Caffeine Pathway, Pharmacokinetics
Pathways in the Caffeine Pathway, Pharmacokinetics SuperPath
| # | Name | Source | Genes |
|---|---|---|---|
| 1 | Caffeine Pathway, Pharmacokinetics | PharmGKB | |
| 2 | Theophylline Pathway, Pharmacokinetics | PharmGKB | |
| 3 | Caffeine and theobromine metabolism | WikiPathways | |
| 4 | Halothane Pathway, Pharmacokinetics | PharmGKB | |
| 5 | Felbamate metabolism | WikiPathways |
Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways
| # | Symbol | Description | Category | # Related Pathways |
|---|---|---|---|---|
| 1 | CYP2E1 | Cytochrome P450 Family 2 Subfamily E Member 1 | Protein Coding | 4 |
| 2 | CYP3A4 | Cytochrome P450 Family 3 Subfamily A Member 4 | Protein Coding | 4 |
| 3 | XDH | Xanthine Dehydrogenase | Protein Coding | 3 |
| 4 | CYP1A2 | Cytochrome P450 Family 1 Subfamily A Member 2 | Protein Coding | 3 |
| 5 | CYP2A6 | Cytochrome P450 Family 2 Subfamily A Member 6 | Protein Coding | 3 |
| 6 | NAT2 | N-Acetyltransferase 2 | Protein Coding | 2 |
| 7 | CASP8 | Caspase 8 | Protein Coding | 1 |
Disorders associated with Caffeine Pathway, Pharmacokinetics SuperPath
according to GeneCards Suite gene sharing
| # | Disorder | Type | Genes | Score |
|---|---|---|---|---|
| 1 | Lung cancer | Enrichment | CASP8, CYP2A6 | 4.49 |
| 2 | Vitamin d-dependent rickets, type 3 | Enrichment | CYP3A4 | 3.83 |
| 3 | Acetylation, slow | Enrichment | NAT2 | 3.53 |
| 4 | Letrozole toxicity | Enrichment | CYP2A6 | 3.53 |
| 5 | Caspase 8 deficiency | Enrichment | CASP8 | 3.53 |
| 6 | Xanthinuria, type i | Enrichment | XDH | 3.23 |
| 7 | Xanthinuria, type ii | Enrichment | XDH | 3.05 |
| 8 | Coumarin resistance | Enrichment | CYP2A6 | 3.05 |
| 9 | Tobacco addiction | Enrichment | CYP2A6 | 2.93 |
| 10 | Adult hepatocellular carcinoma | Enrichment | CASP8 | 2.58 |
| 11 | Hepatocellular carcinoma | Enrichment | CASP8 | 2.19 |
| 12 | Breast cancer | Enrichment | CASP8 | 1.66 |
