Cancer immunotherapy by PD-1 blockade

No Pathway Network information available for Cancer immunotherapy by PD-1 blockade

Pathways in the Cancer immunotherapy by PD-1 blockade SuperPath

#	Name	Source	Genes
1	Cancer immunotherapy by PD-1 blockade	WikiPathways	BATF CD274 CD3D CD3E CD3G CD8A CD8B IFNG JUN LCK NFAT5 NFATC1 NFATC2 NFATC3 NFATC4 NFKB1 PDCD1 PDCD1LG2 PTPN11 STAT3 TRA TRB ZAP70 (see all 23) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CD8B	CD8 Subunit Beta	Protein Coding	1
2	CD8A	CD8 Subunit Alpha	Protein Coding	1
3	CD3G	CD3 Gamma Subunit Of T-Cell Receptor Complex	Protein Coding	1
4	CD3E	CD3 Epsilon Subunit Of T-Cell Receptor Complex	Protein Coding	1
5	CD3D	CD3 Delta Subunit Of T-Cell Receptor Complex	Protein Coding	1
6	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	1
7	TRA	T Cell Receptor Alpha Locus	Protein Coding	1
8	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
9	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
10	PDCD1	Programmed Cell Death 1	Protein Coding	1
11	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
12	NFATC4	Nuclear Factor Of Activated T Cells 4	Protein Coding	1
13	NFATC2	Nuclear Factor Of Activated T Cells 2	Protein Coding	1
14	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
15	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
16	IFNG	Interferon Gamma	Protein Coding	1
17	CD274	CD274 Molecule	Protein Coding	1
18	NFAT5	Nuclear Factor Of Activated T Cells 5	Protein Coding	1
19	BATF	Basic Leucine Zipper ATF-Like Transcription Factor	Protein Coding	1
20	PDCD1LG2	Programmed Cell Death 1 Ligand 2	Protein Coding	1
21	TRB	T Cell Receptor Beta Locus	Protein Coding	1
22	NFATC3	Nuclear Factor Of Activated T Cells 3	Protein Coding	1
23	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	1

Disorders associated with Cancer immunotherapy by PD-1 blockade SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Severe combined immunodeficiency	Enrichment	CD3D, CD3E, CD3G, LCK, ZAP70	8.69
2	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD3D, CD3E	5.08
3	Precursor t-cell acute lymphoblastic leukemia	Enrichment	TRA, TRB	3.17
4	Metachondromatosis	Enrichment	PTPN11	2.77
5	Leopard syndrome 1	Enrichment	PTPN11	2.77
6	Immunodeficiency 116	Enrichment	CD8A	2.77
7	Immunodeficiency 69	Enrichment	IFNG	2.77
8	Immunodeficiency 48	Enrichment	ZAP70	2.77
9	Autoimmune disease, multisystem, infantile-onset, 4	Enrichment	PDCD1	2.77
10	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.77
11	Immunodeficiency 18	Enrichment	CD3E	2.77
12	Systemic lupus erythematosus 2	Enrichment	PDCD1	2.77
13	Autoimmune disease, multisystem, infantile-onset, 2	Enrichment	ZAP70	2.77
14	Immunodeficiency 22	Enrichment	LCK	2.77
15	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.77
16	Immunodeficiency 19, severe combined	Enrichment	CD3D	2.77
17	Autoimmune disease, multisystem, infantile-onset, 5	Enrichment	CD274	2.77
18	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.77
19	Immunodeficiency 19	Enrichment	CD3D	2.77
20	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.77
21	Inflammatory bowel disease-recurrent sinopulmonary infections syndrome	Enrichment	NFAT5	2.77
22	Zap70-related severe combined immunodeficiency	Enrichment	ZAP70	2.77
23	Malignant astrocytoma	Enrichment	PTPN11	2.77
24	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.47
25	Werner syndrome	Enrichment	PTPN11	2.47
26	Trypsinogen deficiency	Enrichment	TRB	2.47
27	Immunodeficiency 17	Enrichment	CD3G	2.47
28	Joint contractures, osteochondromas, and b-cell lymphoma	Enrichment	NFATC2	2.47
29	Common variable immunodeficiency 12	Enrichment	NFKB1	2.47
30	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.29
31	Tuberous sclerosis 1	Enrichment	IFNG	2.29
32	Hepatitis c virus	Enrichment	IFNG	2.29
33	Tuberous sclerosis 2	Enrichment	IFNG	2.29
34	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	2.29
35	Hyper ige syndrome	Enrichment	STAT3	2.29
36	Immunodeficiency 7	Enrichment	TRA	2.29
37	Tricuspid valve insufficiency	Enrichment	PTPN11	2.29
38	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.17
39	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	2.17
40	Vitamin d-dependent rickets, type 2a	Enrichment	TRB	2.07
41	Lymphoma	Enrichment	PTPN11	2.07
42	Idiopathic aplastic anemia	Enrichment	IFNG	2.07
43	Patent ductus arteriosus	Enrichment	PTPN11	1.99
44	Noonan syndrome 3	Enrichment	PTPN11	1.93
45	Common variable immunodeficiency	Enrichment	NFKB1	1.93
46	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.87
47	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.77
48	Aplastic anemia	Enrichment	IFNG	1.77
49	Pectus excavatum	Enrichment	PTPN11	1.73
50	Combined immunodeficiency	Enrichment	ZAP70	1.73
51	Combined t cell and b cell immunodeficiency	Enrichment	ZAP70	1.73
52	Specific learning disability	Enrichment	PTPN11	1.73
53	Combined t and b cell immunodeficiency	Enrichment	ZAP70	1.73
54	Epicanthus	Enrichment	PTPN11	1.70
55	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.70
56	Congenital long qt syndrome	Enrichment	PTPN11	1.70
57	Acute promyelocytic leukemia	Enrichment	STAT3	1.66
58	Hereditary chronic pancreatitis	Enrichment	TRB	1.63
59	Noonan syndrome and noonan-related syndrome	Enrichment	PTPN11	1.60
60	Pancreatitis, hereditary	Enrichment	TRB	1.55
61	Human immunodeficiency virus type 1	Enrichment	IFNG	1.52
62	Patent foramen ovale	Enrichment	PTPN11	1.52
63	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.50
64	Cardiomyopathy, dilated, 1a	Enrichment	NFATC2	1.46
65	Noonan syndrome 1	Enrichment	PTPN11	1.42
66	Scoliosis	Enrichment	PTPN11	1.40
67	Hydrops fetalis, nonimmune	Enrichment	PTPN11	1.36
68	Rasopathy	Enrichment	PTPN11	1.36
69	Strabismus	Enrichment	PTPN11	1.35
70	Long qt syndrome 1	Enrichment	PTPN11	1.30
71	Non-immune hydrops fetalis	Enrichment	PTPN11	1.29
72	Systemic lupus erythematosus	Enrichment	PDCD1	1.19
73	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.15
74	Thrombocytopenia	Enrichment	PTPN11	1.11
75	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	1.04
76	Breast cancer	Enrichment	JUN	0.92
77	Autism spectrum disorder	Enrichment	PTPN11	0.77
78	Microcephaly	Enrichment	PTPN11	0.72
79	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.70

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Cancer immunotherapy by PD-1 blockade

Pathway Network for Cancer immunotherapy by PD-1 blockade

Member Pathways for Cancer immunotherapy by PD-1 blockade

Pathways in the Cancer immunotherapy by PD-1 blockade SuperPath

Associated Genes for Cancer immunotherapy by PD-1 blockade

Associated Disorders for Cancer immunotherapy by PD-1 blockade

Disorders associated with Cancer immunotherapy by PD-1 blockade SuperPath

STRING Interaction Network for Cancer immunotherapy by PD-1 blockade

Sources for Cancer immunotherapy by PD-1 blockade