Cancer immunotherapy by CTLA4 blockade

No Pathway Network information available for Cancer immunotherapy by CTLA4 blockade

Pathways in the Cancer immunotherapy by CTLA4 blockade SuperPath

#	Name	Source	Genes
1	Cancer immunotherapy by CTLA4 blockade	WikiPathways	CD28 CD80 CD86 CTLA4 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PPP2CA PTPN11 PTPN6 TRA TRB (see all 15) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CD86	CD86 Molecule	Protein Coding	1
2	CD80	CD80 Molecule	Protein Coding	1
3	CD28	CD28 Molecule	Protein Coding	1
4	TRA	T Cell Receptor Alpha Locus	Protein Coding	1
5	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
6	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	1
7	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	1
8	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
9	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
10	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
11	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
12	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
13	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	1
14	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
15	TRB	T Cell Receptor Beta Locus	Protein Coding	1

Disorders associated with Cancer immunotherapy by CTLA4 blockade SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Mycosis fungoides	Enrichment	CD28, CTLA4	5.47
2	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	5.47
3	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	5.47
4	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	5.47
5	Saczary syndrome	Enrichment	CD28, CTLA4	5.47
6	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	5.16
7	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	4.29
8	Precursor t-cell acute lymphoblastic leukemia	Enrichment	TRA, TRB	3.55
9	Macrodactyly	Enrichment	PIK3CA	2.96
10	Metachondromatosis	Enrichment	PTPN11	2.96
11	Celiac disease 3	Enrichment	CTLA4	2.96
12	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.96
13	Leopard syndrome 1	Enrichment	PTPN11	2.96
14	Cowden syndrome 5	Enrichment	PIK3CA	2.96
15	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.96
16	Short syndrome	Enrichment	PIK3R1	2.96
17	Type 1 diabetes mellitus 12	Enrichment	CTLA4	2.96
18	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.96
19	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.96
20	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.96
21	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.96
22	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.96
23	Immunodeficiency 123 with hpv-related verrucosis	Enrichment	CD28	2.96
24	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.96
25	Hypospadias	Enrichment	PIK3CA	2.96
26	Rare venous malformation	Enrichment	PIK3CA	2.96
27	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	2.96
28	Bullous pyoderma gangrenosum	Enrichment	PTPN6	2.96
29	Diaphragmatic eventration	Enrichment	PIK3CA	2.96
30	Pustular pyoderma gangrenosum	Enrichment	PTPN6	2.96
31	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.96
32	Rare combined vascular malformation	Enrichment	PIK3CA	2.96
33	Cavernous lymphangioma	Enrichment	PIK3CA	2.96
34	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.96
35	Classic pyoderma gangrenosum	Enrichment	PTPN6	2.96
36	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.96
37	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.96
38	Macrodactyly of toe	Enrichment	PIK3CA	2.96
39	Malignant astrocytoma	Enrichment	PTPN11	2.96
40	Hashimoto thyroiditis	Enrichment	CTLA4	2.66
41	Keratosis, seborrheic	Enrichment	PIK3CA	2.66
42	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.66
43	Noonan syndrome 8	Enrichment	PIK3CA	2.66
44	Werner syndrome	Enrichment	PTPN11	2.66
45	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.66
46	Trypsinogen deficiency	Enrichment	TRB	2.66
47	Immune system disease	Enrichment	PIK3CD	2.66
48	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.66
49	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.48
50	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	2.48
51	Immune dysregulation with autoimmunity, immunodeficiency, and lymphoproliferation	Enrichment	CTLA4	2.48
52	Asparagine synthetase deficiency	Enrichment	CTLA4	2.48
53	Immunodeficiency 7	Enrichment	TRA	2.48
54	Congenital microcephaly - severe encephalopathy - progressive cerebral atrophy syndrome	Enrichment	CTLA4	2.48
55	Adult-onset myasthenia gravis	Enrichment	CTLA4	2.48
56	Tricuspid valve insufficiency	Enrichment	PTPN11	2.48
57	Keratoacanthoma	Enrichment	PIK3CA	2.48
58	Colorectal cancer	Enrichment	PIK3CA, PIK3R1	2.39
59	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	2.35
60	Immunodeficiency, common variable, 1	Enrichment	CTLA4	2.35
61	Cerebrovascular disease	Enrichment	PIK3CA	2.35
62	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.35
63	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	2.35
64	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.35
65	Capillary malformations, congenital	Enrichment	PIK3CA	2.26
66	Vitamin d-dependent rickets, type 2a	Enrichment	TRB	2.26
67	Lymphoma	Enrichment	PTPN11	2.26
68	Hemimegalencephaly	Enrichment	PIK3CA	2.26
69	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	2.18
70	Cowden syndrome 1	Enrichment	PIK3CA	2.18
71	Hemihyperplasia, isolated	Enrichment	PIK3CA	2.18
72	Granulomatosis with polyangiitis	Enrichment	CTLA4	2.18
73	Patent ductus arteriosus	Enrichment	PTPN11	2.18
74	Breast adenocarcinoma	Enrichment	PIK3CA	2.18
75	Lung squamous cell carcinoma	Enrichment	PIK3CA	2.18
76	Nevus, epidermal	Enrichment	PIK3CA	2.11
77	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	2.11
78	Noonan syndrome 3	Enrichment	PTPN11	2.11
79	Gallbladder cancer	Enrichment	PIK3CA	2.11
80	Overgrowth syndrome	Enrichment	PIK3R1	2.11
81	Arteriovenous malformation	Enrichment	PIK3CA	2.00
82	Adult hepatocellular carcinoma	Enrichment	PIK3CA	2.00
83	Cowden syndrome	Enrichment	PIK3CA	2.00
84	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.96
85	Pectus excavatum	Enrichment	PTPN11	1.92
86	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.92
87	Specific learning disability	Enrichment	PTPN11	1.92
88	Epicanthus	Enrichment	PTPN11	1.88
89	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.88
90	Meningioma	Enrichment	PIK3CA	1.88
91	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.88
92	Congenital long qt syndrome	Enrichment	PTPN11	1.88
93	Nk-cell enteropathy	Enrichment	PIK3CB	1.85
94	Hereditary chronic pancreatitis	Enrichment	TRB	1.81
95	Lynch syndrome	Enrichment	PIK3CA	1.78
96	Noonan syndrome and noonan-related syndrome	Enrichment	PTPN11	1.78
97	Pancreatitis, hereditary	Enrichment	TRB	1.73
98	Patent foramen ovale	Enrichment	PTPN11	1.70
99	Endometrial cancer	Enrichment	PIK3CA	1.64
100	Hepatocellular carcinoma	Enrichment	PIK3CA	1.62
101	Noonan syndrome 1	Enrichment	PTPN11	1.60
102	Scoliosis	Enrichment	PTPN11	1.58
103	Hydrops fetalis, nonimmune	Enrichment	PTPN11	1.55
104	Rasopathy	Enrichment	PTPN11	1.55
105	Strabismus	Enrichment	PTPN11	1.53
106	Bladder cancer	Enrichment	PIK3CA	1.50
107	Prostate cancer	Enrichment	PIK3CA	1.50
108	Long qt syndrome 1	Enrichment	PTPN11	1.49
109	Non-immune hydrops fetalis	Enrichment	PTPN11	1.47
110	Lung cancer	Enrichment	PIK3CA	1.46
111	Systemic lupus erythematosus	Enrichment	CTLA4	1.37
112	Gastric cancer	Enrichment	PIK3CA	1.33
113	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.33
114	Hereditary breast carcinoma	Enrichment	PIK3CA	1.32
115	Thrombocytopenia	Enrichment	PTPN11	1.29
116	Hypertelorism	Enrichment	PIK3CA	1.25
117	Myeloma, multiple	Enrichment	PIK3R2	1.22
118	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	1.22
119	Breast cancer	Enrichment	PIK3CA	1.10
120	Ovarian cancer	Enrichment	PIK3CA	0.97
121	Autism spectrum disorder	Enrichment	PTPN11	0.94
122	Microcephaly	Enrichment	PTPN11	0.89
123	Complex neurodevelopmental disorder	Enrichment	PPP2CA	0.89
124	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.86

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Cancer immunotherapy by CTLA4 blockade

Pathway Network for Cancer immunotherapy by CTLA4 blockade

Member Pathways for Cancer immunotherapy by CTLA4 blockade

Pathways in the Cancer immunotherapy by CTLA4 blockade SuperPath

Associated Genes for Cancer immunotherapy by CTLA4 blockade

Associated Disorders for Cancer immunotherapy by CTLA4 blockade

Disorders associated with Cancer immunotherapy by CTLA4 blockade SuperPath

STRING Interaction Network for Cancer immunotherapy by CTLA4 blockade

Sources for Cancer immunotherapy by CTLA4 blockade