Canonical and non-canonical Notch signaling

No Pathway Network information available for Canonical and non-canonical Notch signaling

Pathways in the Canonical and non-canonical Notch signaling SuperPath

#	Name	Source	Genes
1	Canonical and non-canonical Notch signaling	WikiPathways	ADAM10 CHUK CNTN6 DLK1 DLK2 DLL1 DLL3 DLL4 DNER HES1 HEY1 JAG1 JAG2 LEF1 MAML1 MAML2 MAML3 MFAP1 MFAP2 NOTCH1 NOTCH2 NOTCH3 NOTCH4 PSEN1 PSEN2 RBPJ RRAS (see all 27) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DLK1	Delta Like Non-Canonical Notch Ligand 1	Protein Coding	1
2	MAML2	Mastermind Like Transcriptional Coactivator 2	Protein Coding	1
3	RRAS	RAS Related	Protein Coding	1
4	PSEN2	Presenilin 2	Protein Coding	1
5	PSEN1	Presenilin 1	Protein Coding	1
6	MAML3	Mastermind Like Transcriptional Coactivator 3	Protein Coding	1
7	DLL4	Delta Like Canonical Notch Ligand 4	Protein Coding	1
8	LEF1	Lymphoid Enhancer Binding Factor 1	Protein Coding	1
9	NOTCH4	Notch Receptor 4	Protein Coding	1
10	NOTCH3	Notch Receptor 3	Protein Coding	1
11	NOTCH2	Notch Receptor 2	Protein Coding	1
12	NOTCH1	Notch Receptor 1	Protein Coding	1
13	MFAP2	Microfibril Associated Protein 2	Protein Coding	1
14	JAG2	Jagged Canonical Notch Ligand 2	Protein Coding	1
15	RBPJ	Recombination Signal Binding Protein For Immunoglobulin Kappa J Region	Protein Coding	1
16	HES1	Hes Family BHLH Transcription Factor 1	Protein Coding	1
17	DLL1	Delta Like Canonical Notch Ligand 1	Protein Coding	1
18	CNTN6	Contactin 6	Protein Coding	1
19	HEY1	Hes Related Family BHLH Transcription Factor With YRPW Motif 1	Protein Coding	1
20	JAG1	Jagged Canonical Notch Ligand 1	Protein Coding	1
21	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
22	DLL3	Delta Like Canonical Notch Ligand 3	Protein Coding	1
23	ADAM10	ADAM Metallopeptidase Domain 10	Protein Coding	1
24	MAML1	Mastermind Like Transcriptional Coactivator 1	Protein Coding	1
25	DNER	Delta/Notch Like EGF Repeat Containing	Protein Coding	1
26	DLK2	Delta Like Non-Canonical Notch Ligand 2	Protein Coding	1
27	MFAP1	Microfibril Associated Protein 1	Protein Coding	1

Disorders associated with Canonical and non-canonical Notch signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Adams-oliver syndrome	Enrichment	DLL4, NOTCH1, RBPJ	6.61
2	Alzheimer disease 4	Enrichment	PSEN1, PSEN2	4.94
3	Keratoacanthoma	Enrichment	NOTCH1, NOTCH2	4.94
4	Early-onset autosomal dominant alzheimer disease	Enrichment	PSEN1, PSEN2	4.10
5	Tetralogy of fallot	Enrichment	JAG1, NOTCH1	2.92
6	Hajdu-cheney syndrome	Enrichment	NOTCH2	2.70
7	Alagille syndrome 2	Enrichment	NOTCH2	2.70
8	Lateral meningocele syndrome	Enrichment	NOTCH3	2.70
9	Fetal encasement syndrome	Enrichment	CHUK	2.70
10	Ectodermal dysplasia 17 with or without limb malformations	Enrichment	LEF1	2.70
11	Charcot-marie-tooth disease, axonal, type 2hh	Enrichment	JAG1	2.70
12	Adams-oliver syndrome 6	Enrichment	DLL4	2.70
13	Cardiomyopathy, dilated, 1v	Enrichment	PSEN2	2.70
14	Alzheimer disease 18	Enrichment	ADAM10	2.70
15	Cardiomyopathy, dilated, 1u	Enrichment	PSEN1	2.70
16	Reticulate acropigmentation of kitamura	Enrichment	ADAM10	2.70
17	Myofibromatosis, infantile, 2	Enrichment	NOTCH3	2.70
18	Acne inversa, familial, 3	Enrichment	PSEN1	2.70
19	Muscular dystrophy, limb-girdle, autosomal recessive 27	Enrichment	JAG2	2.70
20	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.70
21	Deafness, congenital heart defects, and posterior embryotoxon	Enrichment	JAG1	2.70
22	Transient cerebral ischemia	Enrichment	NOTCH3	2.70
23	Cerebral arteriopathy, autosomal recessive, with subcortical infarcts and leukoencephalopathy 1	Enrichment	NOTCH3	2.70
24	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.70
25	Huntington's disease-like	Enrichment	PSEN2	2.70
26	Ectrodactyly and ectodermal dysplasia without cleft lip/palate	Enrichment	LEF1	2.40
27	Alzheimer disease 3	Enrichment	PSEN1	2.40
28	Pick disease of brain	Enrichment	PSEN1	2.40
29	Adams-oliver syndrome 5	Enrichment	NOTCH1	2.40
30	Adams-oliver syndrome 3	Enrichment	RBPJ	2.40
31	Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures	Enrichment	DLL1	2.40
32	Infantile myofibromatosis	Enrichment	NOTCH3	2.40
33	Split hand-foot malformation	Enrichment	LEF1	2.40
34	Central precocious puberty	Enrichment	DLK1	2.40
35	Lipodystrophy, familial partial, type 1	Enrichment	NOTCH3	2.40
36	Depressive disorder	Enrichment	NOTCH3	2.40
37	Familial isolated dilated cardiomyopathy	Enrichment	PSEN1, PSEN2	2.31
38	Alagille syndrome 1	Enrichment	JAG1	2.22
39	Precocious puberty, central, 2	Enrichment	DLK1	2.22
40	Leukodystrophy and acquired microcephaly with or without dystonia	Enrichment	DLL3	2.22
41	Migraine without aura	Enrichment	NOTCH3	2.22
42	Dowling-degos disease 1	Enrichment	ADAM10	2.10
43	Kagami-ogata syndrome	Enrichment	DLK1	2.10
44	Temple syndrome	Enrichment	DLK1	2.10
45	Cerebrovascular disease	Enrichment	NOTCH3	2.10
46	Genetic central precocious puberty in male	Enrichment	DLK1	2.10
47	Middle aortic syndrome	Enrichment	JAG1	2.10
48	Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1	Enrichment	NOTCH3	2.00
49	Aplasia cutis congenita	Enrichment	DLL4	2.00
50	Vascular dementia	Enrichment	NOTCH3	2.00
51	Dementia	Enrichment	PSEN1	2.00
52	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	PSEN1	1.92
53	Split-hand/foot malformation 1	Enrichment	LEF1	1.92
54	Spondylocostal dysostosis, autosomal recessive	Enrichment	DLL3	1.92
55	Semantic dementia	Enrichment	PSEN1	1.86
56	Spondylocostal dysostosis 1, autosomal recessive	Enrichment	DLL3	1.80
57	Hypoplastic left heart syndrome	Enrichment	NOTCH1	1.80
58	Progressive non-fluent aphasia	Enrichment	PSEN1	1.75
59	Behavioral variant of frontotemporal dementia	Enrichment	PSEN1	1.75
60	Stroke, ischemic	Enrichment	NOTCH3	1.70
61	Migraine with or without aura 1	Enrichment	NOTCH3	1.66
62	Frontotemporal dementia 1	Enrichment	PSEN1	1.66
63	Juvenile myelomonocytic leukemia	Enrichment	RRAS	1.63
64	Aortic valve disease 1	Enrichment	NOTCH1	1.59
65	Alzheimer's disease	Enrichment	PSEN1	1.59
66	Aortic aneurysm, familial thoracic 1	Enrichment	NOTCH1	1.56
67	Septopreoptic holoprosencephaly	Enrichment	DLL1	1.53
68	Midline interhemispheric variant of holoprosencephaly	Enrichment	DLL1	1.53
69	Microform holoprosencephaly	Enrichment	DLL1	1.50
70	Lobar holoprosencephaly	Enrichment	DLL1	1.50
71	Alzheimer disease, familial, 1	Enrichment	PSEN1	1.48
72	Alobar holoprosencephaly	Enrichment	DLL1	1.48
73	Heart, malformation of	Enrichment	JAG1	1.45
74	Semilobar holoprosencephaly	Enrichment	DLL1	1.45
75	Hepatoblastoma	Enrichment	JAG1	1.39
76	Noonan syndrome 1	Enrichment	RRAS	1.35
77	Auditory neuropathy	Enrichment	NOTCH3	1.30
78	Connective tissue disease	Enrichment	NOTCH1	1.21
79	Type 2 diabetes mellitus	Enrichment	RBPJ	1.09
80	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	NOTCH1	1.08
81	Autosomal dominant non-syndromic intellectual disability	Enrichment	DLL1	1.02
82	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PSEN1	0.96
83	Schizophrenia	Enrichment	CNTN6	0.95
84	Primary ovarian insufficiency	Enrichment	NOTCH2	0.95
85	Autism	Enrichment	CNTN6	0.87
86	Congenital nervous system abnormality	Enrichment	PSEN1	0.72
87	Nervous system disease	Enrichment	PSEN1	0.72
88	Autism spectrum disorder	Enrichment	CNTN6	0.71
89	Hereditary retinal dystrophy	Enrichment	JAG1	0.35
90	Fundus dystrophy	Enrichment	JAG1	0.35

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Canonical and non-canonical Notch signaling

Pathway Network for Canonical and non-canonical Notch signaling

Member Pathways for Canonical and non-canonical Notch signaling

Pathways in the Canonical and non-canonical Notch signaling SuperPath

Associated Genes for Canonical and non-canonical Notch signaling

Associated Disorders for Canonical and non-canonical Notch signaling

Disorders associated with Canonical and non-canonical Notch signaling SuperPath

STRING Interaction Network for Canonical and non-canonical Notch signaling

Sources for Canonical and non-canonical Notch signaling