Canonical and non-canonical TGF-B signaling

No Pathway Network information available for Canonical and non-canonical TGF-B signaling

Pathways in the Canonical and non-canonical TGF-B signaling SuperPath

#	Name	Source	Genes
1	Canonical and non-canonical TGF-B signaling	WikiPathways	BMP1 BMPR1A BMPR2 GREM1 LOX LOXL1 LOXL2 LOXL4 MAPK14 MAPK8 MAPK9 SMAD2 SMAD3 SMAD4 TGFB1 TGFBR1 TGFBR2 (see all 17) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	LOXL4	Lysyl Oxidase Like 4	Protein Coding	1
2	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	1
3	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	1
4	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
5	BMPR2	Bone Morphogenetic Protein Receptor Type 2	Protein Coding	1
6	BMPR1A	Bone Morphogenetic Protein Receptor Type 1A	Protein Coding	1
7	BMP1	Bone Morphogenetic Protein 1	Protein Coding	1
8	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
9	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
10	SMAD4	SMAD Family Member 4	Protein Coding	1
11	SMAD3	SMAD Family Member 3	Protein Coding	1
12	SMAD2	SMAD Family Member 2	Protein Coding	1
13	LOXL2	Lysyl Oxidase Like 2	Protein Coding	1
14	LOXL1	Lysyl Oxidase Like 1	Protein Coding	1
15	LOX	Lysyl Oxidase	Protein Coding	1
16	GREM1	Gremlin 1, DAN Family BMP Antagonist	Protein Coding	1
17	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1

Disorders associated with Canonical and non-canonical TGF-B signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	LOX, SMAD2, SMAD3, SMAD4, TGFBR1, TGFBR2	11.16
2	Loeys-dietz syndrome	Enrichment	SMAD2, SMAD3, TGFBR1, TGFBR2	9.64
3	Loeys-dietz syndrome 1	Enrichment	SMAD2, TGFBR1, TGFBR2	8.79
4	Loeys-dietz syndrome 2	Enrichment	TGFBR1, TGFBR2	5.83
5	Hereditary mixed polyposis syndrome	Enrichment	BMPR1A, GREM1	5.83
6	Juvenile polyposis syndrome	Enrichment	BMPR1A, SMAD4	5.35
7	Aortic aneurysm	Enrichment	SMAD3, TGFBR1	5.05
8	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	BMPR1A, SMAD4	4.83
9	Familial thoracic aortic aneurysm and dissection	Enrichment	LOX, SMAD3	4.28
10	Marfan syndrome	Enrichment	TGFBR1, TGFBR2	4.18
11	Aortic aneurysm, familial thoracic 1	Enrichment	LOX, SMAD3	3.88
12	Ehlers-danlos syndrome	Enrichment	SMAD3, TGFBR2	3.60
13	Connective tissue disease	Enrichment	SMAD3, TGFBR2	3.14
14	Polyposis syndrome, hereditary mixed, 2	Enrichment	BMPR1A	2.90
15	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	2.90
16	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	2.90
17	Loeys-dietz syndrome 6	Enrichment	SMAD2	2.90
18	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	2.90
19	Heritable thoracic aortic disease	Enrichment	SMAD4	2.90
20	Primary pulmonary hypertension	Enrichment	BMPR2	2.90
21	Pulmonary hypertension	Enrichment	BMPR2	2.90
22	Drug- or toxin-induced pulmonary arterial hypertension	Enrichment	BMPR2	2.90
23	Myhre syndrome	Enrichment	SMAD4	2.60
24	Camurati-engelmann disease 1	Enrichment	TGFB1	2.60
25	Pulmonary venoocclusive disease 1, autosomal dominant	Enrichment	BMPR2	2.60
26	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.60
27	Microvascular complications of diabetes 5	Enrichment	TGFBR2	2.60
28	Fibrodysplasia ossificans progressiva	Enrichment	BMPR2	2.60
29	Osteogenesis imperfecta, type xiii	Enrichment	BMP1	2.60
30	Loeys-dietz syndrome 3	Enrichment	SMAD3	2.60
31	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	2.60
32	Pulmonary venoocclusive disease 1	Enrichment	BMPR2	2.60
33	Camurati-engelmann disease	Enrichment	TGFB1	2.60
34	Aortic aneurysm, familial thoracic 10	Enrichment	LOX	2.60
35	Pulmonary venoocclusive disease	Enrichment	BMPR2	2.60
36	Juvenile polyposis of infancy	Enrichment	BMPR1A	2.60
37	Idiopathic/heritable pulmonary arterial hypertension	Enrichment	BMPR2	2.60
38	Exfoliation syndrome	Enrichment	LOXL1	2.43
39	High bone mass osteogenesis imperfecta	Enrichment	BMP1	2.43
40	Pulmonary arterial hypertension associated with congenital heart disease	Enrichment	BMPR2	2.43
41	Polyposis syndrome, hereditary mixed, 1	Enrichment	GREM1	2.30
42	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	2.13
43	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	2.13
44	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	2.13
45	Esophageal cancer	Enrichment	TGFBR2	2.06
46	Gallbladder cancer	Enrichment	SMAD4	2.06
47	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	2.06
48	Tooth agenesis, selective, 1	Enrichment	BMPR2	1.95
49	Inherited cancer-predisposing syndrome	Enrichment	BMPR1A, SMAD4	1.93
50	Familial colorectal cancer	Enrichment	GREM1	1.90
51	Pectus excavatum	Enrichment	TGFBR1	1.86
52	Heritable pulmonary arterial hypertension	Enrichment	BMPR2	1.86
53	Familial colorectal cancer type x	Enrichment	BMPR1A	1.86
54	Cutis laxa	Enrichment	LOX	1.83
55	Pulmonary hypertension, primary, 1	Enrichment	BMPR2	1.79
56	Osteogenesis imperfecta, type iii	Enrichment	BMP1	1.73
57	Lynch syndrome	Enrichment	TGFBR2	1.73
58	Brittle bone disorder	Enrichment	BMP1	1.55
59	Pancreatic cancer	Enrichment	SMAD4	1.51
60	Cystic fibrosis	Enrichment	TGFB1	1.40
61	Gastric cancer	Enrichment	SMAD4	1.28
62	Thrombocytopenia	Enrichment	SMAD4	1.23
63	Colorectal cancer	Enrichment	SMAD4	0.98
64	Ovarian cancer	Enrichment	BMPR1A	0.92

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Canonical and non-canonical TGF-B signaling

Pathway Network for Canonical and non-canonical TGF-B signaling

Member Pathways for Canonical and non-canonical TGF-B signaling

Pathways in the Canonical and non-canonical TGF-B signaling SuperPath

Associated Genes for Canonical and non-canonical TGF-B signaling

Associated Disorders for Canonical and non-canonical TGF-B signaling

Disorders associated with Canonical and non-canonical TGF-B signaling SuperPath

STRING Interaction Network for Canonical and non-canonical TGF-B signaling

Sources for Canonical and non-canonical TGF-B signaling