Cell-extracellular matrix interactions

Pathway network for the Cell-extracellular matrix interactions SuperPath

Sources:

Reactome

Pathways in the Cell-extracellular matrix interactions SuperPath

#	Name	Source	Genes
1	Cell-extracellular matrix interactions	Reactome	ACTB ACTG1 ACTN1 ARHGEF6 FBLIM1 FERMT2 FLNA FLNC ILK ITGB1 LIMS1 LIMS2 PARVA PARVB PXN RSU1 TESK1 VASP (see all 18) (see less)
2	Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	Reactome	ACTN1 ARHGEF6 LIMS1 PARVA PARVB PXN RSU1 TESK1 (see all 8) (see less)
3	Localization of the PINCH-ILK-PARVIN complex to focal adhesions	Reactome	ILK ITGB1 PARVA PXN

Gene overlap in member pathways for Cell-extracellular matrix interactions SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PARVA	Parvin Alpha	Protein Coding	3
2	PXN	Paxillin	Protein Coding	3
3	PARVB	Parvin Beta	Protein Coding	2
4	ILK	Integrin Linked Kinase	Protein Coding	2
5	ITGB1	Integrin Subunit Beta 1	Protein Coding	2
6	LIMS1	LIM Zinc Finger Domain Containing 1	Protein Coding	2
7	RSU1	Ras Suppressor Protein 1	Protein Coding	2
8	TESK1	Testis Associated Actin Remodelling Kinase 1	Protein Coding	2
9	ACTN1	Actinin Alpha 1	Protein Coding	2
10	ARHGEF6	Rac/Cdc42 Guanine Nucleotide Exchange Factor 6	Protein Coding	2
11	FERMT2	FERM Domain Containing Kindlin 2	Protein Coding	1
12	FLNA	Filamin A	Protein Coding	1
13	FLNC	Filamin C	Protein Coding	1
14	FBLIM1	Filamin Binding LIM Protein 1	Protein Coding	1
15	LIMS2	LIM Zinc Finger Domain Containing 2	Protein Coding	1
16	ACTB	Actin Beta	Protein Coding	1
17	ACTG1	Actin Gamma 1	Protein Coding	1
18	VASP	Vasodilator Stimulated Phosphoprotein	Protein Coding	1

Disorders associated with Cell-extracellular matrix interactions SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	5.78
2	Patent foramen ovale	Enrichment	FLNA, FLNC	3.60
3	Intellectual developmental disorder, x-linked 46	Enrichment	ARHGEF6	3.23
4	Bleeding disorder, platelet-type, 15	Enrichment	ACTN1	3.23
5	Baraitser-winter syndrome 1	Enrichment	ACTB	2.88
6	Otopalatodigital syndrome, type i	Enrichment	FLNA	2.88
7	Intestinal pseudoobstruction, neuronal, chronic idiopathic, x-linked	Enrichment	FLNA	2.88
8	Terminal osseous dysplasia	Enrichment	FLNA	2.88
9	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.88
10	Fg syndrome 2	Enrichment	FLNA	2.88
11	Otopalatodigital syndrome spectrum disorder	Enrichment	FLNA	2.88
12	Becker nevus syndrome	Enrichment	ACTB	2.88
13	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.88
14	Muscular dystrophy, autosomal recessive, with cardiomyopathy and triangular tongue	Enrichment	LIMS2	2.88
15	X-linked ehlers-danlos syndrome	Enrichment	FLNA	2.88
16	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.88
17	Baraitser-winter syndrome	Enrichment	ACTB	2.88
18	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.88
19	Autosomal recessive limb-girdle muscular dystrophy type 2w	Enrichment	LIMS2	2.88
20	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.88
21	X-linked keloid scarring-reduced joint mobility-increased optic cup-to-disc ratio syndrome	Enrichment	FLNA	2.88
22	Visceral neuropathy, familial, 1, autosomal recessive	Enrichment	FLNA	2.58
23	Otopalatodigital syndrome, type ii	Enrichment	FLNA	2.58
24	Melnick-needles syndrome	Enrichment	FLNA	2.58
25	Frontometaphyseal dysplasia 1	Enrichment	FLNA	2.58
26	Deafness, autosomal dominant 20	Enrichment	ACTG1	2.58
27	Baraitser-winter syndrome 2	Enrichment	ACTG1	2.58
28	Cardiac valvular dysplasia, x-linked	Enrichment	FLNA	2.58
29	Cardiovascular system disease	Enrichment	FLNC	2.58
30	Neural tube defects	Enrichment	ITGB1	2.42
31	Prune belly syndrome	Enrichment	FLNA	2.40
32	Arterial tortuosity syndrome	Enrichment	FLNA	2.40
33	Periventricular nodular heterotopia 1	Enrichment	FLNA	2.40
34	Myopathy, myofibrillar, 5	Enrichment	FLNC	2.40
35	Congenital short bowel syndrome	Enrichment	FLNA	2.40
36	Myopathy, distal, 4	Enrichment	FLNC	2.40
37	Frontometaphyseal dysplasia	Enrichment	FLNA	2.40
38	Aminoacylase 1 deficiency	Enrichment	ACTB	2.28
39	Cardiomyopathy, familial hypertrophic, 26	Enrichment	FLNC	2.28
40	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	2.28
41	Autosomal dominant macrothrombocytopenia	Enrichment	ACTN1	2.23
42	Hemifacial hyperplasia	Enrichment	FLNC	2.18
43	Heart conduction disease	Enrichment	FLNC	2.18
44	Coloboma of choroid and retina	Enrichment	ACTG1	2.18
45	Patent ductus arteriosus	Enrichment	FLNA	2.10
46	Inherited arrhythmogenic cardiomyopathy	Enrichment	FLNC	2.10
47	Myofibrillar myopathy	Enrichment	FLNC	2.03
48	Familial isolated restrictive cardiomyopathy	Enrichment	FLNC	2.03
49	Fanconi anemia, complementation group c	Enrichment	FLNA	1.98
50	Microcephaly	Enrichment	ACTB, ACTG1	1.95
51	Cat eye syndrome	Enrichment	ACTG1	1.88
52	Nemaline myopathy	Enrichment	FLNC	1.88
53	Cardiac conduction defect	Enrichment	FLNC	1.80
54	Restrictive cardiomyopathy	Enrichment	FLNC	1.80
55	Periventricular nodular heterotopia	Enrichment	FLNA	1.73
56	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	FLNC	1.68
57	Non-syndromic x-linked intellectual disability	Enrichment	ARHGEF6	1.68
58	Cleft palate, isolated	Enrichment	FLNA	1.65
59	Cardiomyopathy, dilated, 1a	Enrichment	FLNC	1.56
60	Lissencephaly	Enrichment	ACTG1	1.56
61	Thrombocytopenia	Enrichment	ACTN1	1.55
62	Cardiomyopathy, familial hypertrophic, 1	Enrichment	FLNC	1.50
63	Tetralogy of fallot	Enrichment	FLNC	1.47
64	Familial hypertrophic cardiomyopathy	Enrichment	FLNC	1.37
65	Cakut	Enrichment	ACTG1	1.35
66	Non-syndromic genetic deafness	Enrichment	ACTG1	1.33
67	Nonsyndromic hearing loss	Enrichment	ACTG1	1.27
68	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	FLNA	1.25
69	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1	1.17
70	Spastic ataxia	Enrichment	FLNC	1.17
71	Rare genetic deafness	Enrichment	ACTG1	1.00
72	Dilated cardiomyopathy	Enrichment	FLNC	1.00

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Cell-extracellular matrix interactions

Pathway Network for Cell-extracellular matrix interactions

Pathway network for the Cell-extracellular matrix interactions SuperPath

Member Pathways for Cell-extracellular matrix interactions

Pathways in the Cell-extracellular matrix interactions SuperPath

Gene overlap in member pathways for Cell-extracellular matrix interactions SuperPath

Associated Genes for Cell-extracellular matrix interactions

Associated Disorders for Cell-extracellular matrix interactions

Disorders associated with Cell-extracellular matrix interactions SuperPath

STRING Interaction Network for Cell-extracellular matrix interactions

Sources for Cell-extracellular matrix interactions