Chondroitin sulfate/dermatan sulfate metabolism

Pathway network for the Chondroitin sulfate/dermatan sulfate metabolism SuperPath

Sources:

Reactome
PubChem

Pathways in the Chondroitin sulfate/dermatan sulfate metabolism SuperPath

#	Name	Source	Genes
1	Chondroitin sulfate/dermatan sulfate metabolism	Reactome	ARSB BCAN BGN CHPF CHPF2 CHST11 CHST12 CHST13 CHST14 CHST15 CHST3 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN DSE DSEL GLB1 GLB1L GLB1L2 GLB1L3 GUSB HEXA HEXB HYAL1 HYAL3 HYAL4 IDS IDUA NCAN UST VCAN (see all 37) (see less)
2	CS-GAG biosynthesis	Reactome	BCAN BGN CHPF CHPF2 CHST11 CHST12 CHST13 CHST15 CHST3 CHST7 CHST9 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 CSPG4 CSPG5 DCN NCAN UST VCAN (see all 21) (see less)
3	CS/DS degradation	Reactome	ARSB BCAN BGN CSPG4 CSPG5 DCN GLB1 GLB1L GLB1L2 GLB1L3 GUSB HEXA HEXB HYAL1 HYAL3 HYAL4 IDS IDUA NCAN VCAN (see all 20) (see less)
4	DS-GAG biosynthesis	Reactome	BCAN BGN CHST14 CHST15 CSPG4 CSPG5 DCN DSE DSEL NCAN UST VCAN (see all 12) (see less)
5	Defective CHST3 causes SEDCJD	Reactome	BCAN BGN CHST3 CSPG4 CSPG5 DCN NCAN VCAN (see all 8) (see less)
6	Defective CHSY1 causes TPBS	Reactome	BCAN BGN CHSY1 CSPG4 CSPG5 DCN NCAN VCAN (see all 8) (see less)
7	Defective CHST14 causes EDS, musculocontractural type	Reactome	BCAN BGN CHST14 CSPG4 CSPG5 DCN NCAN VCAN (see all 8) (see less)
8	dermatan sulfate biosynthesis (late stages)	PubChem	CHST14 CHST15 DSE UST

Gene overlap in member pathways for Chondroitin sulfate/dermatan sulfate metabolism SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CSPG5	Chondroitin Sulfate Proteoglycan 5	Protein Coding	7
2	VCAN	Versican	Protein Coding	7
3	NCAN	Neurocan	Protein Coding	7
4	CSPG4	Chondroitin Sulfate Proteoglycan 4	Protein Coding	7
5	DCN	Decorin	Protein Coding	7
6	BGN	Biglycan	Protein Coding	7
7	BCAN	Brevican	Protein Coding	7
8	UST	Uronyl 2-Sulfotransferase	Protein Coding	4
9	CHST14	Carbohydrate Sulfotransferase 14	Protein Coding	4
10	CHST15	Carbohydrate Sulfotransferase 15	Protein Coding	4
11	CHSY1	Chondroitin Sulfate Synthase 1	Protein Coding	3
12	DSE	Dermatan Sulfate Epimerase	Protein Coding	3
13	CHST3	Carbohydrate Sulfotransferase 3	Protein Coding	3
14	GLB1L3	Galactosidase Beta 1 Like 3	Protein Coding	2
15	CHST13	Carbohydrate Sulfotransferase 13	Protein Coding	2
16	HYAL4	Hyaluronidase 4	Protein Coding	2
17	GLB1	Galactosidase Beta 1	Protein Coding	2
18	GUSB	Glucuronidase Beta	Protein Coding	2
19	HEXA	Hexosaminidase Subunit Alpha	Protein Coding	2
20	HEXB	Hexosaminidase Subunit Beta	Protein Coding	2
21	HYAL1	Hyaluronidase 1	Protein Coding	2
22	CHSY3	Chondroitin Sulfate Synthase 3	Protein Coding	2
23	IDS	Iduronate 2-Sulfatase	Protein Coding	2
24	IDUA	Alpha-L-Iduronidase	Protein Coding	2
25	ARSB	Arylsulfatase B	Protein Coding	2
26	CHST11	Carbohydrate Sulfotransferase 11	Protein Coding	2
27	CHPF2	Chondroitin Polymerizing Factor 2	Protein Coding	2
28	CSGALNACT2	Chondroitin Sulfate N-Acetylgalactosaminyltransferase 2	Protein Coding	2
29	CHST12	Carbohydrate Sulfotransferase 12	Protein Coding	2
30	CSGALNACT1	Chondroitin Sulfate N-Acetylgalactosaminyltransferase 1	Protein Coding	2
31	CHST7	Carbohydrate Sulfotransferase 7	Protein Coding	2
32	GLB1L	Galactosidase Beta 1 Like	Protein Coding	2
33	CHPF	Chondroitin Polymerizing Factor	Protein Coding	2
34	CHST9	Carbohydrate Sulfotransferase 9	Protein Coding	2
35	HYAL3	Hyaluronidase 3	Protein Coding	2
36	GLB1L2	Galactosidase Beta 1 Like 2	Protein Coding	2
37	DSEL	Dermatan Sulfate Epimerase Like	Protein Coding	2

Disorders associated with Chondroitin sulfate/dermatan sulfate metabolism SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Spondyloepimetaphyseal dysplasia	Direct
2	Brachydactyly	Direct
3	Ehlers-danlos syndrome	Direct
4	Musculocontractural ehlers-danlos syndrome	Enrichment	CHST14, DSE	6.71
5	Mucopolysaccharidosis, type vi	Enrichment	ARSB, GUSB	5.21
6	Spondyloepiphyseal dysplasia with congenital joint dislocations	Enrichment	CHST3, GLB1	3.97
7	Ehlers-danlos syndrome, musculocontractural type, 2	Enrichment	DSE	3.53
8	Ehlers-danlos syndrome, musculocontractural type, 1	Enrichment	CHST14	3.23
9	Sudden infant death with dysgenesis of the testes syndrome	Enrichment	DSE	3.05
10	Meester-loeys syndrome	Enrichment	BGN	3.05
11	Sandhoff disease	Enrichment	HEXB	2.83
12	Mucopolysaccharidosis, type ix	Enrichment	HYAL1	2.83
13	Glb1-related disorders	Enrichment	GLB1	2.83
14	Osteochondrodysplasia, brachydactyly, and overlapping malformed digits	Enrichment	CHST11	2.81
15	Skeletal dysplasia, mild, with joint laxity and advanced bone age	Enrichment	CSGALNACT1	2.81
16	Wagner vitreoretinopathy	Enrichment	VCAN	2.75
17	Spondyloepimetaphyseal dysplasia, x-linked	Enrichment	BGN	2.75
18	Corneal dystrophy, congenital stromal	Enrichment	DCN	2.75
19	Wagner disease	Enrichment	VCAN	2.75
20	Nephrolithiasis, calcium oxalate, 1	Enrichment	IDUA	2.53
21	Hurler-scheie syndrome	Enrichment	IDUA	2.53
22	Scheie syndrome	Enrichment	IDUA	2.53
23	Mucopolysaccharidosis, type vii	Enrichment	GUSB	2.53
24	Hypersulfaturia	Enrichment	IDUA	2.53
25	Gm2-gangliosidosis, ab variant	Enrichment	HEXA	2.53
26	Calcium oxalate nephrolithiasis	Enrichment	IDUA	2.53
27	Auroneurodental syndrome	Enrichment	HYAL3	2.53
28	Temtamy preaxial brachydactyly syndrome	Enrichment	CHSY1	2.51
29	Gm1-gangliosidosis, type i	Enrichment	GLB1	2.35
30	Mucopolysaccharidosis, type ivb	Enrichment	GLB1	2.35
31	Gm1-gangliosidosis, type ii	Enrichment	GLB1	2.35
32	Mucopolysaccharidosis, type ii	Enrichment	IDS	2.35
33	Hurler syndrome	Enrichment	IDUA	2.35
34	Gm1-gangliosidosis, type iii	Enrichment	GLB1	2.35
35	Tay-sachs disease	Enrichment	HEXA	2.35
36	Gm1 gangliosidosis	Enrichment	GLB1	2.35
37	Mucopolysaccharidosis-plus syndrome	Enrichment	IDUA	2.35
38	Mucopolysaccharidosis with skin involvement	Enrichment	IDS	2.35
39	Larsen syndrome	Enrichment	CHST3	2.33
40	Multiple joint dislocations, short stature, and craniofacial dysmorphism with or without congenital heart defects	Enrichment	CHST3	2.33
41	Larsen-like syndrome b3gat3 type	Enrichment	CHST3	2.33
42	Mucopolysaccharidosis, type iva	Enrichment	IDUA	2.13
43	Gitelman syndrome	Enrichment	IDUA	2.13
44	Stickler syndrome	Enrichment	VCAN	2.05
45	Metachromatic leukodystrophy	Enrichment	ARSB	2.05
46	Mucopolysaccharidosis, type iiia	Enrichment	IDS	2.05
47	Desbuquois dysplasia 1	Enrichment	CSGALNACT1	2.03
48	Progressive familial intrahepatic cholestasis	Enrichment	GLB1	1.99
49	Leukodystrophy	Enrichment	HEXA	1.54
50	Hydrops fetalis, nonimmune	Enrichment	GUSB	1.42
51	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	BGN	1.42
52	Non-immune hydrops fetalis	Enrichment	GUSB	1.35
53	Spastic ataxia	Enrichment	GLB1	1.12
54	Hereditary retinal dystrophy	Enrichment	VCAN	0.64
55	Fundus dystrophy	Enrichment	VCAN	0.64

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Chondroitin sulfate/dermatan sulfate metabolism

Pathway Network for Chondroitin sulfate/dermatan sulfate metabolism

Pathway network for the Chondroitin sulfate/dermatan sulfate metabolism SuperPath

Member Pathways for Chondroitin sulfate/dermatan sulfate metabolism

Pathways in the Chondroitin sulfate/dermatan sulfate metabolism SuperPath

Gene overlap in member pathways for Chondroitin sulfate/dermatan sulfate metabolism SuperPath

Associated Genes for Chondroitin sulfate/dermatan sulfate metabolism

Associated Disorders for Chondroitin sulfate/dermatan sulfate metabolism

Disorders associated with Chondroitin sulfate/dermatan sulfate metabolism SuperPath

STRING Interaction Network for Chondroitin sulfate/dermatan sulfate metabolism

Sources for Chondroitin sulfate/dermatan sulfate metabolism