Calnexin/calreticulin cycle

Pathway network for the Calnexin/calreticulin cycle SuperPath

Sources:

Reactome

Pathways in the Calnexin/calreticulin cycle SuperPath

#	Name	Source	Genes
1	Calnexin/calreticulin cycle	Reactome	AMFR CALR CANX DERL2 EDEM1 EDEM2 EDEM3 GANAB MAN1B1 MARCHF6 OS9 PDIA3 PRKCSH RNF103 RNF139 RNF185 RNF5 RPS27A SEL1L SYVN1 TRIM13 UBA52 UBB UBC UGGT1 UGGT2 (see all 26) (see less)
2	N-glycan trimming in the ER and Calnexin/Calreticulin cycle	Reactome	AMFR CALR CANX DERL1 DERL2 EDEM1 EDEM2 EDEM3 ENGASE GANAB MAN1B1 MARCHF6 MLEC MOGS NGLY1 OS9 PDIA3 PRKCSH PSMC1 RAD23B RNF103 RNF139 RNF185 RNF5 RPS27A SEL1L SYVN1 TRIM13 UBA52 UBB UBC UBXN1 UGGT1 UGGT2 VCP (see all 35) (see less)
3	ER Quality Control Compartment (ERQC)	Reactome	AMFR DERL2 EDEM1 EDEM2 EDEM3 MAN1B1 MARCHF6 OS9 RNF103 RNF139 RNF185 RNF5 RPS27A SEL1L SYVN1 TRIM13 UBA52 UBB UBC UGGT1 UGGT2 (see all 21) (see less)

Gene overlap in member pathways for Calnexin/calreticulin cycle SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TRIM13	Tripartite Motif Containing 13	Protein Coding	3
2	MARCHF6	Membrane Associated Ring-CH-Type Finger 6	Protein Coding	3
3	OS9	OS9 Endoplasmic Reticulum Lectin	Protein Coding	3
4	RNF139	Ring Finger Protein 139	Protein Coding	3
5	MAN1B1	Mannosidase Alpha Class 1B Member 1	Protein Coding	3
6	AMFR	Autocrine Motility Factor Receptor	Protein Coding	3
7	DERL2	Derlin 2	Protein Coding	3
8	EDEM2	ER Degradation Enhancing Alpha-Mannosidase Like Protein 2	Protein Coding	3
9	UGGT2	UDP-Glucose Glycoprotein Glucosyltransferase 2	Protein Coding	3
10	UGGT1	UDP-Glucose Glycoprotein Glucosyltransferase 1	Protein Coding	3
11	RNF5	Ring Finger Protein 5	Protein Coding	3
12	RPS27A	Ribosomal Protein S27a	Protein Coding	3
13	SEL1L	SEL1L Adaptor Subunit Of SYVN1 Ubiquitin Ligase	Protein Coding	3
14	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	3
15	UBB	Ubiquitin B	Protein Coding	3
16	UBC	Ubiquitin C	Protein Coding	3
17	RNF103	Ring Finger Protein 103	Protein Coding	3
18	EDEM3	ER Degradation Enhancing Alpha-Mannosidase Like Protein 3	Protein Coding	3
19	SYVN1	Synoviolin 1	Protein Coding	3
20	RNF185	Ring Finger Protein 185	Protein Coding	3
21	EDEM1	ER Degradation Enhancing Alpha-Mannosidase Like Protein 1	Protein Coding	3
22	GANAB	Glucosidase II Alpha Subunit	Protein Coding	2
23	PDIA3	Protein Disulfide Isomerase Family A Member 3	Protein Coding	2
24	PRKCSH	PRKCSH Beta Subunit Of Glucosidase II	Protein Coding	2
25	CALR	Calreticulin	Protein Coding	2
26	CANX	Calnexin	Protein Coding	2
27	UBXN1	UBX Domain Protein 1	Protein Coding	1
28	NGLY1	N-Glycanase 1	Protein Coding	1
29	PSMC1	Proteasome 26S Subunit, ATPase 1	Protein Coding	1
30	RAD23B	RAD23 Nucleotide Excision Repair Protein B	Protein Coding	1
31	ENGASE	Endo-Beta-N-Acetylglucosaminidase	Protein Coding	1
32	VCP	Valosin Containing Protein	Protein Coding	1
33	MOGS	Mannosyl-Oligosaccharide Glucosidase	Protein Coding	1
34	DERL1	Derlin 1	Protein Coding	1
35	MLEC	Malectin	Protein Coding	1

Disorders associated with Calnexin/calreticulin cycle SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Polycystic liver disease	Enrichment	GANAB, PRKCSH	3.33
2	Autosomal dominant polycystic liver disease	Enrichment	GANAB, PRKCSH	3.33
3	Epilepsy, familial adult myoclonic, 3	Enrichment	MARCHF6	2.81
4	Congenital disorder of glycosylation, type 2v	Enrichment	EDEM3	2.81
5	Neurodevelopmental disorder with poor growth, absent speech, progressive ataxia, and dysmorphic facies	Enrichment	SEL1L	2.81
6	Congenital disorder of glycosylation, type iicc	Enrichment	UGGT1	2.81
7	Man1b1-congenital disorder of glycosylation	Enrichment	MAN1B1	2.81
8	Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 1	Enrichment	VCP	2.59
9	Frontotemporal dementia and/or amyotrophic lateral sclerosis 6	Enrichment	VCP	2.59
10	Congenital disorder of deglycosylation 1	Enrichment	NGLY1	2.59
11	Multisystem proteinopathy	Enrichment	VCP	2.59
12	Ngly1-related congenital disorder of deglycosylation	Enrichment	NGLY1	2.59
13	Adult-onset distal myopathy due to vcp mutation	Enrichment	VCP	2.59
14	Rafiq syndrome	Enrichment	MAN1B1	2.51
15	Spastic paraplegia 89, autosomal recessive	Enrichment	AMFR	2.51
16	Neurodevelopmental disorder with hypotonia, poor growth, dysmorphic facies, and agammaglobulinemia	Enrichment	SEL1L	2.51
17	Submucosal cleft palate	Enrichment	UBB	2.51
18	Cleft hard palate	Enrichment	UBB	2.51
19	Polycystic kidney disease 3	Enrichment	GANAB	2.42
20	Uvula, bifid	Enrichment	UBB	2.33
21	Cleft soft palate	Enrichment	UBB	2.33
22	Congenital disorder of glycosylation, type iib	Enrichment	MOGS	2.29
23	Amyotrophic lateral sclerosis 6 with or without frontotemporal dementia	Enrichment	VCP	2.29
24	Birk-aharoni syndrome	Enrichment	PSMC1	2.29
25	Spastic paraplegia-paget disease of bone syndrome	Enrichment	VCP	2.29
26	Thrombocythemia 1	Enrichment	CALR	2.24
27	Budd-chiari syndrome	Enrichment	CALR	2.12
28	Inclusion body myopathy with paget disease of bone and frontotemporal dementia	Enrichment	VCP	2.11
29	Familial adult myoclonic epilepsy	Enrichment	MARCHF6	2.03
30	Polycystic liver disease 1 with or without kidney cysts	Enrichment	PRKCSH	2.02
31	Polycystic kidney disease 3 with or without polycystic liver disease	Enrichment	GANAB	2.02
32	Polycystic liver disease 1	Enrichment	PRKCSH	2.02
33	Hereditary clear cell renal cell carcinoma	Enrichment	RNF139	1.97
34	Dementia, lewy body	Enrichment	VCP	1.89
35	Charcot-marie-tooth disease, axonal, type 2e	Enrichment	VCP	1.89
36	Myelofibrosis	Enrichment	CALR	1.87
37	Essential thrombocythemia	Enrichment	CALR	1.87
38	Renal cell carcinoma, nonpapillary	Enrichment	RNF139	1.64
39	Progressive non-fluent aphasia	Enrichment	VCP	1.64
40	Behavioral variant of frontotemporal dementia	Enrichment	VCP	1.64
41	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	VCP	1.59
42	Autosomal dominant polycystic kidney disease	Enrichment	GANAB	1.55
43	Alzheimer's disease	Enrichment	VCP	1.48
44	Alzheimer disease, familial, 1	Enrichment	VCP	1.37
45	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	VCP	1.32
46	Peripheral nervous system disease	Enrichment	NGLY1	1.10
47	Neuropathy	Enrichment	NGLY1	1.10
48	Autosomal recessive non-syndromic intellectual disability	Enrichment	MAN1B1	1.06
49	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	VCP	0.86

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Calnexin/calreticulin cycle

Pathway Network for Calnexin/calreticulin cycle

Pathway network for the Calnexin/calreticulin cycle SuperPath

Member Pathways for Calnexin/calreticulin cycle

Pathways in the Calnexin/calreticulin cycle SuperPath

Gene overlap in member pathways for Calnexin/calreticulin cycle SuperPath

Associated Genes for Calnexin/calreticulin cycle

Associated Disorders for Calnexin/calreticulin cycle

Disorders associated with Calnexin/calreticulin cycle SuperPath

STRING Interaction Network for Calnexin/calreticulin cycle

Sources for Calnexin/calreticulin cycle