CAMKK2 pathway

No Pathway Network information available for CAMKK2 pathway

Pathways in the CAMKK2 pathway SuperPath

#	Name	Source	Genes
1	CAMKK2 pathway	WikiPathways	ARHGEF7 CALM1 CAMK1 CAMK4 CAMKK2 CHRM3 CREB1 DNM1L EP300 FIS1 GIT1 HDAC4 HMOX1 ICAM1 MAP1LC3A MAPK1 MAPK3 MTOR NFATC2 NFE2L2 NOS1 RAC1 RELA RPTOR SIRT1 SMC1A SQSTM1 STIM1 TSC1 VCAM1 WFS1 (see all 31) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HDAC4	Histone Deacetylase 4	Protein Coding	1
2	SQSTM1	Sequestosome 1	Protein Coding	1
3	MAP1LC3A	Microtubule Associated Protein 1 Light Chain 3 Alpha	Protein Coding	1
4	SMC1A	Structural Maintenance Of Chromosomes 1A	Protein Coding	1
5	CAMK4	Calcium/Calmodulin Dependent Protein Kinase IV	Protein Coding	1
6	CALM1	Calmodulin 1	Protein Coding	1
7	WFS1	Wolframin ER Transmembrane Glycoprotein	Protein Coding	1
8	VCAM1	Vascular Cell Adhesion Molecule 1	Protein Coding	1
9	TSC1	TSC Complex Subunit 1	Protein Coding	1
10	STIM1	Stromal Interaction Molecule 1	Protein Coding	1
11	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
12	RAC1	Rac Family Small GTPase 1	Protein Coding	1
13	RPTOR	Regulatory Associated Protein Of MTOR Complex 1	Protein Coding	1
14	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
15	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
16	FIS1	Fission, Mitochondrial 1	Protein Coding	1
17	NOS1	Nitric Oxide Synthase 1	Protein Coding	1
18	NFE2L2	NFE2 Like BZIP Transcription Factor 2	Protein Coding	1
19	NFATC2	Nuclear Factor Of Activated T Cells 2	Protein Coding	1
20	ICAM1	Intercellular Adhesion Molecule 1	Protein Coding	1
21	HMOX1	Heme Oxygenase 1	Protein Coding	1
22	GIT1	GIT ArfGAP 1	Protein Coding	1
23	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
24	SIRT1	Sirtuin 1	Protein Coding	1
25	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
26	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
27	CHRM3	Cholinergic Receptor Muscarinic 3	Protein Coding	1
28	CAMKK2	Calcium/Calmodulin Dependent Protein Kinase Kinase 2	Protein Coding	1
29	DNM1L	Dynamin 1 Like	Protein Coding	1
30	ARHGEF7	Rho Guanine Nucleotide Exchange Factor 7	Protein Coding	1
31	CAMK1	Calcium/Calmodulin Dependent Protein Kinase I	Protein Coding	1

Disorders associated with CAMKK2 pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Focal cortical dysplasia, type ii	Enrichment	MTOR, TSC1	4.52
2	Isolated focal cortical dysplasia type ii	Enrichment	MTOR, TSC1	4.52
3	Rare genetic intellectual disability	Enrichment	EP300, MTOR	3.28
4	Cataract 41	Enrichment	WFS1	2.64
5	Pyloric stenosis, infantile hypertrophic, 1	Enrichment	NOS1	2.64
6	Paget disease of bone 3	Enrichment	SQSTM1	2.64
7	Developmental and epileptic encephalopathy 85 with or without midline brain defects	Enrichment	SMC1A	2.64
8	Wolfram syndrome 1	Enrichment	WFS1	2.64
9	Deafness, autosomal dominant 6	Enrichment	WFS1	2.64
10	Optic atrophy 5	Enrichment	DNM1L	2.64
11	Wolfram-like syndrome, autosomal dominant	Enrichment	WFS1	2.64
12	Encephalopathy due to defective mitochondrial and peroxisomal fission 1	Enrichment	DNM1L	2.64
13	Myopathy, distal, with rimmed vacuoles	Enrichment	SQSTM1	2.64
14	Noonan syndrome 13	Enrichment	MAPK1	2.64
15	Frontotemporal dementia and/or amyotrophic lateral sclerosis 3	Enrichment	SQSTM1	2.64
16	Chromosome 2q37 deletion syndrome	Enrichment	HDAC4	2.64
17	Immunodeficiency, developmental delay, and hypohomocysteinemia	Enrichment	NFE2L2	2.64
18	Immunodeficiency 10	Enrichment	STIM1	2.64
19	Heme oxygenase 1 deficiency	Enrichment	HMOX1	2.64
20	Neurodevelopmental disorder with central hypotonia and dysmorphic facies	Enrichment	HDAC4	2.64
21	Wolfram-like syndrome	Enrichment	WFS1	2.64
22	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.64
23	Wfs1 spectrum disorder	Enrichment	WFS1	2.64
24	Encephalopathy due to mitochondrial and peroxisomal fission defect	Enrichment	DNM1L	2.64
25	Microcephaly	Enrichment	EP300, MAPK1, SMC1A	2.57
26	Stormorken syndrome	Enrichment	STIM1	2.34
27	Cornelia de lange syndrome 2	Enrichment	SMC1A	2.34
28	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.34
29	Welander distal myopathy	Enrichment	SQSTM1	2.34
30	Lymphangioleiomyomatosis	Enrichment	TSC1	2.34
31	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	2.34
32	Long qt syndrome 14	Enrichment	CALM1	2.34
33	Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset	Enrichment	SQSTM1	2.34
34	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.34
35	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.34
36	Cebalid syndrome	Enrichment	MTOR	2.34
37	Menke-hennekam syndrome 2	Enrichment	EP300	2.34
38	Rela fusion-positive ependymoma	Enrichment	RELA	2.34
39	Wolfram syndrome	Enrichment	WFS1	2.34
40	Paget's disease of bone	Enrichment	SQSTM1	2.34
41	Smith-kingsmore syndrome	Enrichment	MTOR	2.34
42	Joint contractures, osteochondromas, and b-cell lymphoma	Enrichment	NFATC2	2.34
43	Spastic paraplegia-paget disease of bone syndrome	Enrichment	SQSTM1	2.34
44	Prune belly syndrome	Enrichment	CHRM3	2.16
45	Tuberous sclerosis 1	Enrichment	TSC1	2.16
46	Hamartoma	Enrichment	TSC1	2.16
47	Melanoma of soft tissue	Enrichment	CREB1	2.16
48	Autosomal dominant optic atrophy, classic form	Enrichment	DNM1L	2.16
49	Paget disease of bone 2, early-onset	Enrichment	SQSTM1	2.04
50	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.04
51	Myopathy, autophagic vacuolar, infantile-onset	Enrichment	STIM1	2.04
52	Tuberous sclerosis	Enrichment	TSC1	2.04
53	Idiopathic achalasia	Enrichment	NOS1	2.04
54	Paget's disease of bone 2	Enrichment	SQSTM1	2.04
55	Cerebral malaria	Enrichment	ICAM1	2.04
56	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.94
57	Hemimegalencephaly	Enrichment	MTOR	1.94
58	Rubinstein-taybi syndrome 1	Enrichment	EP300	1.87
59	Wiedemann-steiner syndrome	Enrichment	SMC1A	1.87
60	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	EP300	1.87
61	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.87
62	Keratoconus	Enrichment	TSC1	1.87
63	Polymicrogyria, bilateral perisylvian, x-linked	Enrichment	WFS1	1.80
64	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.80
65	Overgrowth syndrome	Enrichment	MTOR	1.80
66	Colorectal cancer	Enrichment	EP300, NFE2L2	1.78
67	Myopathy, tubular aggregate, 1	Enrichment	STIM1	1.74
68	Rett syndrome, congenital variant	Enrichment	SMC1A	1.74
69	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.74
70	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1	1.74
71	Cornelia de lange syndrome 1	Enrichment	SMC1A	1.69
72	Charge syndrome	Enrichment	EP300	1.69
73	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.69
74	Adult hepatocellular carcinoma	Enrichment	TSC1	1.69
75	Bilateral perisylvian polymicrogyria	Enrichment	WFS1	1.69
76	Cornelia de lange syndrome	Enrichment	SMC1A	1.69
77	Behavioral variant of frontotemporal dementia	Enrichment	SQSTM1	1.69
78	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	SQSTM1	1.65
79	Diabetes mellitus	Enrichment	WFS1	1.60
80	Specific learning disability	Enrichment	MAPK1	1.60
81	Pulmonary disease, chronic obstructive	Enrichment	HMOX1	1.53
82	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.47
83	Polydactyly, postaxial, type a1	Enrichment	EP300	1.47
84	Kidney disease	Enrichment	TSC1	1.47
85	Heart, malformation of	Enrichment	MAPK1	1.39
86	Semilobar holoprosencephaly	Enrichment	SMC1A	1.39
87	Early-onset nuclear cataract	Enrichment	WFS1	1.39
88	Cardiomyopathy, dilated, 1a	Enrichment	NFATC2	1.33
89	Malaria	Enrichment	ICAM1	1.29
90	Bladder cancer	Enrichment	TSC1	1.19
91	Long qt syndrome 1	Enrichment	CALM1	1.18
92	Long qt syndrome	Enrichment	CALM1	1.16
93	Lung cancer	Enrichment	NFE2L2	1.15
94	Cystic fibrosis	Enrichment	HMOX1	1.15
95	Non-syndromic genetic deafness	Enrichment	WFS1	1.10
96	Type 2 diabetes mellitus	Enrichment	WFS1	1.04
97	Nonsyndromic hearing loss	Enrichment	WFS1	1.04
98	Optic atrophy plus syndrome	Enrichment	WFS1	1.02
99	Body mass index quantitative trait locus 11	Enrichment	DNM1L	0.97
100	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	WFS1	0.95
101	Spastic ataxia	Enrichment	WFS1	0.94
102	Myeloma, multiple	Enrichment	HDAC4	0.92
103	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	SQSTM1	0.90
104	Rare genetic deafness	Enrichment	WFS1	0.78
105	Mitochondrial disease	Enrichment	DNM1L	0.74
106	Congenital nervous system abnormality	Enrichment	SMC1A	0.67
107	Nervous system disease	Enrichment	SMC1A	0.67
108	Inherited cancer-predisposing syndrome	Enrichment	TSC1	0.58
109	Hereditary retinal dystrophy	Enrichment	WFS1	0.31
110	Fundus dystrophy	Enrichment	WFS1	0.31

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for CAMKK2 pathway

Member Pathways for CAMKK2 pathway

Pathways in the CAMKK2 pathway SuperPath

Associated Genes for CAMKK2 pathway

Associated Disorders for CAMKK2 pathway

Disorders associated with CAMKK2 pathway SuperPath

STRING Interaction Network for CAMKK2 pathway

Sources for CAMKK2 pathway