Cargo trafficking to the periciliary membrane

Pathway network for the Cargo trafficking to the periciliary membrane SuperPath

Sources:

Reactome

Pathways in the Cargo trafficking to the periciliary membrane SuperPath

#	Name	Source	Genes
1	Cargo trafficking to the periciliary membrane	Reactome	ARF4 ARL13B ARL3 ARL6 ASAP1 BBIP1 BBS1 BBS10 BBS12 BBS2 BBS4 BBS5 BBS7 BBS9 CCT2 CCT3 CCT4 CCT5 CCT8 CNGA2 CNGA4 CNGB1 CYS1 EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6 EXOC7 EXOC8 GBF1 INPP5E LZTFL1 MCHR1 MKKS NPHP3 PDE6D PKD1 PKD2 RAB11A RAB11FIP3 RAB3IP RAB8A RHO RP2 SMO SSTR3 TCP1 TTC8 UNC119B (see all 51) (see less)
2	BBSome-mediated cargo-targeting to cilium	Reactome	ARL6 BBIP1 BBS1 BBS10 BBS12 BBS2 BBS4 BBS5 BBS7 BBS9 CCT2 CCT3 CCT4 CCT5 CCT8 LZTFL1 MCHR1 MKKS RAB3IP SMO SSTR3 TCP1 TTC8 (see all 23) (see less)
3	VxPx cargo-targeting to cilium	Reactome	ARF4 ASAP1 CNGA2 CNGA4 CNGB1 EXOC1 EXOC2 EXOC3 EXOC4 EXOC5 EXOC6 EXOC7 EXOC8 GBF1 PKD1 PKD2 RAB11A RAB11FIP3 RAB3IP RAB8A RHO (see all 21) (see less)
4	Trafficking of myristoylated proteins to the cilium	Reactome	ARL3 CYS1 NPHP3 RP2 UNC119B
5	ARL13B-mediated ciliary trafficking of INPP5E	Reactome	ARL13B INPP5E PDE6D

Gene overlap in member pathways for Cargo trafficking to the periciliary membrane SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RAB3IP	RAB3A Interacting Protein	Protein Coding	3
2	CCT4	Chaperonin Containing TCP1 Subunit 4	Protein Coding	2
3	CCT2	Chaperonin Containing TCP1 Subunit 2	Protein Coding	2
4	EXOC5	Exocyst Complex Component 5	Protein Coding	2
5	CCT8	Chaperonin Containing TCP1 Subunit 8	Protein Coding	2
6	EXOC3	Exocyst Complex Component 3	Protein Coding	2
7	TTC8	Tetratricopeptide Repeat Domain 8	Protein Coding	2
8	CNGB1	Cyclic Nucleotide Gated Channel Subunit Beta 1	Protein Coding	2
9	CNGA2	Cyclic Nucleotide Gated Channel Subunit Alpha 2	Protein Coding	2
10	CNGA4	Cyclic Nucleotide Gated Channel Subunit Alpha 4	Protein Coding	2
11	BBS5	Bardet-Biedl Syndrome 5	Protein Coding	2
12	EXOC8	Exocyst Complex Component 8	Protein Coding	2
13	BBS12	Bardet-Biedl Syndrome 12	Protein Coding	2
14	CYS1	Cystin 1	Protein Coding	2
15	ARL13B	ARF Like GTPase 13B	Protein Coding	2
16	CCT5	Chaperonin Containing TCP1 Subunit 5	Protein Coding	2
17	EXOC7	Exocyst Complex Component 7	Protein Coding	2
18	NPHP3	Nephrocystin 3	Protein Coding	2
19	BBS9	Bardet-Biedl Syndrome 9	Protein Coding	2
20	MCHR1	Melanin Concentrating Hormone Receptor 1	Protein Coding	2
21	ARF4	ARF GTPase 4	Protein Coding	2
22	ARL3	ARF Like GTPase 3	Protein Coding	2
23	RAB8A	RAB8A, Member RAS Oncogene Family	Protein Coding	2
24	ASAP1	ArfGAP With SH3 Domain, Ankyrin Repeat And PH Domain 1	Protein Coding	2
25	PDE6D	Phosphodiesterase 6D	Protein Coding	2
26	PKD1	Polycystin 1, Transient Receptor Potential Channel Interacting	Protein Coding	2
27	PKD2	Polycystin 2, Transient Receptor Potential Cation Channel	Protein Coding	2
28	EXOC6	Exocyst Complex Component 6	Protein Coding	2
29	LZTFL1	Leucine Zipper Transcription Factor Like 1	Protein Coding	2
30	BBS7	Bardet-Biedl Syndrome 7	Protein Coding	2
31	EXOC1	Exocyst Complex Component 1	Protein Coding	2
32	EXOC2	Exocyst Complex Component 2	Protein Coding	2
33	INPP5E	Inositol Polyphosphate-5-Phosphatase E	Protein Coding	2
34	BBS1	Bardet-Biedl Syndrome 1	Protein Coding	2
35	BBS2	Bardet-Biedl Syndrome 2	Protein Coding	2
36	BBS4	Bardet-Biedl Syndrome 4	Protein Coding	2
37	RHO	Rhodopsin	Protein Coding	2
38	EXOC4	Exocyst Complex Component 4	Protein Coding	2
39	RP2	RP2 Activator Of ARL3 GTPase	Protein Coding	2
40	SMO	Smoothened, Frizzled Class Receptor	Protein Coding	2
41	SSTR3	Somatostatin Receptor 3	Protein Coding	2
42	TCP1	T-Complex 1	Protein Coding	2
43	CCT3	Chaperonin Containing TCP1 Subunit 3	Protein Coding	2
44	BBS10	Bardet-Biedl Syndrome 10	Protein Coding	2
45	MKKS	MKKS Centrosomal Shuttling Protein	Protein Coding	2
46	ARL6	ARF Like GTPase 6	Protein Coding	2
47	UNC119B	Unc-119 Lipid Binding Chaperone B	Protein Coding	2
48	GBF1	Golgi Brefeldin A Resistant Guanine Nucleotide Exchange Factor 1	Protein Coding	2
49	RAB11A	RAB11A, Member RAS Oncogene Family	Protein Coding	2
50	BBIP1	BBSome Interacting Protein 1	Protein Coding	2
51	RAB11FIP3	RAB11 Family Interacting Protein 3	Protein Coding	2

Disorders associated with Cargo trafficking to the periciliary membrane SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Bardet-biedl syndrome 1	Enrichment	ARL6, BBS1, BBS10, BBS12, BBS2, BBS4, BBS5, BBS7, BBS9, MKKS	16.00
2	Bardet-biedl syndrome	Enrichment	ARL6, BBIP1, BBS1, BBS10, BBS12, BBS2, BBS4, BBS5, BBS7, BBS9, LZTFL1, MKKS, TTC8	16.00
3	Hereditary retinal dystrophy	Enrichment	ARL6, BBS1, BBS10, BBS12, BBS2, BBS4, BBS5, BBS7, BBS9, CNGB1, INPP5E, MKKS, RHO, RP2, TTC8	16.00
4	Fundus dystrophy	Enrichment	ARL6, BBS1, BBS10, BBS12, BBS2, BBS4, BBS5, BBS7, BBS9, CNGB1, INPP5E, MKKS, RHO, RP2, TTC8	16.00
5	Retinitis pigmentosa	Enrichment	ARL3, ARL6, BBIP1, BBS1, BBS10, BBS12, BBS2, BBS4, BBS7, BBS9, CNGB1, INPP5E, RHO, RP2, TTC8	11.08
6	Isolated joubert syndrome	Enrichment	ARL13B, INPP5E, PDE6D	8.01
7	Polycystic kidney disease	Enrichment	MKKS, NPHP3, PKD1, PKD2	6.28
8	Multicystic kidney dysplasia	Enrichment	MKKS, PKD1, PKD2	6.00
9	Multicystic dysplastic kidney	Enrichment	MKKS, PKD1, PKD2	6.00
10	Polycystic kidney disease 4 with or without polycystic liver disease	Enrichment	CYS1, PKD1, PKD2	5.56
11	Polycystic liver disease 1 with or without kidney cysts	Enrichment	PKD1, PKD2	4.64
12	Polycystic liver disease 1	Enrichment	PKD1, PKD2	4.64
13	Joubert syndrome 1	Enrichment	ARL13B, INPP5E	4.40
14	Polycystic kidney disease 1 with or without polycystic liver disease	Enrichment	PKD1, PKD2	4.32
15	Polycystic kidney disease 1	Enrichment	PKD1, PKD2	4.32
16	Joubert syndrome 8	Enrichment	ARL13B	3.66
17	Joubert syndrome 22	Enrichment	PDE6D	3.66
18	Impaired intellectual development, truncal obesity, retinal dystrophy, and micropenis syndrome	Enrichment	INPP5E	3.66
19	Autosomal dominant polycystic kidney disease	Enrichment	PKD1, PKD2	3.63
20	Hypertension	Enrichment	PKD1, PKD2	3.57
21	Eye disease	Enrichment	ARL6, BBS9, RP2	3.52
22	Joubert syndrome 35	Enrichment	ARL3	3.43
23	Retinitis pigmentosa 83	Enrichment	ARL3	3.43
24	Leber plus disease	Enrichment	BBS1, CCT2, INPP5E, RP2	3.36
25	Short femur	Enrichment	INPP5E	3.35
26	Interstitial lung disease	Enrichment	INPP5E	3.18
27	Respiratory failure	Enrichment	INPP5E	3.18
28	Retinitis pigmentosa 2	Enrichment	RP2	3.13
29	Retinitis pigmentosa 3	Enrichment	RP2	2.96
30	Meckel syndrome, type 7	Enrichment	NPHP3	2.96
31	Nephronophthisis 3	Enrichment	NPHP3	2.96
32	Renal-hepatic-pancreatic dysplasia	Enrichment	NPHP3	2.96
33	Late-onset nephronophthisis	Enrichment	NPHP3	2.96
34	Coach syndrome 1	Enrichment	INPP5E	2.96
35	Joubert syndrome with ocular defect	Enrichment	INPP5E	2.96
36	Cone-rod dystrophy 6	Enrichment	ARL3, MKKS	2.91
37	Patent ductus arteriosus	Enrichment	INPP5E	2.88
38	Renal-hepatic-pancreatic dysplasia 1	Enrichment	NPHP3	2.83
39	Night blindness, congenital stationary, autosomal dominant 1	Enrichment	RHO	2.81
40	Charcot-marie-tooth disease, axonal, type 2gg	Enrichment	GBF1	2.81
41	Retinitis pigmentosa 4	Enrichment	RHO	2.81
42	Retinitis pigmentosa 45	Enrichment	CNGB1	2.81
43	Neurodevelopmental disorder with seizures and brain atrophy	Enrichment	EXOC7	2.81
44	Neurodevelopmental disorder with microcephaly, seizures, and brain atrophy	Enrichment	EXOC8	2.81
45	Renovascular hypertension	Enrichment	PKD1	2.81
46	Bardet-biedl syndrome 3	Enrichment	ARL6	2.77
47	Curry-jones syndrome	Enrichment	SMO	2.77
48	Mckusick-kaufman syndrome	Enrichment	MKKS	2.77
49	Bardet-biedl syndrome 12	Enrichment	BBS12	2.77
50	Bardet-biedl syndrome 17	Enrichment	LZTFL1	2.77
51	Retinitis pigmentosa 55	Enrichment	ARL6	2.77
52	Bardet-biedl syndrome 4	Enrichment	BBS4	2.77
53	Intellectual developmental disorder with polymicrogyria and seizures	Enrichment	TCP1	2.77
54	Neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive	Enrichment	CCT5	2.77
55	Bardet-biedl syndrome 8	Enrichment	TTC8	2.77
56	Autosomal recessive sensory neuropathy with spastic paraplegia	Enrichment	CCT5	2.77
57	Bardet-biedl syndrome 6	Enrichment	MKKS	2.77
58	Bardet-biedl syndrome 18	Enrichment	BBIP1	2.77
59	Bardet-biedl syndrome 7	Enrichment	BBS7	2.77
60	Retinitis pigmentosa 51	Enrichment	TTC8	2.77
61	Retinitis pigmentosa 74	Enrichment	BBS2	2.77
62	Bardet-biedl syndrome 2	Enrichment	BBS2	2.77
63	Neurodevelopmental disorder with speech or visual impairment and brain hypomyelination	Enrichment	CCT3	2.77
64	Syndromic inherited retinal disorder	Enrichment	MKKS	2.77
65	Primary bone dysplasia	Enrichment	INPP5E	2.66
66	Orofaciodigital syndrome vi	Enrichment	PDE6D	2.61
67	Osteochondrodysplasia	Enrichment	INPP5E	2.61
68	Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly	Enrichment	INPP5E	2.54
69	Clubfoot	Enrichment	INPP5E	2.54
70	Infantile nephronophthisis	Enrichment	NPHP3	2.53
71	Cataract 11, multiple types	Enrichment	GBF1	2.51
72	Anterior segment dysgenesis 1	Enrichment	GBF1	2.51
73	Neuropathy, congenital hypomyelinating, 2	Enrichment	RHO	2.51
74	Optic disk drusen	Enrichment	RHO	2.51
75	Polycystic kidney disease 3	Enrichment	PKD1	2.51
76	Neurodevelopmental disorder with dysmorphic facies and cerebellar hypoplasia	Enrichment	EXOC2	2.51
77	Pallister-hall-like syndrome	Enrichment	SMO	2.47
78	Nephronophthisis 4	Enrichment	BBS9	2.47
79	Bardet-biedl syndrome 10	Enrichment	BBS10	2.47
80	Bardet-biedl syndrome 5	Enrichment	BBS5	2.47
81	Bardet-biedl syndrome 9	Enrichment	BBS9	2.47
82	Cleft palate, isolated	Enrichment	INPP5E	2.43
83	Anosmia, isolated congenital	Enrichment	CNGA2	2.33
84	Polycystic kidney disease, infantile severe, with tuberous sclerosis	Enrichment	PKD1	2.33
85	Tuberous sclerosis 2	Enrichment	PKD1	2.33
86	Polycystic kidney disease 2 with or without polycystic liver disease	Enrichment	PKD2	2.33
87	Polycystic kidney disease 2	Enrichment	PKD2	2.33
88	Microcephaly 17, primary, autosomal recessive	Enrichment	RHO	2.33
89	End stage renal disease	Enrichment	PKD1	2.33
90	Senior-loken syndrome 1	Enrichment	NPHP3	2.32
91	Tuberous sclerosis	Enrichment	PKD1	2.21
92	Nephronophthisis	Enrichment	MKKS, NPHP3	2.17
93	Retinal detachment	Enrichment	RHO	2.11
94	Polycystic kidney disease 3 with or without polycystic liver disease	Enrichment	PKD1	2.11
95	Night blindness	Enrichment	RHO	2.11
96	Hemangioma	Enrichment	PKD1	2.11
97	Pseudovaginal perineoscrotal hypospadias	Enrichment	BBIP1	2.07
98	Macular degeneration	Enrichment	BBS10	2.07
99	Renal dysplasia, cystic	Enrichment	PKD1	2.03
100	Fundus albipunctatus	Enrichment	RHO	1.97
101	Coats disease	Enrichment	RHO	1.97
102	Optic atrophy plus syndrome	Enrichment	BBS7, NPHP3	1.93
103	Cystic kidney disease	Enrichment	PKD1	1.86
104	Specific learning disability	Enrichment	BBIP1	1.73
105	Chronic kidney disease	Enrichment	PKD2	1.70
106	Short-rib thoracic dysplasia 3 with or without polydactyly	Enrichment	BBS10	1.70
107	Meningioma	Enrichment	SMO	1.70
108	Cataract	Enrichment	RHO	1.67
109	Kidney disease	Enrichment	PKD1	1.64
110	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	BBIP1	1.63
111	Creatine phosphokinase, elevated serum	Enrichment	PKD1	1.61
112	Isolated elevated serum creatine phosphokinase levels	Enrichment	PKD1	1.61
113	Isolated congenital microcephaly	Enrichment	RAB11A	1.61
114	Cone-rod dystrophy 2	Enrichment	RP2	1.61
115	Polydactyly, postaxial, type a1	Enrichment	BBS12	1.60
116	Polycystic liver disease	Enrichment	PKD2	1.58
117	Autosomal dominant polycystic liver disease	Enrichment	PKD2	1.58
118	Congenital stationary night blindness	Enrichment	RHO	1.46
119	Cone dystrophy	Enrichment	BBS5	1.40
120	Meckel syndrome, type 1	Enrichment	EXOC4	1.36
121	Hirschsprung disease 1	Enrichment	SMO	1.32
122	Usher syndrome	Enrichment	BBS1	1.26
123	Autosomal dominant non-syndromic intellectual disability	Enrichment	RAB11A	1.13
124	Body mass index quantitative trait locus 11	Enrichment	BBIP1	1.09
125	Congenital nervous system abnormality	Enrichment	BBS12	0.78
126	Nervous system disease	Enrichment	BBS12	0.78
127	Inherited cancer-predisposing syndrome	Enrichment	PKD1	0.73

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Cargo trafficking to the periciliary membrane

Pathway Network for Cargo trafficking to the periciliary membrane

Pathway network for the Cargo trafficking to the periciliary membrane SuperPath

Member Pathways for Cargo trafficking to the periciliary membrane

Pathways in the Cargo trafficking to the periciliary membrane SuperPath

Gene overlap in member pathways for Cargo trafficking to the periciliary membrane SuperPath

Associated Genes for Cargo trafficking to the periciliary membrane

Associated Disorders for Cargo trafficking to the periciliary membrane

Disorders associated with Cargo trafficking to the periciliary membrane SuperPath

STRING Interaction Network for Cargo trafficking to the periciliary membrane

Sources for Cargo trafficking to the periciliary membrane