Ceramide Pathway

No Pathway Network information available for Ceramide Pathway

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

Disorders associated with Ceramide Pathway SuperPath

according to GeneCards Suite gene sharing
#DisorderTypeGenesScore
1Noonan syndrome 1EnrichmentHRAS, KRAS, MAP2K1, MRAS, NRAS, RAF1, RRAS, RRAS210.46
2RasopathyEnrichmentHRAS, KRAS, MAP2K1, MRAS, NRAS, RAF1, RRAS29.92
3Noonan syndrome and noonan-related syndromeEnrichmentHRAS, KRAS, MAP2K1, NRAS, RAF17.74
4Lung non-small cell carcinomaEnrichmentHRAS, KRAS, MAP2K1, NRAS6.45
5Schimmelpenning-feuerstein-mims syndromeEnrichmentHRAS, KRAS, NRAS6.10
6Nevus, epidermalEnrichmentHRAS, KRAS, NRAS5.17
7Noonan syndrome 3EnrichmentHRAS, KRAS, RAF15.17
8Melanocytic nevus syndrome, congenitalEnrichmentHRAS, NRAS, RAF14.97
9Ras-associated autoimmune leukoproliferative disorderEnrichmentKRAS, NRAS4.46
10Juvenile myelomonocytic leukemiaEnrichmentKRAS, NRAS, RRAS4.38
11Cardiofaciocutaneous syndrome 1EnrichmentMAP2K1, MAP2K24.23
12Cardiofaciocutaneous syndromeEnrichmentMAP2K1, MAP2K24.23
13Langerhans cell histiocytosisEnrichmentMAP2K1, NRAS3.99
14Large congenital melanocytic nevusEnrichmentHRAS, NRAS3.99
15Chronic myelogenous leukemia, bcr-abl1 positiveEnrichmentKRAS, NRAS3.69
16Histiocytoid hemangiomaEnrichmentFOS, FOSB3.47
17Breast adenocarcinomaEnrichmentAKT1, KRAS3.29
18Differentiated thyroid carcinomaEnrichmentHRAS, KRAS, NRAS3.19
19Thyroid cancer, nonmedullary, 2EnrichmentHRAS, NRAS3.15
20Capillary malformation-arteriovenous malformation 1EnrichmentKRAS, MAP2K13.15
21Leukemia, chronic myeloidEnrichmentKRAS, NRAS3.15
22Pilomyxoid astrocytomaEnrichmentKRAS, RAF13.15
23Follicular thyroid carcinomaEnrichmentHRAS, NRAS3.15
24Lung cancerEnrichmentCASP8, KRAS, PPP2R1B3.06
25Breast cancerEnrichmentAKT1, CASP8, JUN, KRAS3.00
26Arteriovenous malformationEnrichmentHRAS, MAP2K12.92
27Myopathy, x-linked, with excessive autophagyEnrichmentHRAS, MAP2K12.82
28Periodic fever, familial, autosomal dominantEnrichmentTNFRSF1A2.50
29Noonan syndrome 5EnrichmentRAF12.50
30Caspase 8 deficiencyEnrichmentCASP82.50
31Melorheostosis, isolatedEnrichmentMAP2K12.50
32Cardiomyopathy, dilated, 1nnEnrichmentRAF12.50
33Cardiofaciocutaneous syndrome 3EnrichmentMAP2K12.50
34Ceroid lipofuscinosis, neuronal, 10EnrichmentCTSD2.50
35Noonan syndrome 13EnrichmentMAPK12.50
36Thrombocytopenia 4EnrichmentCYCS2.50
37Autoimmune lymphoproliferative syndrome, type iiaEnrichmentCASP102.50
38MelorheostosisEnrichmentMAP2K12.50
39Leopard syndrome 2EnrichmentRAF12.50
40Multiple sclerosis 5EnrichmentTNFRSF1A2.50
41Cardiofaciocutaneous syndrome 4EnrichmentMAP2K22.50
42Immunodeficiency 90 with encephalopathy, functional hyposplenia, and hepatic dysfunctionEnrichmentFADD2.50
43Tnf receptor-associated periodic fever syndromeEnrichmentTNFRSF1A2.50
44Acid sphingomyelinase deficiencyEnrichmentSMPD12.50
45TrigonitisEnrichmentRAF12.50
46Intellectual developmental disorder, autosomal recessive 80, with variant lissencephalyEnrichmentCASP22.50
47Proteus syndromeEnrichmentAKT12.23
48Oculoectodermal syndromeEnrichmentKRAS2.23
49Spinocerebellar ataxia 12EnrichmentPPP2R2B2.23
50Melanosis, neurocutaneousEnrichmentNRAS2.23
51Noonan syndrome 6EnrichmentNRAS2.23
52Ataxia-oculomotor apraxia 3EnrichmentPIK3R52.23
53Autoimmune lymphoproliferative syndrome, type iiiEnrichmentPRKCD2.23
54Noonan syndrome 11EnrichmentMRAS2.23
55Parkinson disease 25, autosomal recessive early-onset, with impaired intellectual developmentEnrichmentPTPA2.23
56Short syndromeEnrichmentPIK3R12.23
57Houge-janssens syndrome 4EnrichmentPPP2R5C2.23
58Deafness, autosomal recessive 68EnrichmentS1PR22.23
59Cardiofaciocutaneous syndrome 2EnrichmentKRAS2.23
60Houge-janssens syndrome 2EnrichmentPPP2R1A2.23
61Immunodeficiency 36 with lymphoproliferationEnrichmentPIK3R12.23
62Cowden syndrome 6EnrichmentAKT12.23
63Achromatopsia 7EnrichmentATF62.23
64Agammaglobulinemia 7, autosomal recessiveEnrichmentPIK3R12.23
65Autoinflammation with episodic fever and lymphadenopathyEnrichmentRIPK12.23
66Congenital pulmonary airway malformationEnrichmentKRAS2.23
67Aplasia cutis-enamel dysplasia syndromeEnrichmentFOSL22.23
68Phakomatosis pigmentokeratoticaEnrichmentHRAS2.23
69Ppp2r1a-related neurodevelopmental disorderEnrichmentPPP2R1A2.23
70Neurocutaneous melanocytosisEnrichmentNRAS2.23
71Scoliosis, isolated 1EnrichmentMAPK72.20
72Immunodeficiency 127EnrichmentTNF2.20
73Intermittent hydrarthrosisEnrichmentTNFRSF1A2.20
74Tafro syndromeEnrichmentMAP2K22.20
75Oculootodental syndromeEnrichmentFADD2.20
76Niemann-pick disease, type aEnrichmentSMPD12.02
77Psoriatic arthritisEnrichmentTNF2.02
78Niemann-pick disease, type bEnrichmentSMPD12.02
79Ceroid lipofuscinosis, neuronal, 6aEnrichmentSMPD12.02
80T-cell acute lymphoblastic leukemiaEnrichmentBAX2.02
81Migraine without auraEnrichmentTNF2.02
82Costello syndromeEnrichmentHRAS1.93
83Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2EnrichmentPIK3R51.93
84Encephalocraniocutaneous lipomatosisEnrichmentKRAS1.93
85Immunodeficiency, common variable, 12, with autoimmunityEnrichmentNFKB11.93
86Noonan syndrome 12EnrichmentRRAS21.93
87Intravascular large b-cell lymphomaEnrichmentBCL21.93
88Immunodeficiency 57 with autoinflammationEnrichmentRIPK11.93
89Houge-janssens syndrome 3EnrichmentPPP2CA1.93
90Common variable immunodeficiency 12EnrichmentNFKB11.93
91Wooly hair nevusEnrichmentHRAS1.93
92Bladder cancerEnrichmentHRAS, KRAS1.90
93Autoimmune lymphoproliferative syndromeEnrichmentCASP101.90
94Neurofibromatosis-noonan syndromeEnrichmentMAP2K21.90
95Chromosome 22q11.2 deletion syndrome, distalEnrichmentMAPK11.90
96Noonan syndrome with multiple lentiginesEnrichmentRAF11.90
97Cerebral malariaEnrichmentTNF1.90
98Non-immune hydrops fetalisEnrichmentHRAS, KRAS1.84
99Colorectal cancerEnrichmentAKT1, NRAS, PIK3R11.83
100Niemann-pick disease, type c1EnrichmentSMPD11.80
101Niemann-pick diseaseEnrichmentSMPD11.80
102Vascular dementiaEnrichmentTNF1.80
103Autosomal thrombocytopenia with normal plateletsEnrichmentCYCS1.80
104Congenital lipomatous overgrowth, vascular malformations, and epidermal neviEnrichmentPIK3R11.75
105Immunodeficiency 14a with lymphoproliferation, autosomal dominantEnrichmentPIK3R11.75
106High-grade b-cell lymphoma double-hit/triple-hitEnrichmentBCL21.75
107Immunodeficiency 14EnrichmentPIK3R11.75
108SpermatocytomaEnrichmentHRAS1.75
109Melanoma of soft tissueEnrichmentATF11.75
110Ovarian cancerEnrichmentAKT1, KRAS, RRAS21.66
111Leukemia, acute myeloidEnrichmentKRAS, NRAS1.63
112Diffuse gastric and lobular breast cancer syndromeEnrichmentKRAS1.63
113Megalencephaly-capillary malformation-polymicrogyria syndromeEnrichmentPIK3R21.63
114Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1EnrichmentPIK3R21.63
115Congenital generalized lipodystrophyEnrichmentFOS1.63
116Lung sarcomatoid carcinomaEnrichmentKRAS1.63
117Pilocytic astrocytomaEnrichmentKRAS1.63
118Epidermolytic nevusEnrichmentHRAS1.63
119Pseudomyogenic hemangioendotheliomaEnrichmentFOSB1.63
120Lymphoma, non-hodgkin, familialEnrichmentCASP101.60
121Lennox-gastaut syndromeEnrichmentMAPK101.60
122Gastric cancerEnrichmentCASP10, KRAS1.58
123Hereditary breast carcinomaEnrichmentAKT1, KRAS1.56
124Charge syndromeEnrichmentTNFRSF1A1.55
125Adult hepatocellular carcinomaEnrichmentCASP81.55
126Follicular lymphomaEnrichmentBCL21.54
127AsthmaEnrichmentTNF1.46
128Specific learning disabilityEnrichmentMAPK11.46
129Inflammatory bowel disease 25, autosomal recessiveEnrichmentRIPK11.46
130Il10-related early-onset inflammatory bowel diseaseEnrichmentRIPK11.46
131Lung squamous cell carcinomaEnrichmentKRAS1.46
132Alzheimer's diseaseEnrichmentTNF1.39
133Gallbladder cancerEnrichmentKRAS1.39
134Common variable immunodeficiencyEnrichmentNFKB11.39
135Overgrowth syndromeEnrichmentPIK3R11.39
136Hereditary breast ovarian cancer syndromeEnrichmentKRAS, RIPK11.38
137Myeloma, multipleEnrichmentKRAS, PIK3R21.37
138Multiple sclerosisEnrichmentTNFRSF1A1.36
139Neuronal ceroid lipofuscinosisEnrichmentCTSD1.33
140Cowden syndromeEnrichmentAKT11.29
141Heart, malformation ofEnrichmentMAPK11.26
142Ciliary dyskinesia, primary, 3EnrichmentNFKB11.24
143AchromatopsiaEnrichmentATF61.24
144Autosomal non-syndromic agammaglobulinemiaEnrichmentPIK3R11.24
145Behcet syndromeEnrichmentTNFRSF1A1.23
146Immune deficiency diseaseEnrichmentRIPK11.20
147Hepatocellular carcinomaEnrichmentCASP81.17
148MeningiomaEnrichmentAKT11.16
149Lip and oral cavity carcinomaEnrichmentHRAS1.16
150MalariaEnrichmentTNF1.15
151Cardiomyopathy, familial hypertrophic, 1EnrichmentRAF11.13
152Autoinflammatory diseaseEnrichmentTNFRSF1A1.13
153Protein-deficiency anemiaEnrichmentNRAS1.13
154Lung cancer susceptibility 3EnrichmentKRAS1.10
155Lynch syndromeEnrichmentKRAS1.07
156Severe covid-19EnrichmentCASP101.06
157RhabdomyosarcomaEnrichmentHRAS1.04
158Familial hypertrophic cardiomyopathyEnrichmentRAF11.00
159Left ventricular noncompactionEnrichmentRAF10.98
160Arteriovenous malformations of the brainEnrichmentKRAS0.97
161Systemic lupus erythematosusEnrichmentTNF0.93
162Pancreatic cancerEnrichmentKRAS0.86
163ThrombocytopeniaEnrichmentCYCS0.85
164Hydrops fetalis, nonimmuneEnrichmentHRAS0.85
165Familial isolated dilated cardiomyopathyEnrichmentRAF10.81
166Dilated cardiomyopathyEnrichmentRAF10.65
167Autism spectrum disorderEnrichmentMAP2K10.53
168MicrocephalyEnrichmentMAPK10.49
169Cone-rod dystrophy 2EnrichmentATF60.48
170Rare autosomal recessive non-syndromic sensorineural deafness type dfnbEnrichmentS1PR20.39
171Complex neurodevelopmental disorderEnrichmentPPP2CA0.28
172Hereditary retinal dystrophyEnrichmentATF60.08
173Fundus dystrophyEnrichmentATF60.08

Loading...
Loading...
Loading...