Canonical NF-kappaB pathway

No Pathway Network information available for Canonical NF-kappaB pathway

Pathways in the Canonical NF-kappaB pathway SuperPath

#	Name	Source	Genes
1	Canonical NF-kappaB pathway	PubChem	ATM BCL10 BIRC2 BTRC CHUK CYLD ERC1 IKBKB IKBKG MALT1 MAP3K3 NFKB1 NFKBIA NOD2 PRKCA RAN RELA RIPK2 TNF TNFAIP3 TNFRSF1A TRAF6 UBE2D3 XPO1 (see all 24) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ERC1	ELKS/RAB6-Interacting/CAST Family Member 1	Protein Coding	1
2	MAP3K3	Mitogen-Activated Protein Kinase Kinase Kinase 3	Protein Coding	1
3	NOD2	Nucleotide Binding Oligomerization Domain Containing 2	Protein Coding	1
4	MALT1	MALT1 Paracaspase	Protein Coding	1
5	BCL10	BCL10 Immune Signaling Adaptor	Protein Coding	1
6	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
7	RIPK2	Receptor Interacting Serine/Threonine Kinase 2	Protein Coding	1
8	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
9	TNFAIP3	TNF Alpha Induced Protein 3	Protein Coding	1
10	UBE2D3	Ubiquitin Conjugating Enzyme E2 D3	Protein Coding	1
11	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	1
12	CYLD	CYLD Lysine 63 Deubiquitinase	Protein Coding	1
13	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	1
14	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
15	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	1
16	BTRC	Beta-Transducin Repeat Containing E3 Ubiquitin Protein Ligase	Protein Coding	1
17	XPO1	Exportin 1	Protein Coding	1
18	BIRC2	Baculoviral IAP Repeat Containing 2	Protein Coding	1
19	RAN	RAN, Member RAS Oncogene Family	Protein Coding	1
20	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
21	TNF	Tumor Necrosis Factor	Protein Coding	1
22	PRKCA	Protein Kinase C Alpha	Protein Coding	1
23	ATM	ATM Serine/Threonine Kinase	Protein Coding	1
24	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1

Disorders associated with Canonical NF-kappaB pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	5.52
2	Lymphoma, mucosa-associated lymphoid type	Enrichment	BCL10, MALT1	4.52
3	Gliosarcoma	Enrichment	ATM, NFKBIA	3.45
4	Giant cell glioblastoma	Enrichment	ATM, NFKBIA	3.40
5	Behcet syndrome	Enrichment	NOD2, TNFRSF1A	3.30
6	Malaria	Enrichment	IKBKG, TNF	3.13
7	Autoinflammatory disease	Enrichment	NOD2, TNFRSF1A	3.09
8	Severe combined immunodeficiency	Enrichment	IKBKB, MALT1	2.81
9	Periodic fever, familial, autosomal dominant	Enrichment	TNFRSF1A	2.75
10	Incontinentia pigmenti	Enrichment	IKBKG	2.75
11	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.75
12	Fetal encasement syndrome	Enrichment	CHUK	2.75
13	Blau syndrome	Enrichment	NOD2	2.75
14	Immunodeficiency 15b	Enrichment	IKBKB	2.75
15	Immunodeficiency 15a	Enrichment	IKBKB	2.75
16	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.75
17	Multiple sclerosis 5	Enrichment	TNFRSF1A	2.75
18	Immunodeficiency 12	Enrichment	MALT1	2.75
19	Endometrial serous adenocarcinoma	Enrichment	ATM	2.75
20	Tnf receptor-associated periodic fever syndrome	Enrichment	TNFRSF1A	2.75
21	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.75
22	Sezary's disease	Enrichment	BCL10	2.75
23	Familial behcet-like autoinflammatory syndrome	Enrichment	TNFAIP3	2.75
24	B-cell non-hodgkin lymphoma	Enrichment	ATM	2.75
25	Cerebral cavernous malformations 5	Enrichment	MAP3K3	2.75
26	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.75
27	Distal monosomy 12p	Enrichment	ERC1	2.75
28	Verrucous hemangioma	Enrichment	MAP3K3	2.75
29	Mucosa-associated lymphoma	Enrichment	BCL10	2.75
30	Systemic lupus erythematosus	Enrichment	TNF, TNFAIP3	2.67
31	Cylindromatosis, familial	Enrichment	CYLD	2.45
32	Trichoepithelioma, multiple familial, 1	Enrichment	CYLD	2.45
33	Immunodeficiency 33	Enrichment	IKBKG	2.45
34	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.45
35	Immunodeficiency 37	Enrichment	BCL10	2.45
36	Yao syndrome	Enrichment	NOD2	2.45
37	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.45
38	Autoinflammatory syndrome, familial, behcet-like 1	Enrichment	TNFAIP3	2.45
39	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	2.45
40	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.45
41	Frontotemporal dementia and/or amyotrophic lateral sclerosis 8	Enrichment	CYLD	2.45
42	Brooke-spiegler syndrome	Enrichment	CYLD	2.45
43	Immunodeficiency 127	Enrichment	TNF	2.45
44	Rela fusion-positive ependymoma	Enrichment	RELA	2.45
45	Macrocephaly, dysmorphic facies, and psychomotor retardation	Enrichment	ERC1	2.45
46	High grade glioma	Enrichment	ATM	2.45
47	T-cell prolymphocytic leukemia	Enrichment	ATM	2.45
48	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.45
49	Intermittent hydrarthrosis	Enrichment	TNFRSF1A	2.45
50	Crohn's disease	Enrichment	NOD2	2.45
51	Primary mediastinal large b-cell lymphoma	Enrichment	XPO1	2.45
52	Common variable immunodeficiency 12	Enrichment	NFKB1	2.45
53	Myeloma, multiple	Enrichment	ATM, CYLD	2.36
54	Mesothelioma, malignant	Enrichment	BCL10	2.28
55	Ataxia-telangiectasia	Enrichment	ATM	2.28
56	Polycythemia vera	Enrichment	ATM	2.28
57	Psoriatic arthritis	Enrichment	TNF	2.28
58	Nasopharyngeal carcinoma	Enrichment	NFKBIA	2.28
59	Koolen-de vries syndrome	Enrichment	ATM	2.28
60	T-cell acute lymphoblastic leukemia	Enrichment	BCL10	2.28
61	Adenocarcinoma	Enrichment	ATM	2.28
62	Migraine without aura	Enrichment	TNF	2.28
63	Testicular cancer	Enrichment	BCL10	2.28
64	Mantle cell lymphoma	Enrichment	ATM	2.15
65	Cerebral malaria	Enrichment	TNF	2.15
66	Oculomotor apraxia	Enrichment	ATM	2.15
67	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	2.05
68	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	2.05
69	Follicular lymphoma	Enrichment	BCL10	2.05
70	Glioblastoma	Enrichment	ATM	2.05
71	Vascular dementia	Enrichment	TNF	2.05
72	Colorectal cancer	Enrichment	ATM, BCL10	1.99
73	Testicular germ cell tumor	Enrichment	BCL10	1.98
74	Clear cell renal cell carcinoma	Enrichment	ATM	1.98
75	Renal cell carcinoma, papillary, 1	Enrichment	ATM	1.91
76	Common variable immunodeficiency	Enrichment	NFKB1	1.91
77	Lymphoma, non-hodgkin, familial	Enrichment	BCL10	1.85
78	Isolated split hand-split foot malformation	Enrichment	BTRC	1.85
79	Charge syndrome	Enrichment	TNFRSF1A	1.80
80	Inflammatory bowel disease 1	Enrichment	NOD2	1.80
81	Coronary heart disease 5	Enrichment	IKBKG	1.80
82	Colonic benign neoplasm	Enrichment	ATM	1.80
83	Lynch syndrome 1	Enrichment	ATM	1.76
84	Leukemia, chronic lymphocytic	Enrichment	ATM	1.76
85	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.76
86	Immune deficiency disease	Enrichment	ATM	1.71
87	Asthma	Enrichment	TNF	1.71
88	Combined immunodeficiency	Enrichment	MALT1	1.71
89	Combined t cell and b cell immunodeficiency	Enrichment	MALT1	1.71
90	Uterine corpus cancer	Enrichment	ATM	1.71
91	Familial colorectal cancer type x	Enrichment	ATM	1.71
92	Combined t and b cell immunodeficiency	Enrichment	MALT1	1.71
93	Inherited cancer-predisposing syndrome	Enrichment	ATM, CYLD	1.65
94	Breast-ovarian cancer, familial 1	Enrichment	ATM	1.64
95	Alzheimer's disease	Enrichment	TNF	1.64
96	Multiple sclerosis	Enrichment	TNFRSF1A	1.61
97	Renal cell carcinoma, nonpapillary	Enrichment	ATM	1.58
98	Endometrial cancer	Enrichment	ATM	1.44
99	Pancreatic cancer	Enrichment	ATM	1.36
100	Bladder cancer	Enrichment	ATM	1.30
101	Prostate cancer	Enrichment	ATM	1.30
102	Differentiated thyroid carcinoma	Enrichment	ERC1	1.30
103	Gastric cancer	Enrichment	ATM	1.13
104	Hereditary breast carcinoma	Enrichment	ATM	1.12
105	Hereditary breast ovarian cancer syndrome	Enrichment	ATM	1.03
106	Breast cancer	Enrichment	ATM	0.90
107	Ovarian cancer	Enrichment	ATM	0.78

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Canonical NF-kappaB pathway

Pathway Network for Canonical NF-kappaB pathway

Member Pathways for Canonical NF-kappaB pathway

Pathways in the Canonical NF-kappaB pathway SuperPath

Associated Genes for Canonical NF-kappaB pathway

Associated Disorders for Canonical NF-kappaB pathway

Disorders associated with Canonical NF-kappaB pathway SuperPath

STRING Interaction Network for Canonical NF-kappaB pathway

Sources for Canonical NF-kappaB pathway