ceramide de novo biosynthesis

No Pathway Network information available for ceramide de novo biosynthesis

#	Name	Source	Genes
1	ceramide de novo biosynthesis	PubChem	CERS1 DEGS1 KDSR SPTLC1 SPTLC2 SPTLC3 SPTSSA (see all 7) (see less)
2	sphingolipid biosynthesis (mammals)	PubChem	CERS1 DEGS1 KDSR SPTLC1 SPTLC2 SPTLC3 SPTSSA (see all 7) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SPTSSA	Serine Palmitoyltransferase Small Subunit A	Protein Coding	2
2	CERS1	Ceramide Synthase 1	Protein Coding	2
3	KDSR	3-Ketodihydrosphingosine Reductase	Protein Coding	2
4	SPTLC3	Serine Palmitoyltransferase Long Chain Base Subunit 3	Protein Coding	2
5	SPTLC1	Serine Palmitoyltransferase Long Chain Base Subunit 1	Protein Coding	2
6	DEGS1	Delta 4-Desaturase, Sphingolipid 1	Protein Coding	2
7	SPTLC2	Serine Palmitoyltransferase Long Chain Base Subunit 2	Protein Coding	2

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hereditary sensory and autonomic neuropathy type 1	Enrichment	SPTLC1, SPTLC2	5.32
2	Neuropathy, hereditary sensory and autonomic, type ia	Enrichment	SPTLC1	3.29
3	Leukodystrophy, hypomyelinating, 18	Enrichment	DEGS1	3.29
4	Amyotrophic lateral sclerosis 27, juvenile	Enrichment	SPTLC1	3.29
5	Neuropathy, hereditary sensory and autonomic, type ic	Enrichment	SPTLC2	3.29
6	Spastic paraplegia 90a, autosomal dominant	Enrichment	SPTSSA	3.29
7	Erythrokeratodermia variabilis et progressiva 4	Enrichment	KDSR	3.29
8	Spastic paraplegia 90b, autosomal recessive	Enrichment	SPTSSA	3.29
9	Epilepsy, progressive myoclonic, 8	Enrichment	CERS1	2.99
10	Right atrial isomerism	Enrichment	CERS1	2.81
11	Congenital heart defects, multiple types, 6	Enrichment	CERS1	2.81
12	Transposition of the great arteries	Enrichment	CERS1	2.69
13	Sensory peripheral neuropathy	Enrichment	SPTLC3	2.59
14	Double outlet right ventricle	Enrichment	CERS1	2.51
15	Erythrokeratodermia variabilis et progressiva 1	Enrichment	KDSR	2.38
16	Juvenile amyotrophic lateral sclerosis	Enrichment	SPTLC1	2.33
17	Beckwith-wiedemann syndrome	Enrichment	SPTLC1	2.03
18	Heart, malformation of	Enrichment	CERS1	2.03
19	Leukodystrophy	Enrichment	DEGS1	1.99
20	Visceral heterotaxy	Enrichment	CERS1	1.95
21	Tetralogy of fallot	Enrichment	CERS1	1.87
22	Visceral heterotaxy 5	Enrichment	CERS1	1.80
23	Peripheral nervous system disease	Enrichment	SPTLC3	1.79
24	Neuropathy	Enrichment	SPTLC3	1.79
25	Charcot-marie-tooth disease	Enrichment	SPTLC1	1.68
26	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	SPTLC1	1.53

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for ceramide de novo biosynthesis