Cell cycle Role of 14-3-3 proteins in cell cycle regulation

No Pathway Network information available for Cell cycle Role of 14-3-3 proteins in cell cycle regulation

Pathways in the Cell cycle Role of 14-3-3 proteins in cell cycle regulation SuperPath

#	Name	Source	Genes
1	Cell cycle Role of 14-3-3 proteins in cell cycle regulation	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 ATM ATR CDC25A CDC25B CDC25C CDK1 CHEK1 CHEK2 HUS1 MAP3K7 MAPK11 MAPK12 MAPK13 MAPK14 MAPKAPK2 SFN TP53 WEE1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ (see all 27) (see less)
2	14-3-3 and Cell Cycle Regulation	QIAGEN	CCNB1 CCNB2 CCNB3 CDC25B CDC25C CDK1 CHEK1 MAPK11 MAPK12 MAPK13 MAPK14 WEE1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ (see all 18) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CDK1	Cyclin Dependent Kinase 1	Protein Coding	2
2	CDC25B	Cell Division Cycle 25B	Protein Coding	2
3	CDC25C	Cell Division Cycle 25C	Protein Coding	2
4	CHEK1	Checkpoint Kinase 1	Protein Coding	2
5	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	2
6	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	2
7	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	2
8	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	2
9	WEE1	WEE1 G2 Checkpoint Kinase	Protein Coding	2
10	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	2
11	YWHAE	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon	Protein Coding	2
12	YWHAG	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma	Protein Coding	2
13	YWHAH	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Eta	Protein Coding	2
14	YWHAZ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta	Protein Coding	2
15	YWHAQ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Theta	Protein Coding	2
16	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
17	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
18	ATM	ATM Serine/Threonine Kinase	Protein Coding	1
19	ATR	ATR Checkpoint Kinase	Protein Coding	1
20	CDC25A	Cell Division Cycle 25A	Protein Coding	1
21	SFN	Stratifin	Protein Coding	1
22	HUS1	HUS1 Checkpoint Clamp Component	Protein Coding	1
23	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
24	TP53	Tumor Protein P53	Protein Coding	1
25	MAPKAPK2	MAPK Activated Protein Kinase 2	Protein Coding	1
26	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
27	CHEK2	Checkpoint Kinase 2	Protein Coding	1
28	CCNB1	Cyclin B1	Protein Coding	1
29	CCNB2	Cyclin B2	Protein Coding	1
30	CCNB3	Cyclin B3	Protein Coding	1

Disorders associated with Cell cycle Role of 14-3-3 proteins in cell cycle regulation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hereditary breast carcinoma	Enrichment	AKT1, ATM, CHEK2, TP53	5.80
2	Li-fraumeni syndrome 1	Enrichment	CHEK2, TP53	5.42
3	Sarcoma	Enrichment	CHEK2, TP53	5.42
4	Osteogenic sarcoma	Enrichment	CHEK2, TP53	4.94
5	Adenocarcinoma	Enrichment	ATM, TP53	4.94
6	Bone osteosarcoma	Enrichment	CHEK2, TP53	4.94
7	Breast cancer	Enrichment	AKT1, ATM, CHEK2, TP53	4.86
8	Pancreatic cancer	Enrichment	ATM, CHEK2, TP53	4.80
9	Colorectal cancer	Enrichment	AKT1, ATM, CHEK2, TP53	4.61
10	Prostate cancer	Enrichment	ATM, CHEK2, TP53	4.61
11	Ovarian cancer	Enrichment	AKT1, ATM, CHEK2, TP53	4.35
12	Li-fraumeni syndrome	Enrichment	CHEK2, TP53	4.24
13	Breast adenocarcinoma	Enrichment	AKT1, TP53	4.24
14	Gastric cancer	Enrichment	ATM, CHEK2, TP53	4.08
15	Colonic benign neoplasm	Enrichment	ATM, CHEK2	3.87
16	Lynch syndrome 1	Enrichment	ATM, CHEK2	3.77
17	Leukemia, chronic lymphocytic	Enrichment	ATM, TP53	3.77
18	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, CHEK2, TP53	3.76
19	Uterine corpus cancer	Enrichment	ATM, CHEK2	3.68
20	Familial colorectal cancer type x	Enrichment	ATM, CHEK2	3.68
21	Breast-ovarian cancer, familial 1	Enrichment	ATM, CHEK2	3.53
22	Gliosarcoma	Enrichment	ATM, TP53	3.35
23	Giant cell glioblastoma	Enrichment	ATM, TP53	3.29
24	Diffuse large b-cell lymphoma	Enrichment	CHEK2, TP53	3.19
25	Endometrial cancer	Enrichment	ATM, CHEK2	3.11
26	Developmental and epileptic encephalopathy 56	Enrichment	YWHAG	2.88
27	Oocyte/zygote/embryo maturation arrest 21	Enrichment	CHEK1	2.88
28	Distal 17p13.3 microdeletion syndrome	Enrichment	YWHAE	2.88
29	Bladder cancer	Enrichment	ATM, TP53	2.82
30	Proteus syndrome	Enrichment	AKT1	2.70
31	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.70
32	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.70
33	Seckel syndrome 1	Enrichment	ATR	2.70
34	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.70
35	Bone marrow failure syndrome 5	Enrichment	TP53	2.70
36	Papilloma of choroid plexus	Enrichment	TP53	2.70
37	Basal cell carcinoma 7	Enrichment	TP53	2.70
38	Anaplastic thyroid carcinoma	Enrichment	TP53	2.70
39	Tumor predisposition syndrome 4	Enrichment	CHEK2	2.70
40	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.70
41	Cutaneous telangiectasia and cancer syndrome, familial	Enrichment	ATR	2.70
42	Cowden syndrome 6	Enrichment	AKT1	2.70
43	Endometrial serous adenocarcinoma	Enrichment	ATM	2.70
44	Ductal carcinoma in situ	Enrichment	TP53	2.70
45	Leiomyosarcoma	Enrichment	CHEK2	2.70
46	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.70
47	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.70
48	Capillary hemangioma	Enrichment	AKT3	2.70
49	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.70
50	B-cell non-hodgkin lymphoma	Enrichment	ATM	2.70
51	Choroid plexus cancer	Enrichment	TP53	2.70
52	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.70
53	Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome	Enrichment	ATR	2.70
54	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.70
55	Inherited cancer-predisposing syndrome	Enrichment	ATM, CHEK2, TP53	2.65
56	Miller-dieker lissencephaly syndrome	Enrichment	YWHAE	2.40
57	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	YWHAE	2.40
58	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.40
59	Cervical cancer	Enrichment	TP53	2.40
60	Lymphoma, hodgkin, classic	Enrichment	TP53	2.40
61	Congenital heart defects, multiple types, 3	Enrichment	CHEK2	2.40
62	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	2.40
63	Senior-loken syndrome 7	Enrichment	AKT3	2.40
64	Congenital fibrosarcoma	Enrichment	TP53	2.40
65	High grade glioma	Enrichment	ATM	2.40
66	Cervix carcinoma	Enrichment	TP53	2.40
67	Hodgkin's lymphoma	Enrichment	TP53	2.40
68	Bardet-biedl syndrome 16	Enrichment	AKT3	2.40
69	T-cell prolymphocytic leukemia	Enrichment	ATM	2.40
70	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.40
71	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	YWHAZ	2.28
72	Pregnancy loss, recurrent 1	Enrichment	CCNB3	2.28
73	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	CHEK1	2.28
74	Myeloma, multiple	Enrichment	ATM, TP53	2.26
75	Ataxia-telangiectasia	Enrichment	ATM	2.22
76	Polycythemia vera	Enrichment	ATM	2.22
77	Nasopharyngeal carcinoma	Enrichment	TP53	2.22
78	Koolen-de vries syndrome	Enrichment	ATM	2.22
79	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.22
80	Anaplastic astrocytoma	Enrichment	TP53	2.22
81	Frontometaphyseal dysplasia	Enrichment	MAP3K7	2.22
82	Squamous cell carcinoma	Enrichment	TP53	2.22
83	Endometrial stromal sarcoma	Enrichment	YWHAE	2.18
84	Kidney clear cell sarcoma	Enrichment	YWHAE	2.10
85	Small cell cancer of the lung	Enrichment	TP53	2.10
86	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.10
87	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3	2.10
88	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	2.10
89	Mantle cell lymphoma	Enrichment	ATM	2.10
90	Lung sarcomatoid carcinoma	Enrichment	TP53	2.10
91	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.10
92	Hemoglobin c disease	Enrichment	CHEK2	2.10
93	Oculomotor apraxia	Enrichment	ATM	2.10
94	Rhabdomyosarcoma 2	Enrichment	TP53	2.00
95	Lymphoma	Enrichment	TP53	2.00
96	Glioblastoma	Enrichment	ATM	2.00
97	Acute megakaryocytic leukemia	Enrichment	TP53	2.00
98	Hemimegalencephaly	Enrichment	AKT3	2.00
99	Wilms tumor 5	Enrichment	CHEK2	1.92
100	Adrenocortical carcinoma	Enrichment	TP53	1.92
101	Clear cell renal cell carcinoma	Enrichment	ATM	1.92
102	Esophageal cancer	Enrichment	TP53	1.86
103	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.86
104	Renal cell carcinoma, papillary, 1	Enrichment	ATM	1.86
105	Essential thrombocythemia	Enrichment	TP53	1.86
106	Gallbladder cancer	Enrichment	TP53	1.86
107	Megacolon	Enrichment	AKT3	1.86
108	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.86
109	Specific learning disability	Enrichment	YWHAG	1.84
110	Glioma susceptibility 1	Enrichment	TP53	1.80
111	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.80
112	Adult hepatocellular carcinoma	Enrichment	TP53	1.75
113	Primary hyperaldosteronism	Enrichment	TP53	1.75
114	Cowden syndrome	Enrichment	AKT1	1.75
115	Polymicrogyria	Enrichment	AKT3	1.70
116	Melanoma	Enrichment	CHEK2	1.70
117	Familial colorectal cancer	Enrichment	TP53	1.70
118	Immune deficiency disease	Enrichment	ATM	1.66
119	Myelodysplastic syndrome	Enrichment	TP53	1.66
120	Meningioma	Enrichment	AKT1	1.63
121	Lip and oral cavity carcinoma	Enrichment	TP53	1.63
122	Nk-cell enteropathy	Enrichment	CHEK2	1.59
123	Lung cancer susceptibility 3	Enrichment	TP53	1.56
124	Seckel syndrome	Enrichment	ATR	1.56
125	Renal cell carcinoma, nonpapillary	Enrichment	ATM	1.53
126	Wilms tumor 1	Enrichment	CHEK2	1.53
127	Lynch syndrome	Enrichment	CHEK2	1.53
128	Rhabdomyosarcoma	Enrichment	TP53	1.50
129	Polycystic liver disease	Enrichment	CDC25A	1.48
130	Autosomal dominant polycystic liver disease	Enrichment	CDC25A	1.48
131	Hepatoblastoma	Enrichment	TP53	1.39
132	Hepatocellular carcinoma	Enrichment	TP53	1.37
133	Diamond-blackfan anemia 1	Enrichment	TP53	1.35
134	Lung cancer	Enrichment	CHEK2	1.21
135	Autosomal dominant non-syndromic intellectual disability	Enrichment	YWHAZ	1.19
136	Diamond-blackfan anemia	Enrichment	TP53	1.16
137	Undetermined early-onset epileptic encephalopathy	Enrichment	YWHAG	1.14
138	Leukemia, acute myeloid	Enrichment	TP53	1.12
139	Type 2 diabetes mellitus	Enrichment	AKT2	1.09
140	Primary ovarian insufficiency	Enrichment	CHEK2	0.95
141	Microcephaly	Enrichment	YWHAG	0.82

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Cell cycle Role of 14-3-3 proteins in cell cycle regulation

Pathway Network for Cell cycle Role of 14-3-3 proteins in cell cycle regulation

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Pathways in the Cell cycle Role of 14-3-3 proteins in cell cycle regulation SuperPath

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Disorders associated with Cell cycle Role of 14-3-3 proteins in cell cycle regulation SuperPath

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