CCR5 Pathway in Macrophages

Pathway network for the CCR5 Pathway in Macrophages SuperPath

Sources:

QIAGEN
WikiPathways

Pathways in the CCR5 Pathway in Macrophages SuperPath

#	Name	Source	Genes
1	CCR5 Pathway in Macrophages	QIAGEN	CACNA1A CACNA1B CACNA1C CACNA1D CACNA1E CACNA1F CACNA1G CACNA1H CACNA1I CACNA1S CACNA2D1 CACNA2D2 CACNA2D3 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 CACNG6 CACNG7 CACNG8 CALM1 CALM2 CALM3 CCL3 CCL4 CCL5 CCR5 CD247 CD3D CD3E CD3G CD4 FAS FASLG FOS GNA11 GNA12 GNA13 GNA14 GNA15 GNAL GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG2 GNG3 GNG4 JUN MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK8 MAPK9 PLCG1 PLCG2 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 PTK2B (see all 78) (see less)
2	Chemokine Signaling	QIAGEN	AKT1 ARRB1 ARRB2 BCAR1 CACNA1A CACNA1B CACNA1C CACNA1D CACNA1E CACNA1F CACNA1G CACNA1H CACNA1I CACNA1S CACNA2D1 CACNA2D2 CACNA2D3 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 CACNG6 CACNG7 CACNG8 CCL1 CCL11 CCL13 CCL14 CCL15 CCL16 CCL17 CCL18 CCL19 CCL2 CCL20 CCL21 CCL22 CCL23 CCL24 CCL25 CCL26 CCL27 CCL28 CCL3 CCL3L1 CCL4 CCL4L1 CCL4L2 CCL5 CCL7 CCL8 CCR1 CCR10 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CCRL2 CRK CX3CL1 CX3CR1 CXCL1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL16 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCL9 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 DIRAS3 ELK1 FOS FPR2 GNA11 GNA12 GNA13 GNA14 GNA15 GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG2 GNG3 GNG4 GRB2 GRK1 GRK2 GRK3 GRK4 GRK5 GRK6 GRK7 HRAS HRH4 JAK2 JUN KRAS MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK4 MAPK6 MAPK7 MAPK8 MAPK9 MRAS NFKB1 NPTN NRAS PDPK1 PF4 PF4V1 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLA2G10 PLA2G12A PLA2G12B PLA2G1B PLA2G2A PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4C PLA2G5 PLA2G6 PLA2G7 PLCB1 PLCB2 PLCB3 PLCB4 PLCG1 PLCG2 PPBPP2 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 PTK2 PTK2B RHOA RHOB RHOC RHOD RHOG RHOH RND2 RND3 RRAS RRAS2 SRF STAT5A STAT5B XCL1 XCL2 XCR1 (see all 195) (see less)
3	Chemokine signaling pathway	WikiPathways	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 AKT1 AKT2 AKT3 ARRB1 ARRB2 BCAR1 BRAF CCL1 CCL11 CCL15 CCL17 CCL19 CCL20 CCL21 CCL22 CCL24 CCL25 CCL26 CCL27 CCL28 CCL3 CCL4 CCL5 CCL7 CCR1 CCR10 CCR2 CCR3 CCR4 CCR6 CCR7 CCR8 CCR9 CDC42 CHUK CRK CRKL CSK CX3CL1 CX3CR1 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL16 CXCL3 CXCL5 CXCL9 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 DOCK2 ELMO1 FGR FOXO3 GNAI1 GNAI2 GNAI3 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRB2 GRK1 GRK2 GRK4 GRK5 GRK6 GSK3B HCK HRAS IKBKB IKBKG ITK JAK2 JAK3 KRAS LOC105372522 LYN MAP2K1 MAPK1 MAPK3 NCF1 NFKB1 NFKBIA NFKBIB NRAS PAK1 PARD3 PF4 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PLCB2 PLCB3 PLCB4 PPBP PREX1 PRKACB PRKACG PRKCB PRKCD PRKCZ PRKX PTK2 PTK2B PXN RAC1 RAC2 RAF1 RAP1A RAP1B RASGRP2 RELA ROCK1 ROCK2 SHC1 SHC2 SHC3 SHC4 SOS1 SOS2 STAT1 STAT2 STAT3 STAT5B TIAM1 TIAM2 VAV1 VAV2 VAV3 WAS WASL XCL1 XCR1 (see all 165) (see less)
4	Androgen Signaling	QIAGEN	AR CACNA1A CACNA1B CACNA1C CACNA1D CACNA1E CACNA1F CACNA1G CACNA1H CACNA1I CACNA1S CACNA2D1 CACNA2D2 CACNA2D3 CACNA2D4 CACNB1 CACNB2 CACNB3 CACNB4 CACNG1 CACNG2 CACNG3 CACNG4 CACNG5 CACNG6 CACNG7 CACNG8 CALM1 CALM2 CALM3 CALR CCND1 CREBBP DNAJB1 EP300 FOS GNA11 GNA12 GNA13 GNA14 GNA15 GNAI1 GNAI2 GNAI3 GNAL GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG2 GNG3 GNG4 GTF2B GTF2E1 GTF2E2 GTF2H1 GTF2H2 GTF2H3 HSP90AA1 HSPA4 JUN KAT2B KAT7 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK4 MAPK6 MAPK7 MAPK8 MAPK9 NCOA1 NCOA2 NCOA4 NFKB1 POLR2A POLR2B POLR2C PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 SHBG SMAD3 SRC SRY TAF2 TBP TGFB1I1 (see all 109) (see less)

Gene overlap in member pathways for CCR5 Pathway in Macrophages SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GNB1	G Protein Subunit Beta 1	Protein Coding	4
2	GNB2	G Protein Subunit Beta 2	Protein Coding	4
3	GNB3	G Protein Subunit Beta 3	Protein Coding	4
4	GNB4	G Protein Subunit Beta 4	Protein Coding	4
5	GNB5	G Protein Subunit Beta 5	Protein Coding	4
6	GNG2	G Protein Subunit Gamma 2	Protein Coding	4
7	GNG3	G Protein Subunit Gamma 3	Protein Coding	4
8	GNG4	G Protein Subunit Gamma 4	Protein Coding	4
9	PRKCB	Protein Kinase C Beta	Protein Coding	4
10	PRKCD	Protein Kinase C Delta	Protein Coding	4
11	PRKCZ	Protein Kinase C Zeta	Protein Coding	4
12	CACNA1A	Calcium Voltage-Gated Channel Subunit Alpha1 A	Protein Coding	3
13	CACNA1B	Calcium Voltage-Gated Channel Subunit Alpha1 B	Protein Coding	3
14	CACNA1C	Calcium Voltage-Gated Channel Subunit Alpha1 C	Protein Coding	3
15	CACNA1D	Calcium Voltage-Gated Channel Subunit Alpha1 D	Protein Coding	3
16	CACNA1E	Calcium Voltage-Gated Channel Subunit Alpha1 E	Protein Coding	3
17	CACNA1F	Calcium Voltage-Gated Channel Subunit Alpha1 F	Protein Coding	3
18	CACNA1G	Calcium Voltage-Gated Channel Subunit Alpha1 G	Protein Coding	3
19	CACNA1H	Calcium Voltage-Gated Channel Subunit Alpha1 H	Protein Coding	3
20	CACNA1I	Calcium Voltage-Gated Channel Subunit Alpha1 I	Protein Coding	3
21	CACNA1S	Calcium Voltage-Gated Channel Subunit Alpha1 S	Protein Coding	3
22	CACNA2D1	Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 1	Protein Coding	3
23	CACNA2D2	Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 2	Protein Coding	3
24	CACNA2D3	Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 3	Protein Coding	3
25	CACNA2D4	Calcium Voltage-Gated Channel Auxiliary Subunit Alpha2delta 4	Protein Coding	3
26	CACNB1	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 1	Protein Coding	3
27	CACNB2	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 2	Protein Coding	3
28	CACNB3	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 3	Protein Coding	3
29	CACNB4	Calcium Voltage-Gated Channel Auxiliary Subunit Beta 4	Protein Coding	3
30	CACNG1	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 1	Protein Coding	3
31	CACNG2	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 2	Protein Coding	3
32	CACNG3	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 3	Protein Coding	3
33	CACNG4	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 4	Protein Coding	3
34	CACNG5	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 5	Protein Coding	3
35	CACNG6	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 6	Protein Coding	3
36	CACNG7	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 7	Protein Coding	3
37	CACNG8	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 8	Protein Coding	3
38	CCL3	C-C Motif Chemokine Ligand 3	Protein Coding	3
39	CCL4	C-C Motif Chemokine Ligand 4	Protein Coding	3
40	CCL5	C-C Motif Chemokine Ligand 5	Protein Coding	3
41	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	3
42	GNA11	G Protein Subunit Alpha 11	Protein Coding	3
43	GNA12	G Protein Subunit Alpha 12	Protein Coding	3
44	GNA13	G Protein Subunit Alpha 13	Protein Coding	3
45	GNA14	G Protein Subunit Alpha 14	Protein Coding	3
46	GNA15	G Protein Subunit Alpha 15	Protein Coding	3
47	GNAS	GNAS Complex Locus	Protein Coding	3
48	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	3
49	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	3
50	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	3
51	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	3
52	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	3
53	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	3
54	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	3
55	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	3
56	PRKCA	Protein Kinase C Alpha	Protein Coding	3
57	PRKCE	Protein Kinase C Epsilon	Protein Coding	3
58	PRKCG	Protein Kinase C Gamma	Protein Coding	3
59	PRKCH	Protein Kinase C Eta	Protein Coding	3
60	PRKCI	Protein Kinase C Iota	Protein Coding	3
61	PRKD1	Protein Kinase D1	Protein Coding	3
62	PRKD3	Protein Kinase D3	Protein Coding	3
63	PRKCQ	Protein Kinase C Theta	Protein Coding	3
64	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	3
65	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	3
66	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	3
67	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	3
68	CALM1	Calmodulin 1	Protein Coding	2
69	CALM2	Calmodulin 2	Protein Coding	2
70	CALM3	Calmodulin 3	Protein Coding	2
71	CCR5	C-C Motif Chemokine Receptor 5	Protein Coding	2
72	GNAL	G Protein Subunit Alpha L	Protein Coding	2
73	PLCG1	Phospholipase C Gamma 1	Protein Coding	2
74	PLCG2	Phospholipase C Gamma 2	Protein Coding	2
75	GRK2	G Protein-Coupled Receptor Kinase 2	Protein Coding	2
76	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
77	ARRB1	Arrestin Beta 1	Protein Coding	2
78	ARRB2	Arrestin Beta 2	Protein Coding	2
79	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	2
80	CXCR5	C-X-C Motif Chemokine Receptor 5	Protein Coding	2
81	CCL1	C-C Motif Chemokine Ligand 1	Protein Coding	2
82	CCL11	C-C Motif Chemokine Ligand 11	Protein Coding	2
83	CCL15	C-C Motif Chemokine Ligand 15	Protein Coding	2
84	CCL17	C-C Motif Chemokine Ligand 17	Protein Coding	2
85	CCL19	C-C Motif Chemokine Ligand 19	Protein Coding	2
86	CCL20	C-C Motif Chemokine Ligand 20	Protein Coding	2
87	CCL21	C-C Motif Chemokine Ligand 21	Protein Coding	2
88	CCL22	C-C Motif Chemokine Ligand 22	Protein Coding	2
89	CCL24	C-C Motif Chemokine Ligand 24	Protein Coding	2
90	CCL25	C-C Motif Chemokine Ligand 25	Protein Coding	2
91	CCL26	C-C Motif Chemokine Ligand 26	Protein Coding	2
92	CCL27	C-C Motif Chemokine Ligand 27	Protein Coding	2
93	CCL28	C-C Motif Chemokine Ligand 28	Protein Coding	2
94	CCL7	C-C Motif Chemokine Ligand 7	Protein Coding	2
95	CCR1	C-C Motif Chemokine Receptor 1	Protein Coding	2
96	CCR2	C-C Motif Chemokine Receptor 2	Protein Coding	2
97	CCR3	C-C Motif Chemokine Receptor 3	Protein Coding	2
98	CCR4	C-C Motif Chemokine Receptor 4	Protein Coding	2
99	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	2
100	CCR7	C-C Motif Chemokine Receptor 7	Protein Coding	2
101	CCR8	C-C Motif Chemokine Receptor 8	Protein Coding	2
102	CCR9	C-C Motif Chemokine Receptor 9	Protein Coding	2
103	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	2
104	CX3CL1	C-X3-C Motif Chemokine Ligand 1	Protein Coding	2
105	CX3CR1	C-X3-C Motif Chemokine Receptor 1	Protein Coding	2
106	CXCL10	C-X-C Motif Chemokine Ligand 10	Protein Coding	2
107	CXCL11	C-X-C Motif Chemokine Ligand 11	Protein Coding	2
108	CXCL12	C-X-C Motif Chemokine Ligand 12	Protein Coding	2
109	CXCL13	C-X-C Motif Chemokine Ligand 13	Protein Coding	2
110	CXCL14	C-X-C Motif Chemokine Ligand 14	Protein Coding	2
111	CXCL16	C-X-C Motif Chemokine Ligand 16	Protein Coding	2
112	CXCL3	C-X-C Motif Chemokine Ligand 3	Protein Coding	2
113	CXCL5	C-X-C Motif Chemokine Ligand 5	Protein Coding	2
114	CXCL9	C-X-C Motif Chemokine Ligand 9	Protein Coding	2
115	CXCR3	C-X-C Motif Chemokine Receptor 3	Protein Coding	2
116	CXCR4	C-X-C Motif Chemokine Receptor 4	Protein Coding	2
117	CXCR6	C-X-C Motif Chemokine Receptor 6	Protein Coding	2
118	CCR10	C-C Motif Chemokine Receptor 10	Protein Coding	2
119	GRK4	G Protein-Coupled Receptor Kinase 4	Protein Coding	2
120	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	2
121	GRK5	G Protein-Coupled Receptor Kinase 5	Protein Coding	2
122	GRK6	G Protein-Coupled Receptor Kinase 6	Protein Coding	2
123	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	2
124	CXCR2	C-X-C Motif Chemokine Receptor 2	Protein Coding	2
125	JAK2	Janus Kinase 2	Protein Coding	2
126	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	2
127	MAPK4	Mitogen-Activated Protein Kinase 4	Protein Coding	2
128	MAPK6	Mitogen-Activated Protein Kinase 6	Protein Coding	2
129	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	2
130	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	2
131	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	2
132	PF4	Platelet Factor 4	Protein Coding	2
133	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	2
134	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	2
135	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	2
136	PLCB2	Phospholipase C Beta 2	Protein Coding	2
137	PLCB3	Phospholipase C Beta 3	Protein Coding	2
138	PLCB4	Phospholipase C Beta 4	Protein Coding	2
139	PTK2	Protein Tyrosine Kinase 2	Protein Coding	2
140	GRK1	G Protein-Coupled Receptor Kinase 1	Protein Coding	2
141	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	2
142	XCL1	X-C Motif Chemokine Ligand 1	Protein Coding	2
143	XCR1	X-C Motif Chemokine Receptor 1	Protein Coding	2
144	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	2
145	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	2
146	GNAI3	G Protein Subunit Alpha I3	Protein Coding	2
147	GNAI2	G Protein Subunit Alpha I2	Protein Coding	2
148	GNAI1	G Protein Subunit Alpha I1	Protein Coding	2
149	CD3D	CD3 Delta Subunit Of T-Cell Receptor Complex	Protein Coding	1
150	CD3E	CD3 Epsilon Subunit Of T-Cell Receptor Complex	Protein Coding	1
151	CD3G	CD3 Gamma Subunit Of T-Cell Receptor Complex	Protein Coding	1
152	CD247	CD247 Molecule	Protein Coding	1
153	CD4	CD4 Molecule	Protein Coding	1
154	FAS	Fas Cell Surface Death Receptor	Protein Coding	1
155	FASLG	Fas Ligand	Protein Coding	1
156	GRK3	G Protein-Coupled Receptor Kinase 3	Protein Coding	1
157	RHOA	Ras Homolog Family Member A	Protein Coding	1
158	RHOB	Ras Homolog Family Member B	Protein Coding	1
159	RHOC	Ras Homolog Family Member C	Protein Coding	1
160	RHOD	Ras Homolog Family Member D	Protein Coding	1
161	RND3	Rho Family GTPase 3	Protein Coding	1
162	RHOG	Ras Homolog Family Member G	Protein Coding	1
163	RHOH	Ras Homolog Family Member H	Protein Coding	1
164	DIRAS3	DIRAS Family GTPase 3	Protein Coding	1
165	RND2	Rho Family GTPase 2	Protein Coding	1
166	CCL13	C-C Motif Chemokine Ligand 13	Protein Coding	1
167	CCL14	C-C Motif Chemokine Ligand 14	Protein Coding	1
168	CCL16	C-C Motif Chemokine Ligand 16	Protein Coding	1
169	CCL18	C-C Motif Chemokine Ligand 18	Protein Coding	1
170	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	1
171	CCL23	C-C Motif Chemokine Ligand 23	Protein Coding	1
172	CCL3L1	C-C Motif Chemokine Ligand 3 Like 1	Protein Coding	1
173	CCL4L1	C-C Motif Chemokine Ligand 4 Like 1	Protein Coding	1
174	CCL4L2	C-C Motif Chemokine Ligand 4 Like 2	Protein Coding	1
175	CCL8	C-C Motif Chemokine Ligand 8	Protein Coding	1
176	CCRL2	C-C Motif Chemokine Receptor Like 2	Protein Coding	1
177	CXCL1	C-X-C Motif Chemokine Ligand 1	Protein Coding	1
178	CXCL2	C-X-C Motif Chemokine Ligand 2	Protein Coding	1
179	CXCL6	C-X-C Motif Chemokine Ligand 6	Protein Coding	1
180	ELK1	ETS Transcription Factor ELK1	Protein Coding	1
181	FPR2	Formyl Peptide Receptor 2	Protein Coding	1
182	GRK7	G Protein-Coupled Receptor Kinase 7	Protein Coding	1
183	HRH4	Histamine Receptor H4	Protein Coding	1
184	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	1
185	CXCR1	C-X-C Motif Chemokine Receptor 1	Protein Coding	1
186	MRAS	Muscle RAS Oncogene Homolog	Protein Coding	1
187	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
188	PF4V1	Platelet Factor 4 Variant 1	Protein Coding	1
189	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	1
190	PLA2G10	Phospholipase A2 Group X	Protein Coding	1
191	PLA2G12A	Phospholipase A2 Group XIIA	Protein Coding	1
192	PLA2G12B	Phospholipase A2 Group XIIB	Protein Coding	1
193	PLA2G1B	Phospholipase A2 Group IB	Protein Coding	1
194	PLA2G2A	Phospholipase A2 Group IIA	Protein Coding	1
195	PLA2G2D	Phospholipase A2 Group IID	Protein Coding	1
196	PLA2G2E	Phospholipase A2 Group IIE	Protein Coding	1
197	PLA2G2F	Phospholipase A2 Group IIF	Protein Coding	1
198	PLA2G3	Phospholipase A2 Group III	Protein Coding	1
199	PLA2G4A	Phospholipase A2 Group IVA	Protein Coding	1
200	PLA2G4C	Phospholipase A2 Group IVC	Protein Coding	1
201	PLA2G5	Phospholipase A2 Group V	Protein Coding	1
202	PLA2G6	Phospholipase A2 Group VI	Protein Coding	1
203	PLA2G7	Phospholipase A2 Group VII	Protein Coding	1
204	PLCB1	Phospholipase C Beta 1	Protein Coding	1
205	PPBPP2	Pro-Platelet Basic Protein Pseudogene 2	Pseudogene	1
206	RRAS	RAS Related	Protein Coding	1
207	RRAS2	RAS Related 2	Protein Coding	1
208	NPTN	Neuroplastin	Protein Coding	1
209	SRF	Serum Response Factor	Protein Coding	1
210	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	1
211	XCL2	X-C Motif Chemokine Ligand 2	Protein Coding	1
212	RAP1B	RAP1B, Member Of RAS Oncogene Family	Protein Coding	1
213	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	1
214	CDC42	Cell Division Cycle 42	Protein Coding	1
215	ELMO1	Engulfment And Cell Motility 1	Protein Coding	1
216	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	1
217	GNG8	G Protein Subunit Gamma 8	Protein Coding	1
218	WASL	WASP Like Actin Nucleation Promoting Factor	Protein Coding	1
219	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	1
220	WAS	WASP Actin Nucleation Promoting Factor	Protein Coding	1
221	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	1
222	TIAM1	TIAM Rac1 Associated GEF 1	Protein Coding	1
223	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
224	STAT2	Signal Transducer And Activator Of Transcription 2	Protein Coding	1
225	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
226	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
227	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	1
228	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
229	NCF1	Neutrophil Cytosolic Factor 1	Protein Coding	1
230	SHC1	SHC Adaptor Protein 1	Protein Coding	1
231	ROCK1	Rho Associated Coiled-Coil Containing Protein Kinase 1	Protein Coding	1
232	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
233	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
234	RAC2	Rac Family Small GTPase 2	Protein Coding	1
235	RAC1	Rac Family Small GTPase 1	Protein Coding	1
236	PXN	Paxillin	Protein Coding	1
237	PARD3	Par-3 Family Cell Polarity Regulator	Protein Coding	1
238	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
239	PPBP	Pro-Platelet Basic Protein	Protein Coding	1
240	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	1
241	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
242	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
243	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
244	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
245	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
246	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
247	JAK3	Janus Kinase 3	Protein Coding	1
248	ITK	IL2 Inducible T Cell Kinase	Protein Coding	1
249	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
250	HCK	HCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
251	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
252	GNGT2	G Protein Subunit Gamma Transducin 2	Protein Coding	1
253	GNGT1	G Protein Subunit Gamma Transducin 1	Protein Coding	1
254	GNG11	G Protein Subunit Gamma 11	Protein Coding	1
255	GNG7	G Protein Subunit Gamma 7	Protein Coding	1
256	GNG5	G Protein Subunit Gamma 5	Protein Coding	1
257	TIAM2	TIAM Rac1 Associated GEF 2	Protein Coding	1
258	FOXO3	Forkhead Box O3	Protein Coding	1
259	FGR	FGR Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
260	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
261	DOCK2	Dedicator Of Cytokinesis 2	Protein Coding	1
262	CSK	C-Terminal Src Kinase	Protein Coding	1
263	CRKL	CRK Like Proto-Oncogene, Adaptor Protein	Protein Coding	1
264	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
265	ADCY8	Adenylate Cyclase 8	Protein Coding	1
266	ADCY7	Adenylate Cyclase 7	Protein Coding	1
267	ADCY6	Adenylate Cyclase 6	Protein Coding	1
268	ADCY5	Adenylate Cyclase 5	Protein Coding	1
269	ADCY3	Adenylate Cyclase 3	Protein Coding	1
270	ADCY2	Adenylate Cyclase 2	Protein Coding	1
271	ADCY1	Adenylate Cyclase 1	Protein Coding	1
272	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	1
273	RASGRP2	RAS Guanyl Releasing Protein 2	Protein Coding	1
274	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
275	ADCY4	Adenylate Cyclase 4	Protein Coding	1
276	ADCY9	Adenylate Cyclase 9	Protein Coding	1
277	LOC105372522	Uncharacterized LOC105372522	RNA Gene	1
278	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	1
279	PREX1	Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1	Protein Coding	1
280	PRKX	Protein Kinase CAMP-Dependent X-Linked Catalytic Subunit	Protein Coding	1
281	GNG12	G Protein Subunit Gamma 12	Protein Coding	1
282	SHC3	SHC Adaptor Protein 3	Protein Coding	1
283	GNG13	G Protein Subunit Gamma 13	Protein Coding	1
284	NFKBIB	NFKB Inhibitor Beta	Protein Coding	1
285	SHC4	SHC Adaptor Protein 4	Protein Coding	1
286	GNG10	G Protein Subunit Gamma 10	Protein Coding	1
287	SHC2	SHC Adaptor Protein 2	Protein Coding	1
288	AR	Androgen Receptor	Protein Coding	1
289	CALR	Calreticulin	Protein Coding	1
290	CCND1	Cyclin D1	Protein Coding	1
291	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	1
292	DNAJB1	DnaJ Heat Shock Protein Family (Hsp40) Member B1	Protein Coding	1
293	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
294	GTF2B	General Transcription Factor IIB	Protein Coding	1
295	GTF2E1	General Transcription Factor IIE Subunit 1	Protein Coding	1
296	GTF2E2	General Transcription Factor IIE Subunit 2	Protein Coding	1
297	GTF2H1	General Transcription Factor IIH Subunit 1	Protein Coding	1
298	GTF2H2	General Transcription Factor IIH Subunit 2	Protein Coding	1
299	GTF2H3	General Transcription Factor IIH Subunit 3	Protein Coding	1
300	KAT7	Lysine Acetyltransferase 7	Protein Coding	1
301	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
302	HSPA4	Heat Shock Protein Family A (Hsp70) Member 4	Protein Coding	1
303	SMAD3	SMAD Family Member 3	Protein Coding	1
304	NCOA1	Nuclear Receptor Coactivator 1	Protein Coding	1
305	NCOA2	Nuclear Receptor Coactivator 2	Protein Coding	1
306	NCOA4	Nuclear Receptor Coactivator 4	Protein Coding	1
307	KAT2B	Lysine Acetyltransferase 2B	Protein Coding	1
308	POLR2A	RNA Polymerase II Subunit A	Protein Coding	1
309	POLR2B	RNA Polymerase II Subunit B	Protein Coding	1
310	POLR2C	RNA Polymerase II Subunit C	Protein Coding	1
311	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
312	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	1
313	PRKAR1B	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta	Protein Coding	1
314	PRKAR2A	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Alpha	Protein Coding	1
315	PRKAR2B	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Beta	Protein Coding	1
316	SHBG	Sex Hormone Binding Globulin	Protein Coding	1
317	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
318	SRY	Sex Determining Region Y	Protein Coding	1
319	TAF2	TATA-Box Binding Protein Associated Factor 2	Protein Coding	1
320	TBP	TATA-Box Binding Protein	Protein Coding	1
321	TGFB1I1	Transforming Growth Factor Beta 1 Induced Transcript 1	Protein Coding	1

Disorders associated with CCR5 Pathway in Macrophages SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Human immunodeficiency virus type 1	Enrichment	CCL11, CCL2, CCL3, CCL3L1, CCL5, CCR2, CCR5, CX3CR1, CXCL12, CXCR1	10.82
2	Noonan syndrome 1	Enrichment	BRAF, HRAS, KRAS, MAP2K1, NRAS, RAF1, SOS1, SOS2	9.74
3	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, HRAS, KRAS, MAP2K1, NRAS, RAF1, SOS1	9.66
4	Rasopathy	Enrichment	BRAF, HRAS, KRAS, MAP2K1, NRAS, RAF1, SOS1, SOS2	9.28
5	Lung non-small cell carcinoma	Enrichment	BRAF, HRAS, KRAS, MAP2K1, NRAS, PIK3CA	8.88
6	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD247, CD3D, CD3E	6.74
7	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS, PIK3CA	6.14
8	Noonan syndrome 3	Enrichment	HRAS, KRAS, RAF1, SOS1	6.14
9	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, HRAS, NRAS, RAF1	5.85
10	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1, NRAS	5.75
11	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	5.15
12	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, KRAS, MAP2K1	5.15
13	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	5.15
14	Cardiofaciocutaneous syndrome	Enrichment	BRAF, KRAS, MAP2K1	5.15
15	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	5.00
16	Long qt syndrome 1	Enrichment	CACNA1C, CALM1, CALM2, CALM3	4.61
17	Long qt syndrome	Enrichment	CACNA1C, CACNA1S, CALM1, CALM2	4.55
18	Breast adenocarcinoma	Enrichment	AKT1, KRAS, PIK3CA	4.46
19	Severe combined immunodeficiency	Enrichment	CD247, CD3D, CD3E, CD3G	4.44
20	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF, HRAS, NRAS	4.22
21	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1, PIK3CA	4.22
22	Gallbladder cancer	Enrichment	BRAF, KRAS, PIK3CA	4.22
23	Pilomyxoid astrocytoma	Enrichment	BRAF, KRAS, RAF1	4.22
24	Follicular thyroid carcinoma	Enrichment	BRAF, HRAS, NRAS	4.22
25	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS, PRKAR1A	4.19
26	46,xy sex reversal 1	Enrichment	AR, SRY	4.19
27	Fibrolamellar carcinoma	Enrichment	DNAJB1, PRKACA	4.19
28	Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures	Enrichment	CACNA1A, CACNA1C	4.01
29	Anastomosing haemangioma	Enrichment	GNA11, GNA14	4.01
30	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, PIK3CA	3.85
31	Pulmonic stenosis	Enrichment	BRAF, SOS1	3.83
32	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	3.83
33	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	3.83
34	Immune system disease	Enrichment	CDC42, PIK3CD	3.83
35	Autoimmune lymphoproliferative syndrome	Enrichment	FAS, FASLG	3.71
36	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, PIK3CA	3.70
37	Congenital stationary night blindness	Enrichment	CACNA1F, CACNA2D4, GNB3, GRK1	3.53
38	Lip and oral cavity carcinoma	Enrichment	BRAF, HRAS, PIK3CA	3.45
39	Differentiated thyroid carcinoma	Enrichment	BRAF, HRAS, KRAS, NRAS	3.40
40	Brugada syndrome	Enrichment	CACNA1C, CACNA2D1, CACNB2	3.36
41	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	3.36
42	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	3.36
43	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	3.36
44	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2, STAT3	3.36
45	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	3.36
46	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS, RRAS	3.23
47	Auriculocondylar syndrome 1	Enrichment	GNAI3, PLCB4	3.06
48	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	CRKL, MAPK1	3.06
49	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	3.06
50	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	3.06
51	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	3.06
52	Lennox-gastaut syndrome	Enrichment	CACNA1A, MAPK10	3.05
53	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	3.03
54	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	3.03
55	Primary hyperaldosteronism	Enrichment	CACNA1H, GNAS	2.94
56	Myelofibrosis	Enrichment	CALR, SRC	2.88
57	Hemimegalencephaly	Enrichment	AKT3, PIK3CA	2.84
58	Cerebral palsy	Enrichment	CACNA1A, CACNA1C, GNB1	2.84
59	Difference of sex development	Enrichment	AR, CACNA1A	2.76
60	Lung squamous cell carcinoma	Enrichment	KRAS, PIK3CA	2.67
61	Breast cancer	Enrichment	AKT1, GNG3, KRAS, PIK3CA, SHC1	2.66
62	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	2.65
63	Cone-rod dystrophy 6	Enrichment	CACNA1F, CACNA2D4	2.55
64	Autosomal dominant non-syndromic intellectual disability	Enrichment	CACNA1I, CACNG2, GNB1	2.53
65	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	2.53
66	Melanoma, uveal	Enrichment	GNA11, PLCB4	2.53
67	46,xy complete gonadal dysgenesis	Enrichment	AR, SRY	2.47
68	Undetermined early-onset epileptic encephalopathy	Enrichment	CACNA1A, CACNA1B, CACNA2D1	2.39
69	Colorectal cancer	Enrichment	AKT1, BRAF, NRAS, PIK3CA, PIK3R1	2.38
70	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF, NCF1	2.30
71	Cowden syndrome	Enrichment	AKT1, PIK3CA	2.30
72	Bladder cancer	Enrichment	HRAS, KRAS, PIK3CA	2.29
73	Hypocalciuric hypercalcemia, familial, type ii	Enrichment	GNA11	2.24
74	Thyrotoxic periodic paralysis 1	Enrichment	CACNA1S	2.24
75	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	2.24
76	Epilepsy, idiopathic generalized 9	Enrichment	CACNB4	2.24
77	Brugada syndrome 4	Enrichment	CACNB2	2.24
78	Osseous heteroplasia, progressive	Enrichment	GNAS	2.24
79	Episodic ataxia, type 5	Enrichment	CACNB4	2.24
80	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.24
81	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	2.24
82	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Enrichment	GNB2	2.24
83	Pituitary adenoma 3, multiple types	Enrichment	GNAS	2.24
84	Neurodevelopmental disorder with speech impairment and with or without seizures	Enrichment	CACNA1I	2.24
85	Congenital myopathy 18	Enrichment	CACNA1S	2.24
86	Okt4 epitope deficiency	Enrichment	CD4	2.24
87	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.24
88	Cone-rod dystrophy, x-linked, 3	Enrichment	CACNA1F	2.24
89	Retinal cone dystrophy 4	Enrichment	CACNA2D4	2.24
90	Immunodeficiency 18	Enrichment	CD3E	2.24
91	Primary aldosteronism, seizures, and neurologic abnormalities	Enrichment	CACNA1D	2.24
92	Immunodeficiency 25	Enrichment	CD247	2.24
93	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	2.24
94	Brugada syndrome 3	Enrichment	CACNA1C	2.24
95	Epilepsy, childhood absence 6	Enrichment	CACNA1H	2.24
96	Malignant hyperthermia 5	Enrichment	CACNA1S	2.24
97	Spinocerebellar ataxia 14	Enrichment	PRKCG	2.24
98	Intellectual developmental disorder, autosomal dominant 10	Enrichment	CACNG2	2.24
99	Sinoatrial node dysfunction and deafness	Enrichment	CACNA1D	2.24
100	Dystonia 25	Enrichment	GNAL	2.24
101	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.24
102	Long qt syndrome 16	Enrichment	CALM3	2.24
103	Hypocalcemia, autosomal dominant 2	Enrichment	GNA11	2.24
104	Charcot-marie-tooth disease, dominant intermediate f	Enrichment	GNB4	2.24
105	Type 1 diabetes mellitus 22	Enrichment	CCR5	2.24
106	Spinocerebellar ataxia 42	Enrichment	CACNA1G	2.24
107	Developmental and epileptic encephalopathy 110	Enrichment	CACNA2D1	2.24
108	Disorders of gnas inactivation	Enrichment	GNAS	2.24
109	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.24
110	Congenital heart defects and ectodermal dysplasia	Enrichment	PRKD1	2.24
111	Spinocerebellar ataxia 42, early-onset, severe, with neurodevelopmental deficits	Enrichment	CACNA1G	2.24
112	Developmental and epileptic encephalopathy 69	Enrichment	CACNA1E	2.24
113	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.24
114	Hyperaldosteronism, familial, type iv	Enrichment	CACNA1H	2.24
115	Sick sinus syndrome 4	Enrichment	GNB2	2.24
116	Immunodeficiency 79	Enrichment	CD4	2.24
117	Immunodeficiency 19, severe combined	Enrichment	CD3D	2.24
118	Long qt syndrome 15	Enrichment	CALM2	2.24
119	Conn's syndrome	Enrichment	CACNA1H	2.24
120	Sporadic hemiplegic migraine	Enrichment	CACNA1A	2.24
121	Atypical timothy syndrome	Enrichment	CACNA1C	2.24
122	Aldosterone-producing adenoma with seizures and neurological abnormalities	Enrichment	CACNA1D	2.24
123	Immunodeficiency 19	Enrichment	CD3D	2.24
124	Monostotic fibrous dysplasia	Enrichment	GNAS	2.24
125	Timothy syndrome type 2	Enrichment	CACNA1C	2.24
126	Periodic paralysis with transient compartment-like syndrome	Enrichment	CACNA1S	2.24
127	Phakomatosis cesiomarmorata	Enrichment	GNA11	2.24
128	Malignant epithelial tumor of salivary glands	Enrichment	PRKD1	2.24
129	Kaposiform hemangioendothelioma	Enrichment	GNA14	2.24
130	Mazabraud syndrome	Enrichment	GNAS	2.24
131	Timothy syndrome type 1	Enrichment	CACNA1C	2.24
132	Cacna1c-related disorders	Enrichment	CACNA1C	2.24
133	Benign paroxysmal torticollis of infancy	Enrichment	CACNA1A	2.24
134	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	2.21
135	Rare genetic intellectual disability	Enrichment	CREBBP, EP300	2.20
136	Lung cancer	Enrichment	BRAF, KRAS, PIK3CA	2.17
137	Acrodysostosis 1 with or without hormone resistance	Enrichment	PRKAR1A	2.09
138	Prostate cancer, hereditary, x-linked 3	Enrichment	AR	2.09
139	Androgen insensitivity, partial	Enrichment	AR	2.09
140	Carney complex, type 1	Enrichment	PRKAR1A	2.09
141	Neurodevelopmental disorder with feeding difficulties, thin corpus callosum, and foot deformity	Enrichment	TAF2	2.09
142	Ventricular tachycardia, familial	Enrichment	GNAI2	2.09
143	Noonan syndrome 13	Enrichment	MAPK1	2.09
144	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.09
145	Trichothiodystrophy 6, nonphotosensitive	Enrichment	GTF2E2	2.09
146	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	2.09
147	Myxoma, intracardiac	Enrichment	PRKAR1A	2.09
148	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.09
149	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.09
150	Thrombocytopenia 6	Enrichment	SRC	2.09
151	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.09
152	45,x/46,xy mixed gonadal dysgenesis	Enrichment	SRY	2.09
153	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.09
154	Prkar1b-related neurodegenerative dementia with intermediate filaments	Enrichment	PRKAR1B	2.09
155	Complete androgen insensitivity syndrome	Enrichment	AR	2.09
156	Menke-hennekam syndrome	Enrichment	CREBBP	2.09
157	Meningioma	Enrichment	AKT1, PIK3CA	2.05
158	Strabismus	Enrichment	CACNA1A, GNB1	1.98
159	Acute promyelocytic leukemia	Enrichment	STAT3, STAT5B	1.98
160	Nk-cell enteropathy	Enrichment	JAK3, PIK3CB	1.98
161	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	1.94
162	Cutis marmorata telangiectatica congenita	Enrichment	GNA11	1.94
163	Timothy syndrome	Enrichment	CACNA1C	1.94
164	Night blindness, congenital stationary, type 2a	Enrichment	CACNA1F	1.94
165	West nile virus	Enrichment	CCR5	1.94
166	Alternating hemiplegia of childhood 1	Enrichment	CACNA1A	1.94
167	Pseudopseudohypoparathyroidism	Enrichment	GNAS	1.94
168	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	1.94
169	Angioma, tufted	Enrichment	GNA14	1.94
170	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	1.94
171	Long qt syndrome 14	Enrichment	CALM1	1.94
172	Long qt syndrome 8	Enrichment	CACNA1C	1.94
173	Autosomal dominant hypocalcemia	Enrichment	GNA11	1.94
174	Pseudohypoparathyroidism	Enrichment	GNAS	1.94
175	Immunodeficiency 17	Enrichment	CD3G	1.94
176	Congenital disorder of glycosylation, type iw, autosomal dominant	Enrichment	CACNA1D	1.94
177	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	1.94
178	Neurodevelopmental disorder with seizures and nonepileptic hyperkinetic movements	Enrichment	CACNA1B	1.94
179	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	1.94
180	Progressive bulbar palsy	Enrichment	CACNA1A	1.94
181	Cerebral visual impairment	Enrichment	GNB1	1.94
182	Phakomatosis cesioflammea	Enrichment	GNA11	1.94
183	Lung cancer susceptibility 3	Enrichment	BRAF, KRAS	1.92
184	Macrodactyly	Enrichment	PIK3CA	1.91
185	Proteus syndrome	Enrichment	AKT1	1.91
186	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	1.91
187	Oculoectodermal syndrome	Enrichment	KRAS	1.91
188	Thrombocytopenia 1	Enrichment	WAS	1.91
189	Incontinentia pigmenti	Enrichment	IKBKG	1.91
190	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	1.91
191	Noonan syndrome 5	Enrichment	RAF1	1.91
192	Noonan syndrome 4	Enrichment	SOS1	1.91
193	Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis	Enrichment	RAC2	1.91
194	Melorheostosis, isolated	Enrichment	MAP2K1	1.91
195	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	1.91
196	Noonan syndrome 7	Enrichment	BRAF	1.91
197	Leopard syndrome 3	Enrichment	BRAF	1.91
198	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	1.91
199	Cowden syndrome 5	Enrichment	PIK3CA	1.91
200	Polycystic lung disease	Enrichment	CCR2	1.91
201	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	1.91
202	Melanosis, neurocutaneous	Enrichment	NRAS	1.91
203	Noonan syndrome 9	Enrichment	SOS2	1.91
204	Bleeding disorder, platelet-type, 18	Enrichment	RASGRP2	1.91
205	Dyskinesia with orofacial involvement, autosomal dominant	Enrichment	ADCY5	1.91
206	Noonan syndrome 6	Enrichment	NRAS	1.91
207	Fetal encasement syndrome	Enrichment	CHUK	1.91
208	Deafness, autosomal recessive 44	Enrichment	ADCY1	1.91
209	Whim syndrome 1	Enrichment	CXCR4	1.91
210	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	1.91
211	Cerebral cavernous malformations 4	Enrichment	PIK3CA	1.91
212	Immunodeficiency 15b	Enrichment	IKBKB	1.91
213	Pseudo-torch syndrome 3	Enrichment	STAT2	1.91
214	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	1.91
215	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	1.91
216	Neurodevelopmental disorder with hyperkinetic movements and dyskinesia	Enrichment	ADCY5	1.91
217	Immunodeficiency 15a	Enrichment	IKBKB	1.91
218	Short syndrome	Enrichment	PIK3R1	1.91
219	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	1.91
220	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	1.91
221	Auriculocondylar syndrome 2a	Enrichment	PLCB4	1.91
222	Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia	Enrichment	RAC2	1.91
223	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	1.91
224	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	1.91
225	Dyskinesia with orofacial involvement, autosomal recessive	Enrichment	ADCY5	1.91
226	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	1.91
227	Lymphangioma	Enrichment	BRAF	1.91
228	Hemifacial myohyperplasia	Enrichment	PIK3CA	1.91
229	Immunodeficiency 40	Enrichment	DOCK2	1.91
230	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	1.91
231	Phace association	Enrichment	BRAF	1.91
232	Lymphoproliferative syndrome 1	Enrichment	ITK	1.91
233	Melorheostosis	Enrichment	MAP2K1	1.91
234	Leopard syndrome 2	Enrichment	RAF1	1.91
235	Immunodeficiency 31a	Enrichment	STAT1	1.91
236	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	1.91
237	Thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies	Enrichment	RAP1B	1.91
238	Cowden syndrome 6	Enrichment	AKT1	1.91
239	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	1.91
240	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	1.91
241	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	1.91
242	Immunodeficiency 31b	Enrichment	STAT1	1.91
243	Macular degeneration, age-related, 12	Enrichment	CX3CR1	1.91
244	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	1.91
245	Was-related disorders	Enrichment	WAS	1.91
246	Takenouchi-kosaki syndrome	Enrichment	CDC42	1.91
247	Bartsocas-papas syndrome 2	Enrichment	CHUK	1.91
248	Autoinflammatory disease, systemic, with vasculitis	Enrichment	LYN	1.91
249	Neurodevelopmental disorder with language delay and seizures	Enrichment	TIAM1	1.91
250	Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia	Enrichment	RAC2	1.91
251	Trigonitis	Enrichment	RAF1	1.91
252	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	1.91
253	Auriculocondylar syndrome 2b	Enrichment	PLCB4	1.91
254	Whim syndrome 2	Enrichment	CXCR2	1.91
255	T-b+ severe combined immunodeficiency due to jak3 deficiency	Enrichment	JAK3	1.91
256	Autoinflammation with pulmonary and cutaneous vasculitis	Enrichment	HCK	1.91
257	Hypospadias	Enrichment	PIK3CA	1.91
258	Capillary hemangioma	Enrichment	AKT3	1.91
259	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	1.91
260	Congenital pulmonary airway malformation	Enrichment	KRAS	1.91
261	Rare venous malformation	Enrichment	PIK3CA	1.91
262	Diaphragmatic eventration	Enrichment	PIK3CA	1.91
263	Infantile lad-like disease due to rac2 deficiency	Enrichment	RAC2	1.91
264	Reticular dysgenesis-like severe combined immunodeficiency	Enrichment	RAC2	1.91
265	Nocarh syndrome	Enrichment	CDC42	1.91
266	Autosomal recessive severe congenital neutropenia due to cxcr2 deficiency	Enrichment	CXCR2	1.91
267	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	1.91
268	Syringocystadenoma papilliferum	Enrichment	BRAF	1.91
269	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	1.91
270	Rare combined vascular malformation	Enrichment	PIK3CA	1.91
271	Ganglioglioma	Enrichment	BRAF	1.91
272	Cavernous lymphangioma	Enrichment	PIK3CA	1.91
273	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	1.91
274	Nongerminomatous germ cell tumor	Enrichment	BRAF	1.91
275	Phace syndrome	Enrichment	BRAF	1.91
276	Phakomatosis pigmentokeratotica	Enrichment	HRAS	1.91
277	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	1.91
278	Classic hairy cell leukemia	Enrichment	BRAF	1.91
279	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	1.91
280	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	1.91
281	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	1.91
282	Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome	Enrichment	RAC2	1.91
283	Macrodactyly of toe	Enrichment	PIK3CA	1.91
284	Neurocutaneous melanocytosis	Enrichment	NRAS	1.91
285	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	1.91
286	Leukemia, acute myeloid	Enrichment	JAK2, KRAS, NRAS	1.90
287	Lynch syndrome	Enrichment	KRAS, PIK3CA	1.86
288	Osteopetrosis and infantile neuroaxonal dystrophy	Enrichment	PLA2G6	1.84
289	Fleck retina, familial benign	Enrichment	PLA2G5	1.84
290	Noonan syndrome 11	Enrichment	MRAS	1.84
291	Neurodegeneration with brain iron accumulation 2a	Enrichment	PLA2G6	1.84
292	Parkinson disease 14, autosomal recessive	Enrichment	PLA2G6	1.84
293	Neurodegeneration with brain iron accumulation 2b	Enrichment	PLA2G6	1.84
294	Cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder	Enrichment	PLA2G4A	1.84
295	Platelet-activating factor acetylhydrolase deficiency	Enrichment	PLA2G7	1.84
296	Gastrointestinal ulceration, recurrent, with dysfunctional platelets	Enrichment	PLA2G4A	1.84
297	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	1.84
298	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	1.84
299	Immunodeficiency 129	Enrichment	RHOH	1.84
300	T-cell immunodeficiency with epidermodysplasia verruciformis	Enrichment	RHOH	1.84
301	Cryptogenic multifocal ulcerous stenosing enteritis	Enrichment	PLA2G4A	1.84
302	Familial benign flecked retina	Enrichment	PLA2G5	1.84
303	Scoliosis, isolated 1	Enrichment	MAPK7	1.80
304	Amelogenesis imperfecta, type ig	Enrichment	PRKAR1A	1.80
305	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	1.80
306	Thumb deformity	Enrichment	CREBBP	1.80
307	Spinal and bulbar muscular atrophy, x-linked 1	Enrichment	AR	1.80
308	Spinocerebellar ataxia 17	Enrichment	TBP	1.80
309	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	1.80
310	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.80
311	Loeys-dietz syndrome 3	Enrichment	SMAD3	1.80
312	Marbach-schaaf neurodevelopmental syndrome	Enrichment	PRKAR1B	1.80
313	Androgen insensitivity syndrome	Enrichment	AR	1.80
314	Menke-hennekam syndrome 2	Enrichment	EP300	1.80
315	Usher syndrome, type iv	Enrichment	PRKAR1A	1.80
316	Hypospadias 1, x-linked	Enrichment	AR	1.80
317	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	1.80
318	Acrodysostosis	Enrichment	PRKAR1A	1.80
319	Ciliary dyskinesia, primary, 18	Enrichment	PRKAR1B	1.80
320	Hypopituitarism	Enrichment	GNAI2	1.80
321	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PRKAR1A	1.80
322	Posterior hypospadias	Enrichment	AR	1.80
323	Common variable immunodeficiency 12	Enrichment	NFKB1	1.80
324	Hereditary breast carcinoma	Enrichment	AKT1, KRAS, PIK3CA	1.79
325	Mccune-albright syndrome	Enrichment	GNAS	1.77
326	Van der woude syndrome 1	Enrichment	CACNA1E	1.77
327	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	FASLG	1.77
328	Hepatitis c virus	Enrichment	CCR5	1.77
329	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	1.77
330	Thyrotoxic periodic paralysis	Enrichment	CACNA1S	1.77
331	Vogt-koyanagi-harada disease	Enrichment	FAS	1.77
332	Hereditary episodic ataxia	Enrichment	CACNA1A	1.77
333	Dystonia	Enrichment	GNAL, GNB1	1.76
334	Eye disease	Enrichment	CACNA1F, CACNA2D4	1.76
335	Developmental and epileptic encephalopathy	Enrichment	CACNA1E, CACNA2D2	1.74
336	Arteriovenous malformations of the brain	Enrichment	BRAF, KRAS	1.66
337	Diffuse large b-cell lymphoma	Enrichment	BRAF, STAT3	1.66
338	Migraine, familial hemiplegic, 1	Enrichment	CACNA1A	1.64
339	Spinocerebellar ataxia 6	Enrichment	CACNA1A	1.64
340	Spastic paraplegia 17, autosomal dominant	Enrichment	GNG3	1.64
341	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	1.64
342	Aland island eye disease	Enrichment	CACNA1F	1.64
343	Developmental and epileptic encephalopathy 2	Enrichment	CACNA1A	1.64
344	Lipodystrophy, congenital generalized, type 2	Enrichment	GNG3	1.64
345	Ventricular fibrillation, paroxysmal familial, 1	Enrichment	CACNA1C	1.64
346	Developmental and epileptic encephalopathy 42	Enrichment	CACNA1A	1.64
347	Congenital generalized lipodystrophy	Enrichment	FOS	1.64
348	Cerebellar atrophy with seizures and variable developmental delay	Enrichment	CACNA2D2	1.64
349	Developmental and epileptic encephalopathy 52	Enrichment	CACNA1A	1.64
350	Hereditary ataxia	Enrichment	PRKCG	1.64
351	Malignant hyperthermia	Enrichment	CACNA1S	1.64
352	Episodic ataxia	Enrichment	CACNA1A	1.64
353	Familial or sporadic hemiplegic migraine	Enrichment	CACNA1A	1.64
354	Familial sick sinus syndrome	Enrichment	GNB2	1.64
355	Thrombocythemia 1	Enrichment	CALR	1.62
356	46,xx sex reversal 1	Enrichment	SRY	1.62
357	Tethered spinal cord syndrome	Enrichment	CREBBP	1.62
358	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	1.62
359	Fibromatosis, gingival, 1	Enrichment	SOS1	1.62
360	Costello syndrome	Enrichment	HRAS	1.62
361	Granulomatous disease, chronic, autosomal recessive, 1	Enrichment	NCF1	1.62
362	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	1.62
363	Neutropenia, severe congenital, x-linked	Enrichment	WAS	1.62
364	Wiskott-aldrich syndrome	Enrichment	WAS	1.62
365	Immunodeficiency 33	Enrichment	IKBKG	1.62
366	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	1.62
367	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	1.62
368	Keratosis, seborrheic	Enrichment	PIK3CA	1.62
369	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	1.62
370	Roifman-chitayat syndrome	Enrichment	PIK3CD	1.62
371	Lethal congenital contracture syndrome 8	Enrichment	ADCY6	1.62
372	Noonan syndrome 8	Enrichment	PIK3CA	1.62
373	Thrombocythemia 3	Enrichment	JAK2	1.62
374	Oguchi disease 2	Enrichment	GRK1	1.62
375	Immunodeficiency 31c	Enrichment	STAT1	1.62
376	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.62
377	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	1.62
378	Rela fusion-positive ependymoma	Enrichment	RELA	1.62
379	Lymphoproliferative syndrome	Enrichment	ITK	1.62
380	Senior-loken syndrome 7	Enrichment	AKT3	1.62
381	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	1.62
382	Body mass index quantitative trait locus 19	Enrichment	ADCY3	1.62
383	Ocular melanoma	Enrichment	PLCB4	1.62
384	Bardet-biedl syndrome 16	Enrichment	AKT3	1.62
385	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	1.62
386	Polycythemia	Enrichment	JAK2	1.62
387	Hypereosinophilic syndrome	Enrichment	JAK2	1.62
388	Oguchi disease	Enrichment	GRK1	1.62
389	Laron syndrome with immunodeficiency	Enrichment	STAT5B	1.62
390	Wooly hair nevus	Enrichment	HRAS	1.62
391	Capillary malformations, congenital	Enrichment	GNA11	1.55
392	Episodic ataxia, type 2	Enrichment	CACNA1A	1.55
393	Heart conduction disease	Enrichment	CACNA1C	1.55
394	Amblyopia	Enrichment	CACNA1F	1.55
395	Cardiac arrest	Enrichment	CACNA2D1	1.55
396	Histiocytoid hemangioma	Enrichment	FOS	1.55
397	Congenital short qt syndrome	Enrichment	CACNA2D1	1.55
398	Noonan syndrome 12	Enrichment	RRAS2	1.54
399	Infantile osteopetrosis with neuroaxonal dysplasia	Enrichment	PLA2G6	1.54
400	Myeloma, multiple	Enrichment	BRAF, KRAS, PIK3R2	1.51
401	Budd-chiari syndrome	Enrichment	CALR	1.50
402	Carney complex variant	Enrichment	PRKAR1A	1.50
403	Arrhythmogenic right ventricular dysplasia, familial, 10	Enrichment	PRKAR1A	1.50
404	Achromatopsia 4	Enrichment	GNAI3	1.50
405	Neurodevelopmental disorder with hypotonia and variable intellectual and behavioral abnormalities	Enrichment	POLR2A	1.50
406	Mantle cell lymphoma	Enrichment	CCND1	1.50
407	Aortic aneurysm	Enrichment	SMAD3	1.50
408	Hypokalemic periodic paralysis, type 1	Enrichment	CACNA1S	1.47
409	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.47
410	Childhood absence epilepsy	Enrichment	CACNA1H	1.47
411	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	JAK3	1.44
412	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.44
413	Ataxia-telangiectasia	Enrichment	BRAF	1.44
414	Polycythemia vera	Enrichment	JAK2	1.44
415	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.44
416	Granulomatous disease, chronic, autosomal recessive, 2	Enrichment	NCF1	1.44
417	Nuchal bleb, familial	Enrichment	SOS1	1.44
418	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.44
419	Hyper ige syndrome	Enrichment	STAT3	1.44
420	Immunodeficiency 44	Enrichment	STAT2	1.44
421	Spermatocytoma	Enrichment	HRAS	1.44
422	Hypomyelination neuropathy-arthrogryposis syndrome	Enrichment	ADCY6	1.44
423	Keratoacanthoma	Enrichment	PIK3CA	1.44
424	Spastic ataxia	Enrichment	CACNA1G, CACNB4	1.43
425	Von hippel-lindau syndrome	Enrichment	CCND1	1.40
426	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.40
427	Nonsyndromic 46,xx testicular disorders/differences of sex development	Enrichment	SRY	1.40
428	Brugada syndrome 1	Enrichment	CACNA2D1	1.40
429	Brachydactyly	Enrichment	GNAS	1.40
430	Oligoarticular juvenile idiopathic arthritis	Enrichment	CD247	1.40
431	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	CD247	1.40
432	Late-onset retinal degeneration	Enrichment	PLA2G5	1.37
433	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	1.35
434	Alternating hemiplegia of childhood	Enrichment	CACNA1A	1.35
435	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.35
436	Hypothyroidism	Enrichment	GNB1	1.35
437	Adrenocortical carcinoma	Enrichment	PRKAR1A	1.33
438	Hypertrichosis	Enrichment	CREBBP	1.33
439	46,xy disorder of sex development	Enrichment	SRY	1.33
440	Chorea, benign hereditary	Enrichment	ADCY5	1.32
441	Erythrocytosis, familial, 1	Enrichment	JAK2	1.32
442	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.32
443	Granulomatous disease, chronic, x-linked	Enrichment	NCF1	1.32
444	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	1.32
445	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.32
446	Cerebrovascular disease	Enrichment	PIK3CA	1.32
447	Craniopharyngioma	Enrichment	BRAF	1.32
448	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.32
449	Pilocytic astrocytoma	Enrichment	KRAS	1.32
450	Newborn respiratory distress syndrome	Enrichment	BRAF	1.32
451	Epidermolytic nevus	Enrichment	HRAS	1.32
452	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.32
453	Adenosine deaminase deficiency	Enrichment	JAK3	1.32
454	Gingival fibromatosis	Enrichment	SOS1	1.32
455	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.32
456	Inflammatory bowel disease 1	Enrichment	PRKCQ	1.30
457	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	CACNA1C	1.30
458	Congenital nervous system abnormality	Enrichment	CACNA1A, CREBBP, GNB5	1.27
459	Nervous system disease	Enrichment	CACNA1A, CREBBP, GNB5	1.27
460	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	1.26
461	Essential thrombocythemia	Enrichment	CALR	1.26
462	Common variable immunodeficiency	Enrichment	NFKB1	1.26
463	Stroke, ischemic	Enrichment	PRKCH	1.25
464	Developmental and epileptic encephalopathy 12	Enrichment	PLCB1	1.25
465	Cone-rod dystrophy 2	Enrichment	CACNA1F, CACNA2D4	1.23
466	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.23
467	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	JAK3	1.23
468	Myeloproliferative neoplasm	Enrichment	JAK2	1.23
469	Diffuse cutaneous systemic sclerosis	Enrichment	CCR6	1.23
470	Migraine with or without aura 1	Enrichment	CACNA1A	1.21
471	Epilepsy, myoclonic juvenile	Enrichment	CACNB4	1.21
472	Epilepsy, idiopathic generalized	Enrichment	CACNA1H	1.21
473	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.21
474	Myelodysplastic syndrome	Enrichment	GNB1	1.21
475	Cardiac conduction defect	Enrichment	CACNA1C	1.17
476	Charge syndrome	Enrichment	EP300	1.15
477	Loeys-dietz syndrome	Enrichment	SMAD3	1.15
478	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.15
479	Trichothiodystrophy	Enrichment	GTF2E2	1.15
480	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.15
481	Cowden syndrome 1	Enrichment	PIK3CA	1.15
482	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.15
483	Wilms tumor 5	Enrichment	BRAF	1.15
484	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.15
485	Limited scleroderma	Enrichment	CCR6	1.15
486	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.14
487	Microcephaly	Enrichment	EP300, GNB1, MAPK1	1.12
488	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.11
489	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.11
490	Megacolon	Enrichment	AKT3	1.09
491	Overgrowth syndrome	Enrichment	PIK3R1	1.09
492	Myopia	Enrichment	CACNA1F	1.08
493	Specific learning disability	Enrichment	MAPK1	1.07
494	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	1.03
495	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.03
496	Hypertension, essential	Enrichment	GNB3	1.03
497	Cleft palate, isolated	Enrichment	GNB1	1.03
498	Sudden infant death syndrome	Enrichment	CALM2	1.03
499	Gastric cancer	Enrichment	KRAS, PIK3CA	1.02
500	Behcet syndrome	Enrichment	FAS	0.98
501	Congenital myopathy	Enrichment	CACNA1S	0.98
502	Coronary heart disease 5	Enrichment	IKBKG	0.98
503	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	0.98
504	Adult hepatocellular carcinoma	Enrichment	PIK3CA	0.98
505	Chronic granulomatous disease	Enrichment	NCF1	0.98
506	Ventricular septal defect	Enrichment	BRAF	0.98
507	Osteoporosis	Enrichment	SRC	0.97
508	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	0.97
509	Heart disease	Enrichment	CREBBP	0.97
510	46,xy partial gonadal dysgenesis	Enrichment	SRY	0.97
511	Polydactyly, postaxial, type a1	Enrichment	EP300	0.94
512	Corpus callosum, agenesis of	Enrichment	CREBBP	0.94
513	Isolated corpus callosum agenesis	Enrichment	CREBBP	0.94
514	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	0.94
515	Centronuclear myopathy	Enrichment	CACNA1S	0.94
516	Polymicrogyria	Enrichment	AKT3	0.94
517	Melanoma	Enrichment	BRAF	0.94
518	Attention deficit-hyperactivity disorder	Enrichment	GNB5	0.92
519	Developmental and epileptic encephalopathy 14	Enrichment	PLCB1	0.91
520	Ovarian cancer	Enrichment	AKT1, KRAS, PIK3CA	0.90
521	Asthma	Enrichment	CCL11	0.90
522	Cardiomyopathy, familial hypertrophic, 1	Enrichment	CACNA1C	0.89
523	Cone dystrophy	Enrichment	CACNA2D4	0.89
524	Neurodegeneration with brain iron accumulation	Enrichment	PLA2G6	0.87
525	Familial colorectal cancer	Enrichment	PLA2G2A	0.87
526	Heart, malformation of	Enrichment	MAPK1	0.87
527	Auditory neuropathy	Enrichment	CACNA1A	0.86
528	Esophageal atresia/tracheoesophageal fistula	Enrichment	POLR2B	0.85
529	Ehlers-danlos syndrome	Enrichment	SMAD3	0.85
530	Parkinson's disease	Enrichment	TBP	0.85
531	Hereditary breast ovarian cancer syndrome	Enrichment	BCAR1, KRAS	0.84
532	Aortic valve disease 1	Enrichment	SOS1	0.83
533	Neural tube defects	Enrichment	PARD3	0.83
534	Protein-deficiency anemia	Enrichment	NRAS	0.83
535	Complex neurodevelopmental disorder	Enrichment	CACNA1C, GNB2	0.80
536	Wilms tumor 1	Enrichment	BRAF	0.78
537	Parkinson disease, late-onset	Enrichment	TBP	0.75
538	Scoliosis	Enrichment	CREBBP	0.75
539	Rhabdomyosarcoma	Enrichment	HRAS	0.75
540	Gliosarcoma	Enrichment	NFKBIA	0.75
541	Melanoma, cutaneous malignant 1	Enrichment	BRAF	0.73
542	Dandy-walker syndrome	Enrichment	BRAF	0.73
543	Giant cell glioblastoma	Enrichment	NFKBIA	0.73
544	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	PLA2G6	0.68
545	Prostate cancer	Enrichment	AR	0.68
546	Williams-beuren syndrome	Enrichment	NCF1	0.66
547	Optic atrophy plus syndrome	Enrichment	CACNA1F	0.65
548	Endometrial cancer	Enrichment	PIK3CA	0.64
549	Connective tissue disease	Enrichment	SMAD3	0.64
550	Hepatocellular carcinoma	Enrichment	PIK3CA	0.63
551	Male infertility	Enrichment	AR	0.62
552	Malaria	Enrichment	IKBKG	0.61
553	Body mass index quantitative trait locus 11	Enrichment	GNAS	0.60
554	Dilated cardiomyopathy	Enrichment	BRAF, RAF1	0.59
555	Pancreatic cancer	Enrichment	KRAS	0.58
556	Jeune thoracic dystrophy	Enrichment	GRK2	0.58
557	Hydrops fetalis, nonimmune	Enrichment	HRAS	0.56
558	Asphyxiating thoracic dystrophy	Enrichment	GRK2	0.54
559	Severe covid-19	Enrichment	JAK3	0.52
560	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD3	0.52
561	Thrombocytopenia	Enrichment	SRC	0.49
562	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	GRK2	0.48
563	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.48
564	Retinitis pigmentosa	Enrichment	CACNA1F, CACNA2D4	0.46
565	Left ventricular noncompaction	Enrichment	RAF1	0.46
566	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	AR	0.44
567	Autism spectrum disorder	Enrichment	GNB1, MAP2K1	0.42
568	Type 2 diabetes mellitus	Enrichment	AKT2	0.40
569	Autism	Enrichment	CREBBP	0.36
570	Benign epilepsy with centrotemporal spikes	Enrichment	PLCB1	0.35
571	Primary ciliary dyskinesia	Enrichment	PRKAR1B	0.34
572	Centralopathic epilepsy	Enrichment	PLCB1	0.33
573	Hypertelorism	Enrichment	PIK3CA	0.33
574	West syndrome	Enrichment	PLCB1	0.33
575	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.32
576	Hereditary retinal dystrophy	Enrichment	CACNA1F, CACNA2D4	0.30
577	Fundus dystrophy	Enrichment	CACNA1F, CACNA2D4	0.30
578	Primary ovarian insufficiency	Enrichment	JAK2	0.29
579	Inherited cancer-predisposing syndrome	Enrichment	PRKAR1A	0.18
580	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	ADCY1	0.18

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

CCR5 Pathway in Macrophages

Pathway Network for CCR5 Pathway in Macrophages

Pathway network for the CCR5 Pathway in Macrophages SuperPath

Member Pathways for CCR5 Pathway in Macrophages

Pathways in the CCR5 Pathway in Macrophages SuperPath

Gene overlap in member pathways for CCR5 Pathway in Macrophages SuperPath

Associated Genes for CCR5 Pathway in Macrophages

Associated Disorders for CCR5 Pathway in Macrophages

Disorders associated with CCR5 Pathway in Macrophages SuperPath

STRING Interaction Network for CCR5 Pathway in Macrophages

Sources for CCR5 Pathway in Macrophages