CD28 Signaling in T-Helper Cell

No Pathway Network information available for CD28 Signaling in T-Helper Cell

Pathways in the CD28 Signaling in T-Helper Cell SuperPath

#	Name	Source	Genes
1	CD28 Signaling in T-Helper Cell	QIAGEN	ACTA1 ACTA2 ACTB ACTG1 ACTG2 ACTR2 ACTR3 AKT1 AKT2 AKT3 BCL10 CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G CARD11 CD247 CD28 CD3D CD3E CD3G CD4 CD80 CD86 CDC42 CHUK CSK CTLA4 FOS FYN GNAL GRAP2 GRB2 HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 IKBKB IKBKE IKBKG ITK ITPR1 ITPR2 ITPR3 JUN LAT LCK LCP2 MALT1 MAP2K4 MAP2K7 MAPK10 MAPK8 MAPK9 NFAT5 NFATC1 NFATC2 NFATC3 NFATC4 NFKB1 NFKBIA NFKBIB NFKBIE PAK1 PIK3C2A PIK3C2B PIK3C2G PIK3C3 PIK3R1 PIK3R3 PLCG1 PLCG2 PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PRKCQ PTEN PTPRC RAC1 RAC2 SYK TEC TXK VAV1 WAS ZAP70 (see all 100) (see less)
2	ICos-ICosL Pathway in T-Helper Cell	QIAGEN	AKT1 AKT2 AKT3 CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G CD247 CD28 CD3D CD3E CD3G CD4 CD40 CD40LG CD80 CD86 CHUK CSK GAB2 GNAL GRAP2 GRB2 HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DPA1 HLA-DQA1 HLA-DQA2 HLA-DQB1 HLA-DRA HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 ICOS ICOSLG IKBKB IKBKE IKBKG IL2 IL2RA IL2RB IL2RG ITK ITPR1 ITPR2 ITPR3 LAT LCK LCP2 NFAT5 NFATC1 NFATC2 NFATC3 NFATC4 NFKB1 NFKBIA NFKBIB NFKBIE PDPK1 PIK3C2A PIK3C2B PIK3C2G PIK3C3 PIK3R1 PIK3R3 PLCG1 PLEKHA1 PLEKHA2 PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PRKCQ PTEN PTPRC RAC1 TEC TRAT1 TXK VAV1 ZAP70 (see all 88) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
2	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	2
3	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	2
4	CALM1	Calmodulin 1	Protein Coding	2
5	CALM2	Calmodulin 2	Protein Coding	2
6	CALM3	Calmodulin 3	Protein Coding	2
7	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	2
8	CAMK2B	Calcium/Calmodulin Dependent Protein Kinase II Beta	Protein Coding	2
9	CAMK2D	Calcium/Calmodulin Dependent Protein Kinase II Delta	Protein Coding	2
10	CAMK2G	Calcium/Calmodulin Dependent Protein Kinase II Gamma	Protein Coding	2
11	CD28	CD28 Molecule	Protein Coding	2
12	CD3D	CD3 Delta Subunit Of T-Cell Receptor Complex	Protein Coding	2
13	CD3E	CD3 Epsilon Subunit Of T-Cell Receptor Complex	Protein Coding	2
14	CD3G	CD3 Gamma Subunit Of T-Cell Receptor Complex	Protein Coding	2
15	CD247	CD247 Molecule	Protein Coding	2
16	CD4	CD4 Molecule	Protein Coding	2
17	CD80	CD80 Molecule	Protein Coding	2
18	CD86	CD86 Molecule	Protein Coding	2
19	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	2
20	CSK	C-Terminal Src Kinase	Protein Coding	2
21	GNAL	G Protein Subunit Alpha L	Protein Coding	2
22	GRAP2	GRB2 Related Adaptor Protein 2	Protein Coding	2
23	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	2
24	HLA-DMA	Major Histocompatibility Complex, Class II, DM Alpha	Protein Coding	2
25	HLA-DMB	Major Histocompatibility Complex, Class II, DM Beta	Protein Coding	2
26	HLA-DOA	Major Histocompatibility Complex, Class II, DO Alpha	Protein Coding	2
27	HLA-DOB	Major Histocompatibility Complex, Class II, DO Beta	Protein Coding	2
28	HLA-DPA1	Major Histocompatibility Complex, Class II, DP Alpha 1	Protein Coding	2
29	HLA-DQA1	Major Histocompatibility Complex, Class II, DQ Alpha 1	Protein Coding	2
30	HLA-DQA2	Major Histocompatibility Complex, Class II, DQ Alpha 2	Protein Coding	2
31	HLA-DQB1	Major Histocompatibility Complex, Class II, DQ Beta 1	Protein Coding	2
32	HLA-DRA	Major Histocompatibility Complex, Class II, DR Alpha	Protein Coding	2
33	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	2
34	HLA-DRB3	Major Histocompatibility Complex, Class II, DR Beta 3	Protein Coding	2
35	HLA-DRB4	Major Histocompatibility Complex, Class II, DR Beta 4	Protein Coding	2
36	HLA-DRB5	Major Histocompatibility Complex, Class II, DR Beta 5	Protein Coding	2
37	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	2
38	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	2
39	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	2
40	ITK	IL2 Inducible T Cell Kinase	Protein Coding	2
41	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	2
42	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	2
43	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	2
44	LAT	Linker For Activation Of T Cells	Protein Coding	2
45	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
46	LCP2	Lymphocyte Cytosolic Protein 2	Protein Coding	2
47	NFAT5	Nuclear Factor Of Activated T Cells 5	Protein Coding	2
48	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	2
49	NFATC2	Nuclear Factor Of Activated T Cells 2	Protein Coding	2
50	NFATC3	Nuclear Factor Of Activated T Cells 3	Protein Coding	2
51	NFATC4	Nuclear Factor Of Activated T Cells 4	Protein Coding	2
52	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	2
53	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	2
54	NFKBIB	NFKB Inhibitor Beta	Protein Coding	2
55	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	2
56	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	2
57	PIK3C2B	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Beta	Protein Coding	2
58	PIK3C2G	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Gamma	Protein Coding	2
59	PIK3C3	Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3	Protein Coding	2
60	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	2
61	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	2
62	PLCG1	Phospholipase C Gamma 1	Protein Coding	2
63	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	2
64	PPP3CB	Protein Phosphatase 3 Catalytic Subunit Beta	Protein Coding	2
65	PPP3CC	Protein Phosphatase 3 Catalytic Subunit Gamma	Protein Coding	2
66	PPP3R1	Protein Phosphatase 3 Regulatory Subunit B, Alpha	Protein Coding	2
67	PPP3R2	Protein Phosphatase 3 Regulatory Subunit B, Beta	Protein Coding	2
68	PRKCQ	Protein Kinase C Theta	Protein Coding	2
69	PTEN	Phosphatase And Tensin Homolog	Protein Coding	2
70	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	2
71	RAC1	Rac Family Small GTPase 1	Protein Coding	2
72	TEC	Tec Protein Tyrosine Kinase	Protein Coding	2
73	TXK	TXK Tyrosine Kinase	Protein Coding	2
74	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	2
75	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	2
76	ACTA1	Actin Alpha 1, Skeletal Muscle	Protein Coding	1
77	ACTA2	Actin Alpha 2, Smooth Muscle	Protein Coding	1
78	ACTB	Actin Beta	Protein Coding	1
79	ACTG1	Actin Gamma 1	Protein Coding	1
80	ACTG2	Actin Gamma 2, Smooth Muscle	Protein Coding	1
81	ACTR2	Actin Related Protein 2	Protein Coding	1
82	ACTR3	Actin Related Protein 3	Protein Coding	1
83	BCL10	BCL10 Immune Signaling Adaptor	Protein Coding	1
84	CARD11	Caspase Recruitment Domain Family Member 11	Protein Coding	1
85	CDC42	Cell Division Cycle 42	Protein Coding	1
86	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	1
87	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
88	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
89	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
90	MALT1	MALT1 Paracaspase	Protein Coding	1
91	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
92	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	1
93	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
94	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
95	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
96	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
97	PLCG2	Phospholipase C Gamma 2	Protein Coding	1
98	RAC2	Rac Family Small GTPase 2	Protein Coding	1
99	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	1
100	WAS	WASP Actin Nucleation Promoting Factor	Protein Coding	1
101	GAB2	GRB2 Associated Binding Protein 2	Protein Coding	1
102	ICOS	Inducible T Cell Costimulator	Protein Coding	1
103	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	1
104	IL2	Interleukin 2	Protein Coding	1
105	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	1
106	IL2RB	Interleukin 2 Receptor Subunit Beta	Protein Coding	1
107	IL2RG	Interleukin 2 Receptor Subunit Gamma	Protein Coding	1
108	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
109	PLEKHA1	Pleckstrin Homology Domain Containing A1	Protein Coding	1
110	PLEKHA2	Pleckstrin Homology Domain Containing A2	Protein Coding	1
111	CD40	CD40 Molecule	Protein Coding	1
112	CD40LG	CD40 Ligand	Protein Coding	1
113	TRAT1	T Cell Receptor Associated Transmembrane Adaptor 1	Protein Coding	1

Disorders associated with CD28 Signaling in T-Helper Cell SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Severe combined immunodeficiency	Enrichment	CD247, CD3D, CD3E, CD3G, IKBKB, LCK, MALT1, PTPRC, ZAP70	10.61
2	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD247, CD3D, CD3E	6.58
3	Oligoarticular juvenile idiopathic arthritis	Enrichment	CD247, IL2RA, IL2RB	5.04
4	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	CD247, IL2RA, IL2RB	5.04
5	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	4.84
6	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3, ITPR3	4.40
7	Celiac disease 1	Enrichment	HLA-DQA1, HLA-DQB1	4.38
8	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	4.38
9	Bullous pemphigoid	Enrichment	HLA-DQB1, HLA-DRB1	4.38
10	Pediatric multiple sclerosis	Enrichment	HLA-DQB1, HLA-DRB1	4.38
11	Combined immunodeficiency	Enrichment	ICOSLG, IL2RG, ZAP70	4.38
12	Combined t cell and b cell immunodeficiency	Enrichment	ICOSLG, IL2RG, ZAP70	4.38
13	Combined t and b cell immunodeficiency	Enrichment	ICOSLG, IL2RG, ZAP70	4.38
14	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	4.27
15	Multiple sclerosis	Enrichment	HLA-DQB1, HLA-DRB1, ITPR1	4.04
16	Mycosis fungoides	Enrichment	CD28, CTLA4	3.79
17	Adult-onset myasthenia gravis	Enrichment	CTLA4, HLA-DQA1	3.79
18	Saczary syndrome	Enrichment	CD28, CTLA4	3.79
19	Idiopathic achalasia	Enrichment	HLA-DQA1, HLA-DQB1	3.61
20	Narcolepsy 2	Enrichment	HLA-DQB1, HLA-DRB1	3.39
21	Hemimegalencephaly	Enrichment	AKT3, PTEN	3.39
22	Lymphoma, mucosa-associated lymphoid type	Enrichment	BCL10, MALT1	3.28
23	Follicular lymphoma	Enrichment	BCL10, HLA-DRB1	3.28
24	Granulomatosis with polyangiitis	Enrichment	CTLA4, HLA-DPA1	3.10
25	Common variable immunodeficiency	Enrichment	CD40LG, NFKB1	3.07
26	Narcolepsy 1	Enrichment	HLA-DQB1, HLA-DRB1	2.94
27	Cowden syndrome	Enrichment	AKT1, PTEN	2.84
28	Meningioma	Enrichment	AKT1, PTEN	2.58
29	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A, CAMK2B, PPP3CA	2.38
30	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	2.19
31	Proteus syndrome	Enrichment	AKT1	2.19
32	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.19
33	Vacterl association with hydrocephalus	Enrichment	PTEN	2.19
34	Incontinentia pigmenti	Enrichment	IKBKG	2.19
35	Type 1 diabetes mellitus 10	Enrichment	IL2RA	2.19
36	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.19
37	Fetal encasement syndrome	Enrichment	CHUK	2.19
38	Transient erythroblastopenia of childhood	Enrichment	TEC	2.19
39	Immunodeficiency 15b	Enrichment	IKBKB	2.19
40	Immunodeficiency 81	Enrichment	LCP2	2.19
41	Immunodeficiency 15a	Enrichment	IKBKB	2.19
42	Immunodeficiency with hyper-igm, type 1	Enrichment	CD40LG	2.19
43	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	2.19
44	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	2.19
45	Immunodeficiency 63 with lymphoproliferation and autoimmunity	Enrichment	IL2RB	2.19
46	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	2.19
47	Intellectual developmental disorder, autosomal dominant 54	Enrichment	CAMK2B	2.19
48	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	2.19
49	Immunodeficiency 48	Enrichment	ZAP70	2.19
50	Short syndrome	Enrichment	PIK3R1	2.19
51	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.19
52	Okt4 epitope deficiency	Enrichment	CD4	2.19
53	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.19
54	Oculoskeletodental syndrome	Enrichment	PIK3C2A	2.19
55	Immunodeficiency 119	Enrichment	ICOSLG	2.19
56	Immunodeficiency 18	Enrichment	CD3E	2.19
57	Papillary tumor of the pineal region	Enrichment	PTEN	2.19
58	Pulmonary alveolar proteinosis, acquired	Enrichment	HLA-DRB1	2.19
59	Immunodeficiency 25	Enrichment	CD247	2.19
60	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.19
61	Immunodeficiency with hyper-igm, type 3	Enrichment	CD40	2.19
62	Lymphoproliferative syndrome 1	Enrichment	ITK	2.19
63	Dystonia 25	Enrichment	GNAL	2.19
64	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.19
65	Long qt syndrome 16	Enrichment	CALM3	2.19
66	Cowden syndrome 6	Enrichment	AKT1	2.19
67	Graham little-piccardi-lassueur syndrome	Enrichment	HLA-DRA	2.19
68	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.19
69	Immunodeficiency 123 with hpv-related verrucosis	Enrichment	CD28	2.19
70	Immunodeficiency 105, severe combined	Enrichment	PTPRC	2.19
71	Glioma susceptibility 2	Enrichment	PTEN	2.19
72	Autoimmune disease, multisystem, infantile-onset, 2	Enrichment	ZAP70	2.19
73	Immunodeficiency 22	Enrichment	LCK	2.19
74	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.19
75	Immunodeficiency 79	Enrichment	CD4	2.19
76	Cd45 deficiency	Enrichment	PTPRC	2.19
77	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	2.19
78	Intellectual developmental disorder, autosomal dominant 59	Enrichment	CAMK2G	2.19
79	Immunodeficiency 19, severe combined	Enrichment	CD3D	2.19
80	Long qt syndrome 15	Enrichment	CALM2	2.19
81	Capillary hemangioma	Enrichment	AKT3	2.19
82	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	2.19
83	Cd40 ligand deficiency	Enrichment	CD40LG	2.19
84	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.19
85	Immunodeficiency 19	Enrichment	CD3D	2.19
86	Oculocerebrodental syndrome	Enrichment	PIK3C2A	2.19
87	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.19
88	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.19
89	Late-onset combined immunodeficiency due to icosl deficiency	Enrichment	ICOSLG	2.19
90	Inflammatory bowel disease-recurrent sinopulmonary infections syndrome	Enrichment	NFAT5	2.19
91	Zap70-related severe combined immunodeficiency	Enrichment	ZAP70	2.19
92	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.19
93	Baraitser-winter syndrome 1	Enrichment	ACTB	2.13
94	Thrombocytopenia 1	Enrichment	WAS	2.13
95	Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis	Enrichment	RAC2	2.13
96	Celiac disease 3	Enrichment	CTLA4	2.13
97	Congenital myopathy 2a, typical, autosomal dominant	Enrichment	ACTA1	2.13
98	Myopathy, scapulohumeroperoneal	Enrichment	ACTA1	2.13
99	Megacystis-microcolon-intestinal hypoperistalsis syndrome 5	Enrichment	ACTG2	2.13
100	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	2.13
101	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.13
102	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.13
103	Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia	Enrichment	RAC2	2.13
104	Type 1 diabetes mellitus 12	Enrichment	CTLA4	2.13
105	Persistent polyclonal b-cell lymphocytosis	Enrichment	CARD11	2.13
106	Becker nevus syndrome	Enrichment	ACTB	2.13
107	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.13
108	Visceral neuropathy, familial, 3, autosomal dominant	Enrichment	ACTG2	2.13
109	Congenital myopathy 2b, severe infantile, autosomal recessive	Enrichment	ACTA1	2.13
110	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.13
111	Immunodeficiency 12	Enrichment	MALT1	2.13
112	Autosomal dominant familial visceral neuropathy	Enrichment	ACTG2	2.13
113	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.13
114	Was-related disorders	Enrichment	WAS	2.13
115	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.13
116	Congenital myopathy 2c, severe infantile, autosomal dominant	Enrichment	ACTA1	2.13
117	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.13
118	Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia	Enrichment	RAC2	2.13
119	Sezary's disease	Enrichment	BCL10	2.13
120	Baraitser-winter syndrome	Enrichment	ACTB	2.13
121	Colitis	Enrichment	SYK	2.13
122	Zebra body myopathy	Enrichment	ACTA1	2.13
123	Infantile lad-like disease due to rac2 deficiency	Enrichment	RAC2	2.13
124	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.13
125	Reticular dysgenesis-like severe combined immunodeficiency	Enrichment	RAC2	2.13
126	Nocarh syndrome	Enrichment	CDC42	2.13
127	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.13
128	Actin-accumulation myopathy	Enrichment	ACTA1	2.13
129	Myopathic intestinal pseudoobstruction	Enrichment	ACTG2	2.13
130	Mucosa-associated lymphoma	Enrichment	BCL10	2.13
131	Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome	Enrichment	RAC2	2.13
132	Actg2 visceral myopathy	Enrichment	ACTG2	2.13
133	Breast cancer	Enrichment	AKT1, IL2, PTEN	1.90
134	Spinocerebellar ataxia 29	Enrichment	ITPR1	1.89
135	Immunodeficiency 33	Enrichment	IKBKG	1.89
136	Immunodeficiency 41 with lymphoproliferation and autoimmunity	Enrichment	IL2RA	1.89
137	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	1.89
138	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	1.89
139	Creutzfeldt-jakob disease	Enrichment	HLA-DQB1	1.89
140	Sarcoidosis 1	Enrichment	HLA-DRB1	1.89
141	Spermatogenic failure 17	Enrichment	PIK3C2G	1.89
142	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.89
143	Long qt syndrome 14	Enrichment	CALM1	1.89
144	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.89
145	Lymphoproliferative syndrome	Enrichment	ITK	1.89
146	Senior-loken syndrome 7	Enrichment	AKT3	1.89
147	Immunodeficiency 104, severe combined	Enrichment	PTPRC	1.89
148	Immunodeficiency 17	Enrichment	CD3G	1.89
149	Bardet-biedl syndrome 16	Enrichment	AKT3	1.89
150	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	1.89
151	Immunodeficiency 52	Enrichment	LAT	1.89
152	Joint contractures, osteochondromas, and b-cell lymphoma	Enrichment	NFATC2	1.89
153	Vacterl with hydrocephalus	Enrichment	PTEN	1.89
154	Common variable immunodeficiency 12	Enrichment	NFKB1	1.89
155	Juvenile polyposis of infancy	Enrichment	PTEN	1.89
156	Hashimoto thyroiditis	Enrichment	CTLA4	1.83
157	Neutropenia, severe congenital, x-linked	Enrichment	WAS	1.83
158	Wiskott-aldrich syndrome	Enrichment	WAS	1.83
159	Aortic aneurysm, familial thoracic 2	Enrichment	ACTA2	1.83
160	Deafness, autosomal dominant 20	Enrichment	ACTG1	1.83
161	Smooth muscle dysfunction syndrome	Enrichment	ACTA2	1.83
162	Aortic aneurysm, familial thoracic 6	Enrichment	ACTA2	1.83
163	Baraitser-winter syndrome 2	Enrichment	ACTG1	1.83
164	Immunodeficiency 11a	Enrichment	CARD11	1.83
165	Immunodeficiency 37	Enrichment	BCL10	1.83
166	Moyamoya disease 5	Enrichment	ACTA2	1.83
167	Immunodeficiency 11b with atopic dermatitis	Enrichment	CARD11	1.83
168	B-cell expansion with nfkb and t-cell anergy	Enrichment	CARD11	1.83
169	Immune system disease	Enrichment	CDC42	1.83
170	Arthritis	Enrichment	SYK	1.83
171	Intestinal obstruction	Enrichment	ACTG2	1.83
172	Long qt syndrome	Enrichment	CALM1, CALM2	1.77
173	Gillespie syndrome	Enrichment	ITPR1	1.71
174	Severe combined immunodeficiency, x-linked	Enrichment	IL2RG	1.71
175	Combined immunodeficiency, x-linked	Enrichment	IL2RG	1.71
176	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.71
177	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	1.71
178	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.71
179	Immunodeficiency 14	Enrichment	PIK3R1	1.71
180	Laryngeal squamous cell carcinoma	Enrichment	PTEN	1.71
181	Vogt-koyanagi-harada disease	Enrichment	HLA-DRB1	1.71
182	Dystonia	Enrichment	CAMK2B, GNAL	1.67
183	Mesothelioma, malignant	Enrichment	BCL10	1.66
184	Immune dysregulation with autoimmunity, immunodeficiency, and lymphoproliferation	Enrichment	CTLA4	1.66
185	Asparagine synthetase deficiency	Enrichment	CTLA4	1.66
186	T-cell acute lymphoblastic leukemia	Enrichment	BCL10	1.66
187	Congenital microcephaly - severe encephalopathy - progressive cerebral atrophy syndrome	Enrichment	CTLA4	1.66
188	Testicular cancer	Enrichment	BCL10	1.66
189	Temporal arteritis	Enrichment	HLA-DRB1	1.59
190	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3	1.59
191	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	1.59
192	Immunodeficiency, common variable, 1	Enrichment	ICOS	1.59
193	Spinocerebellar ataxia 15	Enrichment	ITPR1	1.59
194	Systemic-onset juvenile idiopathic arthritis	Enrichment	HLA-DRB1	1.59
195	Glioma	Enrichment	PTEN	1.59
196	Colorectal cancer	Enrichment	AKT1, BCL10, PIK3R1	1.58
197	Nemaline myopathy 2	Enrichment	ACTA1	1.54
198	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	ACTG2	1.54
199	Autoimmune lymphoproliferative syndrome	Enrichment	ACTA2	1.54
200	Aminoacylase 1 deficiency	Enrichment	ACTB	1.54
201	Congenital generalized lipodystrophy	Enrichment	FOS	1.54
202	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.54
203	Intermediate nemaline myopathy	Enrichment	ACTA1	1.54
204	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.54
205	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.49
206	Macrocephaly/autism syndrome	Enrichment	PTEN	1.49
207	Hemangioma	Enrichment	PTEN	1.49
208	Acute megakaryocytic leukemia	Enrichment	PTEN	1.49
209	Diffuse cutaneous systemic sclerosis	Enrichment	HLA-DRB1	1.49
210	Hereditary breast carcinoma	Enrichment	AKT1, PTEN	1.48
211	Systemic lupus erythematosus	Enrichment	CTLA4, HLA-DRB1	1.48
212	Visceral myopathy 1	Enrichment	ACTG2	1.44
213	Congenital myopathy 3 with rigid spine	Enrichment	ACTA1	1.44
214	Histiocytoid hemangioma	Enrichment	FOS	1.44
215	Coloboma of choroid and retina	Enrichment	ACTG1	1.44
216	Severe congenital nemaline myopathy	Enrichment	ACTA1	1.44
217	Cowden syndrome 1	Enrichment	PTEN	1.42
218	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.42
219	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.42
220	Limited scleroderma	Enrichment	HLA-DRB1	1.42
221	Breast adenocarcinoma	Enrichment	AKT1	1.42
222	Moyamoya disease 1	Enrichment	ACTA2	1.36
223	Testicular germ cell tumor	Enrichment	BCL10	1.36
224	Intestinal pseudo-obstruction	Enrichment	ACTG2	1.36
225	Typical nemaline myopathy	Enrichment	ACTA1	1.36
226	Thyroid cancer, nonmedullary, 2	Enrichment	PTEN	1.35
227	Squamous cell carcinoma, head and neck	Enrichment	PTEN	1.35
228	Megacolon	Enrichment	AKT3	1.35
229	Follicular thyroid carcinoma	Enrichment	PTEN	1.35
230	Overgrowth syndrome	Enrichment	PIK3R1	1.35
231	Childhood-onset nemaline myopathy	Enrichment	ACTA1	1.30
232	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.29
233	Inflammatory bowel disease 1	Enrichment	PRKCQ	1.24
234	Coronary heart disease 5	Enrichment	IKBKG	1.24
235	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.24
236	Lymphoma, non-hodgkin, familial	Enrichment	BCL10	1.24
237	Lennox-gastaut syndrome	Enrichment	MAPK10	1.24
238	Microcephaly	Enrichment	ACTB, ACTG1, CAMK2B	1.20
239	Omenn syndrome	Enrichment	IL2RG	1.20
240	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.20
241	Polymicrogyria	Enrichment	AKT3	1.20
242	Melanoma	Enrichment	PTEN	1.20
243	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.20
244	Meningioma, familial	Enrichment	PTEN	1.16
245	Ichthyosis	Enrichment	IL2RB	1.16
246	Uterine corpus cancer	Enrichment	PTEN	1.16
247	Cat eye syndrome	Enrichment	ACTG1	1.15
248	Nemaline myopathy	Enrichment	ACTA1	1.15
249	Congenital long qt syndrome	Enrichment	ITPR3	1.12
250	Immune deficiency disease	Enrichment	SYK	1.11
251	Asthma	Enrichment	CARD11	1.11
252	Anterior segment dysgenesis	Enrichment	ITPR1	1.03
253	Lung cancer susceptibility 3	Enrichment	ACTA2	1.01
254	Rhabdomyosarcoma	Enrichment	PTEN	1.00
255	Gliosarcoma	Enrichment	NFKBIA	1.00
256	Sudden infant death syndrome	Enrichment	CALM2	0.98
257	Giant cell glioblastoma	Enrichment	NFKBIA	0.98
258	Congenital myopathy 4a, autosomal dominant	Enrichment	ACTA1	0.98
259	Diffuse large b-cell lymphoma	Enrichment	PTEN	0.93
260	Neuromuscular disease	Enrichment	ACTA1	0.90
261	Cardiomyopathy, dilated, 1a	Enrichment	NFATC2	0.89
262	Endometrial cancer	Enrichment	PTEN	0.89
263	Congenital myopathy	Enrichment	ACTA1	0.88
264	Malaria	Enrichment	IKBKG	0.86
265	Ovarian cancer	Enrichment	AKT1, PTEN	0.86
266	Lissencephaly	Enrichment	ACTG1	0.84
267	Centronuclear myopathy	Enrichment	ACTA1	0.84
268	Congenital nervous system abnormality	Enrichment	CAMK2B, PTEN	0.82
269	Nervous system disease	Enrichment	CAMK2B, PTEN	0.82
270	Bladder cancer	Enrichment	PTEN	0.76
271	Prostate cancer	Enrichment	PTEN	0.76
272	Severe covid-19	Enrichment	HLA-DQB1	0.76
273	Hydrops fetalis, nonimmune	Enrichment	ACTA1	0.76
274	Non-immune hydrops fetalis	Enrichment	ACTA1	0.69
275	Lung cancer	Enrichment	ACTA2	0.68
276	Connective tissue disease	Enrichment	ACTA2	0.68
277	Cakut	Enrichment	ACTG1	0.65
278	Non-syndromic genetic deafness	Enrichment	ACTG1	0.63
279	Type 2 diabetes mellitus	Enrichment	AKT2	0.62
280	Fetal akinesia deformation sequence 1	Enrichment	ACTA1	0.62
281	Gastric cancer	Enrichment	PTEN	0.61
282	Myopathy	Enrichment	ACTA1	0.59
283	Distal arthrogryposis	Enrichment	ACTA1	0.57
284	Nonsyndromic hearing loss	Enrichment	ACTG1	0.57
285	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	ACTA2	0.56
286	Spastic ataxia	Enrichment	ITPR1	0.53
287	Thrombocytopenia	Enrichment	WAS	0.52
288	Hereditary breast ovarian cancer syndrome	Enrichment	PTEN	0.52
289	Undetermined early-onset epileptic encephalopathy	Enrichment	PPP3CA	0.51
290	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1	0.50
291	Autism	Enrichment	CAMK2G	0.43
292	Rare genetic deafness	Enrichment	ACTG1	0.35
293	Dilated cardiomyopathy	Enrichment	ACTA1	0.35
294	Autism spectrum disorder	Enrichment	PTEN	0.29
295	Inherited cancer-predisposing syndrome	Enrichment	PTEN	0.24

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

CD28 Signaling in T-Helper Cell

Pathway Network for CD28 Signaling in T-Helper Cell

Member Pathways for CD28 Signaling in T-Helper Cell

Pathways in the CD28 Signaling in T-Helper Cell SuperPath

Associated Genes for CD28 Signaling in T-Helper Cell

Associated Disorders for CD28 Signaling in T-Helper Cell

Disorders associated with CD28 Signaling in T-Helper Cell SuperPath

STRING Interaction Network for CD28 Signaling in T-Helper Cell

Sources for CD28 Signaling in T-Helper Cell