Ca, cAMP and Lipid Signaling

No Pathway Network information available for Ca, cAMP and Lipid Signaling

Pathways in the Ca, cAMP and Lipid Signaling SuperPath

#	Name	Source	Genes
1	Ca, cAMP and Lipid Signaling	Cell Signaling Technology	ADRB1 ADRB2 AKAP1 AKAP5 ALB ALOX5 ANXA1 ANXA2 ANXA5 ANXA7 APOA1 APOA4 APOA5 APOE APOM ATP2A2 CALB1 CALM1 CALR CALU CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CAMLG CASR CD38 CFTR CHKA CNR1 CXCR5 DAGLA DAGLB GNA11 GNAI1 GNAO1 GNAQ GNAZ GNB3 GPR50 GRIA2 GRIA3 GRIA4 GRIN2A GRK3 GRM2 GSN HTR1A HTR4 INPP4B ITPR1 KISS1R MARCKS MCU MCUR1 MICU1 MTMR14 NCS1 NIPSNAP1 P2RX4 P2RX7 PCYT1A PDE4B PDE5A PIP4K2A PIP4K2B PIP5K1A PIP5K1C PKN1 PKN2 PLA2G1B PLA2G4A PLCB3 PLCG1 PLCG2 PLD1 PLD2 PLIN1 PLN PPP1R1B PRDX6 PREX1 PRKACA PRKAR1A PRKAR1B PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD2 PRKD3 RACK1 RAPGEF3 RAPGEF4 RYR1 S100A1 S100A4 S100A6 S100B S100P SAG SCGN SLC12A2 SMPD1 SMPD2 SPHK1 SPHK2 SSTR1 STIM1 STIM2 SYT1 TACSTD2 TGM2 TNNI3 TPT1 TRPV3 TSPO VDR WFS1 (see all 126) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HTR1A	5-Hydroxytryptamine Receptor 1A	Protein Coding	1
2	HTR4	5-Hydroxytryptamine Receptor 4	Protein Coding	1
3	ALOX5	Arachidonate 5-Lipoxygenase	Protein Coding	1
4	ADRB1	Adrenoceptor Beta 1	Protein Coding	1
5	ADRB2	Adrenoceptor Beta 2	Protein Coding	1
6	AKAP1	A-Kinase Anchoring Protein 1	Protein Coding	1
7	AKAP5	A-Kinase Anchoring Protein 5	Protein Coding	1
8	ALB	Albumin	Protein Coding	1
9	ANXA1	Annexin A1	Protein Coding	1
10	ANXA2	Annexin A2	Protein Coding	1
11	ANXA5	Annexin A5	Protein Coding	1
12	ANXA7	Annexin A7	Protein Coding	1
13	APOA1	Apolipoprotein A1	Protein Coding	1
14	APOA4	Apolipoprotein A4	Protein Coding	1
15	APOA5	Apolipoprotein A5	Protein Coding	1
16	APOE	Apolipoprotein E	Protein Coding	1
17	APOM	Apolipoprotein M	Protein Coding	1
18	CALB1	Calbindin 1	Protein Coding	1
19	CALM1	Calmodulin 1	Protein Coding	1
20	CALR	Calreticulin	Protein Coding	1
21	CALU	Calumenin	Protein Coding	1
22	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	1
23	CAMK2B	Calcium/Calmodulin Dependent Protein Kinase II Beta	Protein Coding	1
24	CAMK2D	Calcium/Calmodulin Dependent Protein Kinase II Delta	Protein Coding	1
25	CAMK2G	Calcium/Calmodulin Dependent Protein Kinase II Gamma	Protein Coding	1
26	CAMK4	Calcium/Calmodulin Dependent Protein Kinase IV	Protein Coding	1
27	CAMLG	Calcium Modulating Ligand	Protein Coding	1
28	CASR	Calcium Sensing Receptor	Protein Coding	1
29	CD38	CD38 Molecule	Protein Coding	1
30	CFTR	CF Transmembrane Conductance Regulator	Protein Coding	1
31	CHKA	Choline Kinase Alpha	Protein Coding	1
32	CNR1	Cannabinoid Receptor 1	Protein Coding	1
33	PLA2G4A	Phospholipase A2 Group IVA	Protein Coding	1
34	CXCR5	C-X-C Motif Chemokine Receptor 5	Protein Coding	1
35	DAGLB	Diacylglycerol Lipase Beta	Protein Coding	1
36	PPP1R1B	Protein Phosphatase 1 Regulatory Inhibitor Subunit 1B	Protein Coding	1
37	RAPGEF3	Rap Guanine Nucleotide Exchange Factor 3	Protein Coding	1
38	NCS1	Neuronal Calcium Sensor 1	Protein Coding	1
39	GNA11	G Protein Subunit Alpha 11	Protein Coding	1
40	GNAI1	G Protein Subunit Alpha I1	Protein Coding	1
41	GNAO1	G Protein Subunit Alpha O1	Protein Coding	1
42	GNAQ	G Protein Subunit Alpha Q	Protein Coding	1
43	GNAZ	G Protein Subunit Alpha Z	Protein Coding	1
44	GNB3	G Protein Subunit Beta 3	Protein Coding	1
45	GSN	Gelsolin	Protein Coding	1
46	GRIA2	Glutamate Ionotropic Receptor AMPA Type Subunit 2	Protein Coding	1
47	GRIA3	Glutamate Ionotropic Receptor AMPA Type Subunit 3	Protein Coding	1
48	GRIA4	Glutamate Ionotropic Receptor AMPA Type Subunit 4	Protein Coding	1
49	GPR50	G Protein-Coupled Receptor 50	Protein Coding	1
50	GRK3	G Protein-Coupled Receptor Kinase 3	Protein Coding	1
51	INPP4B	Inositol Polyphosphate-4-Phosphatase Type II B	Protein Coding	1
52	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	1
53	KISS1R	KISS1 Receptor	Protein Coding	1
54	MARCKS	Myristoylated Alanine Rich Protein Kinase C Substrate	Protein Coding	1
55	MCU	Mitochondrial Calcium Uniporter	Protein Coding	1
56	MCUR1	Mitochondrial Calcium Uniporter Regulator 1	Protein Coding	1
57	GRM2	Glutamate Metabotropic Receptor 2	Protein Coding	1
58	MICU1	Mitochondrial Calcium Uptake 1	Protein Coding	1
59	MTMR14	Myotubularin Related Protein 14	Protein Coding	1
60	NIPSNAP1	Nipsnap Homolog 1	Protein Coding	1
61	SLC12A2	Solute Carrier Family 12 Member 2	Protein Coding	1
62	GRIN2A	Glutamate Ionotropic Receptor NMDA Type Subunit 2A	Protein Coding	1
63	DAGLA	Diacylglycerol Lipase Alpha	Protein Coding	1
64	P2RX4	Purinergic Receptor P2X 4	Protein Coding	1
65	P2RX7	Purinergic Receptor P2X 7	Protein Coding	1
66	PCYT1A	Phosphate Cytidylyltransferase 1A, Choline	Protein Coding	1
67	PDE4B	Phosphodiesterase 4B	Protein Coding	1
68	PDE5A	Phosphodiesterase 5A	Protein Coding	1
69	PLIN1	Perilipin 1	Protein Coding	1
70	PIP4K2A	Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Alpha	Protein Coding	1
71	PIP4K2B	Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Beta	Protein Coding	1
72	PIP5K1A	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Alpha	Protein Coding	1
73	PIP5K1C	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Gamma	Protein Coding	1
74	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
75	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	1
76	PRKAR1B	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta	Protein Coding	1
77	PRKCA	Protein Kinase C Alpha	Protein Coding	1
78	PRKCB	Protein Kinase C Beta	Protein Coding	1
79	PRKCD	Protein Kinase C Delta	Protein Coding	1
80	PRKCE	Protein Kinase C Epsilon	Protein Coding	1
81	PRKCG	Protein Kinase C Gamma	Protein Coding	1
82	PRKCH	Protein Kinase C Eta	Protein Coding	1
83	PRKCI	Protein Kinase C Iota	Protein Coding	1
84	PRKCQ	Protein Kinase C Theta	Protein Coding	1
85	PRKCZ	Protein Kinase C Zeta	Protein Coding	1
86	PKN1	Protein Kinase N1	Protein Coding	1
87	PKN2	Protein Kinase N2	Protein Coding	1
88	PLA2G1B	Phospholipase A2 Group IB	Protein Coding	1
89	PLN	Phospholamban	Protein Coding	1
90	PLCB3	Phospholipase C Beta 3	Protein Coding	1
91	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
92	PLCG2	Phospholipase C Gamma 2	Protein Coding	1
93	PLD1	Phospholipase D1	Protein Coding	1
94	PLD2	Phospholipase D2	Protein Coding	1
95	PRDX6	Peroxiredoxin 6	Protein Coding	1
96	PREX1	Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1	Protein Coding	1
97	PRKD1	Protein Kinase D1	Protein Coding	1
98	PRKD2	Protein Kinase D2	Protein Coding	1
99	PRKD3	Protein Kinase D3	Protein Coding	1
100	RACK1	Receptor For Activated C Kinase 1	Protein Coding	1
101	RAPGEF4	Rap Guanine Nucleotide Exchange Factor 4	Protein Coding	1
102	RYR1	Ryanodine Receptor 1	Protein Coding	1
103	S100A1	S100 Calcium Binding Protein A1	Protein Coding	1
104	S100A4	S100 Calcium Binding Protein A4	Protein Coding	1
105	S100A6	S100 Calcium Binding Protein A6	Protein Coding	1
106	S100B	S100 Calcium Binding Protein B	Protein Coding	1
107	S100P	S100 Calcium Binding Protein P	Protein Coding	1
108	SAG	S-Antigen Visual Arrestin	Protein Coding	1
109	SCGN	Secretagogin, EF-Hand Calcium Binding Protein	Protein Coding	1
110	ATP2A2	ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 2	Protein Coding	1
111	SMPD1	Sphingomyelin Phosphodiesterase 1	Protein Coding	1
112	SMPD2	Sphingomyelin Phosphodiesterase 2	Protein Coding	1
113	SPHK1	Sphingosine Kinase 1	Protein Coding	1
114	SPHK2	Sphingosine Kinase 2	Protein Coding	1
115	SSTR1	Somatostatin Receptor 1	Protein Coding	1
116	STIM1	Stromal Interaction Molecule 1	Protein Coding	1
117	STIM2	Stromal Interaction Molecule 2	Protein Coding	1
118	SYT1	Synaptotagmin 1	Protein Coding	1
119	TACSTD2	Tumor Associated Calcium Signal Transducer 2	Protein Coding	1
120	TGM2	Transglutaminase 2	Protein Coding	1
121	TNNI3	Troponin I3, Cardiac Type	Protein Coding	1
122	TPT1	Tumor Protein, Translationally-Controlled 1	Protein Coding	1
123	TRPV3	Transient Receptor Potential Cation Channel Subfamily V Member 3	Protein Coding	1
124	TSPO	Translocator Protein	Protein Coding	1
125	VDR	Vitamin D Receptor	Protein Coding	1
126	WFS1	Wolframin ER Transmembrane Glycoprotein	Protein Coding	1

Disorders associated with Ca, cAMP and Lipid Signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Autosomal dominant hypocalcemia	Enrichment	CASR, GNA11	4.07
2	Phakomatosis cesioflammea	Enrichment	GNA11, GNAQ	4.07
3	Anastomosing haemangioma	Enrichment	GNA11, GNAQ	3.59
4	Capillary malformations, congenital	Enrichment	GNA11, GNAQ	3.08
5	Melanoma, uveal	Enrichment	GNA11, GNAQ	2.90
6	Myopathy, centronuclear, 1	Enrichment	MTMR14, RYR1	2.90
7	Hypertrophic cardiomyopathy	Enrichment	CASR, PLN, TNNI3	2.13
8	Precocious puberty, central, 1	Enrichment	KISS1R	2.03
9	Cataract 41	Enrichment	WFS1	2.03
10	Hypocalciuric hypercalcemia, familial, type ii	Enrichment	GNA11	2.03
11	Acrodysostosis 1 with or without hormone resistance	Enrichment	PRKAR1A	2.03
12	Epilepsy, focal, with speech disorder and with or without impaired intellectual development	Enrichment	GRIN2A	2.03
13	Sea-blue histiocyte disease	Enrichment	APOE	2.03
14	Wolfram syndrome 1	Enrichment	WFS1	2.03
15	Deafness, autosomal dominant 6	Enrichment	WFS1	2.03
16	Hypocalcemia, autosomal dominant 1	Enrichment	CASR	2.03
17	Cardiomyopathy, dilated, 2a	Enrichment	TNNI3	2.03
18	Carney complex, type 1	Enrichment	PRKAR1A	2.03
19	Resting heart rate, variation in	Enrichment	ADRB1	2.03
20	Hypocalciuric hypercalcemia, familial, type i	Enrichment	CASR	2.03
21	Cardiomyopathy, familial hypertrophic, 7	Enrichment	TNNI3	2.03
22	Amyloidosis, finnish type	Enrichment	GSN	2.03
23	Myopathy with extrapyramidal signs	Enrichment	MICU1	2.03
24	Lipoprotein glomerulopathy	Enrichment	APOE	2.03
25	Cardiac valvular dysplasia 1	Enrichment	PLD1	2.03
26	Hypogonadotropic hypogonadism 8 with or without anosmia	Enrichment	KISS1R	2.03
27	Corneal dystrophy, gelatinous drop-like	Enrichment	TACSTD2	2.03
28	Wolfram-like syndrome, autosomal dominant	Enrichment	WFS1	2.03
29	Neurodevelopmental disorder with involuntary movements	Enrichment	GNAO1	2.03
30	Hyperthyroxinemia, familial dysalbuminemic	Enrichment	ALB	2.03
31	Neuroocular syndrome 2, paroxysmal type	Enrichment	DAGLA	2.03
32	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.03
33	Sturge-weber syndrome	Enrichment	GNAQ	2.03
34	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	2.03
35	Neurodevelopmental disorder with microcephaly, movement abnormalities, and seizures	Enrichment	CHKA	2.03
36	Congenital disorder of glycosylation, type iiz	Enrichment	CAMLG	2.03
37	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	2.03
38	Intellectual developmental disorder, autosomal dominant 54	Enrichment	CAMK2B	2.03
39	Tubulointerstitial kidney disease, autosomal dominant 6	Enrichment	APOA4	2.03
40	Baker-gordon syndrome	Enrichment	SYT1	2.03
41	Intellectual developmental disorder, x-linked, syndromic, wu type	Enrichment	GRIA3	2.03
42	Delpire-mcneill syndrome	Enrichment	SLC12A2	2.03
43	Retinitis pigmentosa 47	Enrichment	SAG	2.03
44	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.03
45	Oguchi disease 1	Enrichment	SAG	2.03
46	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	2.03
47	Myxoma, intracardiac	Enrichment	PRKAR1A	2.03
48	Familial apolipoprotein a5 deficiency	Enrichment	APOA5	2.03
49	Immunodeficiency 10	Enrichment	STIM1	2.03
50	Developmental and epileptic encephalopathy 17	Enrichment	GNAO1	2.03
51	Spinocerebellar ataxia 14	Enrichment	PRKCG	2.03
52	Epilepsy, idiopathic generalized 8	Enrichment	CASR	2.03
53	Periodic fever, menstrual cycle-dependent	Enrichment	HTR1A	2.03
54	Olmsted syndrome 1	Enrichment	TRPV3	2.03
55	Cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder	Enrichment	PLA2G4A	2.03
56	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.03
57	Hypocalcemia, autosomal dominant 2	Enrichment	GNA11	2.03
58	Neurodevelopmental disorder with language impairment and behavioral abnormalities	Enrichment	GRIA2	2.03
59	Deafness, autosomal dominant 78	Enrichment	SLC12A2	2.03
60	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.03
61	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.03
62	Congenital heart defects and ectodermal dysplasia	Enrichment	PRKD1	2.03
63	Neurodevelopmental disorder with or without seizures and gait abnormalities	Enrichment	GRIA4	2.03
64	Kilquist syndrome	Enrichment	SLC12A2	2.03
65	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.03
66	Acid sphingomyelinase deficiency	Enrichment	SMPD1	2.03
67	Gastrointestinal ulceration, recurrent, with dysfunctional platelets	Enrichment	PLA2G4A	2.03
68	Palmoplantar keratoderma, nonepidermolytic, focal 2	Enrichment	TRPV3	2.03
69	Congenital analbuminemia	Enrichment	ALB	2.03
70	Short sleep, familial natural, 2	Enrichment	ADRB1	2.03
71	Retinitis pigmentosa 96	Enrichment	SAG	2.03
72	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	2.03
73	Intellectual developmental disorder, autosomal dominant 59	Enrichment	CAMK2G	2.03
74	Congenital myopathy with myasthenic-like onset	Enrichment	RYR1	2.03
75	Analbuminemia	Enrichment	ALB	2.03
76	Syndromic x-linked intellectual disability 94	Enrichment	GRIA3	2.03
77	Rickets	Enrichment	VDR	2.03
78	Hypercalcemia	Enrichment	CASR	2.03
79	Rhabdomyolysis 2	Enrichment	ATP2A2	2.03
80	Prkar1b-related neurodegenerative dementia with intermediate filaments	Enrichment	PRKAR1B	2.03
81	Wolfram-like syndrome	Enrichment	WFS1	2.03
82	Landau-kleffner syndrome	Enrichment	GRIN2A	2.03
83	Familial hypocalciuric hypercalcemia	Enrichment	CASR	2.03
84	Aquagenic palmoplantar keratoderma	Enrichment	CFTR	2.03
85	Atherosclerosis	Enrichment	ALOX5	2.03
86	Cryptogenic multifocal ulcerous stenosing enteritis	Enrichment	PLA2G4A	2.03
87	Gria2-related neurodevelopmental disorder	Enrichment	GRIA2	2.03
88	Early-onset epileptic encephalopathy and intellectual disability due to grin2a mutation	Enrichment	GRIN2A	2.03
89	Grin2a-related disorders	Enrichment	GRIN2A	2.03
90	Gnao1-related disorder	Enrichment	GNAO1	2.03
91	Phakomatosis cesiomarmorata	Enrichment	GNA11	2.03
92	Malignant epithelial tumor of salivary glands	Enrichment	PRKD1	2.03
93	Calf-predominant weakness-gastrocnemius medialis atrophy-distal myopathy	Enrichment	RYR1	2.03
94	Wfs1 spectrum disorder	Enrichment	WFS1	2.03
95	Benign samaritan congenital myopathy	Enrichment	RYR1	2.03
96	Pancreatitis, hereditary	Enrichment	CASR, CFTR	1.97
97	Sudden infant death syndrome	Enrichment	PLN, TNNI3	1.97
98	Spinocerebellar ataxia 29	Enrichment	ITPR1	1.73
99	Malignant hyperthermia 1	Enrichment	RYR1	1.73
100	Cardiomyopathy, familial restrictive, 1	Enrichment	TNNI3	1.73
101	Acrokeratosis verruciformis	Enrichment	ATP2A2	1.73
102	Hyperlipoproteinemia, type v	Enrichment	APOA5	1.73
103	Amelogenesis imperfecta, type ig	Enrichment	PRKAR1A	1.73
104	Cutis marmorata telangiectatica congenita	Enrichment	GNA11	1.73
105	Hyperparathyroidism, neonatal severe	Enrichment	CASR	1.73
106	Spermatogenic failure, y-linked, 2	Enrichment	CFTR	1.73
107	Stormorken syndrome	Enrichment	STIM1	1.73
108	Alzheimer disease 3	Enrichment	APOE	1.73
109	Lethal congenital contracture syndrome 3	Enrichment	PIP5K1C	1.73
110	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	PRKAR1A	1.73
111	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	1.73
112	Cardiomyopathy, dilated, 1p	Enrichment	PLN	1.73
113	Neutrophilia, hereditary	Enrichment	PIP4K2B	1.73
114	Cardiomyopathy, familial hypertrophic, 25	Enrichment	TNNI3	1.73
115	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	1.73
116	Spondylometaphyseal dysplasia with cone-rod dystrophy	Enrichment	PCYT1A	1.73
117	Neutropenia, severe congenital, 7, autosomal recessive	Enrichment	PIP4K2B	1.73
118	Cardiomyopathy, familial hypertrophic, 18	Enrichment	PLN	1.73
119	Palmoplantar keratoderma, nonepidermolytic, focal 1	Enrichment	TRPV3	1.73
120	Cardiomyopathy, dilated, 1ff	Enrichment	TNNI3	1.73
121	Long qt syndrome 14	Enrichment	CALM1	1.73
122	Oguchi disease 2	Enrichment	SAG	1.73
123	Encephalopathy, acute, infection-induced 10	Enrichment	TPT1	1.73
124	Marbach-schaaf neurodevelopmental syndrome	Enrichment	PRKAR1B	1.73
125	Usher syndrome, type iv	Enrichment	PRKAR1A	1.73
126	Hyperlipoproteinemia, type iii	Enrichment	APOE	1.73
127	Intellectual developmental disorder, autosomal dominant 21	Enrichment	GRIN2A	1.73
128	Central precocious puberty	Enrichment	KISS1R	1.73
129	King-denborough syndrome	Enrichment	RYR1	1.73
130	Acrodysostosis	Enrichment	PRKAR1A	1.73
131	Severe congenital neutropenia 7	Enrichment	PIP4K2B	1.73
132	Fibrolamellar carcinoma	Enrichment	PRKACA	1.73
133	Wolfram syndrome	Enrichment	WFS1	1.73
134	Intellectual developmental disorder, autosomal dominant 60, with seizures	Enrichment	PIP5K1A	1.73
135	Ciliary dyskinesia, primary, 18	Enrichment	PRKAR1B	1.73
136	B-lymphoblastic leukemia/lymphoma with hyperdiploidy	Enrichment	PIP4K2A	1.73
137	Hypoalphalipoproteinemia, primary, 2, intermediate	Enrichment	APOA1	1.73
138	Exercise-induced malignant hyperthermia	Enrichment	RYR1	1.73
139	Amyloidosis, hereditary systemic 3	Enrichment	APOA1	1.73
140	Lipodystrophy, congenital generalized, type 5	Enrichment	PCYT1A	1.73
141	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PRKAR1A	1.73
142	Rolandic epilepsy-speech dyspraxia syndrome	Enrichment	GRIN2A	1.73
143	Oguchi disease	Enrichment	SAG	1.73
144	Epilepsy-aphasia spectrum	Enrichment	GRIN2A	1.73
145	Congenital stationary night blindness	Enrichment	GNB3, SAG	1.72
146	Darier-white disease	Enrichment	ATP2A2	1.56
147	Thrombocythemia 1	Enrichment	CALR	1.56
148	Gillespie syndrome	Enrichment	ITPR1	1.56
149	Niemann-pick disease, type a	Enrichment	SMPD1	1.56
150	Nuchal bleb, familial	Enrichment	CFTR	1.56
151	Alzheimer disease 4	Enrichment	APOE	1.56
152	Niemann-pick disease, type b	Enrichment	SMPD1	1.56
153	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	GNA11	1.56
154	Lipodystrophy, familial partial, type 4	Enrichment	PLIN1	1.56
155	Lynch syndrome 5	Enrichment	RYR1	1.56
156	Hypoalphalipoproteinemia, primary, 2	Enrichment	APOA1	1.56
157	Ceroid lipofuscinosis, neuronal, 6a	Enrichment	SMPD1	1.56
158	Bronchopulmonary dysplasia	Enrichment	RYR1	1.56
159	Mutilating palmoplantar keratoderma with periorificial keratotic plaques	Enrichment	TRPV3	1.56
160	Intrinsic cardiomyopathy	Enrichment	PLN	1.56
161	Familial isolated hypoparathyroidism	Enrichment	CASR	1.56
162	Precocious puberty, central, 2	Enrichment	KISS1R	1.56
163	Parathyroid adenoma	Enrichment	CASR	1.56
164	Spastic paraplegia 50, autosomal recessive	Enrichment	APOA1	1.56
165	Ehlers-danlos syndrome, arthrochalasia type, 1	Enrichment	ALB	1.44
166	Congenital myopathy 1a, autosomal dominant, with malignant hyperthermia	Enrichment	RYR1	1.44
167	Hypertriglyceridemia 1	Enrichment	APOA5	1.44
168	Myopathy, centronuclear, 2	Enrichment	RYR1	1.44
169	Sacral defect with anterior meningocele	Enrichment	RYR1	1.44
170	Macular degeneration, age-related, 1	Enrichment	APOE	1.44
171	Budd-chiari syndrome	Enrichment	CALR	1.44
172	Hypoalphalipoproteinemia, primary, 1	Enrichment	APOA1	1.44
173	Carney complex variant	Enrichment	PRKAR1A	1.44
174	Myopathy, autophagic vacuolar, infantile-onset	Enrichment	STIM1	1.44
175	Spinocerebellar ataxia 15	Enrichment	ITPR1	1.44
176	Arrhythmogenic right ventricular dysplasia, familial, 10	Enrichment	PRKAR1A	1.44
177	Pregnancy loss, recurrent 3	Enrichment	ANXA5	1.44
178	Intellectual developmental disorder, autosomal dominant 26	Enrichment	RYR1	1.44
179	Hereditary ataxia	Enrichment	PRKCG	1.44
180	Congenital myopathy 1a	Enrichment	RYR1	1.44
181	Idiopathic bronchiectasis	Enrichment	CFTR	1.44
182	Malignant hyperthermia	Enrichment	RYR1	1.44
183	Primary hyperparathyroidism	Enrichment	CASR	1.44
184	Genetic central precocious puberty in male	Enrichment	KISS1R	1.44
185	Dystonia	Enrichment	CAMK2B, GRIA3	1.38
186	Developmental and epileptic encephalopathy	Enrichment	GNAO1, GRIA3	1.36
187	Alzheimer disease 2	Enrichment	APOE	1.34
188	Amyloidosis, hereditary systemic 2	Enrichment	APOA1	1.34
189	Niemann-pick disease, type c1	Enrichment	SMPD1	1.34
190	Congenital myopathy 1b, autosomal recessive	Enrichment	RYR1	1.34
191	Vitamin d-dependent rickets, type 2a	Enrichment	VDR	1.34
192	Cardiac arrest	Enrichment	PLN	1.34
193	Niemann-pick disease	Enrichment	SMPD1	1.34
194	Klippel-trenaunay-weber syndrome	Enrichment	GNAQ	1.26
195	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.26
196	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.26
197	Lipid metabolism disorder	Enrichment	APOE	1.26
198	Adrenocortical carcinoma	Enrichment	PRKAR1A	1.26
199	West syndrome	Enrichment	GNAO1, GRIA3	1.20
200	Myelofibrosis	Enrichment	CALR	1.20
201	Polymicrogyria, bilateral perisylvian, x-linked	Enrichment	WFS1	1.20
202	Essential thrombocythemia	Enrichment	CALR	1.20
203	Familial isolated restrictive cardiomyopathy	Enrichment	TNNI3	1.20
204	Myopathy, tubular aggregate, 1	Enrichment	STIM1	1.14
205	Multiple pterygium syndrome, lethal type	Enrichment	RYR1	1.14
206	Congenital muscular dystrophy	Enrichment	RYR1	1.14
207	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.14
208	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1	1.14
209	Myocarditis	Enrichment	TNNI3	1.14
210	Choreatic disease	Enrichment	GNAO1	1.14
211	Congenital nervous system abnormality	Enrichment	CAMK2B, GNAO1, MICU1	1.12
212	Nervous system disease	Enrichment	CAMK2B, GNAO1, MICU1	1.12
213	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A, CAMK2B	1.10
214	Cardiomyopathy, familial hypertrophic, 4	Enrichment	TNNI3	1.09
215	Bronchiectasis with or without elevated sweat chloride 1	Enrichment	CFTR	1.09
216	Vas deferens, congenital bilateral aplasia of	Enrichment	CFTR	1.09
217	Ellis-van creveld syndrome	Enrichment	PRKACA	1.09
218	Inflammatory bowel disease 1	Enrichment	PRKCQ	1.09
219	Arrhythmogenic right ventricular dysplasia, familial, 9	Enrichment	PLN	1.09
220	Bilateral perisylvian polymicrogyria	Enrichment	WFS1	1.09
221	Hypogonadotropic hypogonadism	Enrichment	KISS1R	1.09
222	Autosomal dominant cerebellar ataxia	Enrichment	DAGLA	1.09
223	Hydrops fetalis	Enrichment	RYR1	1.09
224	Spastic ataxia	Enrichment	ITPR1, WFS1	1.06
225	Familial isolated dilated cardiomyopathy	Enrichment	PLN, TNNI3	1.06
226	Leukemia, chronic lymphocytic	Enrichment	P2RX7	1.05
227	Stroke, ischemic	Enrichment	PRKCH	1.05
228	Asthma	Enrichment	ALOX5	1.01
229	Movement disease	Enrichment	GNAO1	1.01
230	Diabetes mellitus	Enrichment	WFS1	1.01
231	Cardiac conduction defect	Enrichment	PLN	0.97
232	Restrictive cardiomyopathy	Enrichment	TNNI3	0.97
233	Microcephaly	Enrichment	CAMK2B, CHKA, GNAO1	0.97
234	Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly	Enrichment	RYR1	0.94
235	Pulmonary disease, chronic obstructive	Enrichment	VDR	0.94
236	Acute promyelocytic leukemia	Enrichment	PRKAR1A	0.94
237	Alzheimer's disease	Enrichment	APOE	0.94
238	Clubfoot	Enrichment	RYR1	0.94
239	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	0.94
240	Multiple sclerosis	Enrichment	ITPR1	0.91
241	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	KISS1R	0.91
242	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	PLN	0.91
243	Pituitary stalk interruption syndrome	Enrichment	KISS1R	0.91
244	Hereditary chronic pancreatitis	Enrichment	CFTR	0.91
245	Congenital myopathy 4a, autosomal dominant	Enrichment	RYR1	0.88
246	Anterior segment dysgenesis	Enrichment	ITPR1	0.88
247	Familial hypercholesterolemia	Enrichment	APOE	0.88
248	Lynch syndrome	Enrichment	CFTR	0.88
249	Rare genetic intellectual disability	Enrichment	GNAO1	0.88
250	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	RYR1	0.86
251	Alzheimer disease, familial, 1	Enrichment	APOE	0.83
252	Hypertension, essential	Enrichment	GNB3	0.83
253	Syndromic intellectual disability	Enrichment	SYT1	0.83
254	Beckwith-wiedemann syndrome	Enrichment	RYR1	0.81
255	Neuromuscular disease	Enrichment	RYR1	0.81
256	Early infantile developmental and epileptic encephalopathy	Enrichment	GNAO1	0.81
257	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	KISS1R	0.81
258	Early-onset nuclear cataract	Enrichment	WFS1	0.81
259	Congenital myopathy	Enrichment	RYR1	0.79
260	Dilated cardiomyopathy	Enrichment	PLN, TNNI3	0.77
261	Cardiomyopathy, dilated, 1a	Enrichment	TNNI3	0.75
262	Centronuclear myopathy	Enrichment	RYR1	0.75
263	Hepatocellular carcinoma	Enrichment	VDR	0.73
264	Cardiomyopathy, familial hypertrophic, 1	Enrichment	TNNI3	0.70
265	Cone dystrophy	Enrichment	SAG	0.70
266	Scoliosis	Enrichment	RYR1	0.70
267	Developmental and epileptic encephalopathy 1	Enrichment	GNAO1	0.68
268	Long qt syndrome 1	Enrichment	CALM1	0.61
269	Long qt syndrome	Enrichment	CALM1	0.60
270	Cystic fibrosis	Enrichment	CFTR	0.59
271	Familial hypertrophic cardiomyopathy	Enrichment	TNNI3	0.58
272	Male infertility	Enrichment	CFTR	0.57
273	Left ventricular noncompaction	Enrichment	TNNI3	0.55
274	Non-syndromic genetic deafness	Enrichment	WFS1	0.54
275	Fetal akinesia deformation sequence 1	Enrichment	RYR1	0.53
276	Epilepsy	Enrichment	GRIN2A	0.51
277	Myopathy	Enrichment	RYR1	0.51
278	Benign epilepsy with centrotemporal spikes	Enrichment	GRIN2A	0.50
279	Type 2 diabetes mellitus	Enrichment	WFS1	0.49
280	Distal arthrogryposis	Enrichment	RYR1	0.49
281	Nonsyndromic hearing loss	Enrichment	WFS1	0.49
282	Centralopathic epilepsy	Enrichment	GRIN2A	0.48
283	Optic atrophy plus syndrome	Enrichment	WFS1	0.47
284	Sensorineural hearing loss	Enrichment	SLC12A2	0.44
285	Body mass index quantitative trait locus 11	Enrichment	GRIA4	0.43
286	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	WFS1	0.41
287	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	CFTR	0.39
288	Autosomal recessive non-syndromic intellectual disability	Enrichment	CHKA	0.38
289	Autism	Enrichment	CAMK2G	0.31
290	Primary ciliary dyskinesia	Enrichment	PRKAR1B	0.29
291	Rare genetic deafness	Enrichment	WFS1	0.28
292	Leber plus disease	Enrichment	PCYT1A	0.23
293	Complex neurodevelopmental disorder	Enrichment	GRIA4	0.16
294	Inherited cancer-predisposing syndrome	Enrichment	PRKAR1A	0.15
295	Hereditary retinal dystrophy	Enrichment	SAG, WFS1	0.12
296	Fundus dystrophy	Enrichment	SAG, WFS1	0.12
297	Retinitis pigmentosa	Enrichment	SAG	0.06

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Ca, cAMP and Lipid Signaling

Pathway Network for Ca, cAMP and Lipid Signaling

Member Pathways for Ca, cAMP and Lipid Signaling

Pathways in the Ca, cAMP and Lipid Signaling SuperPath

Associated Genes for Ca, cAMP and Lipid Signaling

Associated Disorders for Ca, cAMP and Lipid Signaling

Disorders associated with Ca, cAMP and Lipid Signaling SuperPath

STRING Interaction Network for Ca, cAMP and Lipid Signaling

Sources for Ca, cAMP and Lipid Signaling