Calmodulin induced events

Pathway network for the Calmodulin induced events SuperPath

Sources:

Reactome
GeneGo (Thomson Reuters)

Pathways in the Calmodulin induced events SuperPath

#	Name	Source	Genes
1	Calmodulin induced events	Reactome	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CAMKK1 CAMKK2 CREB1 GRK2 KPNA2 NBEA PDE1A PDE1B PDE1C PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCG PRKX (see all 37) (see less)
2	Opioid Signalling	Reactome	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 AHCYL1 CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CAMKK1 CAMKK2 CDK5 CREB1 GNA11 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAL GNAQ GNAT3 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRK2 ITPR1 ITPR2 ITPR3 KPNA2 MAPK1 NBEA OPRM1 PDE1A PDE1B PDE1C PDE4A PDE4B PDE4C PDE4D PDYN PLA2G4A PLCB1 PLCB2 PLCB3 PLCB4 POMC PPP1CA PPP1R1B PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5D PPP3CA PPP3CB PPP3CC PPP3R1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCG PRKX (see all 92) (see less)
3	Signal transduction Calcium signaling	GeneGo (Thomson Reuters)	AKAP6 ARHGDIA ATP2A2 CALM1 CALM2 CALM3 CAMK1 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CAMKK1 CAMKK2 CD44 CREB1 EZR FKBP1A GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 HDAC4 HDAC5 HDAC7 ITPR1 ITPR2 ITPR3 MEF2A MEF2B MEF2C MEF2D NFATC2 PLCB1 PLCB2 PLCB3 PLCB4 PLN PPP1CA PPP1CB PPP1CC PPP2CA PPP2CB PPP3CA PPP3CB PPP3CC PRKACA PRKACB PRKACG PRKCA PRKCB PRKCG RCAN1 RHOA ROCK2 RYR1 SLC8A1 (see all 70) (see less)
4	G-protein mediated events	Reactome	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 AHCYL1 CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CAMKK1 CAMKK2 CREB1 GNA11 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAL GNAQ GNAT3 GRK2 ITPR1 ITPR2 ITPR3 KPNA2 MAPK1 NBEA PDE1A PDE1B PDE1C PLA2G4A PLCB1 PLCB2 PLCB3 PLCB4 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCG PRKX (see all 56) (see less)
5	PLC beta mediated events	Reactome	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 AHCYL1 CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CAMKK1 CAMKK2 CREB1 GNA11 GNA14 GNA15 GNAQ GRK2 ITPR1 ITPR2 ITPR3 KPNA2 MAPK1 NBEA PDE1A PDE1B PDE1C PLA2G4A PLCB1 PLCB2 PLCB3 PLCB4 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCG PRKX (see all 51) (see less)
6	DAG and IP3 signaling	Reactome	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 AHCYL1 CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CAMKK1 CAMKK2 CREB1 GRK2 ITPR1 ITPR2 ITPR3 KPNA2 NBEA PDE1A PDE1B PDE1C PLCG1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCE PRKCG PRKX (see all 43) (see less)
7	Ca-dependent events	Reactome	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CAMKK1 CAMKK2 CREB1 GRK2 KPNA2 MAPK1 NBEA PDE1A PDE1B PDE1C PLA2G4A PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCG PRKX (see all 39) (see less)
8	CaM pathway	Reactome	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CAMKK1 CAMKK2 CREB1 GRK2 KPNA2 NBEA PDE1A PDE1B PDE1C PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCD PRKCG PRKX (see all 37) (see less)
9	CaMK IV-mediated phosphorylation of CREB	Reactome	CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G CAMK4 CAMKK1 CAMKK2 CREB1 KPNA2 (see all 12) (see less)
10	CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde	Reactome	CALM1 CALM2 CALM3 CAMK2B CAMK2G CAMK4 CAMKK1 CAMKK2 CREB1 KPNA2 (see all 10) (see less)
11	Cam-PDE 1 activation	Reactome	CALM1 CALM2 CALM3 PDE1A PDE1B PDE1C (see all 6) (see less)

Gene overlap in member pathways for Calmodulin induced events SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CALM1	Calmodulin 1	Protein Coding	11
2	CALM2	Calmodulin 2	Protein Coding	11
3	CALM3	Calmodulin 3	Protein Coding	11
4	CAMKK2	Calcium/Calmodulin Dependent Protein Kinase Kinase 2	Protein Coding	10
5	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	10
6	CAMK4	Calcium/Calmodulin Dependent Protein Kinase IV	Protein Coding	10
7	CAMK2B	Calcium/Calmodulin Dependent Protein Kinase II Beta	Protein Coding	10
8	CAMK2G	Calcium/Calmodulin Dependent Protein Kinase II Gamma	Protein Coding	10
9	CAMKK1	Calcium/Calmodulin Dependent Protein Kinase Kinase 1	Protein Coding	10
10	KPNA2	Karyopherin Subunit Alpha 2	Protein Coding	9
11	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	9
12	CAMK2D	Calcium/Calmodulin Dependent Protein Kinase II Delta	Protein Coding	9
13	PDE1A	Phosphodiesterase 1A	Protein Coding	8
14	PDE1C	Phosphodiesterase 1C	Protein Coding	8
15	PDE1B	Phosphodiesterase 1B	Protein Coding	8
16	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	8
17	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	8
18	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	8
19	PRKCA	Protein Kinase C Alpha	Protein Coding	8
20	PRKCG	Protein Kinase C Gamma	Protein Coding	8
21	ADCY1	Adenylate Cyclase 1	Protein Coding	7
22	ADCY2	Adenylate Cyclase 2	Protein Coding	7
23	ADCY3	Adenylate Cyclase 3	Protein Coding	7
24	ADCY5	Adenylate Cyclase 5	Protein Coding	7
25	ADCY6	Adenylate Cyclase 6	Protein Coding	7
26	ADCY7	Adenylate Cyclase 7	Protein Coding	7
27	ADCY8	Adenylate Cyclase 8	Protein Coding	7
28	ADCY9	Adenylate Cyclase 9	Protein Coding	7
29	GRK2	G Protein-Coupled Receptor Kinase 2	Protein Coding	7
30	ADCY4	Adenylate Cyclase 4	Protein Coding	7
31	NBEA	Neurobeachin	Protein Coding	7
32	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	7
33	PRKAR1B	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta	Protein Coding	7
34	PRKAR2A	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Alpha	Protein Coding	7
35	PRKAR2B	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Beta	Protein Coding	7
36	PRKCD	Protein Kinase C Delta	Protein Coding	7
37	PRKX	Protein Kinase CAMP-Dependent X-Linked Catalytic Subunit	Protein Coding	7
38	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	5
39	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	5
40	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	5
41	AHCYL1	Adenosylhomocysteinase Like 1	Protein Coding	4
42	PLCB1	Phospholipase C Beta 1	Protein Coding	4
43	PLA2G4A	Phospholipase A2 Group IVA	Protein Coding	4
44	PLCB2	Phospholipase C Beta 2	Protein Coding	4
45	PLCB3	Phospholipase C Beta 3	Protein Coding	4
46	PLCB4	Phospholipase C Beta 4	Protein Coding	4
47	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	4
48	GNA11	G Protein Subunit Alpha 11	Protein Coding	3
49	GNA15	G Protein Subunit Alpha 15	Protein Coding	3
50	GNAQ	G Protein Subunit Alpha Q	Protein Coding	3
51	GNA14	G Protein Subunit Alpha 14	Protein Coding	3
52	GNB5	G Protein Subunit Beta 5	Protein Coding	2
53	GNAI1	G Protein Subunit Alpha I1	Protein Coding	2
54	GNAI2	G Protein Subunit Alpha I2	Protein Coding	2
55	GNAI3	G Protein Subunit Alpha I3	Protein Coding	2
56	GNAL	G Protein Subunit Alpha L	Protein Coding	2
57	GNB1	G Protein Subunit Beta 1	Protein Coding	2
58	GNB2	G Protein Subunit Beta 2	Protein Coding	2
59	GNB3	G Protein Subunit Beta 3	Protein Coding	2
60	GNG3	G Protein Subunit Gamma 3	Protein Coding	2
61	GNG4	G Protein Subunit Gamma 4	Protein Coding	2
62	GNG5	G Protein Subunit Gamma 5	Protein Coding	2
63	GNG7	G Protein Subunit Gamma 7	Protein Coding	2
64	GNG10	G Protein Subunit Gamma 10	Protein Coding	2
65	GNG11	G Protein Subunit Gamma 11	Protein Coding	2
66	GNGT1	G Protein Subunit Gamma Transducin 1	Protein Coding	2
67	GNGT2	G Protein Subunit Gamma Transducin 2	Protein Coding	2
68	GNAT3	G Protein Subunit Alpha Transducin 3	Protein Coding	2
69	GNG13	G Protein Subunit Gamma 13	Protein Coding	2
70	GNG2	G Protein Subunit Gamma 2	Protein Coding	2
71	PPP1CA	Protein Phosphatase 1 Catalytic Subunit Alpha	Protein Coding	2
72	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	2
73	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	2
74	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	2
75	PPP3CB	Protein Phosphatase 3 Catalytic Subunit Beta	Protein Coding	2
76	PPP3CC	Protein Phosphatase 3 Catalytic Subunit Gamma	Protein Coding	2
77	GNG12	G Protein Subunit Gamma 12	Protein Coding	2
78	GNB4	G Protein Subunit Beta 4	Protein Coding	2
79	GNG8	G Protein Subunit Gamma 8	Protein Coding	2
80	CDK5	Cyclin Dependent Kinase 5	Protein Coding	1
81	OPRM1	Opioid Receptor Mu 1	Protein Coding	1
82	PDE4A	Phosphodiesterase 4A	Protein Coding	1
83	PDE4B	Phosphodiesterase 4B	Protein Coding	1
84	PDE4C	Phosphodiesterase 4C	Protein Coding	1
85	PDE4D	Phosphodiesterase 4D	Protein Coding	1
86	PDYN	Prodynorphin	Protein Coding	1
87	POMC	Proopiomelanocortin	Protein Coding	1
88	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	1
89	PPP2R1B	Protein Phosphatase 2 Scaffold Subunit Abeta	Protein Coding	1
90	PPP2R5D	Protein Phosphatase 2 Regulatory Subunit B''Delta	Protein Coding	1
91	PPP3R1	Protein Phosphatase 3 Regulatory Subunit B, Alpha	Protein Coding	1
92	PPP1R1B	Protein Phosphatase 1 Regulatory Inhibitor Subunit 1B	Protein Coding	1
93	RHOA	Ras Homolog Family Member A	Protein Coding	1
94	ARHGDIA	Rho GDP Dissociation Inhibitor Alpha	Protein Coding	1
95	ATP2A2	ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 2	Protein Coding	1
96	CD44	CD44 Molecule (IN Blood Group)	Protein Coding	1
97	RCAN1	Regulator Of Calcineurin 1	Protein Coding	1
98	FKBP1A	FKBP Prolyl Isomerase 1A	Protein Coding	1
99	MEF2A	Myocyte Enhancer Factor 2A	Protein Coding	1
100	MEF2C	Myocyte Enhancer Factor 2C	Protein Coding	1
101	MEF2D	Myocyte Enhancer Factor 2D	Protein Coding	1
102	NFATC2	Nuclear Factor Of Activated T Cells 2	Protein Coding	1
103	PLN	Phospholamban	Protein Coding	1
104	PPP1CB	Protein Phosphatase 1 Catalytic Subunit Beta	Protein Coding	1
105	PPP1CC	Protein Phosphatase 1 Catalytic Subunit Gamma	Protein Coding	1
106	PRKCB	Protein Kinase C Beta	Protein Coding	1
107	RYR1	Ryanodine Receptor 1	Protein Coding	1
108	SLC8A1	Solute Carrier Family 8 Member A1	Protein Coding	1
109	EZR	Ezrin	Protein Coding	1
110	CAMK1	Calcium/Calmodulin Dependent Protein Kinase I	Protein Coding	1
111	AKAP6	A-Kinase Anchoring Protein 6	Protein Coding	1
112	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	1
113	HDAC4	Histone Deacetylase 4	Protein Coding	1
114	HDAC5	Histone Deacetylase 5	Protein Coding	1
115	HDAC7	Histone Deacetylase 7	Protein Coding	1
116	MEF2B	Myocyte Enhancer Factor 2B	Protein Coding	1
117	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
118	PRKCE	Protein Kinase C Epsilon	Protein Coding	1

Disorders associated with Calmodulin induced events SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	8.56
2	Anastomosing haemangioma	Enrichment	GNA11, GNA14, GNAQ	7.30
3	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3	6.71
4	Melanoma, uveal	Enrichment	GNA11, GNAQ, PLCB4	6.00
5	Phakomatosis cesioflammea	Enrichment	GNA11, GNAQ	4.86
6	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A, CAMK2B, GNB1, NBEA, PPP3CA	4.67
7	Acrodysostosis	Enrichment	PDE4D, PRKAR1A	4.34
8	Long qt syndrome	Enrichment	CALM1, CALM2	4.12
9	Auriculocondylar syndrome 1	Enrichment	GNAI3, PLCB4	4.00
10	Capillary malformations, congenital	Enrichment	GNA11, GNAQ	3.86
11	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	3.59
12	Long qt syndrome 16	Enrichment	CALM3	3.35
13	Deafness, autosomal dominant 74	Enrichment	PDE1C	3.35
14	Long qt syndrome 15	Enrichment	CALM2	3.35
15	Intellectual developmental disorder, autosomal dominant 54	Enrichment	CAMK2B	3.13
16	Intellectual developmental disorder, autosomal dominant 59	Enrichment	CAMK2G	3.13
17	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	3.05
18	Long qt syndrome 14	Enrichment	CALM1	3.05
19	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	3.05
20	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	3.05
21	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.83
22	Dystonia	Enrichment	CAMK2B, GNAL, GNB1	2.77
23	Melanoma of soft tissue	Enrichment	CREB1	2.66
24	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	2.58
25	Acrodysostosis 1 with or without hormone resistance	Enrichment	PRKAR1A	2.56
26	Carney complex, type 1	Enrichment	PRKAR1A	2.56
27	Dyskinesia with orofacial involvement, autosomal dominant	Enrichment	ADCY5	2.56
28	Deafness, autosomal recessive 44	Enrichment	ADCY1	2.56
29	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.56
30	Neurodevelopmental disorder with hyperkinetic movements and dyskinesia	Enrichment	ADCY5	2.56
31	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.56
32	Myxoma, intracardiac	Enrichment	PRKAR1A	2.56
33	Neurodevelopmental disorder with or without early-onset generalized epilepsy	Enrichment	NBEA	2.56
34	Dyskinesia with orofacial involvement, autosomal recessive	Enrichment	ADCY5	2.56
35	Spinocerebellar ataxia 14	Enrichment	PRKCG	2.56
36	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.56
37	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.56
38	Prkar1b-related neurodegenerative dementia with intermediate filaments	Enrichment	PRKAR1B	2.56
39	Noonan syndrome 13	Enrichment	MAPK1	2.54
40	Cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder	Enrichment	PLA2G4A	2.54
41	Gastrointestinal ulceration, recurrent, with dysfunctional platelets	Enrichment	PLA2G4A	2.54
42	Cryptogenic multifocal ulcerous stenosing enteritis	Enrichment	PLA2G4A	2.54
43	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	2.50
44	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	2.50
45	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.50
46	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	2.50
47	Sudden infant death syndrome	Enrichment	CALM2, PLN	2.47
48	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	2.45
49	Hypocalciuric hypercalcemia, familial, type ii	Enrichment	GNA11	2.42
50	Sturge-weber syndrome	Enrichment	GNAQ	2.42
51	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	2.42
52	Auriculocondylar syndrome 2a	Enrichment	PLCB4	2.42
53	Hypocalcemia, autosomal dominant 2	Enrichment	GNA11	2.42
54	Auriculocondylar syndrome 2b	Enrichment	PLCB4	2.42
55	Phakomatosis cesiomarmorata	Enrichment	GNA11	2.42
56	Kaposiform hemangioendothelioma	Enrichment	GNA14	2.42
57	Ventricular tachycardia, familial	Enrichment	GNAI2	2.38
58	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	2.38
59	Dystonia 25	Enrichment	GNAL	2.38
60	Nephrotic syndrome, type 8	Enrichment	ARHGDIA	2.29
61	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Enrichment	GNB2	2.29
62	Chromosome 2q37 deletion syndrome	Enrichment	HDAC4	2.29
63	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	2.29
64	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	2.29
65	Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language	Enrichment	MEF2C	2.29
66	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	2.29
67	Coronary artery disease, autosomal dominant, 1	Enrichment	MEF2A	2.29
68	Charcot-marie-tooth disease, dominant intermediate f	Enrichment	GNB4	2.29
69	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.29
70	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.29
71	Noonan syndrome-like disorder with loose anagen hair 2	Enrichment	PPP1CB	2.29
72	Sick sinus syndrome 4	Enrichment	GNB2	2.29
73	Neurodevelopmental disorder with central hypotonia and dysmorphic facies	Enrichment	HDAC4	2.29
74	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.29
75	Congenital myopathy with myasthenic-like onset	Enrichment	RYR1	2.29
76	Rhabdomyolysis 2	Enrichment	ATP2A2	2.29
77	5q14.3 microdeletion syndrome	Enrichment	MEF2C	2.29
78	Complete atrioventricular septal defect without ventricular hypoplasia	Enrichment	MEF2C	2.29
79	Mef2c-related disorder	Enrichment	MEF2C	2.29
80	Calf-predominant weakness-gastrocnemius medialis atrophy-distal myopathy	Enrichment	RYR1	2.29
81	Benign samaritan congenital myopathy	Enrichment	RYR1	2.29
82	Amelogenesis imperfecta, type ig	Enrichment	PRKAR1A	2.26
83	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	PRKAR1A	2.26
84	Lethal congenital contracture syndrome 8	Enrichment	ADCY6	2.26
85	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	2.26
86	Marbach-schaaf neurodevelopmental syndrome	Enrichment	PRKAR1B	2.26
87	Cerebellar, ocular, craniofacial, and genital syndrome	Enrichment	NBEA	2.26
88	Usher syndrome, type iv	Enrichment	PRKAR1A	2.26
89	Body mass index quantitative trait locus 19	Enrichment	ADCY3	2.26
90	Fibrolamellar carcinoma	Enrichment	PRKACA	2.26
91	Ciliary dyskinesia, primary, 18	Enrichment	PRKAR1B	2.26
92	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PRKAR1A	2.26
93	Spinocerebellar ataxia 29	Enrichment	ITPR1	2.20
94	Lissencephaly 7 with cerebellar hypoplasia	Enrichment	CDK5	2.17
95	Houge-janssens syndrome 2	Enrichment	PPP2R1A	2.17
96	Acrodysostosis 2 with or without hormone resistance	Enrichment	PDE4D	2.17
97	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	2.17
98	Cutis marmorata telangiectatica congenita	Enrichment	GNA11	2.12
99	Angioma, tufted	Enrichment	GNA14	2.12
100	Autosomal dominant hypocalcemia	Enrichment	GNA11	2.12
101	Ocular melanoma	Enrichment	PLCB4	2.12
102	Hypomyelination neuropathy-arthrogryposis syndrome	Enrichment	ADCY6	2.09
103	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	2.08
104	Hypopituitarism	Enrichment	GNAI2	2.08
105	Gillespie syndrome	Enrichment	ITPR1	2.02
106	Malignant hyperthermia 1	Enrichment	RYR1	1.99
107	Acrokeratosis verruciformis	Enrichment	ATP2A2	1.99
108	Cardiomyopathy, dilated, 1p	Enrichment	PLN	1.99
109	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	1.99
110	Cardiomyopathy, familial hypertrophic, 18	Enrichment	PLN	1.99
111	Noonan syndrome-like disorder with loose anagen hair	Enrichment	PPP1CB	1.99
112	King-denborough syndrome	Enrichment	RYR1	1.99
113	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	1.99
114	Houge-janssens syndrome 3	Enrichment	PPP2CA	1.99
115	Exercise-induced malignant hyperthermia	Enrichment	RYR1	1.99
116	Joint contractures, osteochondromas, and b-cell lymphoma	Enrichment	NFATC2	1.99
117	Cerebral visual impairment	Enrichment	GNB1	1.99
118	Chorea, benign hereditary	Enrichment	ADCY5	1.96
119	Carney complex variant	Enrichment	PRKAR1A	1.96
120	Arrhythmogenic right ventricular dysplasia, familial, 10	Enrichment	PRKAR1A	1.96
121	Hereditary ataxia	Enrichment	PRKCG	1.96
122	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	GNA11	1.95
123	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.94
124	Spinocerebellar ataxia 15	Enrichment	ITPR1	1.90
125	Chromosome 5q12 deletion syndrome	Enrichment	PDE4D	1.87
126	Spinocerebellar ataxia 23	Enrichment	PDYN	1.87
127	Houge-janssens syndrome 1	Enrichment	PPP2R5D	1.87
128	Developmental and epileptic encephalopathy 12	Enrichment	PLCB1	1.83
129	Darier-white disease	Enrichment	ATP2A2	1.81
130	Lynch syndrome 5	Enrichment	RYR1	1.81
131	Bronchopulmonary dysplasia	Enrichment	RYR1	1.81
132	Intrinsic cardiomyopathy	Enrichment	PLN	1.81
133	Adrenocortical carcinoma	Enrichment	PRKAR1A	1.79
134	Achromatopsia 4	Enrichment	GNAI3	1.78
135	Autism	Enrichment	CAMK2G, NBEA	1.78
136	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.72
137	Obesity, early-onset, with adrenal insufficiency and red hair	Enrichment	POMC	1.69
138	Obesity due to pro-opiomelanocortin deficiency	Enrichment	POMC	1.69
139	Congenital myopathy 1a, autosomal dominant, with malignant hyperthermia	Enrichment	RYR1	1.69
140	Spastic paraplegia 17, autosomal dominant	Enrichment	GNG3	1.69
141	Myopathy, centronuclear, 2	Enrichment	RYR1	1.69
142	Sacral defect with anterior meningocele	Enrichment	RYR1	1.69
143	Lipodystrophy, congenital generalized, type 2	Enrichment	GNG3	1.69
144	Intellectual developmental disorder, autosomal dominant 26	Enrichment	RYR1	1.69
145	Congenital myopathy 1a	Enrichment	RYR1	1.69
146	Malignant hyperthermia	Enrichment	RYR1	1.69
147	Familial sick sinus syndrome	Enrichment	GNB2	1.69
148	Klippel-trenaunay-weber syndrome	Enrichment	GNAQ	1.65
149	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	PDE1C	1.64
150	Congenital myopathy 1b, autosomal recessive	Enrichment	RYR1	1.59
151	Cardiac arrest	Enrichment	PLN	1.59
152	Myopathy, centronuclear, 1	Enrichment	RYR1	1.51
153	Hemihyperplasia, isolated	Enrichment	RHOA	1.51
154	Specific learning disability	Enrichment	MAPK1	1.51
155	Developmental and epileptic encephalopathy 14	Enrichment	PLCB1	1.48
156	Acute promyelocytic leukemia	Enrichment	PRKAR1A	1.46
157	Megacolon	Enrichment	SLC8A1	1.45
158	Congenital long qt syndrome	Enrichment	ITPR3	1.43
159	Multiple pterygium syndrome, lethal type	Enrichment	RYR1	1.39
160	Congenital muscular dystrophy	Enrichment	RYR1	1.39
161	Hypothyroidism	Enrichment	GNB1	1.39
162	Multiple sclerosis	Enrichment	ITPR1	1.36
163	Body mass index quantitative trait locus 11	Enrichment	ADCY3, POMC	1.35
164	Arrhythmogenic right ventricular dysplasia, familial, 9	Enrichment	PLN	1.34
165	Hydrops fetalis	Enrichment	RYR1	1.34
166	Anterior segment dysgenesis	Enrichment	ITPR1	1.33
167	Microcephaly	Enrichment	CAMK2B, MAPK1	1.31
168	Heart, malformation of	Enrichment	MAPK1	1.30
169	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.26
170	Myelodysplastic syndrome	Enrichment	GNB1	1.26
171	Cardiac conduction defect	Enrichment	PLN	1.22
172	Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly	Enrichment	RYR1	1.19
173	Clubfoot	Enrichment	RYR1	1.19
174	Jeune thoracic dystrophy	Enrichment	GRK2	1.18
175	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	PLN	1.16
176	Asphyxiating thoracic dystrophy	Enrichment	GRK2	1.13
177	Congenital myopathy 4a, autosomal dominant	Enrichment	RYR1	1.13
178	Congenital nervous system abnormality	Enrichment	CAMK2B	1.12
179	Nervous system disease	Enrichment	CAMK2B	1.12
180	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	RYR1	1.10
181	Hypertension, essential	Enrichment	GNB3	1.07
182	Cleft palate, isolated	Enrichment	GNB1	1.07
183	Dandy-walker syndrome	Enrichment	PPP1CB	1.07
184	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	GRK2	1.06
185	Beckwith-wiedemann syndrome	Enrichment	RYR1	1.05
186	Neuromuscular disease	Enrichment	RYR1	1.05
187	Congenital myopathy	Enrichment	RYR1	1.03
188	Cardiomyopathy, dilated, 1a	Enrichment	NFATC2	0.99
189	Centronuclear myopathy	Enrichment	RYR1	0.99
190	Epilepsy	Enrichment	NBEA	0.98
191	Attention deficit-hyperactivity disorder	Enrichment	GNB5	0.97
192	Autism spectrum disorder	Enrichment	GNB1, MEF2C	0.96
193	Noonan syndrome 1	Enrichment	PPP1CB	0.95
194	Congenital stationary night blindness	Enrichment	GNB3	0.95
195	Scoliosis	Enrichment	RYR1	0.93
196	Rasopathy	Enrichment	PPP1CB	0.90
197	Strabismus	Enrichment	GNB1	0.88
198	Complex neurodevelopmental disorder	Enrichment	GNB2, PPP2CA	0.87
199	Benign epilepsy with centrotemporal spikes	Enrichment	PLCB1	0.84
200	Centralopathic epilepsy	Enrichment	PLCB1	0.82
201	West syndrome	Enrichment	PLCB1	0.82
202	Spastic ataxia	Enrichment	ITPR1	0.81
203	Genetic steroid-resistant nephrotic syndrome	Enrichment	ARHGDIA	0.79
204	Fetal akinesia deformation sequence 1	Enrichment	RYR1	0.76
205	Cerebral palsy	Enrichment	GNB1	0.74
206	Myopathy	Enrichment	RYR1	0.73
207	Primary ciliary dyskinesia	Enrichment	PRKAR1B	0.73
208	Distal arthrogryposis	Enrichment	RYR1	0.71
209	Lung cancer	Enrichment	PPP2R1B	0.71
210	Hypertrophic cardiomyopathy	Enrichment	PLN	0.70
211	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	ADCY1	0.66
212	Familial isolated dilated cardiomyopathy	Enrichment	PLN	0.62
213	Myeloma, multiple	Enrichment	HDAC4	0.60
214	Undetermined early-onset epileptic encephalopathy	Enrichment	PPP3CA	0.60
215	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MEF2C	0.59
216	Autosomal recessive non-syndromic intellectual disability	Enrichment	EZR	0.59
217	Inherited cancer-predisposing syndrome	Enrichment	PRKAR1A	0.52
218	Breast cancer	Enrichment	GNG3	0.49
219	Dilated cardiomyopathy	Enrichment	PLN	0.47

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Calmodulin induced events

Pathway Network for Calmodulin induced events

Pathway network for the Calmodulin induced events SuperPath

Member Pathways for Calmodulin induced events

Pathways in the Calmodulin induced events SuperPath

Gene overlap in member pathways for Calmodulin induced events SuperPath

Associated Genes for Calmodulin induced events

Associated Disorders for Calmodulin induced events

Disorders associated with Calmodulin induced events SuperPath

STRING Interaction Network for Calmodulin induced events

Sources for Calmodulin induced events