Cellular response to heat stress

Pathway network for the Cellular response to heat stress SuperPath

Sources:
  • Reactome

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

Disorders associated with Cellular response to heat stress SuperPath

according to GeneCards Suite gene sharing
#DisorderTypeGenesScore
1Genetic steroid-resistant nephrotic syndromeEnrichmentNUP107, NUP133, NUP160, NUP205, NUP37, NUP85, NUP939.55
2Rare genetic intellectual disabilityEnrichmentCREBBP, EP300, MTOR3.95
3Familial infantile bilateral striatal necrosisEnrichmentNUP54, NUP623.83
4Rubinstein-taybi syndrome 1EnrichmentCREBBP, EP3003.21
5Chromosome 16p13.3 deletion syndrome, proximalEnrichmentCREBBP, EP3003.21
6Renal cell carcinoma, papillary, 1EnrichmentATM, MTOR3.07
7Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmiaEnrichmentHDAC63.05
8Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 1EnrichmentVCP3.05
9Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 6EnrichmentRPA13.05
10Frontotemporal dementia and/or amyotrophic lateral sclerosis 6EnrichmentVCP3.05
11Multisystem proteinopathyEnrichmentVCP3.05
12Adult-onset distal myopathy due to vcp mutationEnrichmentVCP3.05
13Distal 17p13.3 microdeletion syndromeEnrichmentYWHAE3.05
14Galloway-mowat syndromeEnrichmentNUP107, NUP1332.96
15Amyotrophic lateral sclerosis 6 with or without frontotemporal dementiaEnrichmentVCP2.75
16Spastic paraplegia-paget disease of bone syndromeEnrichmentVCP2.75
17Seckel syndromeEnrichmentATR, NUP852.66
18Miller-dieker lissencephaly syndromeEnrichmentYWHAE2.58
19Chromosome 17p13.3, centromeric, duplication syndromeEnrichmentYWHAE2.58
20Inclusion body myopathy with paget disease of bone and frontotemporal dementiaEnrichmentVCP2.58
21Renal cell carcinoma, nonpapillaryEnrichmentATM, MTOR2.38
22Dementia, lewy bodyEnrichmentVCP2.35
23Charcot-marie-tooth disease, axonal, type 2eEnrichmentVCP2.35
24Endometrial stromal sarcomaEnrichmentYWHAE2.35
25Familial isolated dilated cardiomyopathyEnrichmentBAG3, BAG5, CRYAB2.31
26Muscular dystrophy, limb-girdle, autosomal dominant 1EnrichmentDNAJB62.30
27Seckel syndrome 1EnrichmentATR2.30
28Even-plus syndromeEnrichmentHSPA92.30
29Leukodystrophy, hypomyelinating, 13EnrichmentHIKESHI2.30
30Cardiomyopathy, dilated, 1hhEnrichmentBAG32.30
31Anemia, sideroblastic, 4EnrichmentHSPA92.30
32Fetal akinesia deformation sequence 4EnrichmentNUP882.30
33Neurodevelopmental disorder with achalasia, polyneuropathy, and alacrimaEnrichmentNDC12.30
34Atrial fibrillation, familial, 15EnrichmentNUP1552.30
35Noonan syndrome 13EnrichmentMAPK12.30
36Dystonia 37, early-onset, with striatal lesionsEnrichmentNUP542.30
37Cardiomyopathy, dilated, 2fEnrichmentBAG52.30
38Nephrotic syndrome, type 19EnrichmentNUP1602.30
39Galloway-mowat syndrome 8EnrichmentNUP1332.30
40Nephrotic syndrome, type 13EnrichmentNUP2052.30
41Myopathy, myofibrillar, 6EnrichmentBAG32.30
42Microcephaly 24, primary, autosomal recessiveEnrichmentNUP372.30
43Galloway-mowat syndrome 7EnrichmentNUP1072.30
44Cutaneous telangiectasia and cancer syndrome, familialEnrichmentATR2.30
45Nephrotic syndrome, type 12EnrichmentNUP932.30
46Endometrial serous adenocarcinomaEnrichmentATM2.30
47Nephrotic syndrome, type 11EnrichmentNUP1072.30
48Encephalopathy, acute, infection-induced 9EnrichmentNUP2142.30
49Sandestig-stefanova syndromeEnrichmentNUP1882.30
50Ovarian dysgenesis 6EnrichmentNUP1072.30
51Intellectual developmental disorder, autosomal recessive 79EnrichmentTPR2.30
52Nephrotic syndrome, type 18EnrichmentNUP1332.30
53Charcot-marie-tooth disease, axonal, type 2jjEnrichmentBAG32.30
54B-cell non-hodgkin lymphomaEnrichmentATM2.30
55Neuronopathy, distal hereditary motor, autosomal dominant 15EnrichmentBAG32.30
56C11orf73-related autosomal recessive hypomyelinating leukodystrophyEnrichmentHIKESHI2.30
57Familial acute necrotizing encephalopathyEnrichmentRANBP22.30
58Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndromeEnrichmentATR2.30
59Kidney clear cell sarcomaEnrichmentYWHAE2.28
60Cardiomyopathy, dilated, 1iiEnrichmentCRYAB2.19
61Intellectual developmental disorder, autosomal recessive 63EnrichmentCAMK2A2.19
62Intellectual developmental disorder, autosomal dominant 54EnrichmentCAMK2B2.19
63Myopathy, myofibrillar, 2b, infantile-onsetEnrichmentCRYAB2.19
64Charcot-marie-tooth disease, axonal, type 2lEnrichmentHSPB82.19
65Myopathy, myofibrillar, 2a, adult-onsetEnrichmentCRYAB2.19
66Myopathy, myofibrillar, 13, with rimmed vacuolesEnrichmentHSPB82.19
67Menke-hennekam syndrome 1EnrichmentCREBBP2.19
68Intellectual developmental disorder, autosomal dominant 53EnrichmentCAMK2A2.19
69Intellectual developmental disorder, autosomal dominant 59EnrichmentCAMK2G2.19
70Rubinstein-taybi syndrome due to 16p13.3 microdeletionEnrichmentCREBBP2.19
71Menke-hennekam syndromeEnrichmentCREBBP2.19
72Autosomal dominant distal axonal motor neuropathy-myofibrillar myopathy syndromeEnrichmentHSPB82.19
73Progressive non-fluent aphasiaEnrichmentVCP2.10
74Behavioral variant of frontotemporal dementiaEnrichmentVCP2.10
75MicrocephalyEnrichmentCAMK2B, EP300, MAPK1, NUP1882.08
76Frontotemporal dementia and/or amyotrophic lateral sclerosis 1EnrichmentVCP2.05
77Camptodactyly-arthropathy-coxa vara-pericarditis syndromeEnrichmentTPR2.00
78Striatonigral degeneration, infantileEnrichmentNUP622.00
79Cardiac valvular dysplasia, x-linkedEnrichmentATM2.00
80Nephrotic syndrome, type 17EnrichmentNUP852.00
81High grade gliomaEnrichmentATM2.00
82Fibrolamellar carcinomaEnrichmentDNAJB12.00
83T-cell prolymphocytic leukemiaEnrichmentATM2.00
84Autosomal recessive sideroblastic anemiaEnrichmentHSPA92.00
85Acute myeloid leukemia with t(6;9) (p23;q34.1)EnrichmentNUP2142.00
86Acute necrotizing encephalopathy of childhoodEnrichmentRANBP22.00
87Alzheimer's diseaseEnrichmentVCP1.94
88Cardiomyopathy, familial restrictive, 1EnrichmentCRYAB1.89
89Thumb deformityEnrichmentCREBBP1.89
90Cebalid syndromeEnrichmentMTOR1.89
91Menke-hennekam syndrome 2EnrichmentEP3001.89
92Acute myeloid leukemia with kat6a-crebbp fusionEnrichmentCREBBP1.89
93Cataract 16, multiple typesEnrichmentCRYAB1.89
94Smith-kingsmore syndromeEnrichmentMTOR1.89
95Alzheimer disease, familial, 1EnrichmentVCP1.83
96Ataxia-telangiectasiaEnrichmentATM1.82
97Polycythemia veraEnrichmentATM1.82
98Ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessiveEnrichmentRANBP21.82
99Koolen-de vries syndromeEnrichmentATM1.82
100AdenocarcinomaEnrichmentATM1.82
101Neuropathy, hereditary motor and sensory, okinawa typeEnrichmentVCP1.78
102Tethered spinal cord syndromeEnrichmentCREBBP1.71
103Distal myopathyEnrichmentHSPB81.71
104Intraocular pressure quantitative trait locusEnrichmentCREBBP1.71
105Ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessiveEnrichmentRANBP21.70
106Achalasia-addisonianism-alacrima syndromeEnrichmentAAAS1.70
107Chromosome 22q11.2 deletion syndrome, distalEnrichmentMAPK11.70
108Mantle cell lymphomaEnrichmentATM1.70
109Ectodermal dysplasiaEnrichmentRANBP21.70
110Oculomotor apraxiaEnrichmentATM1.70
111Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominantEnrichmentRANBP21.61
112GlioblastomaEnrichmentATM1.61
113Autosomal recessive hypohidrotic ectodermal dysplasia syndromeEnrichmentRANBP21.61
114Focal cortical dysplasia, type iiEnrichmentMTOR1.59
115Myopathy, autophagic vacuolar, infantile-onsetEnrichmentHSPB81.59
116Isolated focal cortical dysplasia type iiEnrichmentMTOR1.59
117Inflammatory myofibroblastic tumorEnrichmentRANBP21.53
118Clear cell renal cell carcinomaEnrichmentATM1.53
119Congenital nervous system abnormalityEnrichmentAAAS, CAMK2B, CREBBP1.50
120Nervous system diseaseEnrichmentAAAS, CAMK2B, CREBBP1.50
121Neuronopathy, distal hereditary motor, autosomal dominant 2EnrichmentHSPB81.49
122Rubinstein-taybi syndrome 2EnrichmentEP3001.49
123HemimegalencephalyEnrichmentMTOR1.49
124Mitochondrial dna depletion syndrome 4aEnrichmentRANBP21.46
125HypertrichosisEnrichmentCREBBP1.42
126Mitochondrial dna depletion syndrome 4bEnrichmentRANBP21.40
127MyocarditisEnrichmentBAG31.40
128Autosomal dominant non-syndromic intellectual disabilityEnrichmentCAMK2A, CAMK2B1.38
129Colonic benign neoplasmEnrichmentATM1.35
130Overgrowth syndromeEnrichmentMTOR1.35
131Lynch syndrome 1EnrichmentATM1.31
132Leukemia, chronic lymphocyticEnrichmentATM1.31
133Frontotemporal dementia and/or amyotrophic lateral sclerosis 7EnrichmentVCP1.30
134Early-onset posterior polar cataractEnrichmentCRYAB1.29
135Myeloma, multipleEnrichmentATM, CREBBP1.29
136Immune deficiency diseaseEnrichmentATM1.27
137Uterine corpus cancerEnrichmentATM1.27
138Familial colorectal cancer type xEnrichmentATM1.27
139Specific learning disabilityEnrichmentMAPK11.27
140Charge syndromeEnrichmentEP3001.24
14146 xx gonadal dysgenesisEnrichmentNUP1071.23
142Breast-ovarian cancer, familial 1EnrichmentATM1.20
143Early-onset lamellar cataractEnrichmentCRYAB1.16
144GliosarcomaEnrichmentATM1.11
145AutismEnrichmentCAMK2G, CREBBP1.10
146Giant cell glioblastomaEnrichmentATM1.09
147Heart, malformation ofEnrichmentMAPK11.06
148Heart diseaseEnrichmentCREBBP1.06
149Parkinson's diseaseEnrichmentDNAJB61.04
150Polydactyly, postaxial, type a1EnrichmentEP3001.03
151Corpus callosum, agenesis ofEnrichmentCREBBP1.03
152Isolated corpus callosum agenesisEnrichmentCREBBP1.03
153Intellectual disability-hypoplastic corpus callosum-preauricular tag syndromeEnrichmentCREBBP1.03
154Focal segmental glomerulosclerosisEnrichmentNUP931.02
155Cardiomyopathy, dilated, 1aEnrichmentBAG31.00
156Endometrial cancerEnrichmentATM1.00
157Tooth agenesisEnrichmentRANBP20.98
158Precursor t-cell acute lymphoblastic leukemiaEnrichmentNUP2140.96
159Colorectal cancerEnrichmentATM, EP3000.96
160Early-onset nuclear cataractEnrichmentCRYAB0.96
161Parkinson disease, late-onsetEnrichmentDNAJB60.94
162Familial atrial fibrillationEnrichmentNUP1550.94
163Diffuse large b-cell lymphomaEnrichmentCREBBP0.93
164Pancreatic cancerEnrichmentATM0.93
165Bladder cancerEnrichmentATM0.87
166Hirschsprung disease 1EnrichmentNUP980.87
167Prostate cancerEnrichmentATM0.87
168Differentiated thyroid carcinomaEnrichmentTPR0.87
169ScoliosisEnrichmentCREBBP0.84
170Primary autosomal recessive microcephalyEnrichmentNUP370.83
171Peripheral nervous system diseaseEnrichmentBAG30.83
172NeuropathyEnrichmentBAG30.83
173Fetal akinesia deformation sequence 1EnrichmentNUP880.77
174Leukemia, acute myeloidEnrichmentNUP2140.74
175Gastric cancerEnrichmentATM0.71
176Nephrotic syndromeEnrichmentNUP930.71
177Hereditary breast carcinomaEnrichmentATM0.70
178DystoniaEnrichmentCAMK2B0.69
179Hereditary breast ovarian cancer syndromeEnrichmentATM0.62
180Autosomal recessive non-syndromic intellectual disabilityEnrichmentTPR0.60
181Breast cancerEnrichmentATM0.50
182Dilated cardiomyopathyEnrichmentBAG30.48
183Ovarian cancerEnrichmentATM0.40
184Inherited cancer-predisposing syndromeEnrichmentATM0.31

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