Cellular Senescence

Pathway network for the Cellular Senescence SuperPath

Sources:

Reactome

Pathways in the Cellular Senescence SuperPath

#	Name	Source	Genes
1	Cellular Senescence	Reactome	ACD AGO1 AGO3 AGO4 ANAPC1 ANAPC10 ANAPC11 ANAPC15 ANAPC16 ANAPC2 ANAPC4 ANAPC5 ANAPC7 ASF1A ATM BMI1 CABIN1 CBX2 CBX4 CBX6 CBX8 CCNA1 CCNA2 CCNE1 CCNE2 CDC16 CDC23 CDC26 CDC27 CDK2 CDK4 CDK6 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C CDKN2D CEBPB COMMD3-BMI1 CXCL8 E2F1 E2F2 E2F3 EED EHMT1 EHMT2 EP400 ERF ETS1 ETS2 EZH2 FOS FZR1 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3-4 H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HIRA HMGA1 HMGA2 ID1 IFNB1 IGFBP7 IL1A IL6 JUN KAT5 KDM6B LMNB1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K5 MAP4K4 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MAPKAPK5 MDM2 MDM4 MINK1 MOV10 MRE11 NBN NFKB1 PHC1 PHC2 PHC3 POT1 RAD50 RB1 RBBP4 RBBP7 RELA RING1 RNF2 RPS27A RPS6KA1 RPS6KA2 RPS6KA3 SCMH1 SP1 STAT3 SUZ12 TERF1 TERF2 TERF2IP TFDP1 TFDP2 TINF2 TNIK TNRC6A TNRC6B TNRC6C TP53 TXN UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 UBE2S UBN1 VENTX (see all 190) (see less)
2	Oxidative Stress Induced Senescence	Reactome	AGO1 AGO3 AGO4 BMI1 CBX2 CBX4 CBX6 CBX8 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CDKN2D COMMD3-BMI1 E2F1 E2F2 E2F3 EED EZH2 FOS H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 IFNB1 JUN KDM6B MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K5 MAP4K4 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 MAPKAPK5 MDM2 MDM4 MINK1 MOV10 PHC1 PHC2 PHC3 RBBP4 RBBP7 RING1 RNF2 RPS27A SCMH1 SUZ12 TFDP1 TFDP2 TNIK TNRC6A TNRC6B TNRC6C TP53 TXN UBA52 UBB UBC (see all 124) (see less)
3	Senescence-Associated Secretory Phenotype (SASP)	Reactome	ANAPC1 ANAPC10 ANAPC11 ANAPC15 ANAPC16 ANAPC2 ANAPC4 ANAPC5 ANAPC7 CCNA1 CCNA2 CDC16 CDC23 CDC26 CDC27 CDK2 CDK4 CDK6 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C CDKN2D CEBPB CXCL8 EHMT1 EHMT2 FOS FZR1 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 IGFBP7 IL1A IL6 JUN MAPK1 MAPK3 MAPK7 NFKB1 RELA RPS27A RPS6KA1 RPS6KA2 RPS6KA3 STAT3 UBA52 UBB UBC UBE2C UBE2D1 UBE2E1 UBE2S VENTX (see all 111) (see less)

Gene overlap in member pathways for Cellular Senescence SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CDK4	Cyclin Dependent Kinase 4	Protein Coding	3
2	CDK6	Cyclin Dependent Kinase 6	Protein Coding	3
3	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	3
4	CDKN2B	Cyclin Dependent Kinase Inhibitor 2B	Protein Coding	3
5	CDKN2C	Cyclin Dependent Kinase Inhibitor 2C	Protein Coding	3
6	CDKN2D	Cyclin Dependent Kinase Inhibitor 2D	Protein Coding	3
7	H4C16	H4 Histone 16	Protein Coding	3
8	H3C14	H3 Clustered Histone 14	Protein Coding	3
9	H2BC26	H2B Clustered Histone 26	Protein Coding	3
10	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	3
11	H2BC1	H2B Clustered Histone 1	Protein Coding	3
12	H2AC8	H2A Clustered Histone 8	Protein Coding	3
13	H2AC7	H2A Clustered Histone 7	Protein Coding	3
14	H2AX	H2A.X Variant Histone	Protein Coding	3
15	H2BC5	H2B Clustered Histone 5	Protein Coding	3
16	H2BC3	H2B Clustered Histone 3	Protein Coding	3
17	H3-3A	H3.3 Histone A	Protein Coding	3
18	H3-3B	H3.3 Histone B	Protein Coding	3
19	H3C15	H3 Clustered Histone 15	Protein Coding	3
20	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	3
21	H2AB1	H2A.B Variant Histone 1	Protein Coding	3
22	H2BC12L	H2B Clustered Histone 12 Like	Protein Coding	3
23	H4C15	H4 Clustered Histone 15	Protein Coding	3
24	H2AJ	H2A.J Histone	Protein Coding	3
25	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	3
26	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	3
27	RPS27A	Ribosomal Protein S27a	Protein Coding	3
28	H3C13	H3 Clustered Histone 13	Protein Coding	3
29	H2AC19	H2A Clustered Histone 19	Protein Coding	3
30	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	3
31	UBB	Ubiquitin B	Protein Coding	3
32	UBC	Ubiquitin C	Protein Coding	3
33	H4C9	H4 Clustered Histone 9	Protein Coding	3
34	H2AC14	H2A Clustered Histone 14	Protein Coding	3
35	H2AC6	H2A Clustered Histone 6	Protein Coding	3
36	H2AC4	H2A Clustered Histone 4	Protein Coding	3
37	H2AC18	H2A Clustered Histone 18	Protein Coding	3
38	H2AC20	H2A Clustered Histone 20	Protein Coding	3
39	H2BC8	H2B Clustered Histone 8	Protein Coding	3
40	H2BC13	H2B Clustered Histone 13	Protein Coding	3
41	H2BC15	H2B Clustered Histone 15	Protein Coding	3
42	H2BC14	H2B Clustered Histone 14	Protein Coding	3
43	H2BC7	H2B Clustered Histone 7	Protein Coding	3
44	H2BC6	H2B Clustered Histone 6	Protein Coding	3
45	H2BC9	H2B Clustered Histone 9	Protein Coding	3
46	H2BC10	H2B Clustered Histone 10	Protein Coding	3
47	H2BC4	H2B Clustered Histone 4	Protein Coding	3
48	H2BC17	H2B Clustered Histone 17	Protein Coding	3
49	H2BC21	H2B Clustered Histone 21	Protein Coding	3
50	H3C1	H3 Clustered Histone 1	Protein Coding	3
51	H3C4	H3 Clustered Histone 4	Protein Coding	3
52	H3C3	H3 Clustered Histone 3	Protein Coding	3
53	H3C6	H3 Clustered Histone 6	Protein Coding	3
54	H3C11	H3 Clustered Histone 11	Protein Coding	3
55	H3C8	H3 Clustered Histone 8	Protein Coding	3
56	H3C12	H3 Clustered Histone 12	Protein Coding	3
57	H3C10	H3 Clustered Histone 10	Protein Coding	3
58	H3C2	H3 Clustered Histone 2	Protein Coding	3
59	H4C1	H4 Clustered Histone 1	Protein Coding	3
60	H4C4	H4 Clustered Histone 4	Protein Coding	3
61	H4C6	H4 Clustered Histone 6	Protein Coding	3
62	H4C12	H4 Clustered Histone 12	Protein Coding	3
63	H4C11	H4 Clustered Histone 11	Protein Coding	3
64	H4C3	H4 Clustered Histone 3	Protein Coding	3
65	H4C8	H4 Clustered Histone 8	Protein Coding	3
66	H4C2	H4 Clustered Histone 2	Protein Coding	3
67	H4C5	H4 Clustered Histone 5	Protein Coding	3
68	H4C13	H4 Clustered Histone 13	Protein Coding	3
69	H4C14	H4 Clustered Histone 14	Protein Coding	3
70	H2BC12	H2B Clustered Histone 12	Protein Coding	3
71	H3C7	H3 Clustered Histone 7	Protein Coding	3
72	H2BC11	H2B Clustered Histone 11	Protein Coding	3
73	H2AZ2	H2A.Z Variant Histone 2	Protein Coding	3
74	COMMD3-BMI1	COMMD3-BMI1 Readthrough	Protein Coding	2
75	CDK2	Cyclin Dependent Kinase 2	Protein Coding	2
76	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	2
77	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	2
78	ANAPC10	Anaphase Promoting Complex Subunit 10	Protein Coding	2
79	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	2
80	EHMT2	Euchromatic Histone Lysine Methyltransferase 2	Protein Coding	2
81	UBE2C	Ubiquitin Conjugating Enzyme E2 C	Protein Coding	2
82	ANAPC16	Anaphase Promoting Complex Subunit 16	Protein Coding	2
83	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	2
84	E2F1	E2F Transcription Factor 1	Protein Coding	2
85	E2F2	E2F Transcription Factor 2	Protein Coding	2
86	E2F3	E2F Transcription Factor 3	Protein Coding	2
87	PHC1	Polyhomeotic Homolog 1	Protein Coding	2
88	PHC2	Polyhomeotic Homolog 2	Protein Coding	2
89	AGO3	Argonaute RISC Catalytic Component 3	Protein Coding	2
90	AGO4	Argonaute RISC Component 4	Protein Coding	2
91	EZH2	Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit	Protein Coding	2
92	SCMH1	Scm Polycomb Group Protein Homolog 1	Protein Coding	2
93	TNIK	TRAF2 And NCK Interacting Kinase	Protein Coding	2
94	TNRC6B	Trinucleotide Repeat Containing Adaptor 6B	Protein Coding	2
95	KDM6B	Lysine Demethylase 6B	Protein Coding	2
96	CBX6	Chromobox 6	Protein Coding	2
97	SUZ12	SUZ12 Polycomb Repressive Complex 2 Subunit	Protein Coding	2
98	CDC26	Cell Division Cycle 26	Protein Coding	2
99	ANAPC15	Anaphase Promoting Complex Subunit 15	Protein Coding	2
100	AGO1	Argonaute RISC Component 1	Protein Coding	2
101	VENTX	VENT Homeobox	Protein Coding	2
102	TNRC6A	Trinucleotide Repeat Containing Adaptor 6A	Protein Coding	2
103	UBE2S	Ubiquitin Conjugating Enzyme E2 S	Protein Coding	2
104	ANAPC2	Anaphase Promoting Complex Subunit 2	Protein Coding	2
105	ANAPC4	Anaphase Promoting Complex Subunit 4	Protein Coding	2
106	IFNB1	Interferon Beta 1	Protein Coding	2
107	IGFBP7	Insulin Like Growth Factor Binding Protein 7	Protein Coding	2
108	IL1A	Interleukin 1 Alpha	Protein Coding	2
109	IL6	Interleukin 6	Protein Coding	2
110	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	2
111	MDM2	MDM2 Proto-Oncogene	Protein Coding	2
112	MDM4	MDM4 Regulator Of P53	Protein Coding	2
113	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	2
114	MOV10	Mov10 RNA Helicase	Protein Coding	2
115	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	2
116	MINK1	Misshapen Like Kinase 1	Protein Coding	2
117	FZR1	Fizzy And Cell Division Cycle 20 Related 1	Protein Coding	2
118	ANAPC5	Anaphase Promoting Complex Subunit 5	Protein Coding	2
119	ANAPC7	Anaphase Promoting Complex Subunit 7	Protein Coding	2
120	ANAPC11	Anaphase Promoting Complex Subunit 11	Protein Coding	2
121	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	2
122	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	2
123	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	2
124	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	2
125	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	2
126	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	2
127	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	2
128	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	2
129	CBX8	Chromobox 8	Protein Coding	2
130	TNRC6C	Trinucleotide Repeat Containing Adaptor 6C	Protein Coding	2
131	RBBP4	RB Binding Protein 4, Chromatin Remodeling Factor	Protein Coding	2
132	RBBP7	RB Binding Protein 7, Chromatin Remodeling Factor	Protein Coding	2
133	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	2
134	RING1	Ring Finger Protein 1	Protein Coding	2
135	RNF2	Ring Finger Protein 2	Protein Coding	2
136	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	2
137	RPS6KA2	Ribosomal Protein S6 Kinase A2	Protein Coding	2
138	RPS6KA3	Ribosomal Protein S6 Kinase A3	Protein Coding	2
139	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	2
140	ANAPC1	Anaphase Promoting Complex Subunit 1	Protein Coding	2
141	BMI1	BMI1 Proto-Oncogene, Polycomb Ring Finger	Protein Coding	2
142	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	2
143	TFDP1	Transcription Factor Dp-1	Protein Coding	2
144	TFDP2	Transcription Factor Dp-2	Protein Coding	2
145	TP53	Tumor Protein P53	Protein Coding	2
146	TXN	Thioredoxin	Protein Coding	2
147	UBE2D1	Ubiquitin Conjugating Enzyme E2 D1	Protein Coding	2
148	UBE2E1	Ubiquitin Conjugating Enzyme E2 E1	Protein Coding	2
149	MAPKAPK3	MAPK Activated Protein Kinase 3	Protein Coding	2
150	EHMT1	Euchromatic Histone Lysine Methyltransferase 1	Protein Coding	2
151	PHC3	Polyhomeotic Homolog 3	Protein Coding	2
152	CBX2	Chromobox 2	Protein Coding	2
153	CBX4	Chromobox 4	Protein Coding	2
154	MAPKAPK5	MAPK Activated Protein Kinase 5	Protein Coding	2
155	CDC23	Cell Division Cycle 23	Protein Coding	2
156	EED	Embryonic Ectoderm Development	Protein Coding	2
157	CDC16	Cell Division Cycle 16	Protein Coding	2
158	CCNA2	Cyclin A2	Protein Coding	2
159	CCNA1	Cyclin A1	Protein Coding	2
160	MAPKAPK2	MAPK Activated Protein Kinase 2	Protein Coding	2
161	MAP4K4	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4	Protein Coding	2
162	CDC27	Cell Division Cycle 27	Protein Coding	2
163	RAD50	RAD50 Double Strand Break Repair Protein	Protein Coding	1
164	KAT5	Lysine Acetyltransferase 5	Protein Coding	1
165	ERF	ETS2 Repressor Factor	Protein Coding	1
166	ETS1	ETS Proto-Oncogene 1, Transcription Factor	Protein Coding	1
167	ETS2	ETS Proto-Oncogene 2, Transcription Factor	Protein Coding	1
168	CABIN1	Calcineurin Binding Protein 1	Protein Coding	1
169	ASF1A	Anti-Silencing Function 1A Histone Chaperone	Protein Coding	1
170	POT1	Protection Of Telomeres 1	Protein Coding	1
171	TINF2	TERF1 Interacting Nuclear Factor 2	Protein Coding	1
172	UBN1	Ubinuclein 1	Protein Coding	1
173	HMGA1	High Mobility Group AT-Hook 1	Protein Coding	1
174	ID1	Inhibitor Of DNA Binding 1	Protein Coding	1
175	LMNB1	Lamin B1	Protein Coding	1
176	MRE11	MRE11 Double Strand Break Repair Nuclease	Protein Coding	1
177	NBN	Nibrin	Protein Coding	1
178	ATM	ATM Serine/Threonine Kinase	Protein Coding	1
179	TERF2IP	TERF2 Interacting Protein	Protein Coding	1
180	EP400	E1A Binding Protein P400	Protein Coding	1
181	RB1	RB Transcriptional Corepressor 1	Protein Coding	1
182	ACD	ACD Shelterin Complex Subunit And Telomerase Recruitment Factor	Protein Coding	1
183	SP1	Sp1 Transcription Factor	Protein Coding	1
184	TERF1	Telomeric Repeat Binding Factor 1	Protein Coding	1
185	TERF2	Telomeric Repeat Binding Factor 2	Protein Coding	1
186	HIRA	Histone Cell Cycle Regulator	Protein Coding	1
187	HMGA2	High Mobility Group AT-Hook 2	Protein Coding	1
188	H3-4	H3.4 Histone, Cluster Member	Protein Coding	1
189	CCNE1	Cyclin E1	Protein Coding	1
190	CCNE2	Cyclin E2	Protein Coding	1

Disorders associated with Cellular Senescence SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Melanoma, cutaneous malignant 1	Enrichment	ACD, CDK4, CDKN2A, CDKN2B, POT1, TERF2IP	7.12
2	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A, CDKN1B, CDKN2B, CDKN2C	6.84
3	Tessadori-bicknell-van haaften neurodevelopmental syndrome 4	Enrichment	H2BC12, H4C1, H4C9	6.27
4	Inherited cancer-predisposing syndrome	Enrichment	ATM, CDK4, CDKN1B, CDKN2A, EZH2, MRE11, NBN, POT1, RAD50, RB1, TP53	5.62
5	Dedifferentiated liposarcoma	Enrichment	CDK4, HMGA2, MDM2	5.57
6	Well-differentiated liposarcoma	Enrichment	CDK4, HMGA2, MDM2	5.57
7	Li-fraumeni syndrome	Enrichment	CDKN2A, MDM2, TP53	4.84
8	Glioma susceptibility 1	Enrichment	H3-3A, H3C1, TP53	4.39
9	Bladder cancer	Enrichment	ATM, CDKN1A, CDKN2A, RB1, TP53	4.34
10	Tessadori-bicknell-van haaften neurodevelopmental syndrome 1	Enrichment	H4C1, H4C3	4.18
11	Tessadori-bicknell-van haaften neurodevelopmental syndrome 2	Enrichment	H4C1, H4C11	4.18
12	Bryant-li-bhoj neurodevelopmental syndrome 2	Enrichment	H3-3A, H3-3B	4.18
13	Breast cancer	Enrichment	ATM, CDKN2B, JUN, MRE11, NBN, RAD50, TP53	4.08
14	Ovarian cancer	Enrichment	ATM, CDKN1B, CDKN2A, MRE11, NBN, RAD50, RB1, TP53	4.07
15	Tessadori-bicknell-van haaften neurodevelopmental syndrome 3	Enrichment	H4C1, H4C5	3.70
16	Weaver syndrome	Enrichment	EZH2, SUZ12	3.61
17	Leukemia, chronic lymphocytic	Enrichment	ATM, POT1, TP53	3.52
18	Gastric cancer	Enrichment	ATM, CDK4, CDKN2A, NBN, TP53	3.50
19	Pancreatic cancer	Enrichment	ATM, CDKN2A, NBN, TP53	3.43
20	Lip and oral cavity carcinoma	Enrichment	CDKN2A, RB1, TP53	3.27
21	Osteogenic sarcoma	Enrichment	RB1, TP53	3.24
22	Squamous cell carcinoma	Enrichment	RB1, TP53	3.24
23	Adenocarcinoma	Enrichment	ATM, TP53	3.24
24	Bone osteosarcoma	Enrichment	RB1, TP53	3.24
25	Complex neurodevelopmental disorder	Enrichment	AGO1, H4C3, H4C5, H4C9, RNF2, TNRC6B	3.02
26	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, MRE11, NBN, RAD50, TP53	3.00
27	Myeloma, multiple	Enrichment	ATM, CDKN2C, ERF, H3C1, TP53	2.96
28	Small cell cancer of the lung	Enrichment	RB1, TP53	2.94
29	Nijmegen breakage syndrome-like disorder	Enrichment	MRE11, RAD50	2.94
30	Adrenocortical carcinoma	Enrichment	CDKN2A, TP53	2.92
31	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	CDKN2A, TP53	2.77
32	Diffuse large b-cell lymphoma	Enrichment	NBN, STAT3, TP53	2.65
33	Hoyeraal-hreidarsson syndrome	Enrichment	ACD, TINF2	2.55
34	Hereditary breast carcinoma	Enrichment	ATM, NBN, RAD50, TP53	2.49
35	Hepatocellular carcinoma	Enrichment	NBN, RAD50, TP53	2.47
36	Specific learning disability	Enrichment	MAPK1, RPS6KA3	2.46
37	Colonic benign neoplasm	Enrichment	ATM, MRE11	2.18
38	Prostate cancer	Enrichment	ATM, NBN, TP53	2.12
39	Coffin-lowry syndrome	Enrichment	RPS6KA3	2.09
40	Melanoma, cutaneous malignant 3	Enrichment	CDK4	2.09
41	Microcephaly 12, primary, autosomal recessive	Enrichment	CDK6	2.09
42	Noonan syndrome 13	Enrichment	MAPK1	2.09
43	Intellectual developmental disorder, x-linked 19	Enrichment	RPS6KA3	2.09
44	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.09
45	Ferguson-bonni neurodevelopmental syndrome	Enrichment	ANAPC7	2.09
46	Developmental and epileptic encephalopathy 109	Enrichment	FZR1	2.09
47	Rothmund-thomson syndrome, type 1	Enrichment	ANAPC1	2.09
48	Neuroendocrine tumor	Enrichment	CDKN1B	2.09
49	Retinal arterial macroaneurysm with supravalvular pulmonic stenosis	Enrichment	IGFBP7	2.09
50	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.09
51	Bryant-li-bhoj neurodevelopmental syndrome 1	Enrichment	H3-3A	2.09
52	Cdkn2a cancer predisposition	Enrichment	CDKN2A	2.09
53	Symptomatic form of coffin-lowry syndrome in female carriers	Enrichment	RPS6KA3	2.09
54	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.09
55	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.09
56	Spermatogenic failure, x-linked, 9	Enrichment	RBBP7	2.04
57	46,xy sex reversal 5	Enrichment	CBX2	2.04
58	Microcephaly 11, primary, autosomal recessive	Enrichment	PHC1	2.04
59	Accelerated tumor formation	Enrichment	MDM2	2.04
60	Global developmental delay with speech and behavioral abnormalities	Enrichment	TNRC6B	2.04
61	Luo-schoch-yamamoto syndrome	Enrichment	RNF2	2.04
62	Lessel-kubisch syndrome	Enrichment	MDM2	2.04
63	Bone marrow failure syndrome 6	Enrichment	MDM4	2.04
64	Bone marrow failure syndrome 5	Enrichment	TP53	2.04
65	Papilloma of choroid plexus	Enrichment	TP53	2.04
66	Basal cell carcinoma 7	Enrichment	TP53	2.04
67	Imagawa-matsumoto syndrome	Enrichment	SUZ12	2.04
68	Anaplastic thyroid carcinoma	Enrichment	TP53	2.04
69	Intellectual developmental disorder, autosomal recessive 54	Enrichment	TNIK	2.04
70	Neurocardiofaciodigital syndrome	Enrichment	MAPKAPK5	2.04
71	Macular dystrophy, patterned, 3	Enrichment	MAPKAPK3	2.04
72	Ductal carcinoma in situ	Enrichment	TP53	2.04
73	Epilepsy, familial adult myoclonic, 6	Enrichment	TNRC6A	2.04
74	Cohen-gibson syndrome	Enrichment	EED	2.04
75	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.04
76	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.04
77	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.04
78	Choroid plexus cancer	Enrichment	TP53	2.04
79	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.04
80	Leukemia, acute lymphoblastic	Enrichment	CDKN2A, NBN	2.01
81	Breast-ovarian cancer, familial 1	Enrichment	ATM, NBN	1.86
82	Leukodystrophy, demyelinating, adult-onset, autosomal dominant, typical	Enrichment	LMNB1	1.85
83	Craniosynostosis 4	Enrichment	ERF	1.85
84	Tumor predisposition syndrome 3	Enrichment	POT1	1.85
85	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 8	Enrichment	POT1	1.85
86	Silver-russell syndrome 5	Enrichment	HMGA2	1.85
87	Adult onset demyelinating leukodystrophy	Enrichment	LMNB1	1.85
88	Ataxia-telangiectasia-like disorder 1	Enrichment	MRE11	1.85
89	Stature quantitative trait locus 9	Enrichment	HMGA2	1.85
90	High-grade astrocytoma with piloid features	Enrichment	POT1	1.85
91	Cerebroretinal microangiopathy with calcifications and cysts 3	Enrichment	POT1	1.85
92	Microcephaly 26, primary, autosomal dominant	Enrichment	LMNB1	1.85
93	Endometrial serous adenocarcinoma	Enrichment	ATM	1.85
94	Chitayat syndrome	Enrichment	ERF	1.85
95	Trilateral retinoblastoma	Enrichment	RB1	1.85
96	B-cell non-hodgkin lymphoma	Enrichment	ATM	1.85
97	Lung oat cell carcinoma	Enrichment	RB1	1.85
98	Lung cancer susceptibility 3	Enrichment	RB1, TP53	1.80
99	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	1.79
100	Scoliosis, isolated 1	Enrichment	MAPK7	1.79
101	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	1.79
102	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.79
103	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	1.79
104	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	1.79
105	Rela fusion-positive ependymoma	Enrichment	RELA	1.79
106	Kleefstra syndrome	Enrichment	EHMT1	1.79
107	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	1.79
108	Kleefstra syndrome due to a point mutation	Enrichment	EHMT1	1.79
109	Common variable immunodeficiency 12	Enrichment	NFKB1	1.79
110	Submucosal cleft palate	Enrichment	UBB	1.79
111	Cleft hard palate	Enrichment	UBB	1.79
112	Adrenocortical carcinoma, hereditary	Enrichment	TP53	1.74
113	Cervical cancer	Enrichment	TP53	1.74
114	Lymphoma, hodgkin, classic	Enrichment	TP53	1.74
115	Neurodevelopmental disorder with language delay and behavioral abnormalities, with or without seizures	Enrichment	AGO1	1.74
116	Congenital fibrosarcoma	Enrichment	TP53	1.74
117	Li-fraumeni syndrome 1	Enrichment	TP53	1.74
118	Sarcoma	Enrichment	TP53	1.74
119	Cervix carcinoma	Enrichment	TP53	1.74
120	Hodgkin's lymphoma	Enrichment	TP53	1.74
121	Stolerman neurodevelopmental syndrome	Enrichment	KDM6B	1.74
122	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	1.74
123	Gliosarcoma	Enrichment	ATM, TP53	1.69
124	Giant cell glioblastoma	Enrichment	ATM, TP53	1.64
125	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.61
126	Uvula, bifid	Enrichment	UBB	1.61
127	Cleft soft palate	Enrichment	UBB	1.61
128	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	1.61
129	Hyper ige syndrome	Enrichment	STAT3	1.61
130	Nasopharyngeal carcinoma	Enrichment	TP53	1.57
131	Anus, imperforate	Enrichment	MAP4K4	1.57
132	Bacteremia 2	Enrichment	MAPKAPK3	1.57
133	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.57
134	Anaplastic astrocytoma	Enrichment	TP53	1.57
135	Revesz syndrome	Enrichment	TINF2	1.56
136	Salivary gland adenoma, pleomorphic	Enrichment	HMGA2	1.56
137	Chromosome 13q14 deletion syndrome	Enrichment	RB1	1.56
138	Neurodevelopmental disorder with dysmorphic facies, sleep disturbance, and brain abnormalities	Enrichment	KAT5	1.56
139	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	1.56
140	Dyskeratosis congenita, autosomal dominant 3	Enrichment	TINF2	1.56
141	Oligodendroglioma	Enrichment	POT1	1.56
142	High grade glioma	Enrichment	ATM	1.56
143	Autosomal dominant primary microcephaly	Enrichment	LMNB1	1.56
144	T-cell prolymphocytic leukemia	Enrichment	ATM	1.56
145	Anaplastic oligodendroglioma	Enrichment	POT1	1.56
146	12q14 microdeletion syndrome	Enrichment	HMGA2	1.56
147	Familial retinoblastoma	Enrichment	RB1	1.56
148	Arteriovenous malformations of the brain	Enrichment	IL6, MAP4K4	1.54
149	Dyskeratosis congenita	Enrichment	POT1, TINF2	1.54
150	Kaposi sarcoma	Enrichment	IL6	1.49
151	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.49
152	Congenital generalized lipodystrophy	Enrichment	FOS	1.49
153	Primary hyperparathyroidism	Enrichment	CDKN1B	1.49
154	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.49
155	Primary autosomal recessive microcephaly	Enrichment	CDK6, PHC1	1.46
156	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.44
157	Lung sarcomatoid carcinoma	Enrichment	TP53	1.44
158	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.44
159	Tuberculosis	Enrichment	MAPKAPK3	1.44
160	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.40
161	Deafness, autosomal recessive 63	Enrichment	ANAPC15	1.40
162	Histiocytoid hemangioma	Enrichment	FOS	1.40
163	Crouzon syndrome	Enrichment	ERF	1.38
164	Craniosynostosis 1	Enrichment	ERF	1.38
165	Jacobsen syndrome	Enrichment	ETS1	1.38
166	Retinoblastoma	Enrichment	RB1	1.38
167	Ataxia-telangiectasia	Enrichment	ATM	1.38
168	Nijmegen breakage syndrome	Enrichment	NBN	1.38
169	Polycythemia vera	Enrichment	ATM	1.38
170	Woolly hair, autosomal recessive 3	Enrichment	RB1	1.38
171	Dyskeratosis congenita, autosomal dominant 6	Enrichment	ACD	1.38
172	Hypotrichosis 8	Enrichment	RB1	1.38
173	Koolen-de vries syndrome	Enrichment	ATM	1.38
174	Rhabdomyosarcoma 2	Enrichment	TP53	1.35
175	Myasthenic syndrome, congenital, 4a, slow-channel	Enrichment	MINK1	1.35
176	Lymphoma	Enrichment	TP53	1.35
177	Myasthenic syndrome, congenital, 4b, fast-channel	Enrichment	MINK1	1.35
178	Acute megakaryocytic leukemia	Enrichment	TP53	1.35
179	Endometrial stromal sarcoma	Enrichment	SUZ12	1.35
180	Type 1 diabetes mellitus	Enrichment	IL6	1.32
181	Kleefstra syndrome 1	Enrichment	EHMT1	1.32
182	Lung squamous cell carcinoma	Enrichment	CDKN2A	1.32
183	Breast adenocarcinoma	Enrichment	TP53	1.27
184	Ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia	Enrichment	MRE11	1.26
185	Lynch syndrome 4	Enrichment	RB1	1.26
186	Mantle cell lymphoma	Enrichment	ATM	1.26
187	Silver-russell syndrome due to a point mutation	Enrichment	HMGA2	1.26
188	Oculomotor apraxia	Enrichment	ATM	1.26
189	Common variable immunodeficiency	Enrichment	NFKB1	1.25
190	Esophageal cancer	Enrichment	TP53	1.21
191	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.21
192	Myasthenic syndrome, congenital, 1a, slow-channel	Enrichment	MINK1	1.21
193	Essential thrombocythemia	Enrichment	TP53	1.21
194	Gallbladder cancer	Enrichment	TP53	1.21
195	Gastroesophageal reflux	Enrichment	RPS6KA3	1.20
196	Orthostatic intolerance	Enrichment	RPS6KA3	1.20
197	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.20
198	Glioblastoma	Enrichment	ATM	1.17
199	Renal hypodysplasia/aplasia 1	Enrichment	MAP4K4	1.15
200	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.15
201	Lennox-gastaut syndrome	Enrichment	MAPK10	1.15
202	Inflammatory bowel disease 1	Enrichment	IL6	1.15
203	Ventricular septal defect	Enrichment	RPS6KA3	1.15
204	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.10
205	Polymicrogyria	Enrichment	EHMT1	1.10
206	Melanoma	Enrichment	CDKN2A	1.10
207	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	TNRC6B	1.10
208	Adult hepatocellular carcinoma	Enrichment	TP53	1.10
209	Primary hyperaldosteronism	Enrichment	TP53	1.10
210	Dyskeratosis congenita, autosomal dominant 1	Enrichment	TINF2	1.09
211	Clear cell renal cell carcinoma	Enrichment	ATM	1.09
212	Myasthenic syndrome, congenital, 4c, associated with acetylcholine receptor deficiency	Enrichment	MINK1	1.06
213	Familial colorectal cancer	Enrichment	TP53	1.06
214	Silver-russell syndrome 1	Enrichment	HMGA2	1.03
215	Renal cell carcinoma, papillary, 1	Enrichment	ATM	1.03
216	Dyskeratosis congenita, autosomal dominant 2	Enrichment	TINF2	1.03
217	Myelodysplastic syndrome	Enrichment	TP53	1.02
218	46,xy complete gonadal dysgenesis	Enrichment	CBX2	1.02
219	Acute promyelocytic leukemia	Enrichment	STAT3	0.99
220	Type 2 diabetes mellitus	Enrichment	HMGA1, IL6	0.93
221	Congenital myasthenic syndrome	Enrichment	MINK1	0.92
222	Lynch syndrome 1	Enrichment	ATM	0.88
223	Aplastic anemia	Enrichment	NBN	0.88
224	Rhabdomyosarcoma	Enrichment	TP53	0.86
225	Isolated congenital microcephaly	Enrichment	PHC1	0.86
226	Heart, malformation of	Enrichment	MAPK1	0.86
227	Immune deficiency disease	Enrichment	ATM	0.84
228	Uterine corpus cancer	Enrichment	ATM	0.84
229	Familial colorectal cancer type x	Enrichment	ATM	0.84
230	Digeorge syndrome	Enrichment	HIRA	0.81
231	Premature menopause	Enrichment	NBN	0.78
232	Precursor t-cell acute lymphoblastic leukemia	Enrichment	CDKN2A	0.76
233	Hepatoblastoma	Enrichment	TP53	0.76
234	Multisystem inflammatory syndrome in children	Enrichment	IFNB1	0.74
235	Diamond-blackfan anemia 1	Enrichment	TP53	0.72
236	Malaria	Enrichment	MAPKAPK3	0.72
237	Renal cell carcinoma, nonpapillary	Enrichment	ATM	0.72
238	Autism spectrum disorder	Enrichment	EED, EHMT1, TNRC6B	0.71
239	Non-syndromic x-linked intellectual disability	Enrichment	RPS6KA3	0.59
240	Endometrial cancer	Enrichment	ATM	0.59
241	Lissencephaly	Enrichment	NBN	0.59
242	Diamond-blackfan anemia	Enrichment	TP53	0.55
243	Leukemia, acute myeloid	Enrichment	TP53	0.51
244	Colorectal cancer	Enrichment	ATM, TP53	0.46
245	Hypertelorism	Enrichment	RPS6KA3	0.46
246	Non-immune hydrops fetalis	Enrichment	UBN1	0.45
247	Undetermined early-onset epileptic encephalopathy	Enrichment	FZR1	0.43
248	Schizophrenia	Enrichment	EHMT1	0.41
249	Autosomal recessive non-syndromic intellectual disability	Enrichment	TNIK	0.38
250	Systemic lupus erythematosus	Enrichment	ETS1	0.37
251	Microcephaly	Enrichment	MAPK1, NBN	0.29
252	Primary ovarian insufficiency	Enrichment	NBN	0.25

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Cellular Senescence

Pathway Network for Cellular Senescence

Pathway network for the Cellular Senescence SuperPath

Member Pathways for Cellular Senescence

Pathways in the Cellular Senescence SuperPath

Gene overlap in member pathways for Cellular Senescence SuperPath

Associated Genes for Cellular Senescence

Associated Disorders for Cellular Senescence

Disorders associated with Cellular Senescence SuperPath

STRING Interaction Network for Cellular Senescence

Sources for Cellular Senescence