CD40/CD40L signaling

No Pathway Network information available for CD40/CD40L signaling

Pathways in the CD40/CD40L signaling SuperPath

#	Name	Source	Genes
1	CD40/CD40L signaling	PubChem	AKT1 BCL2L1 BIRC2 BIRC3 C4BPA CBLB CD40 CD40LG FCAMR IL4 JAK3 JUN MAP2K4 MAP3K1 MAP3K14 MAPK14 MAPK8 MYC NFKB1 NFKBIA RELA STAT5A TDP2 TNFAIP3 TRAF1 TRAF2 TRAF3 TRAF6 (see all 28) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TDP2	Tyrosyl-DNA Phosphodiesterase 2	Protein Coding	1
2	CBLB	Cbl Proto-Oncogene B	Protein Coding	1
3	CD40	CD40 Molecule	Protein Coding	1
4	IL4	Interleukin 4	Protein Coding	1
5	JAK3	Janus Kinase 3	Protein Coding	1
6	C4BPA	Complement Component 4 Binding Protein Alpha	Protein Coding	1
7	BIRC3	Baculoviral IAP Repeat Containing 3	Protein Coding	1
8	CD40LG	CD40 Ligand	Protein Coding	1
9	MAP3K14	Mitogen-Activated Protein Kinase Kinase Kinase 14	Protein Coding	1
10	TRAF3	TNF Receptor Associated Factor 3	Protein Coding	1
11	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
12	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
13	TRAF1	TNF Receptor Associated Factor 1	Protein Coding	1
14	TNFAIP3	TNF Alpha Induced Protein 3	Protein Coding	1
15	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	1
16	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
17	BIRC2	Baculoviral IAP Repeat Containing 2	Protein Coding	1
18	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	1
19	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
20	FCAMR	Fc Alpha And Mu Receptor	Protein Coding	1
21	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
22	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
23	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
24	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
25	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	1
26	BCL2L1	BCL2 Like 1	Protein Coding	1
27	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
28	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1

Disorders associated with CD40/CD40L signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Common variable immunodeficiency	Enrichment	CD40LG, NFKB1	4.07
2	Proteus syndrome	Enrichment	AKT1	2.69
3	Spinocerebellar ataxia, autosomal recessive 23	Enrichment	TDP2	2.69
4	46,xy sex reversal 6	Enrichment	MAP3K1	2.69
5	Immunodeficiency with hyper-igm, type 1	Enrichment	CD40LG	2.69
6	Immunodeficiency 132a	Enrichment	TRAF3	2.69
7	Immunodeficiency 132b	Enrichment	TRAF3	2.69
8	Immunodeficiency with hyper-igm, type 3	Enrichment	CD40	2.69
9	Cowden syndrome 6	Enrichment	AKT1	2.69
10	T-b+ severe combined immunodeficiency due to jak3 deficiency	Enrichment	JAK3	2.69
11	Familial behcet-like autoinflammatory syndrome	Enrichment	TNFAIP3	2.69
12	Immunodeficiency 112	Enrichment	MAP3K14	2.69
13	Cd40 ligand deficiency	Enrichment	CD40LG	2.69
14	Nik deficiency	Enrichment	MAP3K14	2.69
15	Burkitt lymphoma	Enrichment	MYC	2.38
16	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.38
17	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.38
18	Autoinflammatory syndrome, familial, behcet-like 1	Enrichment	TNFAIP3	2.38
19	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.38
20	Autoimmune disease, multisystem, infantile-onset, 3	Enrichment	CBLB	2.38
21	Rela fusion-positive ependymoma	Enrichment	RELA	2.38
22	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	2.38
23	Common variable immunodeficiency 12	Enrichment	NFKB1	2.38
24	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	JAK3	2.21
25	Nasopharyngeal carcinoma	Enrichment	NFKBIA	2.21
26	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	2.21
27	Adenosine deaminase deficiency	Enrichment	JAK3	2.08
28	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.99
29	Lymphoma, mucosa-associated lymphoid type	Enrichment	BIRC3	1.99
30	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	JAK3	1.99
31	Herpes simplex virus encephalitis	Enrichment	TRAF3	1.99
32	Breast cancer	Enrichment	AKT1, JUN	1.98
33	Breast adenocarcinoma	Enrichment	AKT1	1.91
34	Ovarian cancer	Enrichment	AKT1, MAP3K1	1.74
35	Cowden syndrome	Enrichment	AKT1	1.73
36	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.69
37	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.65
38	Meningioma	Enrichment	AKT1	1.61
39	Nk-cell enteropathy	Enrichment	JAK3	1.58
40	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1	1.54
41	Gliosarcoma	Enrichment	NFKBIA	1.49
42	Giant cell glioblastoma	Enrichment	NFKBIA	1.46
43	Multisystem inflammatory syndrome in children	Enrichment	TRAF3	1.35
44	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	1.33
45	Severe covid-19	Enrichment	JAK3	1.23
46	Severe combined immunodeficiency	Enrichment	JAK3	1.18
47	Systemic lupus erythematosus	Enrichment	TNFAIP3	1.11
48	Hereditary breast carcinoma	Enrichment	AKT1	1.06
49	Colorectal cancer	Enrichment	AKT1	0.78

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

CD40/CD40L signaling

Pathway Network for CD40/CD40L signaling

Member Pathways for CD40/CD40L signaling

Pathways in the CD40/CD40L signaling SuperPath

Associated Genes for CD40/CD40L signaling

Associated Disorders for CD40/CD40L signaling

Disorders associated with CD40/CD40L signaling SuperPath

STRING Interaction Network for CD40/CD40L signaling

Sources for CD40/CD40L signaling