM	2.55
80	Fanconi anemia, complementation group d1	Enrichment	BRCA2	2.55
81	T-cell prolymphocytic leukemia	Enrichment	ATM	2.55
82	Peritoneum cancer	Enrichment	BRCA1	2.55
83	Submucosal cleft palate	Enrichment	UBB	2.55
84	Cleft hard palate	Enrichment	UBB	2.55
85	Neuroendocrine tumor of pancreas	Enrichment	BRCA2	2.55
86	Ataxia-telangiectasia	Enrichment	ATM	2.38
87	Nijmegen breakage syndrome	Enrichment	NBN	2.38
88	Polycythemia vera	Enrichment	ATM	2.38
89	Uvula, bifid	Enrichment	UBB	2.38
90	Cleft soft palate	Enrichment	UBB	2.38
91	Tumor predisposition syndrome 1	Enrichment	BRCA2	2.38
92	Fanconi anemia, complementation group f	Enrichment	FANCF	2.38
93	Koolen-de vries syndrome	Enrichment	ATM	2.38
94	Bap1 tumor predisposition syndrome	Enrichment	BRCA2	2.38
95	Basan syndrome	Enrichment	SMARCAD1	2.33
96	Adermatoglyphia	Enrichment	SMARCAD1	2.33
97	Bloom syndrome	Enrichment	BLM	2.33
98	Huriez syndrome	Enrichment	SMARCAD1	2.33
99	Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia	Enrichment	HDAC6	2.33
100	Seckel syndrome 2	Enrichment	RBBP8	2.33
101	Immunodeficiency-centromeric instability-facial anomalies syndrome 4	Enrichment	HELLS	2.33
102	Coffin-siris syndrome 11	Enrichment	SMARCD1	2.33
103	Hydrocephalus, congenital, 5	Enrichment	SMARCC1	2.33
104	Auriculocondylar syndrome 4	Enrichment	HDAC9	2.33
105	Cornelia de lange syndrome 5	Enrichment	HDAC8	2.33
106	Bone marrow failure syndrome 5	Enrichment	TP53	2.33
107	Papilloma of choroid plexus	Enrichment	TP53	2.33
108	Basal cell carcinoma 7	Enrichment	TP53	2.33
109	Anaplastic thyroid carcinoma	Enrichment	TP53	2.33
110	Jawad syndrome	Enrichment	RBBP8	2.33
111	Tumor predisposition syndrome 4	Enrichment	CHEK2	2.33
112	Rhabdoid tumor predisposition syndrome 1	Enrichment	SMARCB1	2.33
113	Immunodeficiency 31a	Enrichment	STAT1	2.33
114	Neurilemmoma	Enrichment	SMARCB1	2.33
115	Immunodeficiency 31b	Enrichment	STAT1	2.33
116	Ductal carcinoma in situ	Enrichment	TP53	2.33
117	Coffin-siris syndrome 3	Enrichment	SMARCB1	2.33
118	Smarca4-deficient sarcoma of thorax	Enrichment	SMARCA4	2.33
119	Ovarian small cell carcinoma	Enrichment	SMARCA4	2.33
120	Mismatch repair cancer syndrome 2	Enrichment	MSH2	2.33
121	Blepharophimosis-impaired intellectual development syndrome	Enrichment	SMARCA2	2.33
122	Leiomyosarcoma	Enrichment	CHEK2	2.33
123	Rectal benign neoplasm	Enrichment	MSH2	2.33
124	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.33
125	Trilateral retinoblastoma	Enrichment	RB1	2.33
126	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.33
127	Ascending colon cancer	Enrichment	MSH2	2.33
128	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.33
129	Keratoderma with scleroatrophy of the extremities	Enrichment	SMARCAD1	2.33
130	Oocyte/zygote/embryo maturation arrest 21	Enrichment	CHEK1	2.33
131	Choroid plexus cancer	Enrichment	TP53	2.33
132	Ovarian cyst	Enrichment	MSH2	2.33
133	Autosomal recessive severe congenital neutropenia	Enrichment	SMARCD2	2.33
134	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.33
135	Lung oat cell carcinoma	Enrichment	RB1	2.33
136	Mirror movements 1	Enrichment	RAD51	2.25
137	Ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia	Enrichment	MRE11	2.25
138	Chordoma	Enrichment	BRCA2	2.25
139	Erythrocytosis, familial, 2	Enrichment	FANCD2	2.25
140	Mantle cell lymphoma	Enrichment	ATM	2.25
141	Vacterl association	Enrichment	FANCL	2.25
142	Oculomotor apraxia	Enrichment	ATM	2.25
143	Fanconi anemia, complementation group d2	Enrichment	FANCD2	2.16
144	Vater/vacterl association	Enrichment	FANCL	2.16
145	Von hippel-lindau syndrome	Enrichment	FANCD2	2.16
146	Kabuki syndrome 1	Enrichment	BRCA2	2.08
147	Clear cell renal cell carcinoma	Enrichment	ATM	2.08
148	Alopecia, androgenetic, 1	Enrichment	SMARCD1	2.03
149	Muir-torre syndrome	Enrichment	MSH2	2.03
150	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.03
151	Specific granule deficiency 1	Enrichment	SMARCD2	2.03
152	Cervical cancer	Enrichment	TP53	2.03
153	Rhabdoid tumor predisposition syndrome 2	Enrichment	SMARCA4	2.03
154	Schwannomatosis 1	Enrichment	SMARCB1	2.03
155	Chromosome 13q14 deletion syndrome	Enrichment	RB1	2.03
156	Lymphoma, hodgkin, classic	Enrichment	TP53	2.03
157	Syndactyly, type iii	Enrichment	HDAC8	2.03
158	Immunodeficiency 31c	Enrichment	STAT1	2.03
159	Congenital heart defects, multiple types, 3	Enrichment	CHEK2	2.03
160	Specific granule deficiency 2	Enrichment	SMARCD2	2.03
161	Coffin-siris syndrome 8	Enrichment	SMARCC2	2.03
162	Wilson-turner syndrome	Enrichment	HDAC8	2.03
163	Congenital fibrosarcoma	Enrichment	TP53	2.03
164	Otosclerosis 12	Enrichment	SMARCA4	2.03
165	Coffin-siris syndrome 4	Enrichment	SMARCA4	2.03
166	Cervix carcinoma	Enrichment	TP53	2.03
167	Hodgkin's lymphoma	Enrichment	TP53	2.03
168	Blepharophimosis - intellectual disability syndrome	Enrichment	SMARCA2	2.03
169	Mismatch repair cancer syndrome 3	Enrichment	MSH6	2.03
170	Familial retinoblastoma	Enrichment	RB1	2.03
171	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.03
172	Specific granule deficiency	Enrichment	SMARCD2	2.03
173	Lung cancer	Enrichment	BRCA1, CHEK2	2.02
174	Renal cell carcinoma, papillary, 1	Enrichment	ATM	2.01
175	Isolated growth hormone deficiency, type ia	Enrichment	BRCA2	1.95
176	Tracheoesophageal fistula with or without esophageal atresia	Enrichment	BRCA2	1.90
177	Polydactyly	Enrichment	BRCA2	1.90
178	Retinoblastoma	Enrichment	RB1	1.86
179	Nasopharyngeal carcinoma	Enrichment	TP53	1.86
180	Woolly hair, autosomal recessive 3	Enrichment	RB1	1.86
181	Lynch syndrome 5	Enrichment	MSH6	1.86
182	Hypotrichosis 8	Enrichment	RB1	1.86
183	Anaplastic astrocytoma	Enrichment	TP53	1.86
184	Cellular ependymoma	Enrichment	MSH2	1.86
185	Tanycytic ependymoma	Enrichment	MSH2	1.86
186	Papillary ependymoma	Enrichment	MSH2	1.86
187	Schwannomatosis	Enrichment	SMARCB1	1.86
188	Intellectual developmental disorder with dysmorphic facies and behavioral abnormalities	Enrichment	MSH6	1.86
189	Colon adenocarcinoma	Enrichment	MSH6	1.86
190	Melanoma of soft tissue	Enrichment	ATF1	1.86
191	Clear cell ependymoma	Enrichment	MSH2	1.86
192	Aplastic anemia	Enrichment	NBN	1.86
193	Isolated tracheo-esophageal fistula	Enrichment	BRCA2	1.86
194	Cerebral palsy	Enrichment	BRCA2, SMARCA4	1.85
195	Leukemia, acute myeloid	Enrichment	FANCD2, TP53	1.83
196	Immune deficiency disease	Enrichment	ATM	1.82
197	Leukemia, acute lymphoblastic	Enrichment	NBN	1.82
198	Premature menopause	Enrichment	NBN	1.74
199	Gaucher disease, type i	Enrichment	MSH6	1.73
200	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.73
201	Nicolaides-baraitser syndrome	Enrichment	SMARCA2	1.73
202	Blepharophimosis	Enrichment	SMARCA2	1.73
203	Lung sarcomatoid carcinoma	Enrichment	TP53	1.73
204	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.73
205	Smarca2-related nicolaides-baraitser syndrome	Enrichment	SMARCA2	1.73
206	Hemoglobin c disease	Enrichment	CHEK2	1.73
207	Full schwannomatosis	Enrichment	SMARCB1	1.73
208	Benign ependymoma	Enrichment	MSH2	1.73
209	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	CHEK1	1.73
210	Medulloblastoma	Enrichment	BRCA2	1.71
211	Periventricular nodular heterotopia	Enrichment	BRCA1	1.71
212	Microcephaly	Enrichment	HDAC8, NBN, SMARCA5	1.71
213	Renal cell carcinoma, nonpapillary	Enrichment	ATM	1.68
214	Rhabdomyosarcoma 2	Enrichment	TP53	1.64
215	Lymphoma	Enrichment	TP53	1.64
216	Acute megakaryocytic leukemia	Enrichment	TP53	1.64
217	Esophageal atresia/tracheoesophageal fistula	Enrichment	BRCA2	1.58
218	Wilms tumor 5	Enrichment	CHEK2	1.56
219	Immunodeficiency-centromeric instability-facial anomalies syndrome	Enrichment	HELLS	1.56
220	Adrenocortical carcinoma	Enrichment	TP53	1.56
221	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.56
222	Breast adenocarcinoma	Enrichment	TP53	1.56
223	Lissencephaly	Enrichment	NBN	1.54
224	Esophageal cancer	Enrichment	TP53	1.49
225	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.49
226	Essential thrombocythemia	Enrichment	TP53	1.49
227	Gallbladder cancer	Enrichment	TP53	1.49
228	Congenital hydrocephalus	Enrichment	SMARCC1	1.49
229	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.49
230	Glioma susceptibility 1	Enrichment	TP53	1.44
231	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.44
232	Ewing sarcoma	Enrichment	SMARCA5	1.44
233	Neuroblastoma	Enrichment	SMARCA4	1.44
234	Cornelia de lange syndrome 1	Enrichment	HDAC8	1.39
235	Adult hepatocellular carcinoma	Enrichment	TP53	1.39
236	Primary hyperaldosteronism	Enrichment	TP53	1.39
237	Ventricular septal defect	Enrichment	SMARCA4	1.39
238	Cornelia de lange syndrome	Enrichment	HDAC8	1.39
239	Melanoma	Enrichment	CHEK2	1.34
240	Meningioma, familial	Enrichment	SMARCB1	1.30
241	Myelodysplastic syndrome	Enrichment	TP53	1.30
242	Meningioma	Enrichment	SMARCB1	1.26
243	Hypercholesterolemia, familial, 1	Enrichment	SMARCA4	1.23
244	Familial hypercholesterolemia	Enrichment	SMARCA4	1.17
245	Cleft palate, isolated	Enrichment	SMARCA4	1.12
246	Polycystic kidney disease	Enrichment	HDAC8	1.09
247	Diamond-blackfan anemia 1	Enrichment	TP53	0.99
248	Non-syndromic x-linked intellectual disability	Enrichment	SMARCA1	0.81
249	Diamond-blackfan anemia	Enrichment	TP53	0.81
250	Autism spectrum disorder	Enrichment	SMARCB1	0.40

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

BRCA1 Pathway

Pathway Network for BRCA1 Pathway

Member Pathways for BRCA1 Pathway

Pathways in the BRCA1 Pathway SuperPath

Associated Genes for BRCA1 Pathway

Associated Disorders for BRCA1 Pathway

Disorders associated with BRCA1 Pathway SuperPath

STRING Interaction Network for BRCA1 Pathway

Sources for BRCA1 Pathway