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CASP8 activity is inhibited
SuperPath
Pathway network
for
CASP8 activity is inhibited
SuperPath
12
Pathways
in the
CASP8 activity is inhibited
SuperPath
Dimerization of procaspase-8
TRAIL signaling
FAS (CD95) signaling pathway
RIPK1-mediated regulated necrosis
Ligand-dependent caspase activation
Ligand-independent caspase activation via DCC
CASP8 activity is inhibited
Regulated Necrosis
Regulation by c-FLIP
TRAIL signaling pathway
Caspase activation via extrinsic apoptotic signalling pathway
Regulation of necroptotic cell death
65
Genes
in the
CASP8 activity is inhibited
SuperPath
CASP8
FADD
CFLAR
RIPK1
TNFSF10
TNFRSF10B
TNFRSF10A
FAS
FASLG
TRAF2
TRADD
BIRC2
BIRC3
CASP10
CASP3
XIAP
CHUK
IKBKB
MAP3K1
PIK3CA
PIK3CB
PIK3R1
MAPK8
SMPD1
IKBKG
RIPK3
MLKL
CD14
TLR3
TLR4
LY96
TICAM1
TICAM2
CASP9
DAPK1
DAPK3
DCC
MAGED1
DAPK2
APPL1
UNC5A
UNC5B
MIR637
AKT1
BID
BTK
CLTC
MAPK14
PDPK1
MAPK11
MAPK9
MAPK10
MAP2K6
MAP2K7
RFC1
SRC
SYK
EZR
FAIM2
MAPK1
MAPK3
MAP2K4
DAP3
TNFRSF10D
TNFRSF10C
*Darkness represents the genes rank within the SuperPath, via the multiplicity of each gene in the constituent pathways.
STRING interaction network
for
CASP8 activity is inhibited
SuperPath