Caloric restriction and aging

No Pathway Network information available for Caloric restriction and aging

Pathways in the Caloric restriction and aging SuperPath

#	Name	Source	Genes
1	Caloric restriction and aging	WikiPathways	AKT1 FOXO1B IGF1 MTOR NAMPT PPARGC1A PRKAB2 SIRT1 TP53 (see all 9) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TP53	Tumor Protein P53	Protein Coding	1
2	IGF1	Insulin Like Growth Factor 1	Protein Coding	1
3	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
4	SIRT1	Sirtuin 1	Protein Coding	1
5	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
6	PPARGC1A	PPARG Coactivator 1 Alpha	Protein Coding	1
7	NAMPT	Nicotinamide Phosphoribosyltransferase	Protein Coding	1
8	PRKAB2	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 2	Protein Coding	1
9	FOXO1B	Forkhead Box O1B (Pseudogene)	Pseudogene	1

Disorders associated with Caloric restriction and aging SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Breast adenocarcinoma	Enrichment	AKT1, TP53	5.23
2	Hereditary breast carcinoma	Enrichment	AKT1, TP53	3.44
3	Proteus syndrome	Enrichment	AKT1	3.18
4	Bone marrow failure syndrome 5	Enrichment	TP53	3.18
5	Papilloma of choroid plexus	Enrichment	TP53	3.18
6	Basal cell carcinoma 7	Enrichment	TP53	3.18
7	Anaplastic thyroid carcinoma	Enrichment	TP53	3.18
8	Cowden syndrome 6	Enrichment	AKT1	3.18
9	Ductal carcinoma in situ	Enrichment	TP53	3.18
10	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	3.18
11	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	3.18
12	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	3.18
13	Choroid plexus cancer	Enrichment	TP53	3.18
14	Pleomorphic xanthoastrocytoma	Enrichment	TP53	3.18
15	Breast cancer	Enrichment	AKT1, TP53	2.98
16	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.88
17	Cervical cancer	Enrichment	TP53	2.88
18	Lymphoma, hodgkin, classic	Enrichment	TP53	2.88
19	Cebalid syndrome	Enrichment	MTOR	2.88
20	Congenital fibrosarcoma	Enrichment	TP53	2.88
21	Li-fraumeni syndrome 1	Enrichment	TP53	2.88
22	Sarcoma	Enrichment	TP53	2.88
23	Cervix carcinoma	Enrichment	TP53	2.88
24	Hodgkin's lymphoma	Enrichment	TP53	2.88
25	Smith-kingsmore syndrome	Enrichment	MTOR	2.88
26	Growth delay due to insulin-like growth factor type 1 deficiency	Enrichment	IGF1	2.88
27	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.88
28	Colorectal cancer	Enrichment	AKT1, TP53	2.85
29	Ovarian cancer	Enrichment	AKT1, TP53	2.72
30	Osteogenic sarcoma	Enrichment	TP53	2.70
31	Nasopharyngeal carcinoma	Enrichment	TP53	2.70
32	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.70
33	Anaplastic astrocytoma	Enrichment	TP53	2.70
34	Squamous cell carcinoma	Enrichment	TP53	2.70
35	Adenocarcinoma	Enrichment	TP53	2.70
36	Bone osteosarcoma	Enrichment	TP53	2.70
37	Small cell cancer of the lung	Enrichment	TP53	2.58
38	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.58
39	Focal cortical dysplasia, type ii	Enrichment	MTOR	2.58
40	Lung sarcomatoid carcinoma	Enrichment	TP53	2.58
41	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.58
42	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	2.58
43	Rhabdomyosarcoma 2	Enrichment	TP53	2.48
44	Insulin-like growth factor i	Enrichment	IGF1	2.48
45	Lymphoma	Enrichment	TP53	2.48
46	Acute megakaryocytic leukemia	Enrichment	TP53	2.48
47	Hemimegalencephaly	Enrichment	MTOR	2.48
48	Li-fraumeni syndrome	Enrichment	TP53	2.40
49	Adrenocortical carcinoma	Enrichment	TP53	2.40
50	Esophageal cancer	Enrichment	TP53	2.33
51	Squamous cell carcinoma, head and neck	Enrichment	TP53	2.33
52	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	2.33
53	Essential thrombocythemia	Enrichment	TP53	2.33
54	Gallbladder cancer	Enrichment	TP53	2.33
55	Overgrowth syndrome	Enrichment	MTOR	2.33
56	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	2.33
57	Glioma susceptibility 1	Enrichment	TP53	2.28
58	Lymphoma, non-hodgkin, familial	Enrichment	TP53	2.28
59	Adult hepatocellular carcinoma	Enrichment	TP53	2.22
60	Primary hyperaldosteronism	Enrichment	TP53	2.22
61	Cowden syndrome	Enrichment	AKT1	2.22
62	Leukemia, chronic lymphocytic	Enrichment	TP53	2.18
63	Familial colorectal cancer	Enrichment	TP53	2.18
64	Myelodysplastic syndrome	Enrichment	TP53	2.14
65	Meningioma	Enrichment	AKT1	2.10
66	Lip and oral cavity carcinoma	Enrichment	TP53	2.10
67	Lung cancer susceptibility 3	Enrichment	TP53	2.03
68	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	2.00
69	Rare genetic intellectual disability	Enrichment	MTOR	2.00
70	Rhabdomyosarcoma	Enrichment	TP53	1.98
71	Gliosarcoma	Enrichment	TP53	1.98
72	Giant cell glioblastoma	Enrichment	TP53	1.95
73	Diffuse large b-cell lymphoma	Enrichment	TP53	1.90
74	Hepatoblastoma	Enrichment	TP53	1.86
75	Hepatocellular carcinoma	Enrichment	TP53	1.84
76	Diamond-blackfan anemia 1	Enrichment	TP53	1.82
77	Pancreatic cancer	Enrichment	TP53	1.78
78	Bladder cancer	Enrichment	TP53	1.72
79	Prostate cancer	Enrichment	TP53	1.72
80	Diamond-blackfan anemia	Enrichment	TP53	1.63
81	Leukemia, acute myeloid	Enrichment	TP53	1.58
82	Gastric cancer	Enrichment	TP53	1.55
83	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	1.44
84	Myeloma, multiple	Enrichment	TP53	1.44
85	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PPARGC1A	1.42
86	Inherited cancer-predisposing syndrome	Enrichment	TP53	1.07

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Caloric restriction and aging

Pathway Network for Caloric restriction and aging

Member Pathways for Caloric restriction and aging

Pathways in the Caloric restriction and aging SuperPath

Associated Genes for Caloric restriction and aging

Associated Disorders for Caloric restriction and aging

Disorders associated with Caloric restriction and aging SuperPath

STRING Interaction Network for Caloric restriction and aging

Sources for Caloric restriction and aging