Cardiogenesis

No Pathway Network information available for Cardiogenesis

Pathways in the Cardiogenesis SuperPath

#	Name	Source	Genes
1	Cardiogenesis	Reactome	CTNNB1 EOMES FOXO4 GATA4 GATA6 HAND1 HAND2 HEY1 HEY2 ISL1 KAT2A KAT5 LDB1 LEF1 MEF2C MESP1 MYOCD NKX2-5 SMAD1 SMAD4 SMYD1 SRF TBX1 TBX20 TBX5 TBXT WDR5 (see all 27) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	KAT5	Lysine Acetyltransferase 5	Protein Coding	1
2	WDR5	WD Repeat Domain 5	Protein Coding	1
3	NKX2-5	NK2 Homeobox 5	Protein Coding	1
4	CTNNB1	Catenin Beta 1	Protein Coding	1
5	SMYD1	SET And MYND Domain Containing 1	Protein Coding	1
6	HEY1	Hes Related Family BHLH Transcription Factor With YRPW Motif 1	Protein Coding	1
7	HEY2	Hes Related Family BHLH Transcription Factor With YRPW Motif 2	Protein Coding	1
8	GATA4	GATA Binding Protein 4	Protein Coding	1
9	GATA6	GATA Binding Protein 6	Protein Coding	1
10	KAT2A	Lysine Acetyltransferase 2A	Protein Coding	1
11	ISL1	ISL LIM Homeobox 1	Protein Coding	1
12	SMAD1	SMAD Family Member 1	Protein Coding	1
13	SMAD4	SMAD Family Member 4	Protein Coding	1
14	MEF2C	Myocyte Enhancer Factor 2C	Protein Coding	1
15	FOXO4	Forkhead Box O4	Protein Coding	1
16	LEF1	Lymphoid Enhancer Binding Factor 1	Protein Coding	1
17	MESP1	Mesoderm Posterior BHLH Transcription Factor 1	Protein Coding	1
18	TBX20	T-Box Transcription Factor 20	Protein Coding	1
19	SRF	Serum Response Factor	Protein Coding	1
20	TBXT	T-Box Transcription Factor T	Protein Coding	1
21	TBX1	T-Box Transcription Factor 1	Protein Coding	1
22	TBX5	T-Box Transcription Factor 5	Protein Coding	1
23	EOMES	Eomesodermin	Protein Coding	1
24	LDB1	LIM Domain Binding 1	Protein Coding	1
25	MYOCD	Myocardin	Protein Coding	1
26	HAND1	Heart And Neural Crest Derivatives Expressed 1	Protein Coding	1
27	HAND2	Heart And Neural Crest Derivatives Expressed 2	Protein Coding	1

Disorders associated with Cardiogenesis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Patent foramen ovale	Enrichment	GATA4, GATA6, NKX2-5, TBX20, TBX5	9.71
2	Tetralogy of fallot	Enrichment	GATA4, GATA6, HEY2, NKX2-5, TBX1	8.87
3	Persistent truncus arteriosus	Enrichment	GATA6, NKX2-5, TBX1	7.15
4	Conotruncal heart malformations	Enrichment	GATA6, NKX2-5, TBX1	6.85
5	Heart disease	Enrichment	GATA4, NKX2-5, TBX5	5.60
6	Familial atrial fibrillation	Enrichment	GATA4, GATA6, NKX2-5	4.86
7	Congenital heart defects, multiple types, 4	Enrichment	GATA4, GATA6	4.42
8	Gallbladder cancer	Enrichment	CTNNB1, SMAD4	4.10
9	Hypoplastic left heart syndrome	Enrichment	NKX2-5, TBX20	3.97
10	Atrial heart septal defect	Enrichment	NKX2-5, TBX5	3.68
11	Interatrial communication	Enrichment	NKX2-5, TBX5	3.68
12	Dilated cardiomyopathy	Enrichment	GATA6, NKX2-5, TBX5	3.28
13	Heart, malformation of	Enrichment	GATA4, TBX5	3.24
14	Atrial septal defect 7 with or without atrioventricular conduction defects	Enrichment	NKX2-5	2.70
15	Velocardiofacial syndrome	Enrichment	TBX1	2.70
16	Hypothyroidism, congenital, nongoitrous, 5	Enrichment	NKX2-5	2.70
17	Holt-oram syndrome	Enrichment	TBX5	2.70
18	Sacral agenesis with vertebral anomalies	Enrichment	TBXT	2.70
19	Atrioventricular septal defect 4	Enrichment	GATA4	2.70
20	Atrioventricular septal defect 5	Enrichment	GATA6	2.70
21	Ectodermal dysplasia 17 with or without limb malformations	Enrichment	LEF1	2.70
22	Megabladder, congenital	Enrichment	MYOCD	2.70
23	Hypoplastic right heart syndrome	Enrichment	TBX20	2.70
24	Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language	Enrichment	MEF2C	2.70
25	Atrial septal defect 4	Enrichment	TBX20	2.70
26	Atrial septal defect 2	Enrichment	GATA4	2.70
27	Ventricular septal defect 3	Enrichment	NKX2-5	2.70
28	Testicular anomalies with or without congenital heart disease	Enrichment	GATA4	2.70
29	Hypoplastic left heart syndrome 2	Enrichment	NKX2-5	2.70
30	Atrial septal defect 9	Enrichment	GATA6	2.70
31	8p23.1 microdeletion syndrome	Enrichment	GATA4	2.70
32	Adenoid ameloblastoma	Enrichment	CTNNB1	2.70
33	Heritable thoracic aortic disease	Enrichment	SMAD4	2.70
34	Sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome	Enrichment	TBXT	2.70
35	5q14.3 microdeletion syndrome	Enrichment	MEF2C	2.70
36	Aortic arch interruption	Enrichment	NKX2-5	2.70
37	Complete atrioventricular septal defect without ventricular hypoplasia	Enrichment	MEF2C	2.70
38	Atrial heart septal defect 7	Enrichment	NKX2-5	2.70
39	Partial atrioventricular septal defect with ventricular hypoplasia	Enrichment	GATA4	2.70
40	Mef2c-related disorder	Enrichment	MEF2C	2.70
41	Microcephaly-polymicrogyria-corpus callosum agenesis syndrome	Enrichment	EOMES	2.70
42	Microcystic stromal tumor	Enrichment	CTNNB1	2.70
43	Left ventricular noncompaction	Enrichment	NKX2-5, TBX20	2.66
44	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	HEY2, SMAD4	2.46
45	Ectrodactyly and ectodermal dysplasia without cleft lip/palate	Enrichment	LEF1	2.40
46	Myhre syndrome	Enrichment	SMAD4	2.40
47	Thumb deformity	Enrichment	TBX5	2.40
48	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.40
49	Chromosome 22q11.2 duplication syndrome	Enrichment	TBX1	2.40
50	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.40
51	Neutropenia, severe congenital, 8, autosomal dominant	Enrichment	GATA6	2.40
52	Neurodevelopmental disorder with dysmorphic facies, sleep disturbance, and brain abnormalities	Enrichment	KAT5	2.40
53	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.40
54	Bladder exstrophy	Enrichment	ISL1	2.40
55	Split hand-foot malformation	Enrichment	LEF1	2.40
56	46,xy sex reversal 3	Enrichment	GATA4	2.40
57	Aortic valve disease 2	Enrichment	TBX5	2.40
58	Familial isolated congenital asplenia	Enrichment	NKX2-5	2.40
59	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.40
60	Deletion 5q35	Enrichment	NKX2-5	2.40
61	Teratoma	Enrichment	CTNNB1	2.40
62	Desmoid disease, hereditary	Enrichment	CTNNB1	2.22
63	Prune belly syndrome	Enrichment	MYOCD	2.22
64	Juvenile polyposis syndrome	Enrichment	SMAD4	2.22
65	Heart defects, congenital, and other congenital anomalies	Enrichment	GATA6	2.22
66	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	2.22
67	Anus, imperforate	Enrichment	CTNNB1	2.22
68	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	2.22
69	Desmoid tumor	Enrichment	CTNNB1	2.22
70	Chordoma	Enrichment	TBXT	2.10
71	Pilomatrixoma	Enrichment	CTNNB1	2.10
72	Alazami syndrome	Enrichment	CTNNB1	2.10
73	Craniopharyngioma	Enrichment	CTNNB1	2.10
74	Hereditary progressive cardiac conduction defect	Enrichment	NKX2-5	2.10
75	Mitral valve insufficiency	Enrichment	TBX5	2.10
76	Transposition of the great arteries	Enrichment	GATA4	2.10
77	Middle aortic syndrome	Enrichment	GATA6	2.10
78	Kbg syndrome	Enrichment	TBX1	2.00
79	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	2.00
80	Atrioventricular septal defect	Enrichment	TBX5	2.00
81	Ventricular septal defect 1	Enrichment	GATA4	2.00
82	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	2.00
83	Atrial septal defect 1	Enrichment	TBX5	1.92
84	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.92
85	Split-hand/foot malformation 1	Enrichment	LEF1	1.92
86	Adrenocortical carcinoma	Enrichment	CTNNB1	1.92
87	Double outlet right ventricle	Enrichment	NKX2-5	1.92
88	Colorectal cancer	Enrichment	CTNNB1, SMAD4	1.89
89	Hypothyroidism, congenital, nongoitrous, 2	Enrichment	NKX2-5	1.86
90	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.86
91	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.80
92	Adult hepatocellular carcinoma	Enrichment	CTNNB1	1.75
93	Ventricular septal defect	Enrichment	TBX5	1.75
94	Digeorge syndrome	Enrichment	TBX1	1.63
95	Aortic valve disease 1	Enrichment	NKX2-5	1.59
96	Diaphragmatic hernia, congenital	Enrichment	GATA6	1.59
97	Neural tube defects	Enrichment	TBXT	1.59
98	Medulloblastoma	Enrichment	CTNNB1	1.56
99	Aortic aneurysm, familial thoracic 1	Enrichment	GATA4	1.56
100	46,xy partial gonadal dysgenesis	Enrichment	GATA4	1.56
101	Wolff-parkinson-white syndrome	Enrichment	TBX20	1.50
102	Polycystic liver disease	Enrichment	CTNNB1	1.48
103	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.48
104	Cardiomyopathy, dilated, 1a	Enrichment	HAND2	1.39
105	Hepatoblastoma	Enrichment	CTNNB1	1.39
106	Hepatocellular carcinoma	Enrichment	CTNNB1	1.37
107	Pancreatic cancer	Enrichment	SMAD4	1.31
108	Bladder cancer	Enrichment	CTNNB1	1.25
109	Long qt syndrome 1	Enrichment	TBX5	1.24
110	Gastric cancer	Enrichment	SMAD4	1.08
111	Thrombocytopenia	Enrichment	SMAD4	1.04
112	Familial isolated dilated cardiomyopathy	Enrichment	HAND2	1.00
113	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	GATA4	0.98
114	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MEF2C	0.96
115	Ovarian cancer	Enrichment	CTNNB1	0.74
116	Congenital nervous system abnormality	Enrichment	CTNNB1	0.72
117	Nervous system disease	Enrichment	CTNNB1	0.72
118	Autism spectrum disorder	Enrichment	MEF2C	0.71
119	Microcephaly	Enrichment	CTNNB1	0.66
120	Inherited cancer-predisposing syndrome	Enrichment	SMAD4	0.63

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Cardiogenesis

Member Pathways for Cardiogenesis

Pathways in the Cardiogenesis SuperPath

Associated Genes for Cardiogenesis

Associated Disorders for Cardiogenesis

Disorders associated with Cardiogenesis SuperPath

STRING Interaction Network for Cardiogenesis

Sources for Cardiogenesis