Chaperonin-mediated protein folding

Pathway network for the Chaperonin-mediated protein folding SuperPath

Sources:

Reactome

Pathways in the Chaperonin-mediated protein folding SuperPath

#	Name	Source	Genes
1	Chaperonin-mediated protein folding	Reactome	ACTB AP3M1 ARFGEF2 CCNE1 CCNE2 CCT2 CCT3 CCT4 CCT5 CCT6A CCT6B CCT7 CCT8 CSNK2A1 CSNK2A2 CSNK2B DCAF7 FBXL3 FBXL5 FBXO4 FBXO6 FBXW10 FBXW2 FBXW4 FBXW5 FBXW7 FBXW9 FKBP9 GAPDHS GBA1 GNA11 GNA14 GNA15 GNAQ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 HDAC3 KIF13A KIFC3 LONP2 NOP56 PDCL PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 RGS11 RGS6 RGS7 RGS9 SKIC2 SPHK1 STAT3 TCP1 TP53 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 VBP1 WRAP53 XRN2 (see all 91) (see less)
2	Protein folding	Reactome	ACTB AP3M1 ARFGEF2 ARL2 CCNE1 CCNE2 CCT2 CCT3 CCT4 CCT5 CCT6A CCT6B CCT7 CCT8 CSNK2A1 CSNK2A2 CSNK2B DCAF7 FBXL3 FBXL5 FBXO4 FBXO6 FBXW10 FBXW2 FBXW4 FBXW5 FBXW7 FBXW9 FKBP9 GAPDHS GBA1 GNA11 GNA14 GNA15 GNAQ GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 HDAC3 KIF13A KIFC3 LONP2 NOP56 PDCL PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 RGS11 RGS6 RGS7 RGS9 SKIC2 SPHK1 STAT3 TBCA TBCB TBCC TBCD TBCE TCP1 TP53 TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA4B TUBA8 TUBAL3 TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 VBP1 WRAP53 XRN2 (see all 97) (see less)
3	Association of TriC/CCT with target proteins during biosynthesis	Reactome	AP3M1 ARFGEF2 CCNE1 CCNE2 CCT2 CCT3 CCT4 CCT5 CCT6A CCT6B CCT7 CCT8 DCAF7 FBXL3 FBXL5 FBXO4 FBXO6 FBXW10 FBXW2 FBXW4 FBXW5 FBXW7 FBXW9 FKBP9 GAPDHS GBA1 HDAC3 KIF13A KIFC3 LONP2 NOP56 SKIC2 SPHK1 STAT3 TCP1 TP53 WRAP53 XRN2 (see all 38) (see less)

Gene overlap in member pathways for Chaperonin-mediated protein folding SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DCAF7	DDB1 And CUL4 Associated Factor 7	Protein Coding	3
2	FBXW10	F-Box And WD Repeat Domain Containing 10	Protein Coding	3
3	NOP56	NOP56 Ribonucleoprotein	Protein Coding	3
4	ARFGEF2	ARF Guanine Nucleotide Exchange Factor 2	Protein Coding	3
5	CCT7	Chaperonin Containing TCP1 Subunit 7	Protein Coding	3
6	CCT4	Chaperonin Containing TCP1 Subunit 4	Protein Coding	3
7	CCT2	Chaperonin Containing TCP1 Subunit 2	Protein Coding	3
8	CCT6B	Chaperonin Containing TCP1 Subunit 6B	Protein Coding	3
9	CCT8	Chaperonin Containing TCP1 Subunit 8	Protein Coding	3
10	FKBP9	FKBP Prolyl Isomerase 9	Protein Coding	3
11	XRN2	5''-3'' Exoribonuclease 2	Protein Coding	3
12	CCT5	Chaperonin Containing TCP1 Subunit 5	Protein Coding	3
13	FBXW2	F-Box And WD Repeat Domain Containing 2	Protein Coding	3
14	FBXL3	F-Box And Leucine Rich Repeat Protein 3	Protein Coding	3
15	FBXL5	F-Box And Leucine Rich Repeat Protein 5	Protein Coding	3
16	FBXO6	F-Box Protein 6	Protein Coding	3
17	FBXO4	F-Box Protein 4	Protein Coding	3
18	GBA1	Glucosylceramidase Beta 1	Protein Coding	3
19	GAPDHS	Glyceraldehyde-3-Phosphate Dehydrogenase, Spermatogenic	Protein Coding	3
20	AP3M1	Adaptor Related Protein Complex 3 Subunit Mu 1	Protein Coding	3
21	KIFC3	Kinesin Family Member C3	Protein Coding	3
22	FBXW5	F-Box And WD Repeat Domain Containing 5	Protein Coding	3
23	WRAP53	WD Repeat Containing Antisense To TP53	Protein Coding	3
24	FBXW7	F-Box And WD Repeat Domain Containing 7	Protein Coding	3
25	KIF13A	Kinesin Family Member 13A	Protein Coding	3
26	FBXW4	F-Box And WD Repeat Domain Containing 4~Name Same As:- HGNC:13612	Protein Coding	3
27	SKIC2	SKI2 Subunit Of Superkiller Complex	Protein Coding	3
28	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	3
29	TCP1	T-Complex 1	Protein Coding	3
30	TP53	Tumor Protein P53	Protein Coding	3
31	CCT3	Chaperonin Containing TCP1 Subunit 3	Protein Coding	3
32	LONP2	Lon Peptidase 2, Peroxisomal	Protein Coding	3
33	FBXW9	F-Box And WD Repeat Domain Containing 9	Protein Coding	3
34	HDAC3	Histone Deacetylase 3	Protein Coding	3
35	SPHK1	Sphingosine Kinase 1	Protein Coding	3
36	CCNE1	Cyclin E1	Protein Coding	3
37	CCT6A	Chaperonin Containing TCP1 Subunit 6A	Protein Coding	3
38	CCNE2	Cyclin E2	Protein Coding	3
39	TUBA1B	Tubulin Alpha 1b	Protein Coding	2
40	TUBB3	Tubulin Beta 3 Class III	Protein Coding	2
41	TUBB4A	Tubulin Beta 4A Class IVa	Protein Coding	2
42	TUBB4B	Tubulin Beta 4B Class IVb	Protein Coding	2
43	PFDN6	Prefoldin Subunit 6	Protein Coding	2
44	GNB5	G Protein Subunit Beta 5	Protein Coding	2
45	TUBA3E	Tubulin Alpha 3e	Protein Coding	2
46	TUBA3D	Tubulin Alpha 3d	Protein Coding	2
47	CSNK2A1	Casein Kinase 2 Alpha 1	Protein Coding	2
48	CSNK2A2	Casein Kinase 2 Alpha 2	Protein Coding	2
49	CSNK2B	Casein Kinase 2 Beta	Protein Coding	2
50	GNA11	G Protein Subunit Alpha 11	Protein Coding	2
51	GNA15	G Protein Subunit Alpha 15	Protein Coding	2
52	GNAQ	G Protein Subunit Alpha Q	Protein Coding	2
53	GNB1	G Protein Subunit Beta 1	Protein Coding	2
54	GNB2	G Protein Subunit Beta 2	Protein Coding	2
55	GNB3	G Protein Subunit Beta 3	Protein Coding	2
56	GNG3	G Protein Subunit Gamma 3	Protein Coding	2
57	GNG4	G Protein Subunit Gamma 4	Protein Coding	2
58	GNG5	G Protein Subunit Gamma 5	Protein Coding	2
59	GNG7	G Protein Subunit Gamma 7	Protein Coding	2
60	GNG10	G Protein Subunit Gamma 10	Protein Coding	2
61	GNG11	G Protein Subunit Gamma 11	Protein Coding	2
62	GNGT1	G Protein Subunit Gamma Transducin 1	Protein Coding	2
63	GNGT2	G Protein Subunit Gamma Transducin 2	Protein Coding	2
64	TUBB2B	Tubulin Beta 2B Class IIb	Protein Coding	2
65	PDCL	Phosducin Like	Protein Coding	2
66	GNG13	G Protein Subunit Gamma 13	Protein Coding	2
67	TUBA8	Tubulin Alpha 8	Protein Coding	2
68	PFDN1	Prefoldin Subunit 1	Protein Coding	2
69	PFDN2	Prefoldin Subunit 2	Protein Coding	2
70	PFDN4	Prefoldin Subunit 4	Protein Coding	2
71	PFDN5	Prefoldin Subunit 5	Protein Coding	2
72	GNG2	G Protein Subunit Gamma 2	Protein Coding	2
73	GNG12	G Protein Subunit Gamma 12	Protein Coding	2
74	GNB4	G Protein Subunit Beta 4	Protein Coding	2
75	ACTB	Actin Beta	Protein Coding	2
76	RGS7	Regulator Of G Protein Signaling 7	Protein Coding	2
77	TUBA4A	Tubulin Alpha 4a	Protein Coding	2
78	TUBA3C	Tubulin Alpha 3c	Protein Coding	2
79	TUBB2A	Tubulin Beta 2A Class IIa	Protein Coding	2
80	VBP1	VHL Binding Protein 1	Protein Coding	2
81	TUBA1A	Tubulin Alpha 1a	Protein Coding	2
82	TUBAL3	Tubulin Alpha Like 3	Protein Coding	2
83	TUBA4B	Tubulin Alpha 4b	Protein Coding	2
84	TUBB1	Tubulin Beta 1 Class VI	Protein Coding	2
85	TUBB6	Tubulin Beta 6 Class V	Protein Coding	2
86	TUBA1C	Tubulin Alpha 1c	Protein Coding	2
87	RGS11	Regulator Of G Protein Signaling 11	Protein Coding	2
88	RGS9	Regulator Of G Protein Signaling 9	Protein Coding	2
89	GNG8	G Protein Subunit Gamma 8	Protein Coding	2
90	RGS6	Regulator Of G Protein Signaling 6	Protein Coding	2
91	GNA14	G Protein Subunit Alpha 14	Protein Coding	2
92	TBCB	Tubulin Folding Cofactor B	Protein Coding	1
93	ARL2	ARF Like GTPase 2	Protein Coding	1
94	TBCA	Tubulin Folding Cofactor A	Protein Coding	1
95	TBCC	Tubulin Folding Cofactor C	Protein Coding	1
96	TBCD	Tubulin Folding Cofactor D	Protein Coding	1
97	TBCE	Tubulin Folding Cofactor E	Protein Coding	1

Disorders associated with Chaperonin-mediated protein folding SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Tubulinopathy-associated dysgyria	Enrichment	TUBA1A, TUBB2B, TUBB3	6.53
2	Anastomosing haemangioma	Enrichment	GNA11, GNA14, GNAQ	6.53
3	Tubulinopathy	Enrichment	TUBA1A, TUBB2A, TUBB2B	5.93
4	Congenital fibrosis of the extraocular muscles	Enrichment	TUBA1A, TUBB2B, TUBB3	5.24
5	Lissencephaly	Enrichment	TUBA1A, TUBA3E, TUBB2B, TUBB3	4.98
6	Phakomatosis cesioflammea	Enrichment	GNA11, GNAQ	4.35
7	Li-fraumeni syndrome	Enrichment	TP53, WRAP53	3.94
8	Capillary malformations, congenital	Enrichment	GNA11, GNAQ	3.36
9	Melanoma, uveal	Enrichment	GNA11, GNAQ	3.18
10	Polymicrogyria, bilateral perisylvian, x-linked	Enrichment	TUBA1A, TUBB2B	3.04
11	Diffuse large b-cell lymphoma	Enrichment	STAT3, TP53	2.90
12	Hepatoblastoma	Enrichment	GBA1, TP53	2.81
13	Bilateral perisylvian polymicrogyria	Enrichment	TUBA1A, TUBB2B	2.81
14	Autosomal dominant macrothrombocytopenia	Enrichment	TUBA8, TUBB1	2.71
15	Cerebral palsy	Enrichment	GNB1, TUBA1A, TUBB4A	2.65
16	Myelodysplastic syndrome	Enrichment	GNB1, TP53	2.63
17	Periventricular heterotopia with microcephaly, autosomal recessive	Enrichment	ARFGEF2	2.55
18	Dyskeratosis congenita, autosomal recessive 3	Enrichment	WRAP53	2.55
19	Bone marrow failure syndrome 5	Enrichment	TP53	2.55
20	Intellectual developmental disorder with polymicrogyria and seizures	Enrichment	TCP1	2.55
21	Papilloma of choroid plexus	Enrichment	TP53	2.55
22	Neuropathy, hereditary sensory, with spastic paraplegia, autosomal recessive	Enrichment	CCT5	2.55
23	Basal cell carcinoma 7	Enrichment	TP53	2.55
24	Anaplastic thyroid carcinoma	Enrichment	TP53	2.55
25	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.55
26	Autosomal recessive sensory neuropathy with spastic paraplegia	Enrichment	CCT5	2.55
27	Intellectual developmental disorder with short stature, facial anomalies, and speech defects	Enrichment	FBXL3	2.55
28	Ductal carcinoma in situ	Enrichment	TP53	2.55
29	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.55
30	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.55
31	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.55
32	Developmental delay, hypotonia, and impaired language	Enrichment	FBXW7	2.55
33	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.55
34	Neurodevelopmental disorder with speech or visual impairment and brain hypomyelination	Enrichment	CCT3	2.55
35	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.55
36	Choroid plexus cancer	Enrichment	TP53	2.55
37	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.55
38	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.55
39	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.25
40	Gaucher disease, type iiic	Enrichment	GBA1	2.25
41	Cervical cancer	Enrichment	TP53	2.25
42	Gaucher disease, perinatal lethal	Enrichment	GBA1	2.25
43	Trichohepatoenteric syndrome 2	Enrichment	SKIC2	2.25
44	Gaucher disease, type iii	Enrichment	GBA1	2.25
45	Lymphoma, hodgkin, classic	Enrichment	TP53	2.25
46	Congenital fibrosarcoma	Enrichment	TP53	2.25
47	Li-fraumeni syndrome 1	Enrichment	TP53	2.25
48	Sarcoma	Enrichment	TP53	2.25
49	Cervix carcinoma	Enrichment	TP53	2.25
50	Hodgkin's lymphoma	Enrichment	TP53	2.25
51	Immunodeficiency 57 with autoinflammation	Enrichment	SKIC2	2.25
52	Buratti-harel syndrome	Enrichment	LONP2	2.25
53	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.25
54	Hypocalciuric hypercalcemia, familial, type ii	Enrichment	GNA11	2.17
55	Baraitser-winter syndrome 1	Enrichment	ACTB	2.17
56	Fibrosis of extraocular muscles, congenital, 3a, with or without extraocular involvement	Enrichment	TUBB3	2.17
57	Macrothrombocytopenia, isolated, 1, autosomal dominant	Enrichment	TUBB1	2.17
58	Sturge-weber syndrome	Enrichment	GNAQ	2.17
59	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Enrichment	GNB2	2.17
60	Leber congenital amaurosis with early-onset deafness	Enrichment	TUBB4B	2.17
61	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.17
62	Oocyte/zygote/embryo maturation arrest 24	Enrichment	TUBA1C	2.17
63	Prolonged electroretinal response suppression 1	Enrichment	RGS9	2.17
64	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	2.17
65	Becker nevus syndrome	Enrichment	ACTB	2.17
66	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.17
67	Cortical dysplasia, complex, with other brain malformations 7	Enrichment	TUBB2B	2.17
68	Hypocalcemia, autosomal dominant 2	Enrichment	GNA11	2.17
69	Oocyte/zygote/embryo maturation arrest 23	Enrichment	TUBA4A	2.17
70	Frontotemporal dementia and/or amyotrophic lateral sclerosis 9	Enrichment	TUBA4A	2.17
71	Charcot-marie-tooth disease, dominant intermediate f	Enrichment	GNB4	2.17
72	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.17
73	Facial palsy, congenital, with ptosis and velopharyngeal dysfunction	Enrichment	TUBB6	2.17
74	Okur-chung neurodevelopmental syndrome	Enrichment	CSNK2A1	2.17
75	Sick sinus syndrome 4	Enrichment	GNB2	2.17
76	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.17
77	Macrothrombocytopenia, isolated, 2, autosomal dominant	Enrichment	TUBA8	2.17
78	Baraitser-winter syndrome	Enrichment	ACTB	2.17
79	Lissencephaly due to tuba1a mutation	Enrichment	TUBA1A	2.17
80	Congenital myopathy 26	Enrichment	TUBA4A	2.17
81	Spastic ataxia 11, autosomal dominant	Enrichment	TUBA4A	2.17
82	Amyotrophic lateral sclerosis type 22	Enrichment	TUBA4A	2.17
83	Craniodigital syndrome and intellectual disability syndrome	Enrichment	CSNK2B	2.17
84	Polymicrogyria with optic nerve hypoplasia	Enrichment	TUBA8	2.17
85	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.17
86	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.17
87	Phakomatosis cesiomarmorata	Enrichment	GNA11	2.17
88	Kaposiform hemangioendothelioma	Enrichment	GNA14	2.17
89	Hypoparathyroidism-retardation-dysmorphism syndrome	Enrichment	TBCE	2.15
90	Kenny-caffey syndrome, type 1	Enrichment	TBCE	2.15
91	Encephalopathy, progressive, with amyotrophy and optic atrophy	Enrichment	TBCE	2.15
92	Early-onset progressive encephalopathy-spastic ataxia-distal spinal muscular atrophy syndrome	Enrichment	TBCE	2.15
93	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.08
94	Gaucher disease, type ii	Enrichment	GBA1	2.08
95	Osteogenic sarcoma	Enrichment	TP53	2.08
96	Nasopharyngeal carcinoma	Enrichment	TP53	2.08
97	Spinocerebellar ataxia 36	Enrichment	NOP56	2.08
98	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	2.08
99	Hyper ige syndrome	Enrichment	STAT3	2.08
100	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.08
101	Anaplastic astrocytoma	Enrichment	TP53	2.08
102	Squamous cell carcinoma	Enrichment	TP53	2.08
103	Adenocarcinoma	Enrichment	TP53	2.08
104	Gaucher's disease	Enrichment	GBA1	2.08
105	Bone osteosarcoma	Enrichment	TP53	2.08
106	Trichohepatoenteric syndrome	Enrichment	SKIC2	2.08
107	Gaucher disease, type i	Enrichment	GBA1	1.95
108	Small cell cancer of the lung	Enrichment	TP53	1.95
109	Trichohepatoenteric syndrome 1	Enrichment	SKIC2	1.95
110	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.95
111	Lung sarcomatoid carcinoma	Enrichment	TP53	1.95
112	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.95
113	Dystonia 4, torsion, autosomal dominant	Enrichment	TUBB4A	1.87
114	Cutis marmorata telangiectatica congenita	Enrichment	GNA11	1.87
115	Angioma, tufted	Enrichment	GNA14	1.87
116	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	1.87
117	Muscular dystrophy, limb-girdle, autosomal recessive 3	Enrichment	TUBA1A	1.87
118	Poirier-bienvenu neurodevelopmental syndrome	Enrichment	CSNK2B	1.87
119	Keratoconus 9	Enrichment	TUBA3D	1.87
120	Autosomal recessive limb-girdle muscular dystrophy type 2d	Enrichment	TUBA1A	1.87
121	Lissencephaly 3	Enrichment	TUBA1A	1.87
122	Autosomal dominant hypocalcemia	Enrichment	GNA11	1.87
123	Cortical dysplasia, complex, with other brain malformations 1	Enrichment	TUBB3	1.87
124	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB	1.87
125	Bradyopsia	Enrichment	RGS9	1.87
126	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	1.87
127	Torsion dystonia 4	Enrichment	TUBB4A	1.87
128	Continuous spikes and waves during sleep	Enrichment	TUBA1A	1.87
129	Cerebral visual impairment	Enrichment	GNB1	1.87
130	Dementia, lewy body	Enrichment	GBA1	1.86
131	Rhabdomyosarcoma 2	Enrichment	TP53	1.86
132	Pervasive developmental disorder	Enrichment	FBXW7	1.86
133	Lymphoma	Enrichment	TP53	1.86
134	Acute megakaryocytic leukemia	Enrichment	TP53	1.86
135	Dementia	Enrichment	GBA1	1.86
136	Rare pervasive developmental disorder	Enrichment	FBXW7	1.86
137	Muscular dystrophy-dystroglycanopathy , type a, 11	Enrichment	TBCE	1.85
138	Encephalopathy, progressive, early-onset, with brain atrophy and thin corpus callosum	Enrichment	TBCD	1.85
139	Seborrhea-like dermatitis with psoriasiform elements	Enrichment	TBCD	1.85
140	Congenital muscular dystrophy-dystroglycanopathy type a11	Enrichment	TBCE	1.85
141	Adrenocortical carcinoma	Enrichment	TP53	1.78
142	Breast adenocarcinoma	Enrichment	TP53	1.78
143	Esophageal cancer	Enrichment	TP53	1.71
144	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.71
145	Parkinsonism	Enrichment	GBA1	1.71
146	Essential thrombocythemia	Enrichment	TP53	1.71
147	Gallbladder cancer	Enrichment	TP53	1.71
148	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.71
149	Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss	Enrichment	TUBB1	1.70
150	Prognathism, mandibular	Enrichment	CSNK2B	1.70
151	Leukodystrophy, hypomyelinating, 6	Enrichment	TUBB4A	1.70
152	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	GNA11	1.70
153	Cortical dysplasia, complex, with other brain malformations 5	Enrichment	TUBB2A	1.70
154	Microcornea, rod-cone dystrophy, cataract, and posterior staphyloma 1	Enrichment	ARL2	1.67
155	Glioma susceptibility 1	Enrichment	TP53	1.65
156	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.65
157	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.65
158	Isolated split hand-split foot malformation	Enrichment	FBXW4	1.65
159	Colorectal cancer	Enrichment	FBXW7, TP53	1.61
160	Adult hepatocellular carcinoma	Enrichment	TP53	1.60
161	Primary hyperaldosteronism	Enrichment	TP53	1.60
162	Leber plus disease	Enrichment	CCT2, RGS9, TUBB4B	1.59
163	Spastic paraplegia 17, autosomal dominant	Enrichment	GNG3	1.58
164	Lipodystrophy, congenital generalized, type 2	Enrichment	GNG3	1.58
165	Aminoacylase 1 deficiency	Enrichment	ACTB	1.58
166	Enophthalmos	Enrichment	CSNK2B	1.58
167	Syndactyly	Enrichment	CSNK2B	1.58
168	Familial sick sinus syndrome	Enrichment	GNB2	1.58
169	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.58
170	Leukemia, chronic lymphocytic	Enrichment	TP53	1.56
171	Familial colorectal cancer	Enrichment	TP53	1.56
172	Movement disease	Enrichment	GBA1	1.52
173	Lip and oral cavity carcinoma	Enrichment	TP53	1.48
174	Congenital nervous system abnormality	Enrichment	GNB5, TUBA1A, TUBB4A	1.46
175	Nervous system disease	Enrichment	GNB5, TUBA1A, TUBB4A	1.46
176	Acute promyelocytic leukemia	Enrichment	STAT3	1.45
177	Autism spectrum disorder	Enrichment	CSNK2A1, CSNK2B, GNB1	1.43
178	Lung cancer susceptibility 3	Enrichment	TP53	1.41
179	Periventricular nodular heterotopia	Enrichment	ARFGEF2	1.41
180	Klippel-trenaunay-weber syndrome	Enrichment	GNAQ	1.40
181	Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1	Enrichment	TUBB2B	1.40
182	Early myoclonic encephalopathy	Enrichment	TUBA1A	1.40
183	Thrombocytopenia	Enrichment	GBA1, TUBB1	1.39
184	Hydrocephalus	Enrichment	ARFGEF2	1.38
185	Hypertension	Enrichment	GBA1	1.36
186	Rhabdomyosarcoma	Enrichment	TP53	1.36
187	Gliosarcoma	Enrichment	TP53	1.36
188	Autosomal dominant non-syndromic intellectual disability	Enrichment	CSNK2B, GNB1	1.35
189	Giant cell glioblastoma	Enrichment	TP53	1.33
190	Microcephaly	Enrichment	ACTB, GNB1, TUBB4A	1.30
191	Parkinson's disease	Enrichment	GBA1	1.28
192	Dyskeratosis congenita	Enrichment	WRAP53	1.28
193	Cryptorchidism	Enrichment	TUBA1A	1.28
194	Hypothyroidism	Enrichment	GNB1	1.28
195	Inherited cancer-predisposing syndrome	Enrichment	TP53, WRAP53	1.28
196	Difference of sex development	Enrichment	TBCE	1.25
197	Cryptorchidism, unilateral or bilateral	Enrichment	TUBA1A	1.23
198	Hepatocellular carcinoma	Enrichment	TP53	1.22
199	Myocardial infarction	Enrichment	CCT7	1.22
200	Diamond-blackfan anemia 1	Enrichment	TP53	1.20
201	Parkinson disease, late-onset	Enrichment	GBA1	1.19
202	Pancreatic cancer	Enrichment	TP53	1.17
203	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.15
204	Congenital hypothyroidism	Enrichment	TUBB1	1.11
205	Bladder cancer	Enrichment	TP53	1.11
206	Prostate cancer	Enrichment	TP53	1.11
207	Breast cancer	Enrichment	GNG3, TP53	1.04
208	Corpus callosum, agenesis of	Enrichment	TUBA1A	1.02
209	Isolated corpus callosum agenesis	Enrichment	TUBA1A	1.02
210	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	TUBA1A	1.02
211	Diamond-blackfan anemia	Enrichment	TP53	1.02
212	Isolated congenital microcephaly	Enrichment	TUBA3E	0.99
213	Leukemia, acute myeloid	Enrichment	TP53	0.97
214	Hypertension, essential	Enrichment	GNB3	0.97
215	Cleft palate, isolated	Enrichment	GNB1	0.97
216	Dandy-walker syndrome	Enrichment	TUBA1A	0.97
217	Gastric cancer	Enrichment	TP53	0.94
218	Hereditary breast carcinoma	Enrichment	TP53	0.93
219	Attention deficit-hyperactivity disorder	Enrichment	GNB5	0.86
220	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	0.84
221	Congenital stationary night blindness	Enrichment	GNB3	0.84
222	Myeloma, multiple	Enrichment	TP53	0.84
223	Auditory neuropathy	Enrichment	TUBB4A	0.79
224	Strabismus	Enrichment	GNB1	0.78
225	Complex neurodevelopmental disorder	Enrichment	CSNK2A1, GNB2	0.69
226	Dystonia	Enrichment	GNB1	0.68
227	Fetal akinesia deformation sequence 1	Enrichment	TUBA1A	0.66
228	Ovarian cancer	Enrichment	TP53	0.61
229	Optic atrophy plus syndrome	Enrichment	TUBB6	0.59
230	West syndrome	Enrichment	TUBA1A	0.59
231	Spastic ataxia	Enrichment	TUBB3	0.52
232	Hereditary retinal dystrophy	Enrichment	RGS9	0.07
233	Fundus dystrophy	Enrichment	RGS9	0.07

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Chaperonin-mediated protein folding

Pathway Network for Chaperonin-mediated protein folding

Pathway network for the Chaperonin-mediated protein folding SuperPath

Member Pathways for Chaperonin-mediated protein folding

Pathways in the Chaperonin-mediated protein folding SuperPath

Gene overlap in member pathways for Chaperonin-mediated protein folding SuperPath

Associated Genes for Chaperonin-mediated protein folding

Associated Disorders for Chaperonin-mediated protein folding

Disorders associated with Chaperonin-mediated protein folding SuperPath

STRING Interaction Network for Chaperonin-mediated protein folding

Sources for Chaperonin-mediated protein folding