Cell adhesion_Cadherin-mediated cell adhesion

No Pathway Network information available for Cell adhesion_Cadherin-mediated cell adhesion

Pathways in the Cell adhesion_Cadherin-mediated cell adhesion SuperPath

#	Name	Source	Genes
1	Cell adhesion_Cadherin-mediated cell adhesion	GeneGo (Thomson Reuters)	ACTA1 ACTA2 ACTB ACTC1 ACTG1 ACTG2 ACTR2 ACTR3 ACTR3B AFDN ARPC1A ARPC1B ARPC2 ARPC3 ARPC4 ARPC5 CDC42 CDH1 CDH15 CDH2 CDH3 CDH5 CTNNA1 CTNNA2 CTNNA3 CTNNB1 CTNND1 CTTN FER FMN1 FYN JUP MET PTK2 PTPN11 PTPRF PTPRJ PTPRM SRC WASL (see all 40) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ACTA1	Actin Alpha 1, Skeletal Muscle	Protein Coding	1
2	ACTA2	Actin Alpha 2, Smooth Muscle	Protein Coding	1
3	ACTB	Actin Beta	Protein Coding	1
4	ACTC1	Actin Alpha Cardiac Muscle 1	Protein Coding	1
5	ACTG1	Actin Gamma 1	Protein Coding	1
6	ACTG2	Actin Gamma 2, Smooth Muscle	Protein Coding	1
7	CDC42	Cell Division Cycle 42	Protein Coding	1
8	CDH1	Cadherin 1	Protein Coding	1
9	CDH2	Cadherin 2	Protein Coding	1
10	CDH3	Cadherin 3	Protein Coding	1
11	CDH5	Cadherin 5	Protein Coding	1
12	CDH15	Cadherin 15	Protein Coding	1
13	CTNNA1	Catenin Alpha 1	Protein Coding	1
14	CTNNA2	Catenin Alpha 2	Protein Coding	1
15	CTNNB1	Catenin Beta 1	Protein Coding	1
16	CTNND1	Catenin Delta 1	Protein Coding	1
17	CTTN	Cortactin	Protein Coding	1
18	FER	FER Tyrosine Kinase	Protein Coding	1
19	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
20	JUP	Junction Plakoglobin	Protein Coding	1
21	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	1
22	AFDN	Afadin, Adherens Junction Formation Factor	Protein Coding	1
23	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
24	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
25	PTPRF	Protein Tyrosine Phosphatase Receptor Type F	Protein Coding	1
26	PTPRJ	Protein Tyrosine Phosphatase Receptor Type J	Protein Coding	1
27	PTPRM	Protein Tyrosine Phosphatase Receptor Type M	Protein Coding	1
28	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
29	WASL	WASP Like Actin Nucleation Promoting Factor	Protein Coding	1
30	ARPC5	Actin Related Protein 2/3 Complex Subunit 5	Protein Coding	1
31	ARPC4	Actin Related Protein 2/3 Complex Subunit 4	Protein Coding	1
32	ARPC3	Actin Related Protein 2/3 Complex Subunit 3	Protein Coding	1
33	ARPC1B	Actin Related Protein 2/3 Complex Subunit 1B	Protein Coding	1
34	ACTR3	Actin Related Protein 3	Protein Coding	1
35	ACTR2	Actin Related Protein 2	Protein Coding	1
36	ARPC2	Actin Related Protein 2/3 Complex Subunit 2	Protein Coding	1
37	ARPC1A	Actin Related Protein 2/3 Complex Subunit 1A	Protein Coding	1
38	CTNNA3	Catenin Alpha 3	Protein Coding	1
39	ACTR3B	Actin Related Protein 3B	Protein Coding	1
40	FMN1	Formin 1	Protein Coding	1

Disorders associated with Cell adhesion_Cadherin-mediated cell adhesion SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Colorectal cancer	Enrichment	CDH1, CTNNA1, CTNNB1, MET, PTPRJ, SRC	6.73
2	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	CDH2, CTNNA3, JUP	5.07
3	Blepharocheilodontic syndrome 1	Enrichment	CDH1, CTNND1	5.07
4	Childhood hepatocellular carcinoma	Enrichment	CTNNB1, MET	5.07
5	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	5.07
6	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CDH1, CTNNA1	4.30
7	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42, PTPN11	4.30
8	Cleft lip with or without cleft palate	Enrichment	CDH1, CTNND1	3.90
9	Microcephaly	Enrichment	ACTB, ACTG1, CTNNB1, PTPN11	3.34
10	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	CTNNA3, JUP	3.26
11	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	CTNNA3, JUP	3.26
12	Hereditary breast ovarian cancer syndrome	Enrichment	CTNNA1, CTNNA2, FMN1	3.25
13	Inherited cancer-predisposing syndrome	Enrichment	CDH1, CTNNA1, MET, PTPN11	3.22
14	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	CTNNA3, JUP	3.00
15	Patent foramen ovale	Enrichment	ACTC1, PTPN11	2.90
16	Dilated cardiomyopathy	Enrichment	ACTA1, ACTC1, JUP	2.78
17	Hepatocellular carcinoma	Enrichment	CTNNB1, MET	2.72
18	Hydrops fetalis, nonimmune	Enrichment	ACTA1, PTPN11	2.58
19	Metachondromatosis	Enrichment	PTPN11	2.53
20	Ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome	Enrichment	CDH3	2.53
21	Baraitser-winter syndrome 1	Enrichment	ACTB	2.53
22	Arrhythmogenic right ventricular dysplasia, familial, 12	Enrichment	JUP	2.53
23	Macular dystrophy, patterned, 2	Enrichment	CTNNA1	2.53
24	Intellectual developmental disorder, autosomal dominant 3	Enrichment	CDH15	2.53
25	Congenital myopathy 2a, typical, autosomal dominant	Enrichment	ACTA1	2.53
26	Breasts and/or nipples, aplasia or hypoplasia of, 1	Enrichment	PTPRF	2.53
27	Leopard syndrome 1	Enrichment	PTPN11	2.53
28	Myopathy, scapulohumeroperoneal	Enrichment	ACTA1	2.53
29	Arrhythmogenic right ventricular dysplasia, familial, 13	Enrichment	CTNNA3	2.53
30	Naxos disease	Enrichment	JUP	2.53
31	Megacystis-microcolon-intestinal hypoperistalsis syndrome 5	Enrichment	ACTG2	2.53
32	Breasts and/or nipples, aplasia or hypoplasia of, 2	Enrichment	PTPRF	2.53
33	Cortical dysplasia, complex, with other brain malformations 9	Enrichment	CTNNA2	2.53
34	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.53
35	Immunodeficiency 71 with inflammatory disease and congenital thrombocytopenia	Enrichment	ARPC1B	2.53
36	Osteofibrous dysplasia	Enrichment	MET	2.53
37	Agenesis of corpus callosum, cardiac, ocular, and genital syndrome	Enrichment	CDH2	2.53
38	Deafness, autosomal recessive 97	Enrichment	MET	2.53
39	Hypotrichosis	Enrichment	CDH3	2.53
40	Becker nevus syndrome	Enrichment	ACTB	2.53
41	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.53
42	Autism 9	Enrichment	MET	2.53
43	Visceral neuropathy, familial, 3, autosomal dominant	Enrichment	ACTG2	2.53
44	Arrhythmogenic right ventricular dysplasia, familial, 14	Enrichment	CDH2	2.53
45	Congenital myopathy 2b, severe infantile, autosomal recessive	Enrichment	ACTA1	2.53
46	Autosomal dominant familial visceral neuropathy	Enrichment	ACTG2	2.53
47	Thrombocytopenia 6	Enrichment	SRC	2.53
48	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.53
49	Congenital myopathy 2c, severe infantile, autosomal dominant	Enrichment	ACTA1	2.53
50	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.53
51	Attention deficit-hyperactivity disorder 8	Enrichment	CDH2	2.53
52	Adenoid ameloblastoma	Enrichment	CTNNB1	2.53
53	Arthrogryposis, distal, type 11	Enrichment	MET	2.53
54	Baraitser-winter syndrome	Enrichment	ACTB	2.53
55	Thrombocytopenia 10	Enrichment	PTPRJ	2.53
56	Breast lobular carcinoma	Enrichment	CDH1	2.53
57	Zebra body myopathy	Enrichment	ACTA1	2.53
58	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.53
59	Nocarh syndrome	Enrichment	CDC42	2.53
60	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.53
61	Actin-accumulation myopathy	Enrichment	ACTA1	2.53
62	Myopathic intestinal pseudoobstruction	Enrichment	ACTG2	2.53
63	Microcystic stromal tumor	Enrichment	CTNNB1	2.53
64	Actg2 visceral myopathy	Enrichment	ACTG2	2.53
65	Malignant astrocytoma	Enrichment	PTPN11	2.53
66	Ovarian cancer	Enrichment	CDH1, CTNNB1, MET	2.49
67	Bladder cancer	Enrichment	CTNNA3, CTNNB1	2.49
68	Non-immune hydrops fetalis	Enrichment	ACTA1, PTPN11	2.43
69	Lung cancer	Enrichment	ACTA2, MET	2.40
70	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.23
71	Hypotrichosis, congenital, with juvenile macular dystrophy	Enrichment	CDH3	2.23
72	Aortic aneurysm, familial thoracic 2	Enrichment	ACTA2	2.23
73	Cardiomyopathy, dilated, 1r	Enrichment	ACTC1	2.23
74	Deafness, autosomal dominant 20	Enrichment	ACTG1	2.23
75	Cardiomyopathy, familial hypertrophic, 11	Enrichment	ACTC1	2.23
76	Smooth muscle dysfunction syndrome	Enrichment	ACTA2	2.23
77	Aortic aneurysm, familial thoracic 6	Enrichment	ACTA2	2.23
78	Baraitser-winter syndrome 2	Enrichment	ACTG1	2.23
79	Moyamoya disease 5	Enrichment	ACTA2	2.23
80	Atrial septal defect 5	Enrichment	ACTC1	2.23
81	Blepharocheilodontic syndrome 2	Enrichment	CTNND1	2.23
82	Developmental delay, language impairment, and ocular abnormalities	Enrichment	ARPC4	2.23
83	Werner syndrome	Enrichment	PTPN11	2.23
84	Papillary renal cell carcinoma	Enrichment	MET	2.23
85	Immunodeficiency 113 with autoimmunity and autoinflammation	Enrichment	ARPC5	2.23
86	Immune system disease	Enrichment	CDC42	2.23
87	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.23
88	Immunodeficiency 133	Enrichment	ARPC5	2.23
89	Teratoma	Enrichment	CTNNB1	2.23
90	Intestinal obstruction	Enrichment	ACTG2	2.23
91	Distal arthrogryposis	Enrichment	ACTA1, ACTC1	2.17
92	Hypertrophic cardiomyopathy	Enrichment	ACTC1, PTPN11	2.15
93	Thrombocytopenia	Enrichment	PTPN11, SRC	2.06
94	Desmoid disease, hereditary	Enrichment	CTNNB1	2.05
95	Epidermolysis bullosa, lethal acantholytic	Enrichment	JUP	2.05
96	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	2.05
97	Breast-ovarian cancer, familial 4	Enrichment	FMN1	2.05
98	Anus, imperforate	Enrichment	CTNNB1	2.05
99	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	2.05
100	Desmoid tumor	Enrichment	CTNNB1	2.05
101	Butterfly-shaped pigment dystrophy	Enrichment	CTNNA1	2.05
102	Tricuspid valve insufficiency	Enrichment	PTPN11	2.05
103	Renal cell carcinoma	Enrichment	MET	2.05
104	Nemaline myopathy 2	Enrichment	ACTA1	1.93
105	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	ACTG2	1.93
106	Polyposis syndrome, hereditary mixed, 1	Enrichment	CTNNA1	1.93
107	Autoimmune lymphoproliferative syndrome	Enrichment	ACTA2	1.93
108	Pilomatrixoma	Enrichment	CTNNB1	1.93
109	Aminoacylase 1 deficiency	Enrichment	ACTB	1.93
110	Alazami syndrome	Enrichment	CTNNB1	1.93
111	Craniopharyngioma	Enrichment	CTNNB1	1.93
112	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	1.93
113	Intermediate nemaline myopathy	Enrichment	ACTA1	1.93
114	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.93
115	Visceral myopathy 1	Enrichment	ACTG2	1.83
116	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.83
117	Congenital myopathy 3 with rigid spine	Enrichment	ACTA1	1.83
118	Lymphoma	Enrichment	PTPN11	1.83
119	Coloboma of choroid and retina	Enrichment	ACTG1	1.83
120	Severe congenital nemaline myopathy	Enrichment	ACTA1	1.83
121	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.76
122	Moyamoya disease 1	Enrichment	ACTA2	1.76
123	Intestinal pseudo-obstruction	Enrichment	ACTG2	1.76
124	Patent ductus arteriosus	Enrichment	PTPN11	1.76
125	Adrenocortical carcinoma	Enrichment	CTNNB1	1.76
126	Typical nemaline myopathy	Enrichment	ACTA1	1.76
127	Myelofibrosis	Enrichment	SRC	1.69
128	Renal cell carcinoma, papillary, 1	Enrichment	MET	1.69
129	Noonan syndrome 3	Enrichment	PTPN11	1.69
130	Gallbladder cancer	Enrichment	CTNNB1	1.69
131	Childhood-onset nemaline myopathy	Enrichment	ACTA1	1.69
132	Arthrogryposis, distal, type 1a	Enrichment	MET	1.63
133	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.63
134	Adult hepatocellular carcinoma	Enrichment	CTNNB1	1.58
135	Hypotrichosis simplex	Enrichment	CDH3	1.58
136	Cat eye syndrome	Enrichment	ACTG1	1.54
137	Nemaline myopathy	Enrichment	ACTA1	1.54
138	Pectus excavatum	Enrichment	PTPN11	1.50
139	Combined immunodeficiency	Enrichment	ARPC1B	1.50
140	Combined t cell and b cell immunodeficiency	Enrichment	ARPC1B	1.50
141	Specific learning disability	Enrichment	PTPN11	1.50
142	Combined t and b cell immunodeficiency	Enrichment	ARPC1B	1.50
143	Epicanthus	Enrichment	PTPN11	1.46
144	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.46
145	Congenital long qt syndrome	Enrichment	PTPN11	1.46
146	Osteoporosis	Enrichment	SRC	1.39
147	Medulloblastoma	Enrichment	CTNNB1	1.39
148	Lung cancer susceptibility 3	Enrichment	ACTA2	1.39
149	Cleft lip/palate	Enrichment	CDH1	1.39
150	Renal cell carcinoma, nonpapillary	Enrichment	MET	1.36
151	Congenital myopathy 4a, autosomal dominant	Enrichment	ACTA1	1.36
152	Corpus callosum, agenesis of	Enrichment	CDH2	1.36
153	Isolated corpus callosum agenesis	Enrichment	CDH2	1.36
154	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CDH2	1.36
155	Noonan syndrome and noonan-related syndrome	Enrichment	PTPN11	1.36
156	Wolff-parkinson-white syndrome	Enrichment	JUP	1.34
157	Polycystic liver disease	Enrichment	CTNNB1	1.31
158	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.31
159	Neuromuscular disease	Enrichment	ACTA1	1.29
160	Arteriovenous malformations of the brain	Enrichment	CDH2	1.26
161	Congenital myopathy	Enrichment	ACTA1	1.26
162	Craniosynostosis	Enrichment	CTNNA1	1.24
163	Endometrial cancer	Enrichment	CDH1	1.22
164	Lissencephaly	Enrichment	ACTG1	1.22
165	Centronuclear myopathy	Enrichment	ACTA1	1.22
166	Hepatoblastoma	Enrichment	CTNNB1	1.22
167	Noonan syndrome 1	Enrichment	PTPN11	1.18
168	Scoliosis	Enrichment	PTPN11	1.16
169	Rasopathy	Enrichment	PTPN11	1.13
170	Auditory neuropathy	Enrichment	CDH2	1.13
171	Strabismus	Enrichment	PTPN11	1.12
172	Prostate cancer	Enrichment	CDH1	1.09
173	Long qt syndrome 1	Enrichment	PTPN11	1.07
174	Long qt syndrome	Enrichment	CTNNA3	1.06
175	Connective tissue disease	Enrichment	ACTA2	1.04
176	Familial hypertrophic cardiomyopathy	Enrichment	ACTC1	1.03
177	Cakut	Enrichment	ACTG1	1.02
178	Left ventricular noncompaction	Enrichment	ACTC1	1.01
179	Non-syndromic genetic deafness	Enrichment	ACTG1	1.00
180	Fetal akinesia deformation sequence 1	Enrichment	ACTA1	0.98
181	Myopathy	Enrichment	ACTA1	0.95
182	Nonsyndromic hearing loss	Enrichment	ACTG1	0.93
183	Gastric cancer	Enrichment	CDH1	0.92
184	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	ACTA2	0.91
185	Hereditary breast carcinoma	Enrichment	CDH1	0.91
186	Autosomal dominant non-syndromic intellectual disability	Enrichment	CDH15	0.86
187	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1	0.85
188	Familial isolated dilated cardiomyopathy	Enrichment	ACTC1	0.84
189	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.82
190	Schizophrenia	Enrichment	PTPRM	0.80
191	Breast cancer	Enrichment	CDH1	0.70
192	Rare genetic deafness	Enrichment	ACTG1	0.68
193	Hereditary retinal dystrophy	Enrichment	CDH3, CTNNA1	0.68
194	Fundus dystrophy	Enrichment	CDH3, CTNNA1	0.68
195	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	MET	0.63
196	Congenital nervous system abnormality	Enrichment	CTNNB1	0.57
197	Nervous system disease	Enrichment	CTNNB1	0.57
198	Autism spectrum disorder	Enrichment	PTPN11	0.56
199	Retinitis pigmentosa	Enrichment	CDH3	0.33

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Cell adhesion_Cadherin-mediated cell adhesion

Pathway Network for Cell adhesion_Cadherin-mediated cell adhesion

Member Pathways for Cell adhesion_Cadherin-mediated cell adhesion

Pathways in the Cell adhesion_Cadherin-mediated cell adhesion SuperPath

Associated Genes for Cell adhesion_Cadherin-mediated cell adhesion

Associated Disorders for Cell adhesion_Cadherin-mediated cell adhesion

Disorders associated with Cell adhesion_Cadherin-mediated cell adhesion SuperPath

STRING Interaction Network for Cell adhesion_Cadherin-mediated cell adhesion

Sources for Cell adhesion_Cadherin-mediated cell adhesion