Cell surface interactions at the vascular wall

Pathway network for the Cell surface interactions at the vascular wall SuperPath

Sources:

Reactome

Pathways in the Cell surface interactions at the vascular wall SuperPath

#	Name	Source	Genes
1	Cell surface interactions at the vascular wall	Reactome	ANGPT1 ANGPT2 ANGPT4 APOB ATP1B1 ATP1B2 ATP1B3 BSG CAV1 CD177 CD2 CD244 CD44 CD47 CD48 CD58 CD74 CD84 CD99 CD99L2 CEACAM1 CEACAM3 CEACAM5 CEACAM6 CEACAM8 COL1A1 COL1A2 CXADR DOK2 EPCAM ESAM F11R F2 FCAMR FCER1G FN1 FYN GAS6 GLG1 GP6 GPC1 GRB14 GRB2 GRB7 GYPA GYPB GYPC HRAS IGLL1 INPP5D ITGA3 ITGA4 ITGA5 ITGA6 ITGAL ITGAM ITGAV ITGAX ITGB1 ITGB2 ITGB3 JAM2 JAM3 JAML JCHAIN KRAS L1CAM LCK LYN MAG MERTK MIF MMP1 NRAS OLR1 PECAM1 PF4 PF4V1 PICK1 PIK3CA PIK3CB PIK3R1 PIK3R2 PLCG1 PPIA PPIL2 PROC PROCR PROS1 PSG1 PSG11 PSG2 PSG3 PSG4 PSG5 PSG6 PSG7 PSG8 PSG9 PTPN11 PTPN6 SDC1 SDC2 SDC3 SDC4 SELE SELL SELP SELPLG SHC1 SIRPA SIRPG SLC16A1 SLC16A3 SLC16A8 SLC3A2 SLC7A10 SLC7A11 SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SOS1 SPN SRC TEK TGFB1 THBD TNFRSF10D TREM1 TSPAN7 VPREB1 VPREB3 YES1 (see all 135) (see less)
2	Tie2 Signaling	Reactome	ANGPT1 ANGPT2 ANGPT4 DOK2 GRB14 GRB2 GRB7 HRAS KRAS NRAS PIK3CA PIK3CB PIK3R1 PIK3R2 PTPN11 SHC1 SOS1 TEK (see all 18) (see less)
3	PECAM1 interactions	Reactome	FYN INPP5D ITGAV ITGB3 LCK LYN PECAM1 PLCG1 PTPN11 PTPN6 SRC YES1 (see all 12) (see less)

Gene overlap in member pathways for Cell surface interactions at the vascular wall SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	3
2	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
3	ANGPT1	Angiopoietin 1	Protein Coding	2
4	ANGPT2	Angiopoietin 2	Protein Coding	2
5	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	2
6	GRB7	Growth Factor Receptor Bound Protein 7	Protein Coding	2
7	GRB14	Growth Factor Receptor Bound Protein 14	Protein Coding	2
8	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	2
9	INPP5D	Inositol Polyphosphate-5-Phosphatase D	Protein Coding	2
10	ITGAV	Integrin Subunit Alpha V	Protein Coding	2
11	ITGB3	Integrin Subunit Beta 3	Protein Coding	2
12	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	2
13	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
14	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
15	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	2
16	ANGPT4	Angiopoietin 4	Protein Coding	2
17	PECAM1	Platelet And Endothelial Cell Adhesion Molecule 1	Protein Coding	2
18	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	2
19	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	2
20	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	2
21	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	2
22	PLCG1	Phospholipase C Gamma 1	Protein Coding	2
23	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	2
24	SHC1	SHC Adaptor Protein 1	Protein Coding	2
25	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	2
26	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	2
27	TEK	TEK Receptor Tyrosine Kinase	Protein Coding	2
28	YES1	YES Proto-Oncogene 1, Src Family Tyrosine Kinase	Protein Coding	2
29	DOK2	Docking Protein 2	Protein Coding	2
30	MERTK	MER Proto-Oncogene, Tyrosine Kinase	Protein Coding	1
31	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	1
32	PROCR	Protein C Receptor	Protein Coding	1
33	CEACAM3	CEA Cell Adhesion Molecule 3	Protein Coding	1
34	CEACAM8	CEA Cell Adhesion Molecule 8	Protein Coding	1
35	SLC7A9	Solute Carrier Family 7 Member 9	Protein Coding	1
36	JAML	Junction Adhesion Molecule Like	Protein Coding	1
37	COL1A1	Collagen Type I Alpha 1 Chain	Protein Coding	1
38	COL1A2	Collagen Type I Alpha 2 Chain	Protein Coding	1
39	SIRPA	Signal Regulatory Protein Alpha	Protein Coding	1
40	CXADR	CXADR Cell Adhesion Molecule	Protein Coding	1
41	F2	Coagulation Factor II, Thrombin	Protein Coding	1
42	FCER1G	Fc Epsilon Receptor Ig	Protein Coding	1
43	FN1	Fibronectin 1	Protein Coding	1
44	SLC7A8	Solute Carrier Family 7 Member 8	Protein Coding	1
45	SLC16A8	Solute Carrier Family 16 Member 8	Protein Coding	1
46	SLC7A11	Solute Carrier Family 7 Member 11	Protein Coding	1
47	PPIL2	Peptidylprolyl Isomerase Like 2	Protein Coding	1
48	GAS6	Growth Arrest Specific 6	Protein Coding	1
49	GLG1	Golgi Glycoprotein 1	Protein Coding	1
50	GPC1	Glypican 1	Protein Coding	1
51	VPREB3	V-Set Pre-B Cell Surrogate Light Chain 3	Protein Coding	1
52	GYPA	Glycophorin A (MNS Blood Group)	Protein Coding	1
53	GYPB	Glycophorin B (MNS Blood Group)	Protein Coding	1
54	GYPC	Glycophorin C (Gerbich Blood Group)	Protein Coding	1
55	APOB	Apolipoprotein B	Protein Coding	1
56	JCHAIN	Joining Chain Of Multimeric IgA And IgM	Protein Coding	1
57	IGLL1	Immunoglobulin Lambda Like Polypeptide 1	Protein Coding	1
58	ITGA6	Integrin Subunit Alpha 6	Protein Coding	1
59	ITGA3	Integrin Subunit Alpha 3	Protein Coding	1
60	ITGA4	Integrin Subunit Alpha 4	Protein Coding	1
61	ITGA5	Integrin Subunit Alpha 5	Protein Coding	1
62	ITGAL	Integrin Subunit Alpha L	Protein Coding	1
63	ITGAM	Integrin Subunit Alpha M	Protein Coding	1
64	ITGAX	Integrin Subunit Alpha X	Protein Coding	1
65	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
66	ITGB2	Integrin Subunit Beta 2	Protein Coding	1
67	L1CAM	L1 Cell Adhesion Molecule	Protein Coding	1
68	EPCAM	Epithelial Cell Adhesion Molecule	Protein Coding	1
69	MAG	Myelin Associated Glycoprotein	Protein Coding	1
70	CD99	CD99 Molecule (Xg Blood Group)	Protein Coding	1
71	MIF	Macrophage Migration Inhibitory Factor	Protein Coding	1
72	MMP1	Matrix Metallopeptidase 1	Protein Coding	1
73	PSG8	Pregnancy Specific Beta-1-Glycoprotein 8	Protein Coding	1
74	CEACAM6	CEA Cell Adhesion Molecule 6	Protein Coding	1
75	ATP1B1	ATPase Na+/K+ Transporting Subunit Beta 1	Protein Coding	1
76	ATP1B2	ATPase Na+/K+ Transporting Subunit Beta 2	Protein Coding	1
77	ATP1B3	ATPase Na+/K+ Transporting Subunit Beta 3	Protein Coding	1
78	OLR1	Oxidized Low Density Lipoprotein Receptor 1	Protein Coding	1
79	F11R	F11 Receptor	Protein Coding	1
80	GP6	Glycoprotein VI Platelet	Protein Coding	1
81	CD244	CD244 Molecule	Protein Coding	1
82	PF4	Platelet Factor 4	Protein Coding	1
83	PF4V1	Platelet Factor 4 Variant 1	Protein Coding	1
84	TREM1	Triggering Receptor Expressed On Myeloid Cells 1	Protein Coding	1
85	PPIA	Peptidylprolyl Isomerase A	Protein Coding	1
86	SIRPG	Signal Regulatory Protein Gamma	Protein Coding	1
87	PROC	Protein C, Inactivator Of Coagulation Factors Va And VIIIa	Protein Coding	1
88	PROS1	Protein S	Protein Coding	1
89	SLC7A10	Solute Carrier Family 7 Member 10	Protein Coding	1
90	PSG1	Pregnancy Specific Beta-1-Glycoprotein 1	Protein Coding	1
91	PSG2	Pregnancy Specific Beta-1-Glycoprotein 2	Protein Coding	1
92	PSG3	Pregnancy Specific Beta-1-Glycoprotein 3	Protein Coding	1
93	PSG4	Pregnancy Specific Beta-1-Glycoprotein 4	Protein Coding	1
94	PSG5	Pregnancy Specific Beta-1-Glycoprotein 5	Protein Coding	1
95	PSG6	Pregnancy Specific Beta-1-Glycoprotein 6	Protein Coding	1
96	PSG7	Pregnancy Specific Beta-1-Glycoprotein 7	Protein Coding	1
97	PSG9	Pregnancy Specific Beta-1-Glycoprotein 9	Protein Coding	1
98	PSG11	Pregnancy Specific Beta-1-Glycoprotein 11	Protein Coding	1
99	CD177	CD177 Molecule	Protein Coding	1
100	JAM2	Junctional Adhesion Molecule 2	Protein Coding	1
101	CEACAM1	CEA Cell Adhesion Molecule 1	Protein Coding	1
102	SDC1	Syndecan 1	Protein Coding	1
103	SDC2	Syndecan 2	Protein Coding	1
104	SDC4	Syndecan 4	Protein Coding	1
105	SELE	Selectin E	Protein Coding	1
106	SELL	Selectin L	Protein Coding	1
107	SELP	Selectin P	Protein Coding	1
108	SELPLG	Selectin P Ligand	Protein Coding	1
109	SLC3A2	Solute Carrier Family 3 Member 2	Protein Coding	1
110	SLC16A1	Solute Carrier Family 16 Member 1	Protein Coding	1
111	SPN	Sialophorin	Protein Coding	1
112	BSG	Basigin (Ok Blood Group)	Protein Coding	1
113	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
114	THBD	Thrombomodulin	Protein Coding	1
115	TSPAN7	Tetraspanin 7	Protein Coding	1
116	VPREB1	V-Set Pre-B Cell Surrogate Light Chain 1	Protein Coding	1
117	SLC7A5	Solute Carrier Family 7 Member 5	Protein Coding	1
118	CD99L2	CD99 Molecule Like 2	Protein Coding	1
119	JAM3	Junctional Adhesion Molecule 3	Protein Coding	1
120	FCAMR	Fc Alpha And Mu Receptor	Protein Coding	1
121	CAV1	Caveolin 1	Protein Coding	1
122	TNFRSF10D	TNF Receptor Superfamily Member 10d	Protein Coding	1
123	CD84	CD84 Molecule	Protein Coding	1
124	SLC7A7	Solute Carrier Family 7 Member 7	Protein Coding	1
125	SLC7A6	Solute Carrier Family 7 Member 6	Protein Coding	1
126	ESAM	Endothelial Cell Adhesion Molecule	Protein Coding	1
127	SLC16A3	Solute Carrier Family 16 Member 3	Protein Coding	1
128	CD2	CD2 Molecule	Protein Coding	1
129	PICK1	Protein Interacting With PRKCA 1	Protein Coding	1
130	CD44	CD44 Molecule (IN Blood Group)	Protein Coding	1
131	CD47	CD47 Molecule	Protein Coding	1
132	CD48	CD48 Molecule	Protein Coding	1
133	CD58	CD58 Molecule	Protein Coding	1
134	SDC3	Syndecan 3	Protein Coding	1
135	CD74	CD74 Molecule	Protein Coding	1

Disorders associated with Cell surface interactions at the vascular wall SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, NRAS, PTPN11, SOS1	10.82
2	Noonan syndrome 1	Enrichment	HRAS, KRAS, NRAS, PTPN11, SOS1	10.02
3	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS, PIK3CA	9.99
4	Noonan syndrome 3	Enrichment	HRAS, KRAS, PTPN11, SOS1	9.99
5	Rasopathy	Enrichment	HRAS, KRAS, NRAS, PTPN11, SOS1	9.85
6	Lung non-small cell carcinoma	Enrichment	HRAS, KRAS, NRAS, PIK3CA	9.14
7	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	8.11
8	Non-immune hydrops fetalis	Enrichment	ANGPT2, HRAS, KRAS, PTPN11	7.18
9	Arteriovenous malformation	Enrichment	HRAS, PIK3CA, TEK	6.79
10	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA, TEK	6.63
11	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS, PTPN11	6.37
12	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	5.78
13	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	5.30
14	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	5.30
15	Bladder cancer	Enrichment	HRAS, KRAS, PIK3CA	5.15
16	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	5.15
17	Thrombocytopenia	Enrichment	ITGB3, PTPN11, SRC	5.05
18	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	5.00
19	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	5.00
20	Breast adenocarcinoma	Enrichment	KRAS, PIK3CA	4.60
21	Lung squamous cell carcinoma	Enrichment	KRAS, PIK3CA	4.60
22	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	4.46
23	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, PIK3CA	4.46
24	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	4.46
25	Gallbladder cancer	Enrichment	KRAS, PIK3CA	4.46
26	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	4.46
27	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	4.33
28	Ehlers-danlos syndrome, arthrochalasia type, 2	Enrichment	COL1A1, COL1A2	4.01
29	Ehlers-danlos/osteogenesis imperfecta syndrome	Enrichment	COL1A1, COL1A2	4.01
30	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	3.96
31	Breast cancer	Enrichment	KRAS, PIK3CA, SHC1	3.90
32	Lynch syndrome	Enrichment	KRAS, PIK3CA	3.76
33	Colorectal cancer	Enrichment	NRAS, PIK3CA, PIK3R1	3.71
34	Cystic fibrosis	Enrichment	CEACAM3, CEACAM6, MIF, TGFB1	3.57
35	High bone mass osteogenesis imperfecta	Enrichment	COL1A1, COL1A2	3.53
36	Osteoporosis	Enrichment	COL1A1, COL1A2, SRC	3.49
37	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11	3.28
38	Ehlers-danlos syndrome, arthrochalasia type, 1	Enrichment	COL1A1, COL1A2	3.23
39	Osteogenesis imperfecta with normal sclerae, dominant form	Enrichment	COL1A1, COL1A2	3.23
40	Lung cancer	Enrichment	KRAS, PIK3CA	3.09
41	Metachondromatosis	Enrichment	PTPN11	3.05
42	Leopard syndrome 1	Enrichment	PTPN11	3.05
43	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	3.05
44	Immunodeficiency 22	Enrichment	LCK	3.05
45	Thrombocytopenia 6	Enrichment	SRC	3.05
46	Autoinflammatory disease, systemic, with vasculitis	Enrichment	LYN	3.05
47	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	3.05
48	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	3.05
49	Bullous pyoderma gangrenosum	Enrichment	PTPN6	3.05
50	Pustular pyoderma gangrenosum	Enrichment	PTPN6	3.05
51	Classic pyoderma gangrenosum	Enrichment	PTPN6	3.05
52	Malignant astrocytoma	Enrichment	PTPN11	3.05
53	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	2.90
54	Macrodactyly	Enrichment	PIK3CA	2.88
55	Oculoectodermal syndrome	Enrichment	KRAS	2.88
56	Noonan syndrome 4	Enrichment	SOS1	2.88
57	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.88
58	Cowden syndrome 5	Enrichment	PIK3CA	2.88
59	Melanosis, neurocutaneous	Enrichment	NRAS	2.88
60	Noonan syndrome 6	Enrichment	NRAS	2.88
61	Angioedema, hereditary, 5	Enrichment	ANGPT1	2.88
62	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.88
63	Venous malformations, multiple cutaneous and mucosal	Enrichment	TEK	2.88
64	Short syndrome	Enrichment	PIK3R1	2.88
65	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.88
66	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.88
67	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.88
68	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.88
69	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.88
70	Glaucoma 3, primary congenital, e	Enrichment	TEK	2.88
71	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.88
72	Hypospadias	Enrichment	PIK3CA	2.88
73	Bockenheimer syndrome	Enrichment	TEK	2.88
74	Congenital pulmonary airway malformation	Enrichment	KRAS	2.88
75	Rare venous malformation	Enrichment	PIK3CA	2.88
76	Diaphragmatic eventration	Enrichment	PIK3CA	2.88
77	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.88
78	Rare combined vascular malformation	Enrichment	PIK3CA	2.88
79	Cavernous lymphangioma	Enrichment	PIK3CA	2.88
80	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.88
81	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.88
82	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.88
83	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.88
84	Macrodactyly of toe	Enrichment	PIK3CA	2.88
85	Neurocutaneous melanocytosis	Enrichment	NRAS	2.88
86	Ehlers-danlos syndrome, classic type, 1	Enrichment	COL1A1, COL1A2	2.84
87	Osteogenesis imperfecta, type i	Enrichment	COL1A1, COL1A2	2.84
88	Classic ehlers-danlos syndrome	Enrichment	COL1A1, COL1A2	2.84
89	Gastric cancer	Enrichment	KRAS, PIK3CA	2.84
90	Malaria	Enrichment	GYPA, GYPB, GYPC	2.83
91	Hereditary breast carcinoma	Enrichment	KRAS, PIK3CA	2.82
92	Werner syndrome	Enrichment	PTPN11	2.75
93	Osteogenesis imperfecta, type ii	Enrichment	COL1A1, COL1A2	2.70
94	Myeloma, multiple	Enrichment	KRAS, PIK3R2	2.61
95	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	2.58
96	Bleeding disorder, platelet-type, 16	Enrichment	ITGB3	2.58
97	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	2.58
98	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	2.58
99	Tricuspid valve insufficiency	Enrichment	PTPN11	2.58
100	Blue rubber bleb nevus	Enrichment	TEK	2.58
101	Fibromatosis, gingival, 1	Enrichment	SOS1	2.58
102	Costello syndrome	Enrichment	HRAS	2.58
103	Pulmonic stenosis	Enrichment	SOS1	2.58
104	Keratosis, seborrheic	Enrichment	PIK3CA	2.58
105	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.58
106	Noonan syndrome 8	Enrichment	PIK3CA	2.58
107	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.58
108	Lymphatic malformation 10	Enrichment	ANGPT2	2.58
109	Wooly hair nevus	Enrichment	HRAS	2.58
110	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.45
111	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	2.45
112	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.40
113	Nuchal bleb, familial	Enrichment	SOS1	2.40
114	Langerhans cell histiocytosis	Enrichment	NRAS	2.40
115	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.40
116	Immunodeficiency 14	Enrichment	PIK3R1	2.40
117	Spermatocytoma	Enrichment	HRAS	2.40
118	Keratoacanthoma	Enrichment	PIK3CA	2.40
119	Autosomal non-syndromic agammaglobulinemia	Enrichment	IGLL1, PIK3R1	2.38
120	Primary bone dysplasia	Enrichment	COL1A1, COL1A2	2.38
121	Glanzmann thrombasthenia 2	Enrichment	ITGB3	2.35
122	Lymphoma	Enrichment	PTPN11	2.35
123	Osteochondrodysplasia	Enrichment	COL1A1, COL1A2	2.29
124	Patent ductus arteriosus	Enrichment	PTPN11	2.28
125	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGB3	2.28
126	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	2.28
127	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.28
128	Glaucoma 3, primary infantile, b	Enrichment	TEK	2.28
129	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	2.28
130	Cardiofaciocutaneous syndrome	Enrichment	KRAS	2.28
131	Lung sarcomatoid carcinoma	Enrichment	KRAS	2.28
132	Cerebrovascular disease	Enrichment	PIK3CA	2.28
133	Pilocytic astrocytoma	Enrichment	KRAS	2.28
134	Epidermolytic nevus	Enrichment	HRAS	2.28
135	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.28
136	Gingival fibromatosis	Enrichment	SOS1	2.28
137	Hereditary angioedema with normal c1inh not related to f12 or plg variant	Enrichment	ANGPT1	2.28
138	Myelofibrosis	Enrichment	SRC	2.21
139	Glanzmann thrombasthenia 1	Enrichment	ITGB3	2.21
140	Capillary malformations, congenital	Enrichment	PIK3CA	2.18
141	Microcephaly 1, primary, autosomal recessive	Enrichment	ANGPT2	2.18
142	Hemimegalencephaly	Enrichment	PIK3CA	2.18
143	Osteogenesis imperfecta, type iv	Enrichment	COL1A1, COL1A2	2.15
144	Ovarian cancer	Enrichment	KRAS, PIK3CA	2.11
145	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	2.10
146	Cowden syndrome 1	Enrichment	PIK3CA	2.10
147	Hemihyperplasia, isolated	Enrichment	PIK3CA	2.10
148	Autosomal dominant macrothrombocytopenia	Enrichment	ITGB3	2.05
149	Glaucoma 3, primary congenital, a	Enrichment	TEK	2.03
150	Pilomyxoid astrocytoma	Enrichment	KRAS	2.03
151	Overgrowth syndrome	Enrichment	PIK3R1	2.03
152	Osteogenesis imperfecta, type iii	Enrichment	COL1A1, COL1A2	2.02
153	Pectus excavatum	Enrichment	PTPN11	2.01
154	Specific learning disability	Enrichment	PTPN11	2.01
155	Thrombophilia due to protein c deficiency, autosomal dominant	Enrichment	PROC	2.00
156	Ehlers-danlos syndrome, cardiac valvular type	Enrichment	COL1A2	2.00
157	Hydrocephalus due to congenital stenosis of aqueduct of sylvius	Enrichment	L1CAM	2.00
158	Systemic lupus erythematosus 6	Enrichment	ITGAM	2.00
159	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	2.00
160	Hemolytic uremic syndrome, atypical 6	Enrichment	THBD	2.00
161	Prothrombin deficiency, congenital	Enrichment	F2	2.00
162	Thrombophilia due to protein s deficiency, autosomal dominant	Enrichment	PROS1	2.00
163	Erythrocyte lactate transporter defect	Enrichment	SLC16A1	2.00
164	Thrombophilia due to protein s deficiency, autosomal recessive	Enrichment	PROS1	2.00
165	Bleeding disorder, platelet-type, 11	Enrichment	GP6	2.00
166	Pulmonary hypertension, primary, 3	Enrichment	CAV1	2.00
167	Basal ganglia calcification, idiopathic, 8, autosomal recessive	Enrichment	JAM2	2.00
168	Corpus callosum, partial agenesis of, x-linked	Enrichment	L1CAM	2.00
169	Hydrocephalus, congenital, x-linked	Enrichment	L1CAM	2.00
170	Intellectual developmental disorder, x-linked 58	Enrichment	TSPAN7	2.00
171	Combined osteogenesis imperfecta and ehlers-danlos syndrome 2	Enrichment	COL1A2	2.00
172	Masa syndrome	Enrichment	L1CAM	2.00
173	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	2.00
174	Thrombophilia due to protein c deficiency, autosomal recessive	Enrichment	PROC	2.00
175	Thrombophilia due to thrombomodulin defect	Enrichment	THBD	2.00
176	Blood group, gerbich system	Enrichment	GYPC	2.00
177	Lynch syndrome 8	Enrichment	EPCAM	2.00
178	Hemorrhagic destruction of the brain, subependymal calcification, and cataracts	Enrichment	JAM3	2.00
179	Pregnancy loss, recurrent 2	Enrichment	F2	2.00
180	Agammaglobulinemia 2, autosomal recessive	Enrichment	IGLL1	2.00
181	Protein s deficiency	Enrichment	PROS1	2.00
182	Spastic paraplegia 75, autosomal recessive	Enrichment	MAG	2.00
183	Asphyxia neonatorum	Enrichment	COL1A1	2.00
184	Prothrombin deficiency	Enrichment	F2	2.00
185	Severe hereditary thrombophilia due to congenital protein c deficiency	Enrichment	PROC	2.00
186	Protein c deficiency	Enrichment	PROC	2.00
187	X-linked complicated spastic paraplegia type 1	Enrichment	L1CAM	2.00
188	Hereditary thrombophilia due to congenital protein s deficiency	Enrichment	PROS1	2.00
189	Porencephaly-microcephaly-bilateral congenital cataract syndrome	Enrichment	JAM3	2.00
190	Epicanthus	Enrichment	PTPN11	1.98
191	Congenital long qt syndrome	Enrichment	PTPN11	1.98
192	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.93
193	Ventricular septal defect	Enrichment	TEK	1.93
194	Cowden syndrome	Enrichment	PIK3CA	1.93
195	Ehlers-danlos syndrome	Enrichment	COL1A1, COL1A2	1.82
196	Meningioma	Enrichment	PIK3CA	1.80
197	Patent foramen ovale	Enrichment	PTPN11	1.80
198	Aortic valve disease 1	Enrichment	SOS1	1.77
199	Protein-deficiency anemia	Enrichment	NRAS	1.77
200	Nk-cell enteropathy	Enrichment	PIK3CB	1.77
201	Lung cancer susceptibility 3	Enrichment	KRAS	1.73
202	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.73
203	Myocardial infarction	Enrichment	ITGB3	1.71
204	Epiphyseal dysplasia, multiple, 1	Enrichment	COL1A1	1.70
205	Leukocyte adhesion deficiency, type i	Enrichment	ITGB2	1.70
206	Camurati-engelmann disease 1	Enrichment	TGFB1	1.70
207	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	FN1	1.70
208	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	FN1	1.70
209	Bruck syndrome 1	Enrichment	COL1A2	1.70
210	Dermatofibrosarcoma protuberans	Enrichment	COL1A1	1.70
211	Leukocyte adhesion deficiency, type iii	Enrichment	ITGB2	1.70
212	Monocarboxylate transporter 1 deficiency	Enrichment	SLC16A1	1.70
213	Diarrhea 5, with tufting enteropathy, congenital	Enrichment	EPCAM	1.70
214	Hypobetalipoproteinemia, familial, 1	Enrichment	APOB	1.70
215	Combined osteogenesis imperfecta and ehlers-danlos syndrome 1	Enrichment	COL1A1	1.70
216	Neurodevelopmental disorder with intracranial hemorrhage, seizures, and spasticity	Enrichment	ESAM	1.70
217	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	1.70
218	Epidermolysis bullosa, junctional 7, with interstitial lung disease and nephrotic syndrome	Enrichment	ITGA3	1.70
219	Recessive dystrophic epidermolysis bullosa	Enrichment	MMP1	1.70
220	Camurati-engelmann disease	Enrichment	TGFB1	1.70
221	Stickler syndrome, type ii	Enrichment	COL1A1	1.70
222	Hyperinsulinemic hypoglycemia, familial, 7	Enrichment	SLC16A1	1.70
223	Hypobetalipoproteinemia	Enrichment	APOB	1.70
224	Retinitis pigmentosa 38	Enrichment	MERTK	1.70
225	Ketoacidosis due to monocarboxylate transporter-1 deficiency	Enrichment	SLC16A1	1.70
226	Dentinogenesis imperfecta	Enrichment	COL1A2	1.70
227	Rhabdomyosarcoma	Enrichment	HRAS	1.68
228	Scoliosis	Enrichment	PTPN11	1.68
229	Brittle bone disorder	Enrichment	COL1A1, COL1A2	1.66
230	Strabismus	Enrichment	PTPN11	1.63
231	Arteriovenous malformations of the brain	Enrichment	KRAS	1.60
232	Severe covid-19	Enrichment	ITGAV	1.60
233	Long qt syndrome 1	Enrichment	PTPN11	1.58
234	Endometrial cancer	Enrichment	PIK3CA	1.56
235	Hepatocellular carcinoma	Enrichment	PIK3CA	1.54
236	Severe combined immunodeficiency	Enrichment	LCK	1.54
237	Hypercholesterolemia, familial, 2	Enrichment	APOB	1.53
238	Lysinuric protein intolerance	Enrichment	SLC7A7	1.53
239	Glomerulopathy with fibronectin deposits 2	Enrichment	FN1	1.53
240	Caffey disease	Enrichment	COL1A1	1.53
241	Epidermolysis bullosa, junctional 6, with pyloric atresia	Enrichment	ITGA6	1.53
242	Cerebral sinovenous thrombosis	Enrichment	F2	1.53
243	Pancreatic cancer	Enrichment	KRAS	1.49
244	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.43
245	Prostate cancer	Enrichment	PIK3CA	1.42
246	Cystinuria	Enrichment	SLC7A9	1.41
247	Phenylketonuria	Enrichment	COL1A1	1.41
248	Retinitis pigmentosa 26	Enrichment	ITGA4	1.41
249	Hereditary elliptocytosis	Enrichment	GYPC	1.41
250	Systemic-onset juvenile idiopathic arthritis	Enrichment	MIF	1.41
251	Primary autosomal recessive microcephaly	Enrichment	ANGPT2	1.38
252	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	1.31
253	Hyperlipidemia, familial combined, 3	Enrichment	APOB	1.31
254	Rheumatoid arthritis, systemic juvenile	Enrichment	MIF	1.31
255	Muscular dystrophy, limb-girdle, autosomal recessive 23	Enrichment	L1CAM	1.31
256	Epidermolysis bullosa	Enrichment	ITGA6	1.31
257	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1	1.31
258	Cerebral palsy	Enrichment	F2, PROC	1.24
259	Epidermolysis bullosa, junctional 5b, with pyloric atresia	Enrichment	ITGA6	1.23
260	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.23
261	Keratoconus	Enrichment	COL1A1	1.23
262	Limited scleroderma	Enrichment	CAV1	1.23
263	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.23
264	Atypical hemolytic uremic syndrome with complement gene abnormality	Enrichment	THBD	1.23
265	Hypertelorism	Enrichment	PIK3CA	1.17
266	Thrombophilia due to thrombin defect	Enrichment	F2	1.17
267	Nephrotic syndrome	Enrichment	FN1, ITGA3	1.17
268	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	1.15
269	Basal ganglia calcification, idiopathic, 1	Enrichment	JAM2	1.11
270	Homozygous familial hypercholesterolemia	Enrichment	APOB	1.11
271	Male infertility due to globozoospermia	Enrichment	PICK1	1.11
272	Rheumatoid arthritis	Enrichment	CD244	1.06
273	Coronary heart disease 5	Enrichment	APOB	1.06
274	Junctional epidermolysis bullosa	Enrichment	ITGA6	1.06
275	Colonic benign neoplasm	Enrichment	EPCAM	1.06
276	Hydrops fetalis	Enrichment	L1CAM	1.06
277	Autism spectrum disorder	Enrichment	PTPN11	1.03
278	Lynch syndrome 1	Enrichment	EPCAM	1.02
279	Stroke, ischemic	Enrichment	F2	1.02
280	Microcephaly	Enrichment	PTPN11	0.98
281	Heritable pulmonary arterial hypertension	Enrichment	CAV1	0.98
282	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.96
283	Hypercholesterolemia, familial, 1	Enrichment	APOB	0.91
284	Neural tube defects	Enrichment	ITGB1	0.91
285	Cataract	Enrichment	SLC7A8	0.88
286	Isolated macular dystrophy	Enrichment	ITGA4	0.88
287	Familial hypercholesterolemia	Enrichment	APOB	0.86
288	Hypertension, essential	Enrichment	ATP1B1	0.81
289	Multisystem inflammatory syndrome in children	Enrichment	CD84	0.70
290	Autoinflammatory disease	Enrichment	SLC7A7	0.67
291	Non-syndromic x-linked intellectual disability	Enrichment	TSPAN7	0.52
292	Systemic lupus erythematosus	Enrichment	ITGAM	0.49
293	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	COL1A1	0.45
294	Body mass index quantitative trait locus 11	Enrichment	SDC3	0.40
295	Cone-rod dystrophy 2	Enrichment	ITGA4	0.31
296	Hereditary retinal dystrophy	Enrichment	ITGA4, MERTK	0.10
297	Fundus dystrophy	Enrichment	ITGA4, MERTK	0.10
298	Retinitis pigmentosa	Enrichment	MERTK	0.05

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Cell surface interactions at the vascular wall

Pathway Network for Cell surface interactions at the vascular wall

Pathway network for the Cell surface interactions at the vascular wall SuperPath

Member Pathways for Cell surface interactions at the vascular wall

Pathways in the Cell surface interactions at the vascular wall SuperPath

Gene overlap in member pathways for Cell surface interactions at the vascular wall SuperPath

Associated Genes for Cell surface interactions at the vascular wall

Associated Disorders for Cell surface interactions at the vascular wall

Disorders associated with Cell surface interactions at the vascular wall SuperPath

STRING Interaction Network for Cell surface interactions at the vascular wall

Sources for Cell surface interactions at the vascular wall