Cell adhesion_Endothelial cell contacts by junctional mechanisms

No Pathway Network information available for Cell adhesion_Endothelial cell contacts by junctional mechanisms

Pathways in the Cell adhesion_Endothelial cell contacts by junctional mechanisms SuperPath

#	Name	Source	Genes
1	Cell adhesion_Endothelial cell contacts by junctional mechanisms	GeneGo (Thomson Reuters)	ACTB ACTG1 ACTN1 ACTN2 ACTN3 ACTN4 AFDN CDH2 CDH5 CGN CLDN1 CLDN14 CLDN3 CLDN5 CTNNA1 CTNNA2 CTNNA3 CTNNB1 CTNND1 DSP F11R GJA1 GJA4 GJA5 JAM2 JUP MAGI1 OCLN PKP4 TJP1 TJP2 VIM (see all 32) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ACTB	Actin Beta	Protein Coding	1
2	ACTG1	Actin Gamma 1	Protein Coding	1
3	ACTN4	Actinin Alpha 4	Protein Coding	1
4	ACTN1	Actinin Alpha 1	Protein Coding	1
5	ACTN2	Actinin Alpha 2	Protein Coding	1
6	ACTN3	Actinin Alpha 3	Protein Coding	1
7	CDH2	Cadherin 2	Protein Coding	1
8	CDH5	Cadherin 5	Protein Coding	1
9	CLDN3	Claudin 3	Protein Coding	1
10	CTNNA1	Catenin Alpha 1	Protein Coding	1
11	CTNNA2	Catenin Alpha 2	Protein Coding	1
12	CTNNB1	Catenin Beta 1	Protein Coding	1
13	CTNND1	Catenin Delta 1	Protein Coding	1
14	DSP	Desmoplakin	Protein Coding	1
15	GJA1	Gap Junction Protein Alpha 1	Protein Coding	1
16	GJA4	Gap Junction Protein Alpha 4	Protein Coding	1
17	GJA5	Gap Junction Protein Alpha 5	Protein Coding	1
18	JUP	Junction Plakoglobin	Protein Coding	1
19	AFDN	Afadin, Adherens Junction Formation Factor	Protein Coding	1
20	TJP1	Tight Junction Protein 1	Protein Coding	1
21	CLDN5	Claudin 5	Protein Coding	1
22	VIM	Vimentin	Protein Coding	1
23	PKP4	Plakophilin 4	Protein Coding	1
24	CLDN1	Claudin 1	Protein Coding	1
25	MAGI1	Membrane Associated Guanylate Kinase, WW And PDZ Domain Containing 1	Protein Coding	1
26	TJP2	Tight Junction Protein 2	Protein Coding	1
27	CLDN14	Claudin 14	Protein Coding	1
28	CTNNA3	Catenin Alpha 3	Protein Coding	1
29	F11R	F11 Receptor	Protein Coding	1
30	CGN	Cingulin	Protein Coding	1
31	JAM2	Junctional Adhesion Molecule 2	Protein Coding	1
32	OCLN	Occludin	Protein Coding	1

Disorders associated with Cell adhesion_Endothelial cell contacts by junctional mechanisms SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	CDH2, CTNNA3, DSP, JUP	7.60
2	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	ACTN2, CTNNA3, DSP, JUP	7.34
3	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	CTNNA3, DSP, JUP	5.59
4	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	CTNNA3, DSP, JUP	5.59
5	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	5.27
6	Epidermolysis bullosa, lethal acantholytic	Enrichment	DSP, JUP	4.79
7	Dilated cardiomyopathy	Enrichment	ACTN2, DSP, JUP	3.06
8	Bladder cancer	Enrichment	CTNNA3, CTNNB1	2.68
9	Palmoplantar keratoderma and congenital alopecia 1	Enrichment	GJA1	2.63
10	Pseudo-torch syndrome 1	Enrichment	OCLN	2.63
11	Hypoplastic left heart syndrome 1	Enrichment	GJA1	2.63
12	Baraitser-winter syndrome 1	Enrichment	ACTB	2.63
13	Focal segmental glomerulosclerosis 1	Enrichment	ACTN4	2.63
14	Arrhythmogenic right ventricular dysplasia, familial, 12	Enrichment	JUP	2.63
15	Macular dystrophy, patterned, 2	Enrichment	CTNNA1	2.63
16	Deafness, autosomal dominant 51	Enrichment	TJP2	2.63
17	Cardiomyopathy, dilated, 1aa, with or without left ventricular noncompaction	Enrichment	ACTN2	2.63
18	Oculodentodigital dysplasia	Enrichment	GJA1	2.63
19	Arrhythmogenic right ventricular dysplasia, familial, 13	Enrichment	CTNNA3	2.63
20	Craniometaphyseal dysplasia, autosomal recessive	Enrichment	GJA1	2.63
21	Naxos disease	Enrichment	JUP	2.63
22	Basal ganglia calcification, idiopathic, 8, autosomal recessive	Enrichment	JAM2	2.63
23	Cortical dysplasia, complex, with other brain malformations 9	Enrichment	CTNNA2	2.63
24	Congenital myopathy 8	Enrichment	ACTN2	2.63
25	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.63
26	Agenesis of corpus callosum, cardiac, ocular, and genital syndrome	Enrichment	CDH2	2.63
27	Oculodentodigital dysplasia, autosomal recessive	Enrichment	GJA1	2.63
28	Actn3 deficiency	Enrichment	ACTN3	2.63
29	Becker nevus syndrome	Enrichment	ACTB	2.63
30	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.63
31	Arrhythmogenic right ventricular dysplasia, familial, 14	Enrichment	CDH2	2.63
32	Bleeding disorder, platelet-type, 15	Enrichment	ACTN1	2.63
33	Hemangioma of liver	Enrichment	GJA4	2.63
34	Erythrokeratodermia variabilis et progressiva 3	Enrichment	GJA1	2.63
35	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.63
36	Myopathy, distal, 6, adult-onset, autosomal dominant	Enrichment	ACTN2	2.63
37	Attention deficit-hyperactivity disorder 8	Enrichment	CDH2	2.63
38	Adenoid ameloblastoma	Enrichment	CTNNB1	2.63
39	Baraitser-winter syndrome	Enrichment	ACTB	2.63
40	Skin fragility-woolly hair-palmoplantar keratoderma syndrome	Enrichment	DSP	2.63
41	Skin hemangioma	Enrichment	GJA4	2.63
42	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.63
43	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.63
44	Premature aging	Enrichment	VIM	2.63
45	Microcystic stromal tumor	Enrichment	CTNNB1	2.63
46	Long qt syndrome	Enrichment	CTNNA3, DSP	2.62
47	Microcephaly	Enrichment	ACTB, ACTG1, CTNNB1	2.53
48	Left ventricular noncompaction	Enrichment	ACTN2, DSP	2.51
49	Blepharocheilodontic syndrome 1	Enrichment	CTNND1	2.33
50	Atrial standstill 1	Enrichment	GJA5	2.33
51	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.33
52	Arrhythmogenic right ventricular dysplasia, familial, 8	Enrichment	DSP	2.33
53	Ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis	Enrichment	CLDN1	2.33
54	Deafness, autosomal dominant 20	Enrichment	ACTG1	2.33
55	Baraitser-winter syndrome 2	Enrichment	ACTG1	2.33
56	Hallermann-streiff syndrome	Enrichment	GJA1	2.33
57	Cholestasis, progressive familial intrahepatic, 4	Enrichment	TJP2	2.33
58	Atrial fibrillation, familial, 11	Enrichment	GJA5	2.33
59	Syndactyly, type iii	Enrichment	GJA1	2.33
60	Syndactyly, type v	Enrichment	GJA1	2.33
61	Keratosis palmoplantaris striata ii	Enrichment	DSP	2.33
62	Cardiomyopathy, dilated, with woolly hair, keratoderma, and tooth agenesis	Enrichment	DSP	2.33
63	Blepharocheilodontic syndrome 2	Enrichment	CTNND1	2.33
64	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.33
65	Craniometaphyseal dysplasia	Enrichment	GJA1	2.33
66	Progressive familial heart block	Enrichment	DSP	2.33
67	Cataract 30	Enrichment	VIM	2.33
68	Cardiomyopathy, dilated, with woolly hair and keratoderma	Enrichment	DSP	2.33
69	Deafness, autosomal recessive 29	Enrichment	CLDN14	2.33
70	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.33
71	Teratoma	Enrichment	CTNNB1	2.33
72	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1, TJP2	2.18
73	Familial isolated dilated cardiomyopathy	Enrichment	ACTN2, DSP	2.16
74	Desmoid disease, hereditary	Enrichment	CTNNB1	2.15
75	Hypercholanemia, familial 1	Enrichment	TJP2	2.15
76	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	2.15
77	Anus, imperforate	Enrichment	CTNNB1	2.15
78	Erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper-ige	Enrichment	DSP	2.15
79	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	2.15
80	Woolly hair-skin fragility syndrome	Enrichment	DSP	2.15
81	Desmoid tumor	Enrichment	CTNNB1	2.15
82	Keratosis palmoplantaris striata	Enrichment	DSP	2.15
83	Intrinsic cardiomyopathy	Enrichment	ACTN2	2.15
84	Butterfly-shaped pigment dystrophy	Enrichment	CTNNA1	2.15
85	Hereditary breast ovarian cancer syndrome	Enrichment	CTNNA1, CTNNA2	2.13
86	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CTNNA1	2.03
87	Polyposis syndrome, hereditary mixed, 1	Enrichment	CTNNA1	2.03
88	Pilomatrixoma	Enrichment	CTNNB1	2.03
89	Aminoacylase 1 deficiency	Enrichment	ACTB	2.03
90	Alazami syndrome	Enrichment	CTNNB1	2.03
91	Craniopharyngioma	Enrichment	CTNNB1	2.03
92	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	2.03
93	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.93
94	Cardiac arrest	Enrichment	DSP	1.93
95	Histiocytoid hemangioma	Enrichment	VIM	1.93
96	Cleft upper lip	Enrichment	GJA1	1.93
97	Coloboma of choroid and retina	Enrichment	ACTG1	1.93
98	Branchiootorenal syndrome 1	Enrichment	TJP2	1.85
99	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.85
100	Adrenocortical carcinoma	Enrichment	CTNNB1	1.85
101	Familial hypercholanemia	Enrichment	TJP2	1.85
102	Inherited arrhythmogenic cardiomyopathy	Enrichment	DSP	1.85
103	Cleft lip with or without cleft palate	Enrichment	CTNND1	1.85
104	Branchiootorenal syndrome	Enrichment	TJP2	1.79
105	Gallbladder cancer	Enrichment	CTNNB1	1.79
106	Colorectal cancer	Enrichment	CTNNA1, CTNNB1	1.75
107	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	CLDN14, GJA1	1.73
108	Erythrokeratodermia variabilis et progressiva 1	Enrichment	GJA1	1.73
109	Basal ganglia calcification, idiopathic, 1	Enrichment	JAM2	1.73
110	Perrault syndrome	Enrichment	CLDN14	1.73
111	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.73
112	Myocarditis	Enrichment	DSP	1.73
113	Hypoplastic left heart syndrome	Enrichment	GJA1	1.73
114	Arrhythmogenic right ventricular dysplasia, familial, 9	Enrichment	DSP	1.68
115	Adult hepatocellular carcinoma	Enrichment	CTNNB1	1.68
116	Primary biliary cholangitis	Enrichment	TJP2	1.68
117	Familial isolated arrhythmogenic right ventricular dysplasia	Enrichment	DSP	1.68
118	Cat eye syndrome	Enrichment	ACTG1	1.63
119	Cataract 30, multiple types	Enrichment	VIM	1.63
120	Autosomal dominant macrothrombocytopenia	Enrichment	ACTN1	1.63
121	Cardiac conduction defect	Enrichment	DSP	1.55
122	Aortic valve disease 1	Enrichment	DSP	1.52
123	Medulloblastoma	Enrichment	CTNNB1	1.49
124	Corpus callosum, agenesis of	Enrichment	CDH2	1.46
125	Isolated corpus callosum agenesis	Enrichment	CDH2	1.46
126	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CDH2	1.46
127	Wolff-parkinson-white syndrome	Enrichment	JUP	1.43
128	Isolated congenital microcephaly	Enrichment	OCLN	1.43
129	Interstitial lung disease 2	Enrichment	DSP	1.40
130	Polycystic liver disease	Enrichment	CTNNB1	1.40
131	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.40
132	Arteriovenous malformations of the brain	Enrichment	CDH2	1.36
133	Craniosynostosis	Enrichment	CTNNA1	1.34
134	Cardiomyopathy, dilated, 1a	Enrichment	DSP	1.31
135	Lissencephaly	Enrichment	ACTG1	1.31
136	Hepatoblastoma	Enrichment	CTNNB1	1.31
137	Hepatocellular carcinoma	Enrichment	CTNNB1	1.30
138	Cardiomyopathy, dilated, 1g	Enrichment	DSP	1.30
139	Familial atrial fibrillation	Enrichment	GJA5	1.26
140	Tetralogy of fallot	Enrichment	GJA5	1.22
141	Auditory neuropathy	Enrichment	CDH2	1.22
142	Long qt syndrome 1	Enrichment	DSP	1.16
143	Familial hypertrophic cardiomyopathy	Enrichment	ACTN2	1.12
144	Cakut	Enrichment	ACTG1	1.11
145	Genetic steroid-resistant nephrotic syndrome	Enrichment	ACTN4	1.11
146	Non-syndromic genetic deafness	Enrichment	ACTG1	1.09
147	Nonsyndromic hearing loss	Enrichment	ACTG1	1.02
148	Hypertrophic cardiomyopathy	Enrichment	ACTN2	1.01
149	Sensorineural hearing loss	Enrichment	CLDN14	0.97
150	Thrombocytopenia	Enrichment	ACTN1	0.97
151	Deafness, autosomal recessive	Enrichment	CLDN14	0.86
152	Autosomal recessive nonsyndromic deafness	Enrichment	CLDN14	0.85
153	Rare genetic deafness	Enrichment	ACTG1	0.77
154	Ovarian cancer	Enrichment	CTNNB1	0.67
155	Congenital nervous system abnormality	Enrichment	CTNNB1	0.65
156	Nervous system disease	Enrichment	CTNNB1	0.65
157	Inherited cancer-predisposing syndrome	Enrichment	CTNNA1	0.57
158	Hereditary retinal dystrophy	Enrichment	CTNNA1	0.30
159	Fundus dystrophy	Enrichment	CTNNA1	0.30

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Cell adhesion_Endothelial cell contacts by junctional mechanisms

Pathway Network for Cell adhesion_Endothelial cell contacts by junctional mechanisms

Member Pathways for Cell adhesion_Endothelial cell contacts by junctional mechanisms

Pathways in the Cell adhesion_Endothelial cell contacts by junctional mechanisms SuperPath

Associated Genes for Cell adhesion_Endothelial cell contacts by junctional mechanisms

Associated Disorders for Cell adhesion_Endothelial cell contacts by junctional mechanisms

Disorders associated with Cell adhesion_Endothelial cell contacts by junctional mechanisms SuperPath

STRING Interaction Network for Cell adhesion_Endothelial cell contacts by junctional mechanisms

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