Calcineurin-regulated NFAT-dependent transcription in lymphocytes

No Pathway Network information available for Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Pathways in the Calcineurin-regulated NFAT-dependent transcription in lymphocytes SuperPath

#	Name	Source	Genes
1	Calcineurin-regulated NFAT-dependent transcription in lymphocytes	PubChem	BATF3 CASP3 CBLB CD40LG CDK4 CSF2 CTLA4 CXCL8 DGKA E2F1 EGR1 EGR2 EGR3 EGR4 FASLG FOS FOSL1 FOXP3 GATA3 GBP3 IFNG IKZF1 IL2 IL2RA IL3 IL4 IL5 IRF4 ITCH JUN JUNB MAF NFATC1 NFATC2 POU2F1 PPARG PRKCQ PTGS2 PTPN1 PTPRK RNF128 SLC3A2 TBX21 TNF (see all 44) (see less)
2	Calcium signaling in the CD4+ TCR pathway	PubChem	AKAP5 BATF3 CABIN1 CD40LG CHP1 CSF2 FASLG FKBP1A FOS FOSL1 IFNG IL2 IL2RA IL3 IL4 JUN JUNB NFATC2 POU2F1 PRKACA PTGS2 RCAN1 RCAN2 (see all 23) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	FOSL1	FOS Like 1, AP-1 Transcription Factor Subunit	Protein Coding	2
2	BATF3	Basic Leucine Zipper ATF-Like Transcription Factor 3	Protein Coding	2
3	IL4	Interleukin 4	Protein Coding	2
4	CD40LG	CD40 Ligand	Protein Coding	2
5	CSF2	Colony Stimulating Factor 2	Protein Coding	2
6	IFNG	Interferon Gamma	Protein Coding	2
7	IL3	Interleukin 3	Protein Coding	2
8	IL2	Interleukin 2	Protein Coding	2
9	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	2
10	NFATC2	Nuclear Factor Of Activated T Cells 2	Protein Coding	2
11	FASLG	Fas Ligand	Protein Coding	2
12	POU2F1	POU Class 2 Homeobox 1	Protein Coding	2
13	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
14	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
15	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
16	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	2
17	GBP3	Guanylate Binding Protein 3	Protein Coding	1
18	EGR3	Early Growth Response 3	Protein Coding	1
19	IKZF1	IKAROS Family Zinc Finger 1	Protein Coding	1
20	EGR4	Early Growth Response 4	Protein Coding	1
21	TBX21	T-Box Transcription Factor 21	Protein Coding	1
22	CBLB	Cbl Proto-Oncogene B	Protein Coding	1
23	DGKA	Diacylglycerol Kinase Alpha	Protein Coding	1
24	IRF4	Interferon Regulatory Factor 4	Protein Coding	1
25	IL5	Interleukin 5	Protein Coding	1
26	MAF	MAF BZIP Transcription Factor	Protein Coding	1
27	FOXP3	Forkhead Box P3~Name Same As:- HGNC:13781	Protein Coding	1
28	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	1
29	RNF128	Ring Finger Protein 128	Protein Coding	1
30	EGR1	Early Growth Response 1	Protein Coding	1
31	GATA3	GATA Binding Protein 3	Protein Coding	1
32	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	1
33	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	1
34	PTPRK	Protein Tyrosine Phosphatase Receptor Type K	Protein Coding	1
35	ITCH	Itchy E3 Ubiquitin Protein Ligase	Protein Coding	1
36	E2F1	E2F Transcription Factor 1	Protein Coding	1
37	PTPN1	Protein Tyrosine Phosphatase Non-Receptor Type 1	Protein Coding	1
38	EGR2	Early Growth Response 2	Protein Coding	1
39	CDK4	Cyclin Dependent Kinase 4	Protein Coding	1
40	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	1
41	TNF	Tumor Necrosis Factor	Protein Coding	1
42	PRKCQ	Protein Kinase C Theta	Protein Coding	1
43	SLC3A2	Solute Carrier Family 3 Member 2	Protein Coding	1
44	CASP3	Caspase 3	Protein Coding	1
45	RCAN2	Regulator Of Calcineurin 2	Protein Coding	1
46	RCAN1	Regulator Of Calcineurin 1	Protein Coding	1
47	CABIN1	Calcineurin Binding Protein 1	Protein Coding	1
48	FKBP1A	FKBP Prolyl Isomerase 1A	Protein Coding	1
49	CHP1	Calcineurin Like EF-Hand Protein 1	Protein Coding	1
50	AKAP5	A-Kinase Anchoring Protein 5	Protein Coding	1
51	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1

Disorders associated with Calcineurin-regulated NFAT-dependent transcription in lymphocytes SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Congenital generalized lipodystrophy	Enrichment	FOS, PPARG	4.21
2	Type 1 diabetes mellitus 10	Enrichment	IL2RA	2.77
3	Immunodeficiency 69	Enrichment	IFNG	2.77
4	Immunodeficiency with hyper-igm, type 1	Enrichment	CD40LG	2.77
5	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.77
6	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.77
7	Spastic ataxia 9, autosomal recessive	Enrichment	CHP1	2.77
8	Cd40 ligand deficiency	Enrichment	CD40LG	2.77
9	Immunodysregulation, polyendocrinopathy, and enteropathy, x-linked	Enrichment	FOXP3	2.49
10	Cataract 21, multiple types	Enrichment	MAF	2.49
11	Charcot-marie-tooth disease, demyelinating, type 1d	Enrichment	EGR2	2.49
12	Melanoma, cutaneous malignant 3	Enrichment	CDK4	2.49
13	Skin/hair/eye pigmentation, variation in, 8	Enrichment	IRF4	2.49
14	Celiac disease 3	Enrichment	CTLA4	2.49
15	Immunodeficiency 131	Enrichment	IRF4	2.49
16	Type 1 diabetes mellitus 12	Enrichment	CTLA4	2.49
17	Ayme-gripp syndrome	Enrichment	MAF	2.49
18	Autoimmune disease, multisystem, with facial dysmorphism	Enrichment	ITCH	2.49
19	Immunodeficiency, common variable, 13	Enrichment	IKZF1	2.49
20	Immunodeficiency 88	Enrichment	TBX21	2.49
21	Pparg-associated congenital generalized lipodystrophy	Enrichment	PPARG	2.49
22	Combined immunodeficiency due to dimerization defective ikaros mutation	Enrichment	IKZF1	2.49
23	Syndromic multisystem autoimmune disease due to itch deficiency	Enrichment	ITCH	2.49
24	Charcot-marie-tooth disease type 1d	Enrichment	EGR2	2.49
25	Early-onset combined immunodeficiency with low ig due to dominant negative ikaros mutation	Enrichment	IKZF1	2.49
26	Whipple disease	Enrichment	IRF4	2.49
27	Immunodeficiency 41 with lymphoproliferation and autoimmunity	Enrichment	IL2RA	2.47
28	Fibrolamellar carcinoma	Enrichment	PRKACA	2.47
29	Joint contractures, osteochondromas, and b-cell lymphoma	Enrichment	NFATC2	2.47
30	Tuberous sclerosis 1	Enrichment	IFNG	2.29
31	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	FASLG	2.29
32	Hepatitis c virus	Enrichment	IFNG	2.29
33	Tuberous sclerosis 2	Enrichment	IFNG	2.29
34	Hashimoto thyroiditis	Enrichment	CTLA4	2.19
35	Hypoparathyroidism, sensorineural deafness, and renal dysplasia syndrome	Enrichment	GATA3	2.19
36	Multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly	Enrichment	FOXP3	2.19
37	Carotid intimal medial thickness 1	Enrichment	PPARG	2.19
38	Neuropathy, congenital hypomyelinating, 1, autosomal recessive	Enrichment	EGR2	2.19
39	Developmental and epileptic encephalopathy 28	Enrichment	MAF	2.19
40	Spinocerebellar ataxia, autosomal recessive 12	Enrichment	MAF	2.19
41	Diamond-blackfan anemia-like	Enrichment	IKZF1	2.19
42	Autoimmune disease, multisystem, infantile-onset, 3	Enrichment	CBLB	2.19
43	Immunodeficiency 127	Enrichment	TNF	2.19
44	Stevens-johnson syndrome	Enrichment	IKZF1	2.19
45	B-lymphoblastic leukemia/lymphoma with hyperdiploidy	Enrichment	GATA3	2.19
46	Hypoparathyroidism-deafness-renal disease syndrome	Enrichment	GATA3	2.19
47	Familial partial lipodystrophy	Enrichment	PPARG	2.19
48	Autosomal dominant nonsyndromic deafness	Enrichment	GATA3	2.19
49	Autoimmune lymphoproliferative syndrome	Enrichment	FASLG	2.17
50	Systemic lupus erythematosus	Enrichment	CTLA4, TNF	2.15
51	Breast cancer	Enrichment	IL2, JUN	2.15
52	Type 2 diabetes mellitus	Enrichment	PPARG, PTPN1	2.09
53	Histiocytoid hemangioma	Enrichment	FOS	2.07
54	Idiopathic aplastic anemia	Enrichment	IFNG	2.07
55	Asthma, nasal polyps, and aspirin intolerance	Enrichment	TBX21	2.01
56	Mycosis fungoides	Enrichment	CTLA4	2.01
57	Psoriatic arthritis	Enrichment	TNF	2.01
58	Immune dysregulation with autoimmunity, immunodeficiency, and lymphoproliferation	Enrichment	CTLA4	2.01
59	Dedifferentiated liposarcoma	Enrichment	CDK4	2.01
60	Asparagine synthetase deficiency	Enrichment	CTLA4	2.01
61	Migraine without aura	Enrichment	TNF	2.01
62	Charcot-marie-tooth disease type 1	Enrichment	EGR2	2.01
63	End stage renal disease	Enrichment	GATA3	2.01
64	Congenital microcephaly - severe encephalopathy - progressive cerebral atrophy syndrome	Enrichment	CTLA4	2.01
65	Adult-onset myasthenia gravis	Enrichment	CTLA4	2.01
66	Well-differentiated liposarcoma	Enrichment	CDK4	2.01
67	Saczary syndrome	Enrichment	CTLA4	2.01
68	Common variable immunodeficiency	Enrichment	CD40LG	1.93
69	Oligoarticular juvenile idiopathic arthritis	Enrichment	IL2RA	1.93
70	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	IL2RA	1.93
71	Lipodystrophy, familial partial, type 3	Enrichment	PPARG	1.89
72	Immunodeficiency, common variable, 1	Enrichment	CTLA4	1.89
73	Leptin deficiency or dysfunction	Enrichment	PPARG	1.89
74	Congenital blue dot cataract	Enrichment	MAF	1.89
75	Cerebral malaria	Enrichment	TNF	1.89
76	Ellis-van creveld syndrome	Enrichment	PRKACA	1.82
77	Hypertrophic neuropathy of dejerine-sottas	Enrichment	EGR2	1.79
78	Vascular dementia	Enrichment	TNF	1.79
79	Aplastic anemia	Enrichment	IFNG	1.77
80	Type 1 diabetes mellitus	Enrichment	FOXP3	1.71
81	Granulomatosis with polyangiitis	Enrichment	CTLA4	1.71
82	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	IKZF1	1.65
83	Cataract - microcornea syndrome	Enrichment	MAF	1.59
84	Inflammatory bowel disease 1	Enrichment	PRKCQ	1.54
85	Hydrops fetalis	Enrichment	FOXP3	1.54
86	Human immunodeficiency virus type 1	Enrichment	IFNG	1.52
87	Cataract 30, multiple types	Enrichment	MAF	1.50
88	Cardiomyopathy, dilated, 1a	Enrichment	NFATC2	1.46
89	Immune deficiency disease	Enrichment	IKZF1	1.45
90	Asthma	Enrichment	TNF	1.45
91	Leukemia, acute lymphoblastic	Enrichment	IKZF1	1.45
92	Alzheimer's disease	Enrichment	TNF	1.38
93	Gliosarcoma	Enrichment	PPARG	1.30
94	Lung cancer	Enrichment	FASLG	1.28
95	Melanoma, cutaneous malignant 1	Enrichment	CDK4	1.27
96	Giant cell glioblastoma	Enrichment	PPARG	1.27
97	Charcot-marie-tooth disease type 4	Enrichment	EGR2	1.25
98	Centronuclear myopathy	Enrichment	FOXP3	1.18
99	Malaria	Enrichment	TNF	1.14
100	Developmental and epileptic encephalopathy 1	Enrichment	MAF	1.11
101	Differentiated thyroid carcinoma	Enrichment	PPARG	1.05
102	Cakut	Enrichment	GATA3	0.98
103	Benign epilepsy with centrotemporal spikes	Enrichment	MAF	0.90
104	Centralopathic epilepsy	Enrichment	MAF	0.88
105	Gastric cancer	Enrichment	CDK4	0.88
106	West syndrome	Enrichment	MAF	0.87
107	Body mass index quantitative trait locus 11	Enrichment	PPARG	0.82
108	Colorectal cancer	Enrichment	PPARG	0.61
109	Inherited cancer-predisposing syndrome	Enrichment	CDK4	0.46

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Pathway Network for Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Member Pathways for Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Pathways in the Calcineurin-regulated NFAT-dependent transcription in lymphocytes SuperPath

Associated Genes for Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Associated Disorders for Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Disorders associated with Calcineurin-regulated NFAT-dependent transcription in lymphocytes SuperPath

STRING Interaction Network for Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Sources for Calcineurin-regulated NFAT-dependent transcription in lymphocytes