C-MYC pathway

No Pathway Network information available for C-MYC pathway

Pathways in the C-MYC pathway SuperPath

#	Name	Source	Genes
1	C-MYC pathway	PubChem	ACTL6A AXIN1 CDKN2A FBXW7 GSK3B HBP1 KAT2A KAT5 MAX MYC PAK2 PIN1 PML PPP2CA PPP2R5A RUVBL1 RUVBL2 SKP2 SUPT3H SUPT7L TAF10 TAF12 TAF9 TRRAP ZBTB17 (see all 25) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HBP1	HMG-Box Transcription Factor 1	Protein Coding	1
2	FBXW7	F-Box And WD Repeat Domain Containing 7	Protein Coding	1
3	PPP2R5A	Protein Phosphatase 2 Regulatory Subunit B''Alpha	Protein Coding	1
4	SUPT7L	SPT7 Like, STAGA Complex Subunit Gamma	Protein Coding	1
5	SUPT3H	SPT3 Homolog, SAGA And STAGA Complex Component	Protein Coding	1
6	KAT2A	Lysine Acetyltransferase 2A	Protein Coding	1
7	TAF9	TATA-Box Binding Protein Associated Factor 9	Protein Coding	1
8	TAF12	TATA-Box Binding Protein Associated Factor 12	Protein Coding	1
9	TAF10	TATA-Box Binding Protein Associated Factor 10	Protein Coding	1
10	ZBTB17	Zinc Finger And BTB Domain Containing 17	Protein Coding	1
11	RUVBL2	RuvB Like AAA ATPase 2	Protein Coding	1
12	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	1
13	MAX	MYC Associated Transcriptional Regulator X	Protein Coding	1
14	PIN1	Peptidylprolyl Cis/Trans Isomerase, NIMA-Interacting 1	Protein Coding	1
15	PML	PML Nuclear Body Scaffold	Protein Coding	1
16	TRRAP	Transformation/Transcription Domain Associated Protein	Protein Coding	1
17	AXIN1	Axin 1	Protein Coding	1
18	ACTL6A	Actin Like 6A	Protein Coding	1
19	RUVBL1	RuvB Like AAA ATPase 1	Protein Coding	1
20	KAT5	Lysine Acetyltransferase 5	Protein Coding	1
21	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	1
22	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
23	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	1
24	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
25	SKP2	S-Phase Kinase Associated Protein 2	Protein Coding	1

Disorders associated with C-MYC pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Precursor t-cell acute lymphoblastic leukemia	Enrichment	CDKN2A, MYC	3.09
2	Torticollis	Enrichment	ACTL6A	2.73
3	Caudal duplication anomaly	Enrichment	AXIN1	2.73
4	Knobloch syndrome 2	Enrichment	PAK2	2.73
5	Polydactyly-macrocephaly syndrome	Enrichment	MAX	2.73
6	Deafness, autosomal dominant 75	Enrichment	TRRAP	2.73
7	Developmental delay with or without dysmorphic facies and autism	Enrichment	TRRAP	2.73
8	Craniometadiaphyseal osteosclerosis with hip dysplasia	Enrichment	AXIN1	2.73
9	Developmental delay, hypotonia, and impaired language	Enrichment	FBXW7	2.73
10	Cdkn2a cancer predisposition	Enrichment	CDKN2A	2.73
11	Fischer-zirnsak progeroid syndrome	Enrichment	SUPT7L	2.73
12	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	2.43
13	Burkitt lymphoma	Enrichment	MYC	2.43
14	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	2.43
15	Neurodevelopmental disorder with dysmorphic facies, sleep disturbance, and brain abnormalities	Enrichment	KAT5	2.43
16	Immunodeficiency, common variable, 15	Enrichment	RUVBL1	2.43
17	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	2.43
18	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.43
19	Cleidocranial dysplasia 1	Enrichment	SUPT3H	2.26
20	Neurodevelopmental disorder with progressive spasticity and brain abnormalities	Enrichment	RUVBL1	2.26
21	Umbilical hernia	Enrichment	ACTL6A	2.26
22	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	2.26
23	Cleidocranial dysplasia	Enrichment	SUPT3H	2.26
24	Knobloch syndrome	Enrichment	PAK2	2.13
25	Knobloch syndrome 1	Enrichment	PAK2	2.04
26	Pervasive developmental disorder	Enrichment	FBXW7	2.04
27	Rare pervasive developmental disorder	Enrichment	FBXW7	2.04
28	Li-fraumeni syndrome	Enrichment	CDKN2A	1.96
29	Inguinal hernia	Enrichment	ACTL6A	1.96
30	Adrenocortical carcinoma	Enrichment	CDKN2A	1.96
31	Lung squamous cell carcinoma	Enrichment	CDKN2A	1.96
32	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	CDKN2A	1.89
33	Gastroesophageal reflux	Enrichment	ACTL6A	1.83
34	Adult hepatocellular carcinoma	Enrichment	AXIN1	1.78
35	Melanoma	Enrichment	CDKN2A	1.74
36	Leukemia, acute lymphoblastic	Enrichment	CDKN2A	1.70
37	Atrial heart septal defect	Enrichment	ACTL6A	1.70
38	Interatrial communication	Enrichment	ACTL6A	1.70
39	Complex neurodevelopmental disorder	Enrichment	ACTL6A, PPP2CA	1.66
40	Lip and oral cavity carcinoma	Enrichment	CDKN2A	1.66
41	Acute promyelocytic leukemia	Enrichment	PML	1.63
42	Inherited cancer-predisposing syndrome	Enrichment	CDKN2A, MAX	1.61
43	Pheochromocytoma	Enrichment	MAX	1.59
44	Melanoma, cutaneous malignant 1	Enrichment	CDKN2A	1.51
45	Polycystic liver disease	Enrichment	RUVBL1	1.51
46	Autosomal dominant polycystic liver disease	Enrichment	RUVBL1	1.51
47	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	MAX	1.42
48	Hepatocellular carcinoma	Enrichment	AXIN1	1.40
49	Pancreatic cancer	Enrichment	CDKN2A	1.35
50	Bladder cancer	Enrichment	CDKN2A	1.28
51	Gastric cancer	Enrichment	CDKN2A	1.12
52	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	TRRAP	1.04
53	Colorectal cancer	Enrichment	FBXW7	0.83
54	Ovarian cancer	Enrichment	CDKN2A	0.77

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for C-MYC pathway

Member Pathways for C-MYC pathway

Pathways in the C-MYC pathway SuperPath

Associated Genes for C-MYC pathway

Associated Disorders for C-MYC pathway

Disorders associated with C-MYC pathway SuperPath

STRING Interaction Network for C-MYC pathway

Sources for C-MYC pathway