Cell cycle Regulation of G1/S transition (part 1)

Pathway network for the Cell cycle Regulation of G1/S transition (part 1) SuperPath

Sources:

GeneGo (Thomson Reuters)
QIAGEN

Pathways in the Cell cycle Regulation of G1/S transition (part 1) SuperPath

#	Name	Source	Genes
1	Cell cycle Regulation of G1/S transition (part 1)	GeneGo (Thomson Reuters)	ANAPC1 ANAPC10 ANAPC11 ANAPC13 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BRCA1 BTRC CCNA1 CCNA2 CCND1 CCND2 CCND3 CCNE1 CDC16 CDC23 CDC25A CDC26 CDC27 CDK2 CDK4 CDK6 CDKN1A CDKN1B CDKN2A CDKN2B CHEK2 CUL1 FBXW11 FBXW7 FZR1 GSK3B JUNB PLK3 PPP2CA PPP2CB PPP2R2A PPP2R2B PPP2R2C PPP2R3A PPP2R3B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PTPA RBX1 RPS6KB1 SKP1 SKP2 SMAD2 SMAD3 SMAD4 SP1 TGFB1 TGFB2 TGFBR1 TGFBR2 UBA52 UBB UBC ZFYVE9 (see all 65) (see less)
2	Mitotic Roles of Polo Like Kinases	QIAGEN	ANAPC1 ANAPC10 ANAPC11 ANAPC13 ANAPC2 ANAPC4 ANAPC5 ANAPC7 CCNB1 CCNB2 CDC16 CDC20 CDC23 CDC25C CDC27 CDC7 CDK1 CHEK2 CKS1BP7 ESPL1 FZR1 HSP90AA1 KIF11 KIF23 LEFTY2 MYT1 PLK1 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A PPP2R2B PPP2R2C PPP2R3A PPP2R3B PPP2R5A PPP2R5B PPP2R5C PPP2R5E PRC1 PTPA PTTG1 SLK SMC1A SMC1B STAG2 TGFB1 TGFB2 TGFB3 UBB UBC UBD WEE1 (see all 54) (see less)
3	Cell cycle Role of SCF complex in cell cycle regulation	GeneGo (Thomson Reuters)	ANAPC1 ANAPC10 ANAPC11 ANAPC13 ANAPC2 ANAPC4 ANAPC5 ANAPC7 BTRC CCND1 CCNE1 CDC16 CDC23 CDC25A CDC26 CDC27 CDC34 CDK1 CDK2 CDK4 CDKN1A CDKN1B CDT1 CHEK1 CKS1B CUL1 E2F1 FBXO5 FBXW11 FBXW7 FZR1 NEDD8 PLK1 RBL2 RBX1 SKP1 SKP2 SMAD3 UBA1 UBA52 UBB UBC WEE1 (see all 43) (see less)
4	Cell cycle ESR1 regulation of G1/S transition	GeneGo (Thomson Reuters)	ATF2 BTRC CARM1 CCNA1 CCNA2 CCND1 CCNE1 CDC25A CDK2 CDK4 CDK6 CDKN1A CDKN1B CKS1B CUL1 E2F1 E2F4 ESR1 FBXW11 FBXW7 FOS JUN MAPK1 MYC NCOA3 RB1 RBL2 RBX1 SKP1 SKP2 SP1 TFDP1 UBA52 UBB UBC XPO1 (see all 36) (see less)
5	Immune response MIF-JAB1 signaling	GeneGo (Thomson Reuters)	BTRC CCND1 CCND2 CCND3 CCNE1 CDK2 CDK4 CDKN1B COPS5 CUL1 FBXW11 FBXW7 GRB2 JUN MAPK10 MAPK8 MAPK9 MIF NCOA1 NCOR1 NFKB1 NR3C1 PGR RBX1 RELA SKP1 SKP2 UBA52 UBB UBC UCHL1 XPO1 (see all 32) (see less)

Gene overlap in member pathways for Cell cycle Regulation of G1/S transition (part 1) SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	UBB	Ubiquitin B	Protein Coding	5
2	UBC	Ubiquitin C	Protein Coding	5
3	CCND1	Cyclin D1	Protein Coding	4
4	CCNE1	Cyclin E1	Protein Coding	4
5	CDK2	Cyclin Dependent Kinase 2	Protein Coding	4
6	CDK4	Cyclin Dependent Kinase 4	Protein Coding	4
7	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	4
8	SKP1	S-Phase Kinase Associated Protein 1	Protein Coding	4
9	SKP2	S-Phase Kinase Associated Protein 2	Protein Coding	4
10	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	4
11	CUL1	Cullin 1	Protein Coding	4
12	BTRC	Beta-Transducin Repeat Containing E3 Ubiquitin Protein Ligase	Protein Coding	4
13	RBX1	Ring-Box 1	Protein Coding	4
14	FBXW11	F-Box And WD Repeat Domain Containing 11	Protein Coding	4
15	FBXW7	F-Box And WD Repeat Domain Containing 7	Protein Coding	4
16	CDC25A	Cell Division Cycle 25A	Protein Coding	3
17	CDC27	Cell Division Cycle 27	Protein Coding	3
18	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	3
19	CDC23	Cell Division Cycle 23	Protein Coding	3
20	CDC16	Cell Division Cycle 16	Protein Coding	3
21	ANAPC10	Anaphase Promoting Complex Subunit 10	Protein Coding	3
22	ANAPC13	Anaphase Promoting Complex Subunit 13	Protein Coding	3
23	ANAPC2	Anaphase Promoting Complex Subunit 2	Protein Coding	3
24	ANAPC4	Anaphase Promoting Complex Subunit 4	Protein Coding	3
25	FZR1	Fizzy And Cell Division Cycle 20 Related 1	Protein Coding	3
26	ANAPC5	Anaphase Promoting Complex Subunit 5	Protein Coding	3
27	ANAPC7	Anaphase Promoting Complex Subunit 7	Protein Coding	3
28	ANAPC11	Anaphase Promoting Complex Subunit 11	Protein Coding	3
29	ANAPC1	Anaphase Promoting Complex Subunit 1	Protein Coding	3
30	CCNA2	Cyclin A2	Protein Coding	2
31	CCND2	Cyclin D2	Protein Coding	2
32	CCND3	Cyclin D3	Protein Coding	2
33	CDK6	Cyclin Dependent Kinase 6	Protein Coding	2
34	SMAD3	SMAD Family Member 3	Protein Coding	2
35	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	2
36	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	2
37	PPP2R2A	Protein Phosphatase 2 Regulatory Subunit Balpha	Protein Coding	2
38	PPP2R2B	Protein Phosphatase 2 Regulatory Subunit Bbeta	Protein Coding	2
39	PPP2R2C	Protein Phosphatase 2 Regulatory Subunit Bgamma	Protein Coding	2
40	PPP2R3A	Protein Phosphatase 2 Regulatory Subunit B''''Alpha	Protein Coding	2
41	PTPA	Protein Phosphatase 2 Phosphatase Activator	Protein Coding	2
42	PPP2R5A	Protein Phosphatase 2 Regulatory Subunit B''Alpha	Protein Coding	2
43	PPP2R5B	Protein Phosphatase 2 Regulatory Subunit B''Beta	Protein Coding	2
44	PPP2R5C	Protein Phosphatase 2 Regulatory Subunit B''Gamma	Protein Coding	2
45	PPP2R5E	Protein Phosphatase 2 Regulatory Subunit B''Epsilon	Protein Coding	2
46	SP1	Sp1 Transcription Factor	Protein Coding	2
47	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	2
48	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	2
49	CCNA1	Cyclin A1	Protein Coding	2
50	CHEK2	Checkpoint Kinase 2	Protein Coding	2
51	PPP2R3B	Protein Phosphatase 2 Regulatory Subunit B''''Beta~Name Same As:- HGNC:9310	Protein Coding	2
52	CDC26	Cell Division Cycle 26	Protein Coding	2
53	CDK1	Cyclin Dependent Kinase 1	Protein Coding	2
54	PLK1	Polo Like Kinase 1	Protein Coding	2
55	WEE1	WEE1 G2 Checkpoint Kinase	Protein Coding	2
56	CKS1B	CDC28 Protein Kinase Regulatory Subunit 1B	Protein Coding	2
57	E2F1	E2F Transcription Factor 1	Protein Coding	2
58	RBL2	RB Transcriptional Corepressor Like 2	Protein Coding	2
59	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
60	XPO1	Exportin 1	Protein Coding	2
61	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	1
62	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	1
63	CDKN2B	Cyclin Dependent Kinase Inhibitor 2B	Protein Coding	1
64	PLK3	Polo Like Kinase 3	Protein Coding	1
65	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
66	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
67	SMAD2	SMAD Family Member 2	Protein Coding	1
68	SMAD4	SMAD Family Member 4	Protein Coding	1
69	PPP2R5D	Protein Phosphatase 2 Regulatory Subunit B''Delta	Protein Coding	1
70	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
71	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	1
72	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	1
73	ZFYVE9	Zinc Finger FYVE-Type Containing 9	Protein Coding	1
74	CCNB1	Cyclin B1	Protein Coding	1
75	CCNB2	Cyclin B2	Protein Coding	1
76	CDC20	Cell Division Cycle 20	Protein Coding	1
77	CDC25C	Cell Division Cycle 25C	Protein Coding	1
78	CDC7	Cell Division Cycle 7	Protein Coding	1
79	CKS1BP7	CDC28 Protein Kinase Regulatory Subunit 1B Pseudogene 7	Pseudogene	1
80	LEFTY2	Left-Right Determination Factor 2	Protein Coding	1
81	ESPL1	Extra Spindle Pole Bodies Like 1, Separase	Protein Coding	1
82	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
83	KIF11	Kinesin Family Member 11	Protein Coding	1
84	KIF23	Kinesin Family Member 23	Protein Coding	1
85	MYT1	Myelin Transcription Factor 1	Protein Coding	1
86	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	1
87	PPP2R1B	Protein Phosphatase 2 Scaffold Subunit Abeta	Protein Coding	1
88	PRC1	Protein Regulator Of Cytokinesis 1	Protein Coding	1
89	PTTG1	PTTG1 Regulator Of Sister Chromatid Separation, Securin	Protein Coding	1
90	SLK	STE20 Like Kinase	Protein Coding	1
91	SMC1A	Structural Maintenance Of Chromosomes 1A	Protein Coding	1
92	SMC1B	Structural Maintenance Of Chromosomes 1B	Protein Coding	1
93	STAG2	STAG2 Cohesin Complex Component	Protein Coding	1
94	TGFB3	Transforming Growth Factor Beta 3	Protein Coding	1
95	UBD	Ubiquitin Like Modifier D	Protein Coding	1
96	CDC34	Cell Division Cycle 34, Ubiquitin Conjugating Enzyme	Protein Coding	1
97	CHEK1	Checkpoint Kinase 1	Protein Coding	1
98	NEDD8	NEDD8 Ubiquitin Like Modifier	Protein Coding	1
99	UBA1	Ubiquitin Like Modifier Activating Enzyme 1	Protein Coding	1
100	FBXO5	F-Box Protein 5	Protein Coding	1
101	CDT1	Chromatin Licensing And DNA Replication Factor 1	Protein Coding	1
102	ATF2	Activating Transcription Factor 2	Protein Coding	1
103	E2F4	E2F Transcription Factor 4	Protein Coding	1
104	ESR1	Estrogen Receptor 1	Protein Coding	1
105	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
106	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
107	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
108	RB1	RB Transcriptional Corepressor 1	Protein Coding	1
109	TFDP1	Transcription Factor Dp-1	Protein Coding	1
110	NCOA3	Nuclear Receptor Coactivator 3	Protein Coding	1
111	CARM1	Coactivator Associated Arginine Methyltransferase 1	Protein Coding	1
112	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
113	NR3C1	Nuclear Receptor Subfamily 3 Group C Member 1	Protein Coding	1
114	MIF	Macrophage Migration Inhibitory Factor	Protein Coding	1
115	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
116	PGR	Progesterone Receptor	Protein Coding	1
117	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
118	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
119	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
120	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
121	UCHL1	Ubiquitin C-Terminal Hydrolase L1	Protein Coding	1
122	NCOA1	Nuclear Receptor Coactivator 1	Protein Coding	1
123	NCOR1	Nuclear Receptor Corepressor 1	Protein Coding	1
124	COPS5	COP9 Signalosome Subunit 5	Protein Coding	1

Disorders associated with Cell cycle Regulation of G1/S transition (part 1) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Loeys-dietz syndrome	Enrichment	SMAD2, SMAD3, TGFB2, TGFBR1, TGFBR2	9.54
2	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD2, SMAD3, SMAD4, TGFB2, TGFBR1, TGFBR2	7.23
3	Loeys-dietz syndrome 1	Enrichment	SMAD2, TGFBR1, TGFBR2	6.98
4	Gastric cancer	Enrichment	BRCA1, CDK4, CDKN2A, CHEK2, SMAD4	5.74
5	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A, CDKN1B, CDKN2B	5.44
6	Pancreatic cancer	Enrichment	BRCA1, CDKN2A, CHEK2, SMAD4	5.25
7	Marfan syndrome	Enrichment	TGFB2, TGFBR1, TGFBR2	4.91
8	Loeys-dietz syndrome 4	Enrichment	TGFB2, TGFB3	4.81
9	Loeys-dietz syndrome 2	Enrichment	TGFBR1, TGFBR2	4.65
10	Inherited cancer-predisposing syndrome	Enrichment	BRCA1, CDK4, CDKN1B, CDKN2A, CHEK2, SMAD4	4.41
11	Colorectal cancer	Enrichment	BRCA1, CCND1, CHEK2, FBXW7, SMAD4	4.23
12	Melanoma, cutaneous malignant 1	Enrichment	CDK4, CDKN2A, CDKN2B	4.17
13	Ehlers-danlos syndrome	Enrichment	SMAD3, TGFB2, TGFBR2	4.02
14	Aortic aneurysm	Enrichment	SMAD3, TGFBR1	3.87
15	Li-fraumeni syndrome	Enrichment	CDKN2A, CHEK2	3.48
16	Bladder cancer	Enrichment	BRCA1, CDKN1A, CDKN2A	3.45
17	Melanoma	Enrichment	CDKN2A, CHEK2	3.00
18	Breast cancer	Enrichment	CKS1B, ESR1, JUN	2.99
19	Uterine corpus cancer	Enrichment	BRCA1, CHEK2	2.92
20	Ovarian cancer	Enrichment	BRCA1, CDKN1B, CDKN2A, CHEK2	2.86
21	Breast-ovarian cancer, familial 1	Enrichment	BRCA1, CHEK2	2.77
22	Lynch syndrome	Enrichment	CHEK2, TGFBR2	2.64
23	Semilobar holoprosencephaly	Enrichment	SMC1A, STAG2	2.64
24	Melanoma, cutaneous malignant 3	Enrichment	CDK4	2.63
25	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3	Enrichment	CCND2	2.63
26	Glucocorticoid resistance, generalized	Enrichment	NR3C1	2.63
27	Neurodevelopmental, jaw, eye, and digital syndrome	Enrichment	FBXW11	2.63
28	Progesterone resistance	Enrichment	PGR	2.63
29	Neuroendocrine tumor	Enrichment	CDKN1B	2.63
30	Parkinson disease 5, autosomal dominant	Enrichment	UCHL1	2.63
31	Developmental delay, hypotonia, and impaired language	Enrichment	FBXW7	2.63
32	Microcephaly 12, primary, autosomal recessive	Enrichment	CDK6	2.58
33	Noonan syndrome 13	Enrichment	MAPK1	2.58
34	Brunet-wagner neurodevelopmental syndrome	Enrichment	RBL2	2.58
35	Trilateral retinoblastoma	Enrichment	RB1	2.58
36	Lung oat cell carcinoma	Enrichment	RB1	2.58
37	Meier-gorlin syndrome 4	Enrichment	CDT1	2.50
38	Ferguson-bonni neurodevelopmental syndrome	Enrichment	ANAPC7	2.50
39	Developmental and epileptic encephalopathy 109	Enrichment	FZR1	2.50
40	Rothmund-thomson syndrome, type 1	Enrichment	ANAPC1	2.50
41	Oocyte/zygote/embryo maturation arrest 21	Enrichment	CHEK1	2.50
42	Microcephaly with or without chorioretinopathy, lymphedema, or impaired intellectual development	Enrichment	KIF11	2.40
43	Developmental and epileptic encephalopathy 85 with or without midline brain defects	Enrichment	SMC1A	2.40
44	Holoprosencephaly 13, x-linked	Enrichment	STAG2	2.40
45	Spinocerebellar ataxia 12	Enrichment	PPP2R2B	2.40
46	Parkinson disease 25, autosomal recessive early-onset, with impaired intellectual development	Enrichment	PTPA	2.40
47	Oocyte/zygote/embryo maturation arrest 14	Enrichment	CDC20	2.40
48	Mullegama-klein-martinez syndrome	Enrichment	STAG2	2.40
49	Houge-janssens syndrome 4	Enrichment	PPP2R5C	2.40
50	Houge-janssens syndrome 2	Enrichment	PPP2R1A	2.40
51	Tumor predisposition syndrome 4	Enrichment	CHEK2	2.40
52	Camurati-engelmann disease 2	Enrichment	TGFB2	2.40
53	Loeys-dietz syndrome 5	Enrichment	TGFB3	2.40
54	Xq25 microduplication syndrome	Enrichment	STAG2	2.40
55	Leiomyosarcoma	Enrichment	CHEK2	2.40
56	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	2.40
57	Endometrial cancer	Enrichment	BRCA1, CHEK2	2.35
58	Galactosemia ii	Enrichment	NR3C1	2.33
59	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.33
60	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	2.33
61	Spastic paraplegia 79b, autosomal recessive	Enrichment	UCHL1	2.33
62	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.33
63	Rela fusion-positive ependymoma	Enrichment	RELA	2.33
64	Hereditary spastic paraplegia 79a	Enrichment	UCHL1	2.33
65	Spastic paraplegia 79a, autosomal dominant, with ataxia	Enrichment	UCHL1	2.33
66	Primary mediastinal large b-cell lymphoma	Enrichment	XPO1	2.33
67	Common variable immunodeficiency 12	Enrichment	NFKB1	2.33
68	Submucosal cleft palate	Enrichment	UBB	2.33
69	Cleft hard palate	Enrichment	UBB	2.33
70	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	2.32
71	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	2.32
72	Infant-type hemispheric glioma	Enrichment	BRCA1	2.32
73	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	2.32
74	Loeys-dietz syndrome 6	Enrichment	SMAD2	2.32
75	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	2.32
76	Cdkn2a cancer predisposition	Enrichment	CDKN2A	2.32
77	Heritable thoracic aortic disease	Enrichment	SMAD4	2.32
78	Primary peritoneal carcinoma	Enrichment	BRCA1	2.32
79	Burkitt lymphoma	Enrichment	MYC	2.28
80	Chromosome 13q14 deletion syndrome	Enrichment	RB1	2.28
81	Familial retinoblastoma	Enrichment	RB1	2.28
82	Vexas syndrome	Enrichment	UBA1	2.20
83	Loeys-dietz syndrome 3	Enrichment	SMAD3	2.20
84	Spinal muscular atrophy, x-linked 2	Enrichment	UBA1	2.20
85	Uvula, bifid	Enrichment	UBB	2.15
86	Cleft soft palate	Enrichment	UBB	2.15
87	Dedifferentiated liposarcoma	Enrichment	CDK4	2.15
88	Well-differentiated liposarcoma	Enrichment	CDK4	2.15
89	Lung cancer	Enrichment	CHEK2, PPP2R1B	2.15
90	Retinoblastoma	Enrichment	RB1	2.10
91	Osteogenic sarcoma	Enrichment	RB1	2.10
92	Estrogen resistance	Enrichment	ESR1	2.10
93	Woolly hair, autosomal recessive 3	Enrichment	RB1	2.10
94	Hypotrichosis 8	Enrichment	RB1	2.10
95	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	2.10
96	Squamous cell carcinoma	Enrichment	RB1	2.10
97	Migraine without aura	Enrichment	ESR1	2.10
98	Bone osteosarcoma	Enrichment	RB1	2.10
99	Anemia, congenital dyserythropoietic, type iiia	Enrichment	KIF23	2.10
100	Camurati-engelmann disease 1	Enrichment	TGFB1	2.10
101	Microcephaly and chorioretinopathy, autosomal recessive, 1	Enrichment	KIF11	2.10
102	Cornelia de lange syndrome 2	Enrichment	SMC1A	2.10
103	Congenital heart defects, multiple types, 3	Enrichment	CHEK2	2.10
104	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	2.10
105	Microcephaly and chorioretinopathy 1	Enrichment	KIF11	2.10
106	Camurati-engelmann disease	Enrichment	TGFB1	2.10
107	Li-fraumeni syndrome 1	Enrichment	CHEK2	2.10
108	Sarcoma	Enrichment	CHEK2	2.10
109	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.10
110	Prostate cancer	Enrichment	BRCA1, CHEK2	2.07
111	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	CCND2	2.03
112	Mantle cell lymphoma	Enrichment	CCND1	2.03
113	Primary hyperparathyroidism	Enrichment	CDKN1B	2.03
114	Systemic-onset juvenile idiopathic arthritis	Enrichment	MIF	2.03
115	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	2.02
116	Myhre syndrome	Enrichment	SMAD4	2.02
117	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	2.02
118	Microvascular complications of diabetes 5	Enrichment	TGFBR2	2.02
119	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	2.02
120	Houge-janssens syndrome 1	Enrichment	PPP2R5D	2.02
121	Fanconi anemia, complementation group s	Enrichment	BRCA1	2.02
122	Pancreatic cancer 4	Enrichment	BRCA1	2.02
123	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	2.02
124	Inflammatory breast carcinoma	Enrichment	BRCA1	2.02
125	Peritoneum cancer	Enrichment	BRCA1	2.02
126	Bilateral breast cancer	Enrichment	BRCA1	2.02
127	Connective tissue disease	Enrichment	SMAD3, TGFBR2	1.99
128	Small cell cancer of the lung	Enrichment	RB1	1.98
129	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.98
130	Lynch syndrome 4	Enrichment	RB1	1.98
131	Congenital generalized lipodystrophy	Enrichment	FOS	1.98
132	Arthrogryposis multiplex congenita 3, myogenic type	Enrichment	ESR1	1.98
133	Von hippel-lindau syndrome	Enrichment	CCND1	1.93
134	Rheumatoid arthritis, systemic juvenile	Enrichment	MIF	1.93
135	Pervasive developmental disorder	Enrichment	FBXW7	1.93
136	Rare pervasive developmental disorder	Enrichment	FBXW7	1.93
137	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	CHEK1	1.90
138	Microcephaly	Enrichment	KIF11, KIF23, SMC1A	1.89
139	Histiocytoid hemangioma	Enrichment	FOS	1.88
140	Juvenile polyposis syndrome	Enrichment	SMAD4	1.84
141	Hemoglobin c disease	Enrichment	CHEK2	1.80
142	Common variable immunodeficiency	Enrichment	NFKB1	1.79
143	Lennox-gastaut syndrome	Enrichment	MAPK10	1.73
144	Isolated split hand-split foot malformation	Enrichment	BTRC	1.73
145	Hereditary breast carcinoma	Enrichment	BRCA1, CHEK2	1.73
146	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA1	1.72
147	Cholangiocarcinoma	Enrichment	BRCA1	1.72
148	Arrhythmogenic right ventricular dysplasia, familial, 1	Enrichment	TGFB3	1.70
149	Arrhythmogenic right ventricular dysplasia 1	Enrichment	TGFB3	1.70
150	Primary hyperaldosteronism	Enrichment	NR3C1	1.68
151	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.63
152	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.63
153	Atrial septal defect 1	Enrichment	TGFB2	1.63
154	Wilms tumor 5	Enrichment	CHEK2	1.63
155	Wiedemann-steiner syndrome	Enrichment	SMC1A	1.63
156	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.63
157	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.63
158	Syndromic rod-cone dystrophy	Enrichment	KIF11	1.63
159	Breast-ovarian cancer, familial 2	Enrichment	BRCA1	1.62
160	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	1.62
161	Early-onset parkinson's disease	Enrichment	UCHL1	1.55
162	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.55
163	Adrenocortical carcinoma	Enrichment	CDKN2A	1.55
164	Lung squamous cell carcinoma	Enrichment	CDKN2A	1.55
165	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	1.55
166	Hereditary breast ovarian cancer syndrome	Enrichment	BRCA1, CHEK2	1.54
167	Migraine with or without aura 1	Enrichment	ESR1	1.54
168	Specific learning disability	Enrichment	MAPK1	1.54
169	Meier-gorlin syndrome 1	Enrichment	CDT1	1.50
170	Lip and oral cavity carcinoma	Enrichment	RB1	1.50
171	Rett syndrome, congenital variant	Enrichment	SMC1A	1.50
172	Esophageal cancer	Enrichment	TGFBR2	1.48
173	Gallbladder cancer	Enrichment	SMAD4	1.48
174	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.48
175	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	CDKN2A	1.48
176	Cornelia de lange syndrome 1	Enrichment	SMC1A	1.45
177	Colonic benign neoplasm	Enrichment	CHEK2	1.45
178	Cornelia de lange syndrome	Enrichment	SMC1A	1.45
179	Lung cancer susceptibility 3	Enrichment	RB1	1.44
180	Lynch syndrome 1	Enrichment	CHEK2	1.41
181	Familial colorectal cancer type x	Enrichment	CHEK2	1.37
182	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	1.36
183	Polycystic liver disease	Enrichment	CDC25A	1.35
184	Autosomal dominant polycystic liver disease	Enrichment	CDC25A	1.35
185	Heart, malformation of	Enrichment	MAPK1	1.33
186	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	TGFB3	1.33
187	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	TGFB3	1.33
188	Nk-cell enteropathy	Enrichment	CHEK2	1.30
189	Pectus excavatum	Enrichment	TGFBR1	1.29
190	Leukemia, acute lymphoblastic	Enrichment	CDKN2A	1.29
191	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	TGFB3	1.26
192	Myocardial infarction	Enrichment	ESR1	1.25
193	Wilms tumor 1	Enrichment	CHEK2	1.24
194	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	1.23
195	Periventricular nodular heterotopia	Enrichment	BRCA1	1.19
196	Alobar holoprosencephaly	Enrichment	STAG2	1.18
197	Cystic fibrosis	Enrichment	MIF	1.14
198	Diffuse large b-cell lymphoma	Enrichment	CHEK2	1.14
199	Rhabdomyosarcoma	Enrichment	BRCA1	1.13
200	Primary autosomal recessive microcephaly	Enrichment	CDK6	1.09
201	Visceral heterotaxy	Enrichment	LEFTY2	1.08
202	Complex neurodevelopmental disorder	Enrichment	FBXW11, PPP2CA	0.92
203	Myeloma, multiple	Enrichment	CCND1	0.91
204	Fanconi anemia, complementation group a	Enrichment	BRCA1	0.81
205	Undetermined early-onset epileptic encephalopathy	Enrichment	FZR1	0.79
206	Thrombocytopenia	Enrichment	SMAD4	0.69
207	Primary ovarian insufficiency	Enrichment	CHEK2	0.68
208	Congenital nervous system abnormality	Enrichment	SMC1A	0.46
209	Nervous system disease	Enrichment	SMC1A	0.46
210	Retinitis pigmentosa	Enrichment	KIF11	0.24
211	Hereditary retinal dystrophy	Enrichment	KIF11	0.16
212	Fundus dystrophy	Enrichment	KIF11	0.16

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Cell cycle Regulation of G1/S transition (part 1)

Pathway Network for Cell cycle Regulation of G1/S transition (part 1)

Pathway network for the Cell cycle Regulation of G1/S transition (part 1) SuperPath

Member Pathways for Cell cycle Regulation of G1/S transition (part 1)

Pathways in the Cell cycle Regulation of G1/S transition (part 1) SuperPath

Gene overlap in member pathways for Cell cycle Regulation of G1/S transition (part 1) SuperPath

Associated Genes for Cell cycle Regulation of G1/S transition (part 1)

Associated Disorders for Cell cycle Regulation of G1/S transition (part 1)

Disorders associated with Cell cycle Regulation of G1/S transition (part 1) SuperPath

STRING Interaction Network for Cell cycle Regulation of G1/S transition (part 1)

Sources for Cell cycle Regulation of G1/S transition (part 1)