Busulfan Pathway, Pharmacodynamics

Pathway network for the Busulfan Pathway, Pharmacodynamics SuperPath

Sources:

PharmGKB
WikiPathways
Reactome

Pathways in the Busulfan Pathway, Pharmacodynamics SuperPath

#	Name	Source	Genes
1	Busulfan Pathway, Pharmacodynamics	PharmGKB	APEX1 BAG3 BBC3 BCL2 BCL2L1 BCL2L10 BIK BIRC2 BNIP3 CDK1 CHEK2 CTH DPEP1 DPEP2 DPEP3 FMO1 FMO2 FMO3 FMO4 FMO5 GGT1 GGT2P GSTA1 GSTM1 GSTP1 LTBR MGMT MGST2 MLH1 MPG MSH2 MYC NAT1 NAT2 STAT3 XIAP (see all 36) (see less)
2	Catalytic cycle of mammalian flavin-containing monooxygenases (FMOs)	WikiPathways	FMO1 FMO2 FMO3 FMO4 FMO5
3	FMO oxidises nucleophiles	Reactome	FMO1 FMO2 FMO3
4	Defective FMO3 causes TMAU	Reactome	FMO3

Gene overlap in member pathways for Busulfan Pathway, Pharmacodynamics SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	FMO3	Flavin Containing Dimethylaniline Monoxygenase 3	Protein Coding	4
2	FMO2	Flavin Containing Dimethylaniline Monoxygenase 2	Protein Coding	3
3	FMO1	Flavin Containing Dimethylaniline Monoxygenase 1	Protein Coding	3
4	FMO4	Flavin Containing Dimethylaniline Monoxygenase 4	Protein Coding	2
5	FMO5	Flavin Containing Dimethylaniline Monoxygenase 5	Protein Coding	2
6	BIK	BCL2 Interacting Killer	Protein Coding	1
7	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
8	BCL2L1	BCL2 Like 1	Protein Coding	1
9	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
10	BNIP3	BCL2 Interacting Protein 3	Protein Coding	1
11	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
12	MGMT	O-6-Methylguanine-DNA Methyltransferase	Protein Coding	1
13	MGST2	Microsomal Glutathione S-Transferase 2	Protein Coding	1
14	MLH1	MutL Homolog 1	Protein Coding	1
15	CDK1	Cyclin Dependent Kinase 1	Protein Coding	1
16	NAT2	N-Acetyltransferase 2	Protein Coding	1
17	BCL2L10	BCL2 Like 10	Protein Coding	1
18	MSH2	MutS Homolog 2	Protein Coding	1
19	BIRC2	Baculoviral IAP Repeat Containing 2	Protein Coding	1
20	XIAP	X-Linked Inhibitor Of Apoptosis	Protein Coding	1
21	MPG	N-Methylpurine DNA Glycosylase	Protein Coding	1
22	LTBR	Lymphotoxin Beta Receptor	Protein Coding	1
23	GSTA1	Glutathione S-Transferase Alpha 1	Protein Coding	1
24	GSTM1	Glutathione S-Transferase Mu 1	Protein Coding	1
25	GSTP1	Glutathione S-Transferase Pi 1	Protein Coding	1
26	DPEP1	Dipeptidase 1	Protein Coding	1
27	CTH	Cystathionine Gamma-Lyase	Protein Coding	1
28	NAT1	N-Acetyltransferase 1	Protein Coding	1
29	CHEK2	Checkpoint Kinase 2	Protein Coding	1
30	BBC3	BCL2 Binding Component 3	Protein Coding	1
31	GGT1	Gamma-Glutamyltransferase 1	Protein Coding	1
32	BAG3	BAG Cochaperone 3	Protein Coding	1
33	APEX1	Apurinic/Apyrimidinic Endodeoxyribonuclease 1	Protein Coding	1
34	DPEP3	Dipeptidase 3	Protein Coding	1
35	DPEP2	Dipeptidase 2	Protein Coding	1
36	GGT2P	Gamma-Glutamyltransferase 2, Pseudogene	Pseudogene	1

Disorders associated with Busulfan Pathway, Pharmacodynamics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Inherited metabolic disorder	Direct
2	Lynch syndrome 1	Enrichment	CHEK2, MLH1, MSH2	5.69
3	Muir-torre syndrome	Enrichment	MLH1, MSH2	5.16
4	Lynch syndrome	Enrichment	CHEK2, MLH1, MSH2	5.12
5	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2, MYC	4.69
6	Endometrial cancer	Enrichment	CHEK2, MLH1, MSH2	4.66
7	Mismatch repair cancer syndrome 1	Enrichment	MLH1, MSH2	4.39
8	Gastric cancer	Enrichment	CHEK2, MLH1, MSH2	3.71
9	Hereditary breast carcinoma	Enrichment	CHEK2, MLH1, MSH2	3.68
10	Severe primary trimethylaminuria	Enrichment	FMO3	3.66
11	Colonic benign neoplasm	Enrichment	CHEK2, MLH1	3.61
12	Familial colorectal cancer	Enrichment	MLH1, MSH2	3.52
13	Uterine corpus cancer	Enrichment	CHEK2, MSH2	3.43
14	Hereditary breast ovarian cancer syndrome	Enrichment	CHEK2, MLH1, MSH2	3.39
15	Trimethylaminuria	Enrichment	FMO3	3.35
16	Primary trimethylaminuria	Enrichment	FMO3	3.35
17	Breast-ovarian cancer, familial 1	Enrichment	CHEK2, MSH2	3.28
18	Gliosarcoma	Enrichment	MGMT, MSH2	3.10
19	Giant cell glioblastoma	Enrichment	MGMT, MSH2	3.04
20	Breast cancer	Enrichment	CHEK2, MLH1, MSH2	2.99
21	Diffuse large b-cell lymphoma	Enrichment	CHEK2, STAT3	2.94
22	Colorectal cancer	Enrichment	CHEK2, MLH1, MSH2	2.81
23	Cystathioninuria	Enrichment	CTH	2.58
24	Acetylation, slow	Enrichment	NAT2	2.58
25	Lymphoproliferative syndrome, x-linked, 2	Enrichment	XIAP	2.58
26	Glutathionuria	Enrichment	GGT1	2.58
27	Cardiomyopathy, dilated, 1hh	Enrichment	BAG3	2.58
28	Lynch syndrome 2	Enrichment	MLH1	2.58
29	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.58
30	Tumor predisposition syndrome 4	Enrichment	CHEK2	2.58
31	Myopathy, myofibrillar, 6	Enrichment	BAG3	2.58
32	Mismatch repair cancer syndrome 2	Enrichment	MSH2	2.58
33	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.58
34	Leiomyosarcoma	Enrichment	CHEK2	2.58
35	Rectal benign neoplasm	Enrichment	MSH2	2.58
36	Charcot-marie-tooth disease, axonal, type 2jj	Enrichment	BAG3	2.58
37	Ascending colon cancer	Enrichment	MSH2	2.58
38	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.58
39	Ovarian cyst	Enrichment	MSH2	2.58
40	Neuronopathy, distal hereditary motor, autosomal dominant 15	Enrichment	BAG3	2.58
41	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.58
42	Lung cancer	Enrichment	CHEK2, MLH1	2.49
43	Inherited cancer-predisposing syndrome	Enrichment	CHEK2, MLH1, MSH2	2.29
44	Burkitt lymphoma	Enrichment	MYC	2.28
45	Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome	Enrichment	GGT2P	2.28
46	Congenital heart defects, multiple types, 3	Enrichment	CHEK2	2.28
47	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.28
48	Kala-azar 2	Enrichment	GSTP1	2.28
49	Li-fraumeni syndrome 1	Enrichment	CHEK2	2.28
50	Sarcoma	Enrichment	CHEK2	2.28
51	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.10
52	Osteogenic sarcoma	Enrichment	CHEK2	2.10
53	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	2.10
54	Hyper ige syndrome	Enrichment	STAT3	2.10
55	Cellular ependymoma	Enrichment	MSH2	2.10
56	Tanycytic ependymoma	Enrichment	MSH2	2.10
57	Papillary ependymoma	Enrichment	MSH2	2.10
58	Bone osteosarcoma	Enrichment	CHEK2	2.10
59	Clear cell ependymoma	Enrichment	MSH2	2.10
60	Lymphoproliferative syndrome 2	Enrichment	XIAP	1.98
61	Lynch syndrome 4	Enrichment	MSH2	1.98
62	Hemoglobin c disease	Enrichment	CHEK2	1.98
63	Benign ependymoma	Enrichment	MSH2	1.98
64	Follicular lymphoma	Enrichment	BCL2	1.88
65	Glioblastoma	Enrichment	MSH2	1.88
66	Li-fraumeni syndrome	Enrichment	CHEK2	1.80
67	Wilms tumor 5	Enrichment	CHEK2	1.80
68	Myocarditis	Enrichment	BAG3	1.68
69	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.68
70	Melanoma	Enrichment	CHEK2	1.58
71	Familial colorectal cancer type x	Enrichment	CHEK2	1.54
72	Ovarian cancer	Enrichment	CHEK2, MSH2	1.53
73	Acute promyelocytic leukemia	Enrichment	STAT3	1.47
74	Nk-cell enteropathy	Enrichment	CHEK2	1.47
75	Wilms tumor 1	Enrichment	CHEK2	1.41
76	Rhabdomyosarcoma	Enrichment	MSH2	1.38
77	Melanoma, cutaneous malignant 1	Enrichment	MGMT	1.35
78	Cardiomyopathy, dilated, 1a	Enrichment	BAG3	1.27
79	Hepatoblastoma	Enrichment	MSH2	1.27
80	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	1.23
81	Autoinflammatory disease	Enrichment	XIAP	1.21
82	Pancreatic cancer	Enrichment	CHEK2	1.19
83	Prostate cancer	Enrichment	CHEK2	1.13
84	Peripheral nervous system disease	Enrichment	BAG3	1.09
85	Neuropathy	Enrichment	BAG3	1.09
86	Familial isolated dilated cardiomyopathy	Enrichment	BAG3	0.88
87	Primary ovarian insufficiency	Enrichment	CHEK2	0.84
88	Dilated cardiomyopathy	Enrichment	BAG3	0.72

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Busulfan Pathway, Pharmacodynamics

Pathway Network for Busulfan Pathway, Pharmacodynamics

Pathway network for the Busulfan Pathway, Pharmacodynamics SuperPath

Member Pathways for Busulfan Pathway, Pharmacodynamics

Pathways in the Busulfan Pathway, Pharmacodynamics SuperPath

Gene overlap in member pathways for Busulfan Pathway, Pharmacodynamics SuperPath

Associated Genes for Busulfan Pathway, Pharmacodynamics

Associated Disorders for Busulfan Pathway, Pharmacodynamics

Disorders associated with Busulfan Pathway, Pharmacodynamics SuperPath

STRING Interaction Network for Busulfan Pathway, Pharmacodynamics

Sources for Busulfan Pathway, Pharmacodynamics