Bupropion Pathway, Pharmacokinetics

No Pathway Network information available for Bupropion Pathway, Pharmacokinetics

#	Name	Source	Genes
1	Bupropion Pathway, Pharmacokinetics	PharmGKB	AKR1C1 AKR1C2 AKR1C3 AKR7A2 AKR7A3 CBR1 CYP2B6 CYP2C19 CYP2D6 HSD11B1 UGT1A3 UGT1A4 UGT1A9 UGT2B4 UGT2B7 (see all 15) (see less)
2	Oxcarbazepine Pathway, Pharmacokinetics	PharmGKB	AADAC ABCB1 ABCC2 AKR1C1 AKR1C2 AKR1C3 AKR1C4 CBR1 CBR3 UGT1A9 UGT2B7 (see all 11) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	UGT2B7	UDP Glucuronosyltransferase Family 2 Member B7	Protein Coding	2
2	UGT1A9	UDP Glucuronosyltransferase Family 1 Member A9	Protein Coding	2
3	CBR1	Carbonyl Reductase 1	Protein Coding	2
4	AKR1C3	Aldo-Keto Reductase Family 1 Member C3	Protein Coding	2
5	AKR1C1	Aldo-Keto Reductase Family 1 Member C1	Protein Coding	2
6	AKR1C2	Aldo-Keto Reductase Family 1 Member C2	Protein Coding	2
7	UGT2B4	UDP Glucuronosyltransferase Family 2 Member B4	Protein Coding	1
8	UGT1A4	UDP Glucuronosyltransferase Family 1 Member A4	Protein Coding	1
9	UGT1A3	UDP Glucuronosyltransferase Family 1 Member A3	Protein Coding	1
10	AKR7A2	Aldo-Keto Reductase Family 7 Member A2	Protein Coding	1
11	HSD11B1	Hydroxysteroid 11-Beta Dehydrogenase 1	Protein Coding	1
12	AKR7A3	Aldo-Keto Reductase Family 7 Member A3	Protein Coding	1
13	CYP2B6	Cytochrome P450 Family 2 Subfamily B Member 6	Protein Coding	1
14	CYP2C19	Cytochrome P450 Family 2 Subfamily C Member 19	Protein Coding	1
15	CYP2D6	Cytochrome P450 Family 2 Subfamily D Member 6 (Gene/Pseudogene)	Protein Coding	1
16	AKR1C4	Aldo-Keto Reductase Family 1 Member C4	Protein Coding	1
17	CBR3	Carbonyl Reductase 3	Protein Coding	1
18	ABCB1	ATP Binding Cassette Subfamily B Member 1	Protein Coding	1
19	ABCC2	ATP Binding Cassette Subfamily C Member 2	Protein Coding	1
20	AADAC	Arylacetamide Deacetylase	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Crigler-najjar syndrome, type i	Enrichment	UGT1A3, UGT1A4, UGT1A9	6.88
2	Hyperbilirubinemia, transient familial neonatal	Enrichment	UGT1A3, UGT1A4, UGT1A9	6.88
3	Bilirubin, serum level of, quantitative trait locus 1	Enrichment	UGT1A3, UGT1A4, UGT1A9	6.88
4	Crigler-najjar syndrome, type ii	Enrichment	UGT1A3, UGT1A4, UGT1A9	6.88
5	Gilbert syndrome	Enrichment	UGT1A3, UGT1A4, UGT1A9	6.75
6	Bilirubin metabolic disorder	Enrichment	UGT1A3, UGT1A4, UGT1A9	6.75
7	46,xy sex reversal 8	Enrichment	AKR1C2, AKR1C4	5.75
8	Colchicine resistance	Enrichment	ABCB1	3.09
9	Encephalopathy, acute transient	Enrichment	ABCB1	3.09
10	Inflammatory bowel disease 13	Enrichment	ABCB1	3.09
11	Drug metabolism, poor, cyp2c19-related	Enrichment	CYP2C19	2.96
12	Drug metabolism, poor, cyp2d6-related	Enrichment	CYP2D6	2.96
13	Efavirenz, poor metabolism of	Enrichment	CYP2B6	2.96
14	Cic-rearranged sarcoma	Enrichment	AKR1C2	2.79
15	Cortisone reductase deficiency 2	Enrichment	HSD11B1	2.66
16	Cortisone reductase deficiency	Enrichment	HSD11B1	2.66
17	Dubin-johnson syndrome	Enrichment	ABCC2	2.61
18	Developmental dysplasia of the hip 1	Enrichment	AKR1C1	2.31
19	Pseudoxanthoma elasticum	Enrichment	ABCC2	2.31
20	Epilepsy, idiopathic generalized	Enrichment	ABCB1	2.05

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Bupropion Pathway, Pharmacokinetics