Cardiac progenitor differentiation

No Pathway Network information available for Cardiac progenitor differentiation

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

Disorders associated with Cardiac progenitor differentiation SuperPath

according to GeneCards Suite gene sharing
#DisorderTypeGenesScore
1Patent foramen ovaleEnrichmentACTC1, GATA4, MYH6, NKX2-5, TBX20, TBX510.24
2Dilated cardiomyopathyEnrichmentACTC1, MYH6, MYL2, NKX2-5, SCN5A, TBX5, TNNI3, TNNT29.11
3Left ventricular noncompactionEnrichmentACTC1, NKX2-5, SCN5A, TBX20, TNNI3, TNNT28.40
4Hypoplastic left heart syndromeEnrichmentMYH6, NKX2-5, NOTCH1, TBX207.84
5Heart diseaseEnrichmentGATA4, MYL2, NKX2-5, TBX56.69
6Wolff-parkinson-white syndromeEnrichmentNODAL, SCN5A, TBX20, TNNT26.44
7Heart, malformation ofEnrichmentGATA4, MYH6, NODAL, TBX56.21
8Familial isolated dilated cardiomyopathyEnrichmentACTC1, MYH6, SCN5A, TNNI3, TNNT25.73
9Familial isolated restrictive cardiomyopathyEnrichmentMYL2, TNNI3, TNNT25.71
10Tetralogy of fallotEnrichmentGATA4, KDR, NKX2-5, NOTCH15.54
11Familial hypertrophic cardiomyopathyEnrichmentACTC1, MYL2, TNNI3, TNNT25.11
12Hypertrophic cardiomyopathyEnrichmentACTC1, MYL2, TNNI3, TNNT24.64
13Osteoporosis, juvenileEnrichmentDKK1, WNT3A4.35
14Hereditary progressive cardiac conduction defectEnrichmentNKX2-5, SCN5A4.05
15Familial sick sinus syndromeEnrichmentMYH6, SCN5A4.05
16Cardiomyopathy, familial hypertrophic, 1EnrichmentMYH6, TNNI3, TNNT23.97
17Familial atrial fibrillationEnrichmentGATA4, NKX2-5, SCN5A3.97
18Ventricular septal defect 1EnrichmentGATA4, IRX43.83
19Anterior segment dysgenesis 5EnrichmentBMP4, PAX63.65
20Gastrointestinal stromal tumorEnrichmentKIT, PDGFRA3.51
21MyocarditisEnrichmentTNNI3, TNNT23.38
22Cardiomyopathy, familial hypertrophic, 4EnrichmentTNNI3, TNNT23.28
23Distal arthrogryposisEnrichmentACTC1, ROR2, SCN5A3.24
24Peters-plus syndromeEnrichmentBMP4, PAX63.18
25Atrial heart septal defectEnrichmentNKX2-5, TBX53.09
26Interatrial communicationEnrichmentNKX2-5, TBX53.09
27Restrictive cardiomyopathyEnrichmentTNNI3, TNNT23.02
28Aortic valve disease 1EnrichmentNKX2-5, NOTCH12.94
29Aortic aneurysm, familial thoracic 1EnrichmentGATA4, NOTCH12.88
30Cleft lip/palateEnrichmentBMP4, PDGFRA2.88
31Sudden infant death syndromeEnrichmentSCN5A, TNNI32.71
32Cardiomyopathy, dilated, 1eEnrichmentMYL2, SCN5A2.71
33Macs syndromeEnrichmentPAX6, SOX22.57
34MicrophthalmiaEnrichmentPAX6, SOX22.48
35Cardiomyopathy, familial hypertrophic, 2EnrichmentTNNT22.41
36Brachydactyly, type b1EnrichmentROR22.41
37Chiari malformation type iEnrichmentDKK12.41
38Atrial septal defect 7 with or without atrioventricular conduction defectsEnrichmentNKX2-52.41
39Stapes ankylosis with broad thumbs and toesEnrichmentNOG2.41
40Tarsal-carpal coalition syndromeEnrichmentNOG2.41
41Hypothyroidism, congenital, nongoitrous, 5EnrichmentNKX2-52.41
42Cardiomyopathy, dilated, 2aEnrichmentTNNI32.41
43Hypereosinophilic syndrome, idiopathicEnrichmentPDGFRA2.41
44Mastocytosis, cutaneousEnrichmentKIT2.41
45Cardiomyopathy, familial restrictive, 3EnrichmentTNNT22.41
46Holt-oram syndromeEnrichmentTBX52.41
47Brachydactyly, type b2EnrichmentNOG2.41
48Cardiomyopathy, familial hypertrophic, 7EnrichmentTNNI32.41
49Symphalangism, proximal, 1aEnrichmentNOG2.41
50Sacral agenesis with vertebral anomaliesEnrichmentTBXT2.41
51Multiple synostoses syndrome 1EnrichmentNOG2.41
52Cardiomyopathy, dilated, 1eeEnrichmentMYH62.41
53Sick sinus syndrome 3EnrichmentMYH62.41
54Vesicoureteral reflux 3EnrichmentSOX172.41
55Gist-plus syndromeEnrichmentPDGFRA2.41
56Whim syndrome 1EnrichmentCXCR42.41
57Atrioventricular septal defect 4EnrichmentGATA42.41
58Heterotaxy, visceral, 5, autosomalEnrichmentNODAL2.41
59Microphthalmia, syndromic 6EnrichmentBMP42.41
60Myeloid and lymphoid neoplasms associated with pdgfra rearrangementEnrichmentPDGFRA2.41
61Orofacial cleft 11EnrichmentBMP42.41
62Hypoplastic right heart syndromeEnrichmentTBX202.41
63Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired languageEnrichmentMEF2C2.41
64Ovary adenocarcinomaEnrichmentINHBA2.41
65Atrial septal defect 4EnrichmentTBX202.41
66Atrial septal defect 2EnrichmentGATA42.41
67Cardiomyopathy, familial hypertrophic, 14EnrichmentMYH62.41
68Ventricular septal defect 3EnrichmentNKX2-52.41
69Testicular anomalies with or without congenital heart diseaseEnrichmentGATA42.41
70Hypoplastic left heart syndrome 2EnrichmentNKX2-52.41
718p23.1 microdeletion syndromeEnrichmentGATA42.41
72Chronic mast cell leukemiaEnrichmentKIT2.41
73Tufted angioma of skinEnrichmentKDR2.41
74Pulmonary hypertension, primary, 7EnrichmentSOX172.41
75Non-acquired combined pituitary hormone deficiencyEnrichmentFOXA22.41
76Sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndromeEnrichmentTBXT2.41
775q14.3 microdeletion syndromeEnrichmentMEF2C2.41
78Aortic arch interruptionEnrichmentNKX2-52.41
79Isolated bone marrow mastocytosisEnrichmentKIT2.41
80Smoldering systemic mastocytosisEnrichmentKIT2.41
81Complete atrioventricular septal defect without ventricular hypoplasiaEnrichmentMEF2C2.41
82Atrial heart septal defect 7EnrichmentNKX2-52.41
83MastocytosisEnrichmentKIT2.41
84Partial atrioventricular septal defect with ventricular hypoplasiaEnrichmentGATA42.41
85Cutaneous mastocytomaEnrichmentKIT2.41
86Typical urticaria pigmentosaEnrichmentKIT2.41
87Mef2c-related disorderEnrichmentMEF2C2.41
88Nodular urticaria pigmentosaEnrichmentKIT2.41
89Pseudoxanthomatous diffuse cutaneous mastocytosisEnrichmentKIT2.41
90Telangiectasia macularis eruptiva perstansEnrichmentKIT2.41
91Acute mast cell leukemiaEnrichmentKIT2.41
92Plaque-form urticaria pigmentosaEnrichmentKIT2.41
93Bullous diffuse cutaneous mastocytosisEnrichmentKIT2.41
94Testis seminomaEnrichmentKIT2.41
95Long qt syndrome 1EnrichmentSCN5A, TBX52.22
96Long qt syndromeEnrichmentMYH6, SCN5A2.19
97Keratitis, hereditaryEnrichmentPAX62.11
98Atrial standstill 1EnrichmentSCN5A2.11
99Progressive familial heart block, type iaEnrichmentSCN5A2.11
100Foveal hypoplasia 1EnrichmentPAX62.11
101Cardiomyopathy, familial restrictive, 1EnrichmentTNNI32.11
102Camurati-engelmann disease 1EnrichmentTGFB12.11
103Thumb deformityEnrichmentTBX52.11
104Spondylocostal dysostosis 2, autosomal recessiveEnrichmentMESP22.11
105Cardiomyopathy, dilated, 1rEnrichmentACTC12.11
106Sick sinus syndrome 1EnrichmentSCN5A2.11
107Piebald traitEnrichmentKIT2.11
108Cardiomyopathy, familial hypertrophic, 11EnrichmentACTC12.11
109Optic nerve hypoplasia, bilateralEnrichmentPAX62.11
110Adams-oliver syndrome 5EnrichmentNOTCH12.11
111Silver-russell syndrome 3EnrichmentIGF22.11
112Osteogenesis imperfecta, type xiiiEnrichmentBMP12.11
113Cardiomyopathy, familial hypertrophic, 25EnrichmentTNNI32.11
114Angioma, tuftedEnrichmentKDR2.11
115Atrial fibrillation, familial, 10EnrichmentSCN5A2.11
116Maturity-onset diabetes of the young, type 10EnrichmentINS2.11
117Cardiomyopathy, dilated, 1ddEnrichmentTNNT22.11
118Cardiomyopathy, dilated, 1ffEnrichmentTNNI32.11
119Atrial septal defect 5EnrichmentACTC12.11
120Long qt syndrome 3EnrichmentSCN5A2.11
121Cardiomyopathy, dilated, 1dEnrichmentTNNT22.11
122Sinoatrial node diseaseEnrichmentSCN5A2.11
123HyperproinsulinemiaEnrichmentINS2.11
124Inflammatory bowel disease, immunodeficiency, and encephalopathyEnrichmentTGFB12.11
125Atrial septal defect 3EnrichmentMYH62.11
126Bladder exstrophyEnrichmentISL12.11
127Cardiomyopathy, familial hypertrophic, 10EnrichmentMYL22.11
128Camurati-engelmann diseaseEnrichmentTGFB12.11
12946,xy sex reversal 3EnrichmentGATA42.11
130Diabetes mellitus, permanent neonatal, 4EnrichmentINS2.11
131Aortic valve disease 2EnrichmentTBX52.11
132Myopathy, myofibrillar, 12, infantile-onset, with cardiomyopathyEnrichmentMYL22.11
133Proximal symphalangismEnrichmentNOG2.11
134Familial isolated congenital aspleniaEnrichmentNKX2-52.11
135Chronic eosinophilic leukemiaEnrichmentPDGFRA2.11
136Growth delay due to insulin-like growth factor type 1 deficiencyEnrichmentIGF12.11
137Deletion 5q35EnrichmentNKX2-52.11
138Isolated atrial standstillEnrichmentSCN5A2.11
139B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormalityEnrichmentPDGFRA2.11
140B-lymphoblastic leukemia/lymphoma with tEnrichmentKIT2.11
141Silver-russell syndrome due to an imprinting defect of 11p15EnrichmentIGF22.11
142Silver-russell syndrome due to 11p15 microduplicationEnrichmentIGF22.11
143Fetal akinesia deformation sequence 1EnrichmentROR2, SCN5A2.04
144Type 1 diabetes mellitus 2EnrichmentINS1.93
145Spondylocostal dysostosis 5EnrichmentMESP21.93
146Gillespie syndromeEnrichmentPAX61.93
147Testicular germ cell cancerEnrichmentKIT1.93
148Familial vesicoureteral refluxEnrichmentSOX171.93
149High bone mass osteogenesis imperfectaEnrichmentBMP11.93
150KeratoacanthomaEnrichmentNOTCH11.93
151Beckwith-wiedemann syndrome due to imprinting defect of 11p15EnrichmentIGF21.93
152Aniridia 1EnrichmentPAX61.81
153ChordomaEnrichmentTBXT1.81
154Microphthalmia, syndromic 3EnrichmentSOX21.81
155Ventricular fibrillation, paroxysmal familial, 1EnrichmentSCN5A1.81
156Long qt syndrome 2EnrichmentSCN5A1.81
157Multiple synostoses syndromeEnrichmentNOG1.81
158Atrial fibrillationEnrichmentSCN5A1.81
159Neonatal diabetes mellitusEnrichmentINS1.81
160Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)EnrichmentKIT1.81
161Eyelid colobomaEnrichmentPAX61.81
162Sick sinus syndromeEnrichmentSCN5A1.81
163Silver-russell syndrome due to a point mutationEnrichmentIGF21.81
164Mitral valve insufficiencyEnrichmentTBX51.81
165Systemic mastocytosis with associated hematologic neoplasmEnrichmentKIT1.81
166Transposition of the great arteriesEnrichmentGATA41.81
167Lens colobomaEnrichmentPAX61.81
168Paroxysmal familial ventricular fibrillationEnrichmentSCN5A1.81
169Robinow syndrome, autosomal recessive 1EnrichmentROR21.71
170Atrioventricular septal defectEnrichmentTBX51.71
171Insulin-like growth factor iEnrichmentIGF11.71
172Congenital heart defects, multiple types, 4EnrichmentGATA41.71
173Heart conduction diseaseEnrichmentSCN5A1.71
174Cardiac arrestEnrichmentSCN5A1.71
175Acute myeloid leukemia with maturationEnrichmentKIT1.71
176AniridiaEnrichmentPAX61.71
177Coloboma of choroid and retinaEnrichmentPAX61.71
178Acute myeloid leukemia with t(8;21)(q22;q22) translocationEnrichmentKIT1.71
179Persistent truncus arteriosusEnrichmentNKX2-51.71
180Primary hypereosinophilic syndromeEnrichmentPDGFRA1.71
181Atrial septal defect 1EnrichmentTBX51.63
182Coloboma of optic nerveEnrichmentPAX61.63
183Conotruncal heart malformationsEnrichmentNKX2-51.63
184Hemihyperplasia, isolatedEnrichmentIGF21.63
185Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndromeEnrichmentPAX61.63
186Type 1 diabetes mellitusEnrichmentINS1.63
187Testicular germ cell tumorEnrichmentKIT1.63
188Hemangioma, capillary infantileEnrichmentKDR1.63
189Inflammatory bowel disease 25, autosomal recessiveEnrichmentTGFB11.63
190Autosomal recessive robinow syndromeEnrichmentROR21.63
191Double outlet right ventricleEnrichmentNKX2-51.63
192Il10-related early-onset inflammatory bowel diseaseEnrichmentTGFB11.63
193Spondylocostal dysostosis, autosomal recessiveEnrichmentMESP21.63
194Hypothyroidism, congenital, nongoitrous, 2EnrichmentNKX2-51.57
195Silver-russell syndrome 1EnrichmentIGF21.57
196Brugada syndrome 1EnrichmentSCN5A1.57
197Adams-oliver syndromeEnrichmentNOTCH11.57
198Spondylocostal dysostosis 1, autosomal recessiveEnrichmentMESP21.51
199NeuroblastomaEnrichmentLIN28B1.51
200Permanent neonatal diabetes mellitusEnrichmentINS1.51
201Combined pituitary hormone deficiencyEnrichmentFOXA21.51
202Ventricular septal defectEnrichmentTBX51.46
203Familial isolated arrhythmogenic right ventricular dysplasiaEnrichmentSCN5A1.46
204Cat eye syndromeEnrichmentPAX61.42
205Stickler syndromeEnrichmentBMP41.42
206NanophthalmosEnrichmentSOX21.38
207Diabetes mellitusEnrichmentINS1.38
208Heritable pulmonary arterial hypertensionEnrichmentSOX171.38
209Cardiac conduction defectEnrichmentSCN5A1.34
210Septooptic dysplasiaEnrichmentSOX21.34
211Renal hypodysplasia/aplasia 3EnrichmentBMP41.34
212Lip and oral cavity carcinomaEnrichmentKIT1.34
213Congenital long qt syndromeEnrichmentSCN5A1.34
214Microphthalmia/coloboma 12EnrichmentPAX61.30
215Neural tube defectsEnrichmentTBXT1.30
216Pulmonary hypertension, primary, 1EnrichmentSOX171.30
21746,xy partial gonadal dysgenesisEnrichmentGATA41.27
218Coloboma of maculaEnrichmentPAX61.24
219Wilms tumor 1EnrichmentIGF21.24
220Congenital myopathy 4a, autosomal dominantEnrichmentMYL21.24
221Osteogenesis imperfecta, type iiiEnrichmentBMP11.24
222Anterior segment dysgenesisEnrichmentPAX61.24
223Septopreoptic holoprosencephalyEnrichmentNODAL1.24
224Midline interhemispheric variant of holoprosencephalyEnrichmentNODAL1.24
225Ovarian cancerEnrichmentKIT, PDGFRA1.23
226Arrhythmogenic right ventricular cardiomyopathyEnrichmentSCN5A1.22
227Microform holoprosencephalyEnrichmentNODAL1.22
228Lobar holoprosencephalyEnrichmentNODAL1.22
229Alobar holoprosencephalyEnrichmentNODAL1.19
230Beckwith-wiedemann syndromeEnrichmentIGF21.17
231Semilobar holoprosencephalyEnrichmentNODAL1.17
232Maturity-onset diabetes of the youngEnrichmentINS1.12
233Cardiomyopathy, dilated, 1aEnrichmentTNNI31.10
234Visceral heterotaxyEnrichmentNODAL1.08
235Brittle bone disorderEnrichmentBMP11.06
236Inherited cancer-predisposing syndromeEnrichmentKIT, PDGFRA1.03
237Brugada syndromeEnrichmentSCN5A1.01
238Visceral heterotaxy 5EnrichmentNODAL0.94
239Cystic fibrosisEnrichmentTGFB10.93
240Connective tissue diseaseEnrichmentNOTCH10.93
241Leukemia, acute myeloidEnrichmentKIT0.84
242Familial thoracic aortic aneurysm and aortic dissectionEnrichmentNOTCH10.80
243HypertelorismEnrichmentPAX60.73
244Male infertility with azoospermia or oligozoospermia due to single gene mutationEnrichmentGATA40.71
245Frontotemporal dementia and/or amyotrophic lateral sclerosis 7EnrichmentMEF2C0.69
246Primary ovarian insufficiencyEnrichmentKDR0.68
247Colorectal cancerEnrichmentIGF20.54
248Autism spectrum disorderEnrichmentMEF2C0.46

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