Canonical Wnt Pathway

No Pathway Network information available for Canonical Wnt Pathway

Pathways in the Canonical Wnt Pathway SuperPath

#	Name	Source	Genes
1	Canonical Wnt Pathway	Sino Biological	ANAPC10 ANAPC11 ANAPC13 ANAPC15 ANAPC16 ANAPC2 ANAPC5 CDH1 CDH11 CDH12 CDH13 CDH15 CDH16 CDH17 CDH18 CDH19 CDH2 CDH24 CDH26 CDH3 CDH4 CDH5 CDH6 CDH8 CSNK1A1 CTNNB1 DKK1 DKK2 DKK3 DKK4 GSK3B LEF1 TCF21 TCF25 TCF4 WNT1 WNT10A WNT11 WNT16 WNT2 WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT9A (see all 49) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ANAPC10	Anaphase Promoting Complex Subunit 10	Protein Coding	1
2	ANAPC11	Anaphase Promoting Complex Subunit 11	Protein Coding	1
3	ANAPC13	Anaphase Promoting Complex Subunit 13	Protein Coding	1
4	ANAPC15	Anaphase Promoting Complex Subunit 15	Protein Coding	1
5	ANAPC16	Anaphase Promoting Complex Subunit 16	Protein Coding	1
6	ANAPC2	Anaphase Promoting Complex Subunit 2	Protein Coding	1
7	ANAPC5	Anaphase Promoting Complex Subunit 5	Protein Coding	1
8	CDH1	Cadherin 1	Protein Coding	1
9	CDH11	Cadherin 11	Protein Coding	1
10	CDH12	Cadherin 12	Protein Coding	1
11	CDH13	Cadherin 13	Protein Coding	1
12	CDH15	Cadherin 15	Protein Coding	1
13	CDH16	Cadherin 16	Protein Coding	1
14	CDH17	Cadherin 17	Protein Coding	1
15	CDH18	Cadherin 18	Protein Coding	1
16	CDH19	Cadherin 19	Protein Coding	1
17	CDH2	Cadherin 2	Protein Coding	1
18	CDH24	Cadherin 24	Protein Coding	1
19	CDH26	Cadherin 26	Protein Coding	1
20	CDH3	Cadherin 3	Protein Coding	1
21	CDH4	Cadherin 4	Protein Coding	1
22	CDH5	Cadherin 5	Protein Coding	1
23	CDH6	Cadherin 6	Protein Coding	1
24	CDH8	Cadherin 8	Protein Coding	1
25	CSNK1A1	Casein Kinase 1 Alpha 1	Protein Coding	1
26	CTNNB1	Catenin Beta 1	Protein Coding	1
27	DKK1	Dickkopf Wnt Signaling Pathway Inhibitor 1	Protein Coding	1
28	DKK2	Dickkopf Wnt Signaling Pathway Inhibitor 2	Protein Coding	1
29	DKK3	Dickkopf Wnt Signaling Pathway Inhibitor 3	Protein Coding	1
30	DKK4	Dickkopf Wnt Signaling Pathway Inhibitor 4	Protein Coding	1
31	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
32	LEF1	Lymphoid Enhancer Binding Factor 1	Protein Coding	1
33	TCF21	Transcription Factor 21	Protein Coding	1
34	TCF25	TCF25 Ribosome Quality Control Complex Subunit	Protein Coding	1
35	TCF4	Transcription Factor 4	Protein Coding	1
36	WNT1	Wnt Family Member 1	Protein Coding	1
37	WNT10A	Wnt Family Member 10A	Protein Coding	1
38	WNT11	Wnt Family Member 11	Protein Coding	1
39	WNT16	Wnt Family Member 16	Protein Coding	1
40	WNT2	Wnt Family Member 2	Protein Coding	1
41	WNT3	Wnt Family Member 3	Protein Coding	1
42	WNT3A	Wnt Family Member 3A	Protein Coding	1
43	WNT4	Wnt Family Member 4	Protein Coding	1
44	WNT5A	Wnt Family Member 5A	Protein Coding	1
45	WNT5B	Wnt Family Member 5B	Protein Coding	1
46	WNT6	Wnt Family Member 6	Protein Coding	1
47	WNT7A	Wnt Family Member 7A	Protein Coding	1
48	WNT7B	Wnt Family Member 7B	Protein Coding	1
49	WNT9A	Wnt Family Member 9A	Protein Coding	1

Disorders associated with Canonical Wnt Pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Osteoporosis, juvenile	Enrichment	DKK1, WNT1, WNT3A	7.35
2	Polycystic liver disease	Enrichment	CTNNB1, DKK3	2.77
3	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1, DKK3	2.77
4	Chiari malformation type i	Enrichment	DKK1	2.44
5	Mullerian aplasia and hyperandrogenism	Enrichment	WNT4	2.44
6	Ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome	Enrichment	CDH3	2.44
7	Elsahy-waters syndrome	Enrichment	CDH11	2.44
8	46,xx sex reversal with dysgenesis of kidneys, adrenals, and lungs	Enrichment	WNT4	2.44
9	Intellectual developmental disorder, autosomal dominant 3	Enrichment	CDH15	2.44
10	Ectodermal dysplasia 17 with or without limb malformations	Enrichment	LEF1	2.44
11	Teebi hypertelorism syndrome 2	Enrichment	CDH11	2.44
12	Agenesis of corpus callosum, cardiac, ocular, and genital syndrome	Enrichment	CDH2	2.44
13	Bone mineral density quantitative trait locus 16	Enrichment	WNT1	2.44
14	Hypotrichosis	Enrichment	CDH3	2.44
15	Santos syndrome	Enrichment	WNT7A	2.44
16	Arrhythmogenic right ventricular dysplasia, familial, 14	Enrichment	CDH2	2.44
17	Corneal dystrophy, fuchs endothelial, 3	Enrichment	TCF4	2.44
18	Attention deficit-hyperactivity disorder 8	Enrichment	CDH2	2.44
19	Adenoid ameloblastoma	Enrichment	CTNNB1	2.44
20	Breast lobular carcinoma	Enrichment	CDH1	2.44
21	Microcystic stromal tumor	Enrichment	CTNNB1	2.44
22	Ectrodactyly and ectodermal dysplasia without cleft lip/palate	Enrichment	LEF1	2.14
23	Blepharocheilodontic syndrome 1	Enrichment	CDH1	2.14
24	Tooth agenesis, selective, 4	Enrichment	WNT10A	2.14
25	Schopf-schulz-passarge syndrome	Enrichment	WNT10A	2.14
26	Ulna and fibula, absence of, with severe limb deficiency	Enrichment	WNT7A	2.14
27	Bladder exstrophy and epispadias complex	Enrichment	WNT3	2.14
28	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.14
29	Hypotrichosis, congenital, with juvenile macular dystrophy	Enrichment	CDH3	2.14
30	Odontoonychodermal dysplasia	Enrichment	WNT10A	2.14
31	Tetraamelia syndrome 1	Enrichment	WNT3	2.14
32	Osteogenesis imperfecta, type xv	Enrichment	WNT1	2.14
33	Fibular aplasia or hypoplasia, femoral bowing, and poly-, syn-, and oligodactyly	Enrichment	WNT7A	2.14
34	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.14
35	Split hand-foot malformation	Enrichment	LEF1	2.14
36	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.14
37	Teratoma	Enrichment	CTNNB1	2.14
38	Bladder exstrophy-epispadias-cloacal exstrophy complex	Enrichment	WNT3	2.14
39	Desmoid disease, hereditary	Enrichment	CTNNB1	1.97
40	Mullerian duct aplasia, unilateral renal agenesis, and cervicothoracic somite anomalies	Enrichment	WNT4	1.97
41	Microphthalmia, syndromic 9	Enrichment	WNT7B	1.97
42	Tooth agenesis, selective, 2	Enrichment	WNT10A	1.97
43	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.97
44	Anus, imperforate	Enrichment	CTNNB1	1.97
45	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.97
46	Desmoid tumor	Enrichment	CTNNB1	1.97
47	Tetraamelia syndrome	Enrichment	WNT3	1.97
48	Autosomal dominant non-syndromic intellectual disability	Enrichment	CDH15, TCF4	1.85
49	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CDH1	1.84
50	Ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	WNT10A	1.84
51	Robinow syndrome, autosomal dominant 1	Enrichment	WNT5A	1.84
52	Pitt-hopkins syndrome	Enrichment	TCF4	1.84
53	Pilomatrixoma	Enrichment	CTNNB1	1.84
54	Alazami syndrome	Enrichment	CTNNB1	1.84
55	Ectodermal dysplasia	Enrichment	WNT10A	1.84
56	Craniopharyngioma	Enrichment	CTNNB1	1.84
57	Autosomal dominant robinow syndrome	Enrichment	WNT5A	1.84
58	Vacterl association	Enrichment	CDH13	1.84
59	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.75
60	Vater/vacterl association	Enrichment	CDH13	1.75
61	Robinow syndrome, autosomal recessive 1	Enrichment	WNT5A	1.75
62	Deafness, autosomal recessive 63	Enrichment	ANAPC15	1.75
63	Cholangitis, primary sclerosing	Enrichment	TCF4	1.75
64	Fuchs' endothelial dystrophy	Enrichment	TCF4	1.75
65	Autosomal recessive hypohidrotic ectodermal dysplasia syndrome	Enrichment	WNT10A	1.75
66	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.67
67	Split-hand/foot malformation 1	Enrichment	LEF1	1.67
68	Autosomal recessive robinow syndrome	Enrichment	WNT5A	1.67
69	Adrenocortical carcinoma	Enrichment	CTNNB1	1.67
70	Cleft lip with or without cleft palate	Enrichment	CDH1	1.67
71	Gallbladder cancer	Enrichment	CTNNB1	1.60
72	Spastic paraplegia 4, autosomal dominant	Enrichment	TCF4	1.54
73	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.54
74	Adult hepatocellular carcinoma	Enrichment	CTNNB1	1.49
75	Hypotrichosis simplex	Enrichment	CDH3	1.49
76	Colorectal cancer	Enrichment	CDH1, CTNNB1	1.40
77	Epicanthus	Enrichment	TCF4	1.37
78	Osteogenesis imperfecta, type iv	Enrichment	WNT1	1.34
79	Stereotypic movement disorder	Enrichment	TCF4	1.34
80	Osteoporosis	Enrichment	WNT1	1.31
81	Medulloblastoma	Enrichment	CTNNB1	1.31
82	Cleft lip/palate	Enrichment	CDH1	1.31
83	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	CDH2	1.31
84	Ovarian cancer	Enrichment	CDH1, CTNNB1	1.29
85	Corpus callosum, agenesis of	Enrichment	CDH2	1.28
86	Osteogenesis imperfecta, type iii	Enrichment	WNT1	1.28
87	Isolated corpus callosum agenesis	Enrichment	CDH2	1.28
88	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CDH2	1.28
89	Arteriovenous malformations of the brain	Enrichment	CDH2	1.18
90	Macs syndrome	Enrichment	WNT7B	1.16
91	Microcephaly	Enrichment	CTNNB1, TCF4	1.14
92	Endometrial cancer	Enrichment	CDH1	1.14
93	Hepatoblastoma	Enrichment	CTNNB1	1.14
94	Hepatocellular carcinoma	Enrichment	CTNNB1	1.12
95	Microphthalmia	Enrichment	WNT7B	1.12
96	Tooth agenesis	Enrichment	WNT10A	1.12
97	Brittle bone disorder	Enrichment	WNT1	1.10
98	Auditory neuropathy	Enrichment	CDH2	1.05
99	Bladder cancer	Enrichment	CTNNB1	1.00
100	Prostate cancer	Enrichment	CDH1	1.00
101	Gastric cancer	Enrichment	CDH1	0.84
102	Hereditary breast carcinoma	Enrichment	CDH1	0.83
103	Breast cancer	Enrichment	CDH1	0.62
104	Congenital nervous system abnormality	Enrichment	CTNNB1	0.50
105	Nervous system disease	Enrichment	CTNNB1	0.50
106	Autism spectrum disorder	Enrichment	TCF4	0.49
107	Inherited cancer-predisposing syndrome	Enrichment	CDH1	0.42
108	Retinitis pigmentosa	Enrichment	CDH3	0.27
109	Hereditary retinal dystrophy	Enrichment	CDH3	0.18
110	Fundus dystrophy	Enrichment	CDH3	0.18

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Canonical Wnt Pathway

Pathway Network for Canonical Wnt Pathway

Member Pathways for Canonical Wnt Pathway

Pathways in the Canonical Wnt Pathway SuperPath

Associated Genes for Canonical Wnt Pathway

Associated Disorders for Canonical Wnt Pathway

Disorders associated with Canonical Wnt Pathway SuperPath

STRING Interaction Network for Canonical Wnt Pathway

Sources for Canonical Wnt Pathway