Cell adhesion_Plasmin signaling

No Pathway Network information available for Cell adhesion_Plasmin signaling

Pathways in the Cell adhesion_Plasmin signaling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

Disorders associated with Cell adhesion_Plasmin signaling SuperPath

according to GeneCards Suite gene sharing
#DisorderTypeGenesScore
1Angioedema, hereditary, 1EnrichmentF12, PLG, SERPING17.35
2Dysfibrinogenemia, congenitalEnrichmentFGA, FGB, FGG7.35
3Familial dysfibrinogenemiaEnrichmentFGA, FGB, FGG7.35
4Familial hypofibrinogenemiaEnrichmentFGA, FGB, FGG7.35
5Digenic alport syndromeEnrichmentCOL4A3, COL4A4, COL4A57.35
6Afibrinogenemia, congenitalEnrichmentFGA, FGB, FGG6.75
7Alport syndrome 3a, autosomal dominantEnrichmentCOL4A3, COL4A4, COL4A56.36
8Autosomal dominant alport syndromeEnrichmentCOL4A3, COL4A4, COL4A56.36
9Alport syndromeEnrichmentCOL4A3, COL4A4, COL4A56.36
10Loeys-dietz syndromeEnrichmentTGFB2, TGFBR1, TGFBR25.44
11Marfan syndromeEnrichmentTGFB2, TGFBR1, TGFBR25.28
12Loeys-dietz syndrome 2EnrichmentTGFBR1, TGFBR24.89
13Rosette-forming glioneuronal tumorEnrichmentFGFR1, PIK3CA4.89
14Hereditary angioedemaEnrichmentF12, PLG4.89
15AngioedemaEnrichmentF12, SERPING14.89
16X-linked diffuse leiomyomatosis-alport syndromeEnrichmentCOL4A5, COL4A64.89
17Nephrotic syndromeEnrichmentCOL4A3, COL4A4, COL4A5, FN14.78
18Kidney diseaseEnrichmentCOL4A3, COL4A4, COL4A54.71
19HypertensionEnrichmentCOL4A4, COL4A5, F124.62
20Hematuria, benign familial, 1EnrichmentCOL4A3, COL4A44.42
21Congenital lipomatous overgrowth, vascular malformations, and epidermal neviEnrichmentPIK3CA, PIK3R14.42
22Immunodeficiency 14a with lymphoproliferation, autosomal dominantEnrichmentPIK3CD, PIK3R14.42
23Loeys-dietz syndrome 1EnrichmentTGFBR1, TGFBR24.42
24Immunodeficiency 14EnrichmentPIK3CD, PIK3R14.42
25Brain small vessel disease 1 with or without ocular anomaliesEnrichmentCOL4A1, COL4A24.12
26Alport syndrome 2, autosomal recessiveEnrichmentCOL4A3, COL4A44.12
27Megalencephaly-capillary malformation-polymicrogyria syndromeEnrichmentPIK3CA, PIK3R24.12
28Autosomal recessive alport syndromeEnrichmentCOL4A3, COL4A44.12
29Familial porencephalyEnrichmentCOL4A1, COL4A23.90
30Hemorrhage, intracerebralEnrichmentCOL4A1, COL4A23.72
31Familial thoracic aortic aneurysm and aortic dissectionEnrichmentTGFB2, TGFBR1, TGFBR23.28
32Autosomal non-syndromic agammaglobulinemiaEnrichmentPIK3CD, PIK3R13.25
33Chronic kidney diseaseEnrichmentCOL4A4, COL4A53.01
34Lynch syndromeEnrichmentPIK3CA, TGFBR22.89
35Ehlers-danlos syndromeEnrichmentTGFB2, TGFBR22.68
36Focal segmental glomerulosclerosisEnrichmentCOL4A4, COL4A52.63
37MacrodactylyEnrichmentPIK3CA2.44
38Complement component 4, partial deficiency ofEnrichmentSERPING12.44
39Osteoglophonic dysplasiaEnrichmentFGFR12.44
40Cardiospondylocarpofacial syndromeEnrichmentMAP3K72.44
41Trigonocephaly 1EnrichmentFGFR12.44
42Alport syndrome 1, x-linkedEnrichmentCOL4A52.44
43Lymphoproliferative syndrome, x-linked, 2EnrichmentXIAP2.44
44Angioedema, hereditary, 3EnrichmentF122.44
45Encephalopathy, familial, with neuroserpin inclusion bodiesEnrichmentSERPINI12.44
46Prekallikrein deficiencyEnrichmentKLKB12.44
47Megalencephaly, autosomal dominantEnrichmentPIK3CA2.44
48Multiple self-healing squamous epitheliomaEnrichmentTGFBR12.44
49Cowden syndrome 5EnrichmentPIK3CA2.44
50Lissencephaly 5EnrichmentLAMB12.44
51Frontometaphyseal dysplasia 2EnrichmentMAP3K72.44
52Angioedema, hereditary, 4EnrichmentPLG2.44
53Cerebral cavernous malformations 4EnrichmentPIK3CA2.44
54Deafness, x-linked 6EnrichmentCOL4A62.44
55Short syndromeEnrichmentPIK3R12.44
56PorencephalyEnrichmentCOL4A12.44
57Netherton syndromeEnrichmentSPINK52.44
58Microvascular complications of diabetes 1EnrichmentVEGFA2.44
59Camurati-engelmann disease 2EnrichmentTGFB22.44
60Hemifacial myohyperplasiaEnrichmentPIK3CA2.44
61Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowthEnrichmentPIK3CA2.44
62Colorectal cancer, hereditary nonpolyposis, type 6EnrichmentTGFBR22.44
63Immunodeficiency 36 with lymphoproliferationEnrichmentPIK3R12.44
64Immunodeficiency 14b, autosomal recessiveEnrichmentPIK3CD2.44
65Agammaglobulinemia 7, autosomal recessiveEnrichmentPIK3R12.44
66Hartsfield syndromeEnrichmentFGFR12.44
67Segmental progressive overgrowth syndrome with fibroadipose hyperplasiaEnrichmentPIK3CA2.44
68Tufted angioma of skinEnrichmentKDR2.44
69Col4a1-related disordersEnrichmentCOL4A12.44
70Congenital fibrinogen deficiencyEnrichmentFGG2.44
71HypospadiasEnrichmentPIK3CA2.44
72C1 inhibitor deficiencyEnrichmentSERPING12.44
73Ichthyosis linearis circumflexaEnrichmentSPINK52.44
74Rare venous malformationEnrichmentPIK3CA2.44
75Col4a1 or col4a2-related cerebral small vessel diseaseEnrichmentCOL4A12.44
76Diaphragmatic eventrationEnrichmentPIK3CA2.44
77UrticariaEnrichmentF122.44
78X-linked alport syndromeEnrichmentCOL4A52.44
79Pik3ca-related overgrowth spectrumEnrichmentPIK3CA2.44
80Rare combined vascular malformationEnrichmentPIK3CA2.44
81Hereditary angioedema with c1inh deficiencyEnrichmentSERPING12.44
82Cavernous lymphangiomaEnrichmentPIK3CA2.44
83Pik3ca-related overgrowth syndromeEnrichmentPIK3CA2.44
84Lethal hydranencephaly-diaphragmatic hernia syndromeEnrichmentPLAT2.44
85Hartsfield-bixler-demyer syndromeEnrichmentFGFR12.44
86Hemihyperplasia-multiple lipomatosis syndromeEnrichmentPIK3CA2.44
87Eccrine angiomatous hamartomaEnrichmentPIK3CA2.44
88F12-associated cold autoinflammatory syndromeEnrichmentF122.44
89Macrodactyly of toeEnrichmentPIK3CA2.44
90Inherited prekallikrein deficiencyEnrichmentKLKB12.44
91Cystic fibrosisEnrichmentPLG, TGFB12.23
92Camurati-engelmann disease 1EnrichmentTGFB12.14
93Spondyloepimetaphyseal dysplasia, strudwick typeEnrichmentFN12.14
94Spondylometaphyseal dysplasia, corner fracture typeEnrichmentFN12.14
95Metaphyseal dysplasia, spahr typeEnrichmentMMP132.14
96Plasminogen deficiency, type iEnrichmentPLG2.14
97Spondyloepimetaphyseal dysplasia, missouri typeEnrichmentMMP132.14
98Quebec platelet disorderEnrichmentPLAU2.14
99Microvascular complications of diabetes 5EnrichmentTGFBR22.14
100Keratosis, seborrheicEnrichmentPIK3CA2.14
101Pfeiffer syndromeEnrichmentFGFR12.14
102Jackson-weiss syndromeEnrichmentFGFR12.14
103Lissencephaly 1EnrichmentLAMB12.14
104Encephalocraniocutaneous lipomatosisEnrichmentFGFR12.14
105Roifman-chitayat syndromeEnrichmentPIK3CD2.14
106Specific language impairment 5EnrichmentCOL4A42.14
107Factor xii deficiencyEnrichmentF122.14
108Angioma, tuftedEnrichmentKDR2.14
109Noonan syndrome 8EnrichmentPIK3CA2.14
110Encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy, 1EnrichmentCOL4A22.14
111Inflammatory bowel disease, immunodeficiency, and encephalopathyEnrichmentTGFB12.14
112Camurati-engelmann diseaseEnrichmentTGFB12.14
113GlomerulonephritisEnrichmentCOL4A42.14
114Loeys-dietz syndrome 4EnrichmentTGFB22.14
115Immune system diseaseEnrichmentPIK3CD2.14
116Interfrontal craniofaciosynostosisEnrichmentFGFR12.14
117Metaphyseal anadysplasiaEnrichmentMMP132.14
118Cerebral palsyEnrichmentCOL4A1, COL4A22.06
119Retinal arteries, tortuosity ofEnrichmentCOL4A11.97
120Hypogonadotropic hypogonadism 2 with or without anosmiaEnrichmentFGFR11.97
121Pompe disease, infantile-onsetEnrichmentPIK3CA1.97
122Glomerulopathy with fibronectin deposits 2EnrichmentFN11.97
123Brain small vessel disease 2EnrichmentCOL4A21.97
124Chromosome 8p11 myeloproliferative syndromeEnrichmentFGFR11.97
125Microangiopathy and leukoencephalopathy, pontine, autosomal dominantEnrichmentCOL4A11.97
126Pilarowski-bjornsson syndromeEnrichmentCOL4A31.97
127Alport syndrome 3b, autosomal recessiveEnrichmentCOL4A31.97
128Poretti-boltshauser syndromeEnrichmentLAMA11.97
129Angiopathy, hereditary, with nephropathy, aneurysms, and muscle crampsEnrichmentCOL4A11.97
130Frontometaphyseal dysplasiaEnrichmentMAP3K71.97
131Hematuria, benign familial, 2EnrichmentCOL4A31.97
132KeratoacanthomaEnrichmentPIK3CA1.97
133Otitis mediaEnrichmentSPINK51.84
134SchizencephalyEnrichmentCOL4A11.84
135Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1EnrichmentPIK3R21.84
136Lymphoproliferative syndrome 2EnrichmentXIAP1.84
137Cerebrovascular diseaseEnrichmentPIK3CA1.84
138Aortic aneurysmEnrichmentTGFBR11.84
139Familial cerebral cavernous malformationsEnrichmentPIK3CA1.84
140Rare x-linked non-syndromic sensorineural deafness type dfnEnrichmentCOL4A61.84
141Capillary malformations, congenitalEnrichmentPIK3CA1.75
142Alzheimer disease 2EnrichmentPLAU1.75
143Amyloidosis, hereditary systemic 2EnrichmentFGA1.75
144HoloprosencephalyEnrichmentFGFR11.75
145HemimegalencephalyEnrichmentPIK3CA1.75
146Primary hypereosinophilic syndromeEnrichmentFGFR11.75
147Familial cerebral saccular aneurysmEnrichmentTGFBR31.75
148Atrial septal defect 1EnrichmentTGFB21.67
149Klippel-trenaunay-weber syndromeEnrichmentPIK3CA1.67
150Cowden syndrome 1EnrichmentPIK3CA1.67
151Hemihyperplasia, isolatedEnrichmentPIK3CA1.67
152Holoprosencephaly 1EnrichmentFGFR11.67
153Hemangioma, capillary infantileEnrichmentKDR1.67
154Anterior segment dysgenesis 5EnrichmentCOL4A11.67
155Inflammatory bowel disease 25, autosomal recessiveEnrichmentTGFB11.67
156KeratoconusEnrichmentCOL4A11.67
157Il10-related early-onset inflammatory bowel diseaseEnrichmentTGFB11.67
158Breast adenocarcinomaEnrichmentPIK3CA1.67
159Lung squamous cell carcinomaEnrichmentPIK3CA1.67
160Classic ehlers-danlos syndromeEnrichmentTGFBR11.67
161Esophageal cancerEnrichmentTGFBR21.60
162Nevus, epidermalEnrichmentPIK3CA1.60
163Thrombophilia due to thrombin defectEnrichmentFGA1.60
164Capillary malformation-arteriovenous malformation 1EnrichmentPIK3CA1.60
165Gallbladder cancerEnrichmentPIK3CA1.60
166Pilomyxoid astrocytomaEnrichmentFGFR11.60
167Overgrowth syndromeEnrichmentPIK3R11.60
168Spastic paraplegia 4, autosomal dominantEnrichmentFGG1.54
169Arteriovenous malformationEnrichmentPIK3CA1.49
170Adult hepatocellular carcinomaEnrichmentPIK3CA1.49
171Hypogonadotropic hypogonadismEnrichmentFGFR11.49
172Cowden syndromeEnrichmentPIK3CA1.49
173Peters-plus syndromeEnrichmentCOL4A11.45
174Myopathy, x-linked, with excessive autophagyEnrichmentPIK3CA1.45
175Pectus excavatumEnrichmentTGFBR11.41
176Bilirubin metabolic disorderEnrichmentF121.41
177Lung non-small cell carcinomaEnrichmentPIK3CA1.41
178Colorectal cancerEnrichmentPIK3CA, PIK3R11.40
179Septooptic dysplasiaEnrichmentFGFR11.37
180MeningiomaEnrichmentPIK3CA1.37
181Lip and oral cavity carcinomaEnrichmentPIK3CA1.37
182Nk-cell enteropathyEnrichmentPIK3CB1.34
183Multiple sclerosisEnrichmentLAMB11.31
184Hypogonadotropic hypogonadism 7 with or without anosmiaEnrichmentFGFR11.31
185Walker-warburg syndromeEnrichmentCOL4A11.31
186Isolated macular dystrophyEnrichmentCOL4A51.31
187Corpus callosum, agenesis ofEnrichmentCOL4A11.28
188MyopiaEnrichmentCOL4A41.28
189Anterior segment dysgenesisEnrichmentCOL4A11.28
190Atypical hemolytic-uremic syndromeEnrichmentCOL4A51.28
191Isolated corpus callosum agenesisEnrichmentCOL4A11.28
192Intellectual disability-hypoplastic corpus callosum-preauricular tag syndromeEnrichmentCOL4A11.28
193GliosarcomaEnrichmentFGFR11.25
194Microform holoprosencephalyEnrichmentFGFR11.25
195Lobar holoprosencephalyEnrichmentFGFR11.25
196Alzheimer disease, familial, 1EnrichmentPLAU1.22
197Giant cell glioblastomaEnrichmentFGFR11.22
198Polycystic kidney diseaseEnrichmentCOL4A41.20
199Semilobar holoprosencephalyEnrichmentFGFR11.20
200Normosmic congenital hypogonadotropic hypogonadismEnrichmentFGFR11.20
201Endometrial cancerEnrichmentPIK3CA1.14
202Hepatocellular carcinomaEnrichmentPIK3CA1.12
203Tooth agenesisEnrichmentFGFR11.12
204Kallmann syndromeEnrichmentFGFR11.10
205Autoinflammatory diseaseEnrichmentXIAP1.08
206Tetralogy of fallotEnrichmentKDR1.05
207Bladder cancerEnrichmentPIK3CA1.00
208Prostate cancerEnrichmentPIK3CA1.00
209Lung cancerEnrichmentPIK3CA0.96
210Connective tissue diseaseEnrichmentTGFBR20.96
211CakutEnrichmentCOL4A10.94
212Genetic steroid-resistant nephrotic syndromeEnrichmentCOL4A30.94
213Gastric cancerEnrichmentPIK3CA0.84
214Hereditary breast carcinomaEnrichmentPIK3CA0.83
215ThrombocytopeniaEnrichmentFGG0.80
216HypertelorismEnrichmentPIK3CA0.76
217Myeloma, multipleEnrichmentPIK3R20.74
218Primary ovarian insufficiencyEnrichmentKDR0.72
219Breast cancerEnrichmentPIK3CA0.62
220Rare genetic deafnessEnrichmentCOL4A50.60
221Ovarian cancerEnrichmentPIK3CA0.51
222Congenital nervous system abnormalityEnrichmentSERPINI10.50
223Nervous system diseaseEnrichmentSERPINI10.50
224MicrocephalyEnrichmentCOL4A10.44
225Hereditary retinal dystrophyEnrichmentLAMA10.18
226Fundus dystrophyEnrichmentLAMA10.18

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