Chromatin modifying enzymes

Pathway network for the Chromatin modifying enzymes SuperPath

Sources:

Reactome

Pathways in the Chromatin modifying enzymes SuperPath

#	Name	Source	Genes
1	Chromatin modifying enzymes	Reactome	ACTB ACTL6A ACTL6B AEBP2 ARID1A ARID1B ARID2 ARID4A ARID4B ARID5B ASH1L ASH2L ATF2 ATF7IP ATXN7 ATXN7L3 BRD1 BRD8 BRMS1 BRPF1 BRPF3 BRWD1 CARM1 CCND1 CDK4 CHD3 CHD4 CLOCK COPRS CREBBP DMAP1 DNMT3A DOT1L DPY30 DR1 EED EHMT1 EHMT2 ELP1 ELP2 ELP3 ELP4 ELP5 ELP6 ENY2 EP300 EP400 EPC1 EZH2 GATAD2A GATAD2B GPS2 H2AB1 H2AC1 H2AC11 H2AC12 H2AC13 H2AC14 H2AC15 H2AC16 H2AC17 H2AC18 H2AC19 H2AC20 H2AC21 H2AC25 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC13 H2BC14 H2BC15 H2BC17 H2BC18 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HAT1 HCFC1 HDAC1 HDAC10 HDAC2 HDAC3 HDAC8 HMG20B ING3 ING4 ING5 JADE1 JADE2 JADE3 JAK2 JMJD6 KANSL1 KANSL2 KANSL3 KAT14 KAT2A KAT2B KAT5 KAT6A KAT6B KAT7 KAT8 KDM1A KDM1B KDM2A KDM2B KDM3A KDM3B KDM4A KDM4B KDM4C KDM4D KDM5A KDM5B KDM5C KDM5D KDM6A KDM6B KDM7A KMT2A KMT2B KMT2C KMT2D KMT5A KMT5B KMT5C MBD3 MBIP MCRS1 MEAF6 MECOM MORF4L1 MORF4L2 MRGBP MSL1 MSL2 MSL3 MTA1 MTA2 MTA3 NCOA1 NCOA2 NCOR1 NCOR2 NFKB1 NFKB2 NSD1 NSD2 NSD3 PADI1 PADI2 PADI3 PADI4 PADI6 PAX3 PBRM1 PHF2 PHF20 PHF21A PHF8 PRDM16 PRDM9 PRMT1 PRMT3 PRMT5 PRMT6 PRMT7 RBBP4 RBBP5 RBBP7 RCOR1 RELA REST RIOX2 RPS2 RUVBL1 RUVBL2 SAP130 SAP18 SAP30 SAP30L SETD1A SETD1B SETD2 SETD3 SETD6 SETD7 SETDB1 SETDB2 SGF29 SMARCA2 SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCD2 SMARCD3 SMARCE1 SMYD2 SMYD3 SUDS3 SUPT20H SUPT3H SUPT7L SUV39H1 SUV39H2 SUZ12 TADA1 TADA2A TADA2B TADA3 TAF10 TAF12 TAF5L TAF6L TAF9 TBL1X TBL1XR1 TRRAP USP22 UTY VPS72 WDR5 WDR77 YEATS2 YEATS4 ZZZ3 (see all 271) (see less)
2	Chromatin organization	Reactome	ACTB ACTL6A ACTL6B AEBP2 ARID1A ARID1B ARID2 ARID4A ARID4B ARID5B ASH1L ASH2L ATF2 ATF7IP ATXN7 ATXN7L3 BCL11A BCL11B BCL7A BCL7B BCL7C BICRA BICRAL BRD1 BRD7 BRD8 BRD9 BRMS1 BRPF1 BRPF3 BRWD1 CARM1 CCND1 CDK4 CHD3 CHD4 CLOCK COPRS CREBBP DMAP1 DNMT3A DOT1L DPF1 DPF2 DPF3 DPY30 DR1 EED EHMT1 EHMT2 ELP1 ELP2 ELP3 ELP4 ELP5 ELP6 ENY2 EP300 EP400 EPC1 EZH2 GATAD2A GATAD2B GPS2 H2AB1 H2AC1 H2AC11 H2AC12 H2AC13 H2AC14 H2AC15 H2AC16 H2AC17 H2AC18 H2AC19 H2AC20 H2AC21 H2AC25 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC13 H2BC14 H2BC15 H2BC17 H2BC18 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HAT1 HCFC1 HDAC1 HDAC10 HDAC2 HDAC3 HDAC8 HMG20B ING3 ING4 ING5 JADE1 JADE2 JADE3 JAK2 JMJD6 KANSL1 KANSL2 KANSL3 KAT14 KAT2A KAT2B KAT5 KAT6A KAT6B KAT7 KAT8 KDM1A KDM1B KDM2A KDM2B KDM3A KDM3B KDM4A KDM4B KDM4C KDM4D KDM5A KDM5B KDM5C KDM5D KDM6A KDM6B KDM7A KMT2A KMT2B KMT2C KMT2D KMT5A KMT5B KMT5C MBD3 MBIP MCRS1 MEAF6 MECOM MORF4L1 MORF4L2 MRGBP MSL1 MSL2 MSL3 MTA1 MTA2 MTA3 NCOA1 NCOA2 NCOR1 NCOR2 NFKB1 NFKB2 NSD1 NSD2 NSD3 PADI1 PADI2 PADI3 PADI4 PADI6 PAX3 PBRM1 PHF10 PHF2 PHF20 PHF21A PHF8 PRDM16 PRDM9 PRMT1 PRMT3 PRMT5 PRMT6 PRMT7 RBBP4 RBBP5 RBBP7 RCOR1 RELA REST RIOX2 RPS2 RUVBL1 RUVBL2 SAP130 SAP18 SAP30 SAP30L SETD1A SETD1B SETD2 SETD3 SETD6 SETD7 SETDB1 SETDB2 SGF29 SMARCA2 SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCD2 SMARCD3 SMARCE1 SMYD2 SMYD3 SS18 SS18L1 SUDS3 SUPT20H SUPT3H SUPT7L SUV39H1 SUV39H2 SUZ12 TADA1 TADA2A TADA2B TADA3 TAF10 TAF12 TAF5L TAF6L TAF9 TBL1X TBL1XR1 TRRAP USP22 UTY VPS72 WDR5 WDR77 YEATS2 YEATS4 ZZZ3 (see all 286) (see less)
3	HATs acetylate histones	Reactome	ACTB ACTL6A ATF2 ATXN7 ATXN7L3 BRD1 BRD8 BRPF1 BRPF3 CLOCK CREBBP DMAP1 DR1 ELP1 ELP2 ELP3 ELP4 ELP5 ELP6 ENY2 EP300 EP400 EPC1 H2AC1 H2AC11 H2AC12 H2AC13 H2AC14 H2AC15 H2AC16 H2AC17 H2AC18 H2AC19 H2AC20 H2AC21 H2AC25 H2AC4 H2AC6 H2AC7 H2AC8 H2BC1 H2BC10 H2BC11 H2BC12 H2BC13 H2BC14 H2BC15 H2BC17 H2BC18 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HAT1 HCFC1 ING3 ING4 ING5 JADE1 JADE2 JADE3 KANSL1 KANSL2 KANSL3 KAT14 KAT2A KAT2B KAT5 KAT6A KAT6B KAT7 KAT8 MBIP MCRS1 MEAF6 MORF4L1 MORF4L2 MRGBP MSL1 MSL2 MSL3 NCOA1 NCOA2 PAX3 PHF20 RBBP7 RUVBL1 RUVBL2 SAP130 SGF29 SUPT20H SUPT3H SUPT7L TADA1 TADA2A TADA2B TADA3 TAF10 TAF12 TAF5L TAF6L TAF9 TRRAP USP22 VPS72 WDR5 YEATS2 YEATS4 ZZZ3 (see all 141) (see less)

Gene overlap in member pathways for Chromatin modifying enzymes SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MCRS1	Microspherule Protein 1	Protein Coding	3
2	TADA3	Transcriptional Adaptor 3	Protein Coding	3
3	NCOA2	Nuclear Receptor Coactivator 2	Protein Coding	3
4	KAT5	Lysine Acetyltransferase 5	Protein Coding	3
5	TAF6L	TATA-Box Binding Protein Associated Factor 6 Like	Protein Coding	3
6	RUVBL2	RuvB Like AAA ATPase 2	Protein Coding	3
7	BRD8	Bromodomain Containing 8	Protein Coding	3
8	MORF4L1	Mortality Factor 4 Like 1	Protein Coding	3
9	MSL3	MSL Complex Subunit 3	Protein Coding	3
10	WDR5	WD Repeat Domain 5	Protein Coding	3
11	KAT7	Lysine Acetyltransferase 7	Protein Coding	3
12	SGF29	SAGA Complex Associated Factor 29	Protein Coding	3
13	TADA1	Transcriptional Adaptor 1	Protein Coding	3
14	H4C16	H4 Histone 16	Protein Coding	3
15	H3C14	H3 Clustered Histone 14	Protein Coding	3
16	H2BC26	H2B Clustered Histone 26	Protein Coding	3
17	ATF2	Activating Transcription Factor 2	Protein Coding	3
18	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	3
19	DR1	Down-Regulator Of Transcription 1	Protein Coding	3
20	EP300	EP300 Lysine Acetyltransferase	Protein Coding	3
21	H2AC1	H2A Clustered Histone 1	Protein Coding	3
22	USP22	Ubiquitin Specific Peptidase 22	Protein Coding	3
23	JADE2	Jade Family PHD Finger 2	Protein Coding	3
24	KAT6B	Lysine Acetyltransferase 6B	Protein Coding	3
25	ELP5	Elongator Acetyltransferase Complex Subunit 5	Protein Coding	3
26	BRD1	Bromodomain Containing 1	Protein Coding	3
27	H2BC1	H2B Clustered Histone 1	Protein Coding	3
28	ZZZ3	Zinc Finger ZZ-Type Containing 3	Protein Coding	3
29	KAT2A	Lysine Acetyltransferase 2A	Protein Coding	3
30	ELP4	Elongator Acetyltransferase Complex Subunit 4	Protein Coding	3
31	TAF5L	TATA-Box Binding Protein Associated Factor 5 Like	Protein Coding	3
32	BRPF3	Bromodomain And PHD Finger Containing 3	Protein Coding	3
33	KANSL1	KAT8 Regulatory NSL Complex Subunit 1	Protein Coding	3
34	H2AC8	H2A Clustered Histone 8	Protein Coding	3
35	H2AC7	H2A Clustered Histone 7	Protein Coding	3
36	H2BC5	H2B Clustered Histone 5	Protein Coding	3
37	H2BC3	H2B Clustered Histone 3	Protein Coding	3
38	HCFC1	Host Cell Factor C1	Protein Coding	3
39	H2AC21	H2A Clustered Histone 21	Protein Coding	3
40	H3C15	H3 Clustered Histone 15	Protein Coding	3
41	MSL1	MSL Complex Subunit 1	Protein Coding	3
42	H2BC18	H2B Clustered Histone 18	Protein Coding	3
43	PAX3	Paired Box 3	Protein Coding	3
44	ING4	Inhibitor Of Growth Family Member 4	Protein Coding	3
45	PHF20	PHD Finger Protein 20	Protein Coding	3
46	MBIP	MAP3K12 Binding Inhibitory Protein 1	Protein Coding	3
47	ING3	Inhibitor Of Growth Family Member 3	Protein Coding	3
48	ELP6	Elongator Acetyltransferase Complex Subunit 6	Protein Coding	3
49	KANSL2	KAT8 Regulatory NSL Complex Subunit 2	Protein Coding	3
50	ELP3	Elongator Acetyltransferase Complex Subunit 3	Protein Coding	3
51	MSL2	MSL Complex Subunit 2	Protein Coding	3
52	ELP2	Elongator Acetyltransferase Complex Subunit 2	Protein Coding	3
53	MRGBP	MRG Domain Binding Protein	Protein Coding	3
54	H4C15	H4 Clustered Histone 15	Protein Coding	3
55	SUPT20H	SPT20 Homolog, SAGA Complex Component	Protein Coding	3
56	KANSL3	KAT8 Regulatory NSL Complex Subunit 3	Protein Coding	3
57	YEATS2	YEATS Domain Containing 2	Protein Coding	3
58	DMAP1	DNA Methyltransferase 1 Associated Protein 1	Protein Coding	3
59	ENY2	ENY2 Transcription And Export Complex 2 Subunit	Protein Coding	3
60	ATXN7L3	Ataxin 7 Like 3	Protein Coding	3
61	KAT14	Lysine Acetyltransferase 14	Protein Coding	3
62	EP400	E1A Binding Protein P400	Protein Coding	3
63	RBBP7	RB Binding Protein 7, Chromatin Remodeling Factor	Protein Coding	3
64	ACTB	Actin Beta	Protein Coding	3
65	ATXN7	Ataxin 7	Protein Coding	3
66	MEAF6	MYST/Esa1 Associated Factor 6	Protein Coding	3
67	H3C13	H3 Clustered Histone 13	Protein Coding	3
68	TADA2A	Transcriptional Adaptor 2A	Protein Coding	3
69	TAF9	TATA-Box Binding Protein Associated Factor 9	Protein Coding	3
70	TAF10	TATA-Box Binding Protein Associated Factor 10	Protein Coding	3
71	TAF12	TATA-Box Binding Protein Associated Factor 12	Protein Coding	3
72	VPS72	Vacuolar Protein Sorting 72 Homolog	Protein Coding	3
73	H2AC19	H2A Clustered Histone 19	Protein Coding	3
74	BRPF1	Bromodomain And PHD Finger Containing 1	Protein Coding	3
75	SAP130	Sin3A Associated Protein 130	Protein Coding	3
76	KAT6A	Lysine Acetyltransferase 6A	Protein Coding	3
77	JADE1	Jade Family PHD Finger 1	Protein Coding	3
78	EPC1	Enhancer Of Polycomb 1	Protein Coding	3
79	YEATS4	YEATS Domain Containing 4	Protein Coding	3
80	H4C9	H4 Clustered Histone 9	Protein Coding	3
81	TRRAP	Transformation/Transcription Domain Associated Protein	Protein Coding	3
82	H2AC13	H2A Clustered Histone 13	Protein Coding	3
83	H2AC15	H2A Clustered Histone 15	Protein Coding	3
84	H2AC14	H2A Clustered Histone 14	Protein Coding	3
85	H2AC16	H2A Clustered Histone 16	Protein Coding	3
86	H2AC6	H2A Clustered Histone 6	Protein Coding	3
87	H2AC4	H2A Clustered Histone 4	Protein Coding	3
88	H2AC17	H2A Clustered Histone 17	Protein Coding	3
89	H2AC18	H2A Clustered Histone 18	Protein Coding	3
90	H2AC20	H2A Clustered Histone 20	Protein Coding	3
91	H2BC8	H2B Clustered Histone 8	Protein Coding	3
92	H2BC13	H2B Clustered Histone 13	Protein Coding	3
93	H2BC15	H2B Clustered Histone 15	Protein Coding	3
94	H2BC14	H2B Clustered Histone 14	Protein Coding	3
95	H2BC7	H2B Clustered Histone 7	Protein Coding	3
96	H2BC6	H2B Clustered Histone 6	Protein Coding	3
97	H2BC9	H2B Clustered Histone 9	Protein Coding	3
98	H2BC10	H2B Clustered Histone 10	Protein Coding	3
99	H2BC4	H2B Clustered Histone 4	Protein Coding	3
100	H2BC17	H2B Clustered Histone 17	Protein Coding	3
101	H2BC21	H2B Clustered Histone 21	Protein Coding	3
102	H3C1	H3 Clustered Histone 1	Protein Coding	3
103	H3C4	H3 Clustered Histone 4	Protein Coding	3
104	H3C3	H3 Clustered Histone 3	Protein Coding	3
105	H3C6	H3 Clustered Histone 6	Protein Coding	3
106	H3C11	H3 Clustered Histone 11	Protein Coding	3
107	H3C8	H3 Clustered Histone 8	Protein Coding	3
108	H3C12	H3 Clustered Histone 12	Protein Coding	3
109	H3C10	H3 Clustered Histone 10	Protein Coding	3
110	H3C2	H3 Clustered Histone 2	Protein Coding	3
111	H4C1	H4 Clustered Histone 1	Protein Coding	3
112	H4C4	H4 Clustered Histone 4	Protein Coding	3
113	H4C6	H4 Clustered Histone 6	Protein Coding	3
114	H4C12	H4 Clustered Histone 12	Protein Coding	3
115	H4C11	H4 Clustered Histone 11	Protein Coding	3
116	H4C3	H4 Clustered Histone 3	Protein Coding	3
117	H4C8	H4 Clustered Histone 8	Protein Coding	3
118	H4C2	H4 Clustered Histone 2	Protein Coding	3
119	H4C5	H4 Clustered Histone 5	Protein Coding	3
120	H4C13	H4 Clustered Histone 13	Protein Coding	3
121	H4C14	H4 Clustered Histone 14	Protein Coding	3
122	KAT8	Lysine Acetyltransferase 8	Protein Coding	3
123	ING5	Inhibitor Of Growth Family Member 5	Protein Coding	3
124	SUPT3H	SPT3 Homolog, SAGA And STAGA Complex Component	Protein Coding	3
125	ELP1	Elongator Acetyltransferase Complex Subunit 1	Protein Coding	3
126	HAT1	Histone Acetyltransferase 1	Protein Coding	3
127	H2AC12	H2A Clustered Histone 12	Protein Coding	3
128	H2BC12	H2B Clustered Histone 12	Protein Coding	3
129	ACTL6A	Actin Like 6A	Protein Coding	3
130	RUVBL1	RuvB Like AAA ATPase 1	Protein Coding	3
131	NCOA1	Nuclear Receptor Coactivator 1	Protein Coding	3
132	KAT2B	Lysine Acetyltransferase 2B	Protein Coding	3
133	H3C7	H3 Clustered Histone 7	Protein Coding	3
134	H2AC11	H2A Clustered Histone 11	Protein Coding	3
135	H2BC11	H2B Clustered Histone 11	Protein Coding	3
136	H2AC25	H2A Clustered Histone 25	Protein Coding	3
137	TADA2B	Transcriptional Adaptor 2B	Protein Coding	3
138	CLOCK	Clock Circadian Regulator	Protein Coding	3
139	MORF4L2	Mortality Factor 4 Like 2	Protein Coding	3
140	JADE3	Jade Family PHD Finger 3	Protein Coding	3
141	SUPT7L	SPT7 Like, STAGA Complex Subunit Gamma	Protein Coding	3
142	CDK4	Cyclin Dependent Kinase 4	Protein Coding	2
143	PRMT3	Protein Arginine Methyltransferase 3	Protein Coding	2
144	SAP18	Sin3A Associated Protein 18	Protein Coding	2
145	HMG20B	High Mobility Group 20B	Protein Coding	2
146	PRMT5	Protein Arginine Methyltransferase 5	Protein Coding	2
147	CARM1	Coactivator Associated Arginine Methyltransferase 1	Protein Coding	2
148	KDM5B	Lysine Demethylase 5B	Protein Coding	2
149	EHMT2	Euchromatic Histone Lysine Methyltransferase 2	Protein Coding	2
150	CHD3	Chromodomain Helicase DNA Binding Protein 3	Protein Coding	2
151	CHD4	Chromodomain Helicase DNA Binding Protein 4	Protein Coding	2
152	PADI2	Peptidyl Arginine Deiminase 2	Protein Coding	2
153	AEBP2	AE Binding Protein 2	Protein Coding	2
154	DNMT3A	DNA Methyltransferase 3 Alpha	Protein Coding	2
155	ARID2	AT-Rich Interaction Domain 2	Protein Coding	2
156	MECOM	MDS1 And EVI1 Complex Locus	Protein Coding	2
157	EZH2	Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit	Protein Coding	2
158	KDM1B	Lysine Demethylase 1B	Protein Coding	2
159	KDM2A	Lysine Demethylase 2A	Protein Coding	2
160	KDM1A	Lysine Demethylase 1A	Protein Coding	2
161	KDM4B	Lysine Demethylase 4B	Protein Coding	2
162	SETD1B	SET Domain Containing 1B, Histone Lysine Methyltransferase	Protein Coding	2
163	KDM4C	Lysine Demethylase 4C	Protein Coding	2
164	PHF8	PHD Finger Protein 8	Protein Coding	2
165	KDM6B	Lysine Demethylase 6B	Protein Coding	2
166	RCOR1	REST Corepressor 1	Protein Coding	2
167	JMJD6	Jumonji Domain Containing 6, Arginine Demethylase And Lysine Hydroxylase	Protein Coding	2
168	SUZ12	SUZ12 Polycomb Repressive Complex 2 Subunit	Protein Coding	2
169	PADI4	Peptidyl Arginine Deiminase 4	Protein Coding	2
170	BRMS1	BRMS1 Transcriptional Repressor And Anoikis Regulator	Protein Coding	2
171	GPS2	G Protein Pathway Suppressor 2	Protein Coding	2
172	SETD2	SET Domain Containing 2, Histone Lysine Methyltransferase	Protein Coding	2
173	PADI1	Peptidyl Arginine Deiminase 1	Protein Coding	2
174	H2AX	H2A.X Variant Histone	Protein Coding	2
175	HDAC1	Histone Deacetylase 1	Protein Coding	2
176	HDAC2	Histone Deacetylase 2	Protein Coding	2
177	PRMT1	Protein Arginine Methyltransferase 1	Protein Coding	2
178	PADI6	Peptidyl Arginine Deiminase 6	Protein Coding	2
179	JAK2	Janus Kinase 2	Protein Coding	2
180	KMT5A	Lysine Methyltransferase 5A	Protein Coding	2
181	KMT2A	Lysine Methyltransferase 2A	Protein Coding	2
182	H2AB1	H2A.B Variant Histone 1	Protein Coding	2
183	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	2
184	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	2
185	KMT5B	Lysine Methyltransferase 5B	Protein Coding	2
186	PHF21A	PHD Finger Protein 21A	Protein Coding	2
187	ACTL6B	Actin Like 6B	Protein Coding	2
188	PADI3	Peptidyl Arginine Deiminase 3	Protein Coding	2
189	ARID4B	AT-Rich Interaction Domain 4B	Protein Coding	2
190	KDM3B	Lysine Demethylase 3B	Protein Coding	2
191	PHF2	PHD Finger Protein 2	Protein Coding	2
192	MBD3	Methyl-CpG Binding Domain Protein 3	Protein Coding	2
193	BRWD1	Bromodomain And WD Repeat Domain Containing 1	Protein Coding	2
194	PRMT7	Protein Arginine Methyltransferase 7	Protein Coding	2
195	GATAD2A	GATA Zinc Finger Domain Containing 2A	Protein Coding	2
196	NSD3	Nuclear Receptor Binding SET Domain Protein 3	Protein Coding	2
197	PRMT6	Protein Arginine Methyltransferase 6	Protein Coding	2
198	PBRM1	Polybromo 1	Protein Coding	2
199	COPRS	Coordinator Of PRMT5 And Differentiation Stimulator	Protein Coding	2
200	KDM4D	Lysine Demethylase 4D	Protein Coding	2
201	ATF7IP	Activating Transcription Factor 7 Interacting Protein	Protein Coding	2
202	H2AJ	H2A.J Histone	Protein Coding	2
203	KDM3A	Lysine Demethylase 3A	Protein Coding	2
204	HDAC8	Histone Deacetylase 8	Protein Coding	2
205	ASH1L	ASH1 Like Histone Lysine Methyltransferase	Protein Coding	2
206	SMYD2	SET And MYND Domain Containing 2	Protein Coding	2
207	PRDM9	PR/SET Domain 9	Protein Coding	2
208	GATAD2B	GATA Zinc Finger Domain Containing 2B	Protein Coding	2
209	ARID1B	AT-Rich Interaction Domain 1B	Protein Coding	2
210	MTA3	Metastasis Associated 1 Family Member 3	Protein Coding	2
211	KMT2C	Lysine Methyltransferase 2C	Protein Coding	2
212	ARID4A	AT-Rich Interaction Domain 4A	Protein Coding	2
213	KDM5A	Lysine Demethylase 5A	Protein Coding	2
214	RBBP4	RB Binding Protein 4, Chromatin Remodeling Factor	Protein Coding	2
215	RBBP5	RB Binding Protein 5, Histone Lysine Methyltransferase Complex Subunit	Protein Coding	2
216	CCND1	Cyclin D1	Protein Coding	2
217	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	2
218	REST	RE1 Silencing Transcription Factor	Protein Coding	2
219	RPS2	Ribosomal Protein S2	Protein Coding	2
220	PRDM16	PR/SET Domain 16	Protein Coding	2
221	NSD1	Nuclear Receptor Binding SET Domain Protein 1	Protein Coding	2
222	SUDS3	SIN3A Corepressor Complex Component SDS3	Protein Coding	2
223	SMYD3	SET And MYND Domain Containing 3	Protein Coding	2
224	SMARCA2	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit ATPase 2	Protein Coding	2
225	SMARCA4	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit ATPase 4	Protein Coding	2
226	SMARCB1	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit B1	Protein Coding	2
227	SMARCC1	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit C1	Protein Coding	2
228	SMARCC2	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit C2	Protein Coding	2
229	SMARCD1	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit D1	Protein Coding	2
230	SMARCD2	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit D2	Protein Coding	2
231	SMARCD3	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit D3	Protein Coding	2
232	SMARCE1	SWI/SNF Related BAF Chromatin Remodeling Complex Subunit E1	Protein Coding	2
233	SUV39H1	SUV39H1 Histone Lysine Methyltransferase	Protein Coding	2
234	TBL1X	Transducin Beta Like 1 X-Linked	Protein Coding	2
235	KDM6A	Lysine Demethylase 6A	Protein Coding	2
236	UTY	Ubiquitously Transcribed Tetratricopeptide Repeat Containing, Y-Linked	Protein Coding	2
237	NSD2	Nuclear Receptor Binding SET Domain Protein 2	Protein Coding	2
238	WDR77	WD Repeat Domain 77	Protein Coding	2
239	SAP30L	SAP30 Like	Protein Coding	2
240	TBL1XR1	TBL1X/Y Related 1	Protein Coding	2
241	SUV39H2	SUV39H2 Histone Lysine Methyltransferase	Protein Coding	2
242	EHMT1	Euchromatic Histone Lysine Methyltransferase 1	Protein Coding	2
243	SETD6	SET Domain Containing 6, Protein Lysine Methyltransferase	Protein Coding	2
244	KMT2D	Lysine Methyltransferase 2D	Protein Coding	2
245	KDM7A	Lysine Demethylase 7A	Protein Coding	2
246	SETD7	SET Domain Containing 7, Histone Lysine Methyltransferase	Protein Coding	2
247	KDM5C	Lysine Demethylase 5C	Protein Coding	2
248	KDM5D	Lysine Demethylase 5D	Protein Coding	2
249	ARID1A	AT-Rich Interaction Domain 1A	Protein Coding	2
250	SETDB2	SET Domain Bifurcated Histone Lysine Methyltransferase 2	Protein Coding	2
251	HDAC10	Histone Deacetylase 10	Protein Coding	2
252	ARID5B	AT-Rich Interaction Domain 5B	Protein Coding	2
253	SETD3	SET Domain Containing 3, Actin N3(Tau)-Histidine Methyltransferase	Protein Coding	2
254	DOT1L	DOT1 Like Histone Lysine Methyltransferase	Protein Coding	2
255	DPY30	Dpy-30 Histone Methyltransferase Complex Regulatory Subunit	Protein Coding	2
256	KDM2B	Lysine Demethylase 2B	Protein Coding	2
257	KMT5C	Lysine Methyltransferase 5C	Protein Coding	2
258	RIOX2	Ribosomal Oxygenase 2	Protein Coding	2
259	EED	Embryonic Ectoderm Development	Protein Coding	2
260	SAP30	Sin3A Associated Protein 30	Protein Coding	2
261	HDAC3	Histone Deacetylase 3	Protein Coding	2
262	ASH2L	ASH2 Like, Histone Lysine Methyltransferase Complex Subunit	Protein Coding	2
263	MTA1	Metastasis Associated 1	Protein Coding	2
264	MTA2	Metastasis Associated 1 Family Member 2	Protein Coding	2
265	H2AZ2	H2A.Z Variant Histone 2	Protein Coding	2
266	NCOR1	Nuclear Receptor Corepressor 1	Protein Coding	2
267	NCOR2	Nuclear Receptor Corepressor 2	Protein Coding	2
268	KDM4A	Lysine Demethylase 4A	Protein Coding	2
269	SETD1A	SET Domain Containing 1A, Histone Lysine Methyltransferase	Protein Coding	2
270	KMT2B	Lysine Methyltransferase 2B	Protein Coding	2
271	SETDB1	SET Domain Bifurcated Histone Lysine Methyltransferase 1	Protein Coding	2
272	BICRAL	BICRA Like Chromatin Remodeling Complex Associated Protein	Protein Coding	1
273	SS18L1	SS18L1 Subunit Of BAF Chromatin Remodeling Complex	Protein Coding	1
274	BRD7	Bromodomain Containing 7	Protein Coding	1
275	BICRA	BRD4 Interacting Chromatin Remodeling Complex Associated Protein	Protein Coding	1
276	BCL11A	BCL11 Transcription Factor A	Protein Coding	1
277	PHF10	PHD Finger Protein 10	Protein Coding	1
278	DPF2	Double PHD Fingers 2	Protein Coding	1
279	BCL7A	BAF Chromatin Remodeling Complex Subunit BCL7A	Protein Coding	1
280	BCL11B	BCL11 Transcription Factor B	Protein Coding	1
281	BRD9	Bromodomain Containing 9	Protein Coding	1
282	SS18	SS18 Subunit Of BAF Chromatin Remodeling Complex	Protein Coding	1
283	DPF3	Double PHD Fingers 3	Protein Coding	1
284	DPF1	Double PHD Fingers 1	Protein Coding	1
285	BCL7C	BAF Chromatin Remodeling Complex Subunit BCL7C	Protein Coding	1
286	BCL7B	BAF Chromatin Remodeling Complex Subunit BCL7B	Protein Coding	1

Disorders associated with Chromatin modifying enzymes SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Coffin-siris syndrome 1	Enrichment	ARID1A, ARID1B, ARID2, DPF2, SMARCA4, SMARCB1, SMARCC2, SMARCD1, SMARCE1	10.83
2	Autism spectrum disorder	Enrichment	ACTL6B, ARID1B, BCL11B, DNMT3A, EED, EHMT1, KAT6A, KDM3B, KDM5B, KDM6A, KMT2A, KMT2C, KMT5B, SETD1A, SETD2, SMARCB1	8.98
3	Myeloma, multiple	Enrichment	ARID4A, CCND1, CREBBP, DNMT3A, H2AC16, H2AC17, H3C1, KDM5C, KMT2C, KMT2D, NCOR2	7.95
4	Rare genetic intellectual disability	Enrichment	ARID1B, CREBBP, DNMT3A, EP300, KDM3B, KMT2A	6.59
5	Tessadori-bicknell-van haaften neurodevelopmental syndrome 4	Enrichment	H2BC12, H4C1, H4C9	5.96
6	Weaver syndrome	Enrichment	EZH2, NSD1, SUZ12	5.10
7	Blepharophimosis	Enrichment	ARID1B, KAT6B, SMARCA2	4.51
8	Tessadori-bicknell-van haaften neurodevelopmental syndrome 1	Enrichment	H4C1, H4C3	3.97
9	Tessadori-bicknell-van haaften neurodevelopmental syndrome 2	Enrichment	H4C1, H4C11	3.97
10	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP, KAT6A	3.97
11	Kabuki syndrome 1	Enrichment	KDM6A, KMT2A, KMT2D	3.82
12	Complex neurodevelopmental disorder	Enrichment	ACTL6A, ACTL6B, H4C3, H4C5, H4C9, KAT8, KDM4B, KMT2B, MSL2, SETD1A	3.72
13	Corpus callosum, agenesis of	Enrichment	ARID1B, BCL11A, CREBBP, SETD2	3.66
14	Isolated corpus callosum agenesis	Enrichment	ARID1B, BCL11A, CREBBP, SETD2	3.66
15	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	ARID1B, BCL11A, CREBBP, SETD2	3.66
16	Tessadori-bicknell-van haaften neurodevelopmental syndrome 3	Enrichment	H4C1, H4C5	3.50
17	Rhabdoid tumor predisposition syndrome	Enrichment	SMARCA4, SMARCB1	3.40
18	Kleefstra syndrome	Enrichment	EHMT1, KMT2C	3.40
19	Kleefstra syndrome due to a point mutation	Enrichment	EHMT1, KMT2C	3.40
20	Charge syndrome	Enrichment	EP300, KDM6A, KMT2D	3.22
21	Atrial heart septal defect	Enrichment	ACTL6A, HDAC8, SMARCA4	2.94
22	Interatrial communication	Enrichment	ACTL6A, HDAC8, SMARCA4	2.94
23	Microcephaly	Enrichment	ACTB, ARID1A, ARID1B, BCL11B, EP300, HDAC8, KDM2B, KMT2A, KMT2D	2.93
24	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	2.81
25	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	2.81
26	Nicolaides-baraitser syndrome	Enrichment	ARID1B, SMARCA2	2.63
27	Smarca2-related nicolaides-baraitser syndrome	Enrichment	ARID1B, SMARCA2	2.63
28	Myeloproliferative neoplasm	Enrichment	DNMT3A, JAK2	2.42
29	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	ARID1A, ARID1B, BCL11A	2.37
30	Wiedemann-steiner syndrome	Enrichment	ARID1B, KMT2A	2.25
31	Kleefstra syndrome 1	Enrichment	EHMT1, KMT2C	2.25
32	Renal hypoplasia	Enrichment	KAT6B, PRMT7	2.25
33	Hypertrichosis	Enrichment	ARID1B, CREBBP	2.25
34	Diffuse large b-cell lymphoma	Enrichment	CREBBP, DNMT3A, TBL1XR1	2.22
35	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	2.11
36	Leukemia, acute myeloid	Enrichment	DNMT3A, JAK2, KMT2A, NSD1	2.09
37	Craniofacial-deafness-hand syndrome	Enrichment	PAX3	1.98
38	Waardenburg syndrome, type 3	Enrichment	PAX3	1.98
39	Torticollis	Enrichment	ACTL6A	1.98
40	Baraitser-winter syndrome 1	Enrichment	ACTB	1.98
41	Basilicata-akhtar syndrome	Enrichment	MSL3	1.98
42	Neuropathy, hereditary sensory and autonomic, type iii	Enrichment	ELP1	1.98
43	Spermatogenic failure, x-linked, 9	Enrichment	RBBP7	1.98
44	Aniridia 2	Enrichment	ELP4	1.98
45	Intellectual developmental disorder with dysmorphic facies and ptosis	Enrichment	BRPF1	1.98
46	Li-ghorbani-weisz-hubshman syndrome	Enrichment	KAT8	1.98
47	Intellectual developmental disorder, autosomal recessive 58	Enrichment	ELP2	1.98
48	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	1.98
49	Ohdo syndrome, sbbys variant	Enrichment	KAT6B	1.98
50	Becker nevus syndrome	Enrichment	ACTB	1.98
51	Dystonia-deafness syndrome 1	Enrichment	ACTB	1.98
52	Epilepsy, familial adult myoclonic, 4	Enrichment	YEATS2	1.98
53	Arboleda-tham syndrome	Enrichment	KAT6A	1.98
54	Karayol-borroto-haghshenas neurodevelopmental syndrome	Enrichment	MSL2	1.98
55	Harel-tora neurodevelopmental syndrome	Enrichment	ATXN7L3	1.98
56	Deafness, autosomal dominant 75	Enrichment	TRRAP	1.98
57	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	1.98
58	Menke-hennekam syndrome 1	Enrichment	CREBBP	1.98
59	Developmental delay with or without dysmorphic facies and autism	Enrichment	TRRAP	1.98
60	Baraitser-winter syndrome	Enrichment	ACTB	1.98
61	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	1.98
62	Fischer-zirnsak progeroid syndrome	Enrichment	SUPT7L	1.98
63	Kat6b-related multiple congenital anomalies syndrome	Enrichment	KAT6B	1.98
64	Congenital smooth muscle hamartoma	Enrichment	ACTB	1.98
65	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	1.98
66	Menke-hennekam syndrome	Enrichment	CREBBP	1.98
67	Cornelia de lange syndrome 1	Enrichment	HDAC8, KMT2A	1.88
68	Ventricular septal defect	Enrichment	NSD2, SMARCA4	1.88
69	Cornelia de lange syndrome	Enrichment	HDAC8, KMT2A	1.88
70	Autism	Enrichment	ACTL6B, CREBBP, KMT2B, KMT2D, MSL2	1.84
71	Meningioma, familial	Enrichment	SMARCB1, SMARCE1	1.71
72	Specific learning disability	Enrichment	DNMT3A, KMT2B	1.71
73	Intellectual developmental disorder, x-linked, syndromic, siderius type	Enrichment	PHF8	1.70
74	Kabuki syndrome 2	Enrichment	KDM6A	1.70
75	Hypothyroidism, congenital, nongoitrous, 8	Enrichment	TBL1X	1.70
76	Branchial cleft anomalies	Enrichment	KMT2D	1.70
77	Melanoma, cutaneous malignant 3	Enrichment	CDK4	1.70
78	Acanthosis nigricans	Enrichment	PRMT7	1.70
79	Coffin-siris syndrome 5	Enrichment	SMARCE1	1.70
80	Gand syndrome	Enrichment	GATAD2B	1.70
81	Wilms tumor 6	Enrichment	REST	1.70
82	Intellectual developmental disorder with severe speech and ambulation defects	Enrichment	ACTL6B	1.70
83	Coffin-siris syndrome 11	Enrichment	SMARCD1	1.70
84	Neurodevelopmental disorder with speech impairment and dysmorphic facies	Enrichment	SETD1A	1.70
85	Hydrocephalus, congenital, 5	Enrichment	SMARCC1	1.70
86	Intellectual developmental disorder, autosomal dominant 70	Enrichment	SETD2	1.70
87	Cornelia de lange syndrome 5	Enrichment	HDAC8	1.70
88	Ciliary dyskinesia, primary, 51	Enrichment	BRWD1	1.70
89	Syndromic x-linked intellectual disability siderius type	Enrichment	PHF8	1.70
90	Heyn-sproul-jackson syndrome	Enrichment	DNMT3A	1.70
91	Imagawa-matsumoto syndrome	Enrichment	SUZ12	1.70
92	Nil-deshwar neurodevelopmental syndrome	Enrichment	DOT1L	1.70
93	Left ventricular noncompaction 8	Enrichment	PRDM16	1.70
94	Radioulnar synostosis with amegakaryocytic thrombocytopenia 2	Enrichment	MECOM	1.70
95	Intellectual developmental disorder, autosomal recessive 65	Enrichment	KDM5B	1.70
96	Rhabdoid tumor predisposition syndrome 1	Enrichment	SMARCB1	1.70
97	Deafness, autosomal dominant 27	Enrichment	REST	1.70
98	Intellectual developmental disorder with behavioral abnormalities and craniofacial dysmorphism with or without seizures	Enrichment	PHF21A	1.70
99	Cleft palate, psychomotor retardation, and distinctive facial features	Enrichment	KDM1A	1.70
100	Epilepsy, early-onset, 2, with or without developmental delay	Enrichment	SETD1A	1.70
101	Intellectual developmental disorder with seizures and language delay	Enrichment	SETD1B	1.70
102	Neurilemmoma	Enrichment	SMARCB1	1.70
103	Branchial arch abnormalities, choanal atresia, athelia, hearing loss, and hypothyroidism syndrome	Enrichment	KMT2D	1.70
104	Coffin-siris syndrome 3	Enrichment	SMARCB1	1.70
105	Fibromatosis, gingival, 5	Enrichment	REST	1.70
106	Kleefstra syndrome 2	Enrichment	KMT2C	1.70
107	Intellectual developmental disorder, autosomal dominant 51	Enrichment	KMT5B	1.70
108	Intellectual developmental disorder, autosomal dominant 52	Enrichment	ASH1L	1.70
109	Smarca4-deficient sarcoma of thorax	Enrichment	SMARCA4	1.70
110	Arid1b-related disorder	Enrichment	ARID1B	1.70
111	Ovarian small cell carcinoma	Enrichment	SMARCA4	1.70
112	Cohen-gibson syndrome	Enrichment	EED	1.70
113	Short stature, brachydactyly, impaired intellectual development, and seizures	Enrichment	PRMT7	1.70
114	Intellectual developmental disorder, autosomal dominant 68	Enrichment	KMT2B	1.70
115	Rare genetic epilepsy	Enrichment	KDM3B	1.70
116	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	1.70
117	Blepharophimosis-impaired intellectual development syndrome	Enrichment	SMARCA2	1.70
118	Rauch-steindl syndrome	Enrichment	NSD2	1.70
119	Generalized isolated dystonia	Enrichment	KMT2B	1.70
120	Severe intellectual disability-poor language-strabismus-grimacing face-long fingers syndrome	Enrichment	GATAD2B	1.70
121	Central centrifugal cicatricial alopecia	Enrichment	PADI3	1.70
122	Luscan-lumish syndrome	Enrichment	SETD2	1.70
123	Rabin-pappas syndrome	Enrichment	SETD2	1.70
124	Kmt2b-related disorders	Enrichment	KMT2B	1.70
125	Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome	Enrichment	KDM1A	1.70
126	Acute myeloid leukemia with mll rearrangement	Enrichment	KMT2A	1.70
127	Facial cleft	Enrichment	SMARCE1	1.70
128	Acth-independent macronodular adrenal hyperplasia 3	Enrichment	KDM1A	1.70
129	Autosomal recessive severe congenital neutropenia	Enrichment	SMARCD2	1.70
130	5q35 microduplication syndrome	Enrichment	NSD1	1.70
131	Keratitis, hereditary	Enrichment	ELP4	1.68
132	Spinocerebellar ataxia 7	Enrichment	ATXN7	1.68
133	Foveal hypoplasia 1	Enrichment	ELP4	1.68
134	Thumb deformity	Enrichment	CREBBP	1.68
135	Genitopatellar syndrome	Enrichment	KAT6B	1.68
136	Optic nerve hypoplasia, bilateral	Enrichment	ELP4	1.68
137	Neurodevelopmental disorder with dysmorphic facies, sleep disturbance, and brain abnormalities	Enrichment	KAT5	1.68
138	Immunodeficiency, common variable, 15	Enrichment	RUVBL1	1.68
139	Menke-hennekam syndrome 2	Enrichment	EP300	1.68
140	Mitochondrial complex iv deficiency, nuclear type 19	Enrichment	KAT14	1.68
141	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB	1.68
142	3p25.3 microdeletion syndrome	Enrichment	BRPF1	1.68
143	Fetal hemoglobin quantitative trait locus 5	Enrichment	BCL11A	1.68
144	Immunodeficiency 49, severe combined	Enrichment	BCL11B	1.68
145	Intellectual developmental disorder with speech delay, dysmorphic facies, and t-cell abnormalities	Enrichment	BCL11B	1.68
146	Intellectual developmental disorder with persistence of fetal hemoglobin	Enrichment	BCL11A	1.68
147	Coffin-siris syndrome 7	Enrichment	DPF2	1.68
148	Bcl11a-related intellectual disability	Enrichment	BCL11A	1.68
149	Meningioma	Enrichment	SMARCB1, SMARCE1	1.64
150	Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly	Enrichment	KAT6B, NSD2	1.57
151	Clubfoot	Enrichment	KAT6B, NSD2	1.57
152	Cleidocranial dysplasia 1	Enrichment	SUPT3H	1.51
153	Retinal arteries, tortuosity of	Enrichment	KAT6B	1.51
154	Telecanthus	Enrichment	KAT6B	1.51
155	Methylmalonic aciduria and homocystinuria, cblx type	Enrichment	HCFC1	1.51
156	Epilepsy, familial temporal lobe, 1	Enrichment	KAT6B	1.51
157	Neurodevelopmental disorder with progressive spasticity and brain abnormalities	Enrichment	RUVBL1	1.51
158	Microangiopathy and leukoencephalopathy, pontine, autosomal dominant	Enrichment	KAT6B	1.51
159	Tethered spinal cord syndrome	Enrichment	CREBBP	1.51
160	Umbilical hernia	Enrichment	ACTL6A	1.51
161	Koolen-de vries syndrome	Enrichment	KANSL1	1.51
162	Angiopathy, hereditary, with nephropathy, aneurysms, and muscle cramps	Enrichment	KAT6B	1.51
163	Cleidocranial dysplasia	Enrichment	SUPT3H	1.51
164	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	1.51
165	Renal cell carcinoma, nonpapillary	Enrichment	PBRM1, SETD2	1.45
166	Polydactyly, postaxial, type a1	Enrichment	BCL11A, EP300	1.41
167	Holoprosencephaly 2	Enrichment	NSD1	1.40
168	Fibromatosis, gingival, 1	Enrichment	REST	1.40
169	Alopecia, androgenetic, 1	Enrichment	SMARCD1	1.40
170	Trichomegaly	Enrichment	ARID1B	1.40
171	Specific granule deficiency 1	Enrichment	SMARCD2	1.40
172	Rhabdoid tumor predisposition syndrome 2	Enrichment	SMARCA4	1.40
173	Macroglossia	Enrichment	NSD2	1.40
174	Schwannomatosis 1	Enrichment	SMARCB1	1.40
175	Complement component c1s deficiency	Enrichment	KMT2D	1.40
176	Chromosome 6q24-q25 deletion syndrome	Enrichment	ARID1B	1.40
177	Sifrim-hitz-weiss syndrome	Enrichment	CHD4	1.40
178	Choanal atresia, posterior	Enrichment	KMT2D	1.40
179	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.40
180	Immunodeficiency, common variable, 10	Enrichment	NFKB2	1.40
181	Thrombocythemia 3	Enrichment	JAK2	1.40
182	Syndactyly, type iii	Enrichment	HDAC8	1.40
183	Uncombable hair syndrome 1	Enrichment	PADI3	1.40
184	Severe combined immunodeficiency with sensitivity to ionizing radiation	Enrichment	ARID1B	1.40
185	Intellectual developmental disorder, autosomal dominant 65	Enrichment	KDM4B	1.40
186	Coffin-siris syndrome 6	Enrichment	ARID2	1.40
187	Epilepsy, progressive myoclonic, 12	Enrichment	PRMT7	1.40
188	Specific granule deficiency 2	Enrichment	SMARCD2	1.40
189	Snijders blok-campeau syndrome	Enrichment	CHD3	1.40
190	Coffin-siris syndrome 8	Enrichment	SMARCC2	1.40
191	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	1.40
192	Wilson-turner syndrome	Enrichment	HDAC8	1.40
193	Diets-jongmans syndrome	Enrichment	KDM3B	1.40
194	Rela fusion-positive ependymoma	Enrichment	RELA	1.40
195	Otosclerosis 12	Enrichment	SMARCA4	1.40
196	El hayek-chahrour neurodevelopmental syndrome	Enrichment	KDM5A	1.40
197	Coffin-siris syndrome 4	Enrichment	SMARCA4	1.40
198	Tatton-brown-rahman syndrome	Enrichment	DNMT3A	1.40
199	Polycythemia	Enrichment	JAK2	1.40
200	Stolerman neurodevelopmental syndrome	Enrichment	KDM6B	1.40
201	Blepharophimosis - intellectual disability syndrome	Enrichment	SMARCA2	1.40
202	Dystonia 28, childhood-onset	Enrichment	KMT2B	1.40
203	Fissured tongue	Enrichment	NSD2	1.40
204	Developmental and epileptic encephalopathy 76	Enrichment	ACTL6B	1.40
205	Bronchiectasis	Enrichment	BRWD1	1.40
206	Radioulnar synostosis	Enrichment	MECOM	1.40
207	Deletion 5q35	Enrichment	NSD1	1.40
208	Hypereosinophilic syndrome	Enrichment	JAK2	1.40
209	Acute myeloid leukemia with t(9;11)(p22;q23)	Enrichment	KMT2A	1.40
210	Acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2)	Enrichment	MECOM	1.40
211	Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2)	Enrichment	KMT2A	1.40
212	B-lymphoblastic leukemia/lymphoma with t	Enrichment	KMT2A	1.40
213	Common variable immunodeficiency 12	Enrichment	NFKB1	1.40
214	Radio-ulnar synostosis-amegakaryocytic thrombocytopenia syndrome	Enrichment	MECOM	1.40
215	Specific granule deficiency	Enrichment	SMARCD2	1.40
216	Brain small vessel disease 1 with or without ocular anomalies	Enrichment	KAT6B	1.39
217	Aniridia 1	Enrichment	ELP4	1.39
218	Aminoacylase 1 deficiency	Enrichment	ACTB	1.39
219	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.39
220	Coffin-siris syndrome 12	Enrichment	BICRA	1.38
221	Malignant granular cell myoblastoma	Enrichment	BRD7	1.38
222	Granular cell carcinoma	Enrichment	BRD7	1.38
223	Dandy-walker syndrome	Enrichment	KMT2D, SETD2	1.35
224	Syndromic intellectual disability	Enrichment	KAT6A, NSD2	1.35
225	Inherited cancer-predisposing syndrome	Enrichment	CDK4, EZH2, MECOM, SMARCA4, SMARCB1, SMARCE1	1.31
226	Kbg syndrome	Enrichment	KAT6B	1.29
227	Fabry disease	Enrichment	ELP1	1.29
228	Rhabdomyosarcoma 2	Enrichment	PAX3	1.29
229	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.29
230	Familial porencephaly	Enrichment	KAT6B	1.29
231	Dystonia 12	Enrichment	KMT2B	1.23
232	Visceral steatosis, congenital	Enrichment	PRMT7	1.23
233	Polycythemia vera	Enrichment	JAK2	1.23
234	Intellectual developmental disorder, x-linked, syndromic, claes-jensen type	Enrichment	KDM5C	1.23
235	Pierpont syndrome	Enrichment	TBL1XR1	1.23
236	Oocyte/zygote/embryo maturation arrest 16	Enrichment	PADI6	1.23
237	Nail disorder, nonsyndromic congenital, 9	Enrichment	ARID1B	1.23
238	Coffin-siris syndrome 2	Enrichment	ARID1A	1.23
239	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2	1.23
240	Dedifferentiated liposarcoma	Enrichment	CDK4	1.23
241	Atypical teratoid rhabdoid tumor	Enrichment	SMARCB1	1.23
242	Periventricular leukomalacia	Enrichment	ARID1A	1.23
243	Intellectual developmental disorder, autosomal dominant 41	Enrichment	TBL1XR1	1.23
244	Desmoplastic/nodular medulloblastoma	Enrichment	ARID2	1.23
245	Schwannomatosis	Enrichment	SMARCB1	1.23
246	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	KDM1A	1.23
247	Syndromic x-linked intellectual disability claes-jensen type	Enrichment	KDM5C	1.23
248	Well-differentiated liposarcoma	Enrichment	CDK4	1.23
249	Mixed phenotype acute leukemia with t	Enrichment	KMT2A	1.23
250	Steatotic liver disease	Enrichment	PRMT7	1.23
251	Coloboma of optic nerve	Enrichment	ELP4	1.22
252	Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndrome	Enrichment	ELP4	1.22
253	Anterior segment dysgenesis 5	Enrichment	ELP4	1.22
254	Hemorrhage, intracerebral	Enrichment	KAT6B	1.22
255	Familial adult myoclonic epilepsy	Enrichment	YEATS2	1.22
256	Inguinal hernia	Enrichment	ACTL6A	1.22
257	Waardenburg syndrome	Enrichment	PAX3	1.22
258	Sarcoma, synovial	Enrichment	SS18	1.21
259	Waardenburg syndrome, type 1	Enrichment	PAX3	1.15
260	Squamous cell carcinoma, head and neck	Enrichment	ING3	1.15
261	Vesicoureteral reflux	Enrichment	KAT6B	1.15
262	Erythrocytosis, familial, 1	Enrichment	JAK2	1.11
263	Budd-chiari syndrome	Enrichment	JAK2	1.11
264	Microtia-anotia	Enrichment	KMT2D	1.11
265	Potocki-shaffer syndrome	Enrichment	PHF21A	1.11
266	Lipodystrophy, congenital generalized, type 2	Enrichment	ACTL6B	1.11
267	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.11
268	Intellectual developmental disorder, autosomal dominant 26	Enrichment	KMT2D	1.11
269	Mantle cell lymphoma	Enrichment	CCND1	1.11
270	Sotos syndrome 1	Enrichment	NSD1	1.11
271	Full schwannomatosis	Enrichment	SMARCB1	1.11
272	Clear cell papillary renal cell carcinoma	Enrichment	PBRM1	1.11
273	Gingival fibromatosis	Enrichment	REST	1.11
274	Autosomal dominant non-syndromic intellectual disability	Enrichment	ASH1L, KDM5B, SETD1B	1.11
275	Glioma susceptibility 1	Enrichment	H3C1	1.10
276	Gastroesophageal reflux	Enrichment	ACTL6A	1.10
277	Methylmalonic aciduria and homocystinuria, cblc type	Enrichment	HCFC1	1.10
278	Cryptorchidism	Enrichment	KAT6B	1.10
279	Scoliosis	Enrichment	CREBBP, NSD1	1.08
280	Hypertelorism	Enrichment	ELP4, KAT6B, NSD1	1.07
281	Rheumatoid arthritis	Enrichment	SUPT20H	1.05
282	Cryptorchidism, unilateral or bilateral	Enrichment	KAT6B	1.05
283	Hydrops fetalis, nonimmune	Enrichment	ARID1A, NSD1	1.02
284	Sotos syndrome	Enrichment	NSD1	1.02
285	Von hippel-lindau syndrome	Enrichment	CCND1	1.02
286	Pre-eclampsia	Enrichment	NSD1	1.02
287	Amblyopia	Enrichment	KMT2D	1.02
288	Lymphoma	Enrichment	KMT2D	1.02
289	Glioblastoma	Enrichment	DNMT3A	1.02
290	Hypoglycemia	Enrichment	NSD2	1.02
291	Acute megakaryocytic leukemia	Enrichment	KMT2A	1.02
292	Endometrial stromal sarcoma	Enrichment	SUZ12	1.02
293	Peters-plus syndrome	Enrichment	ELP4	1.00
294	Hereditary persistence of fetal hemoglobin-sickle cell disease syndrome	Enrichment	BCL11A	1.00
295	Bladder cancer	Enrichment	ARID1A, KDM6A	0.94
296	Primary ovarian insufficiency	Enrichment	BRWD1, JAK2, MECOM	0.94
297	Dyskeratosis congenita, autosomal dominant 1	Enrichment	MECOM	0.94
298	Wolf-hirschhorn syndrome	Enrichment	NSD2	0.94
299	Clear cell renal cell carcinoma	Enrichment	PBRM1	0.94
300	Early myoclonic encephalopathy	Enrichment	PRMT7	0.94
301	Sporadic pheochromocytoma/secreting paraganglioma	Enrichment	DNMT3A	0.94
302	Epicanthus	Enrichment	KAT6B	0.93
303	Non-immune hydrops fetalis	Enrichment	ARID1A, NSD1	0.90
304	Microphthalmia/coloboma 12	Enrichment	ELP4	0.90
305	Myelofibrosis	Enrichment	JAK2	0.88
306	Dyskeratosis congenita, autosomal dominant 2	Enrichment	MECOM	0.88
307	Brachydactyly	Enrichment	PRMT7	0.88
308	Essential thrombocythemia	Enrichment	JAK2	0.88
309	Congenital hydrocephalus	Enrichment	SMARCC1	0.88
310	Overgrowth syndrome	Enrichment	NSD1	0.88
311	Medulloblastoma	Enrichment	ELP1	0.87
312	Heart disease	Enrichment	CREBBP	0.87
313	Coloboma of macula	Enrichment	ELP4	0.84
314	Fanconi anemia, complementation group c	Enrichment	HDAC8	0.83
315	Neuroblastoma	Enrichment	SMARCA4	0.83
316	Polycystic liver disease	Enrichment	RUVBL1	0.79
317	Autosomal dominant polycystic liver disease	Enrichment	RUVBL1	0.79
318	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	0.78
319	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	SETD1A	0.78
320	Leukemia, chronic lymphocytic	Enrichment	CCND1	0.74
321	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	0.74
322	Polymicrogyria	Enrichment	EHMT1	0.74
323	Melanoma	Enrichment	DNMT3A	0.74
324	Primary bone dysplasia	Enrichment	PRMT7	0.74
325	Craniosynostosis	Enrichment	KAT6A	0.72
326	Osteochondrodysplasia	Enrichment	PRMT7	0.70
327	Combined immunodeficiency	Enrichment	BCL11B	0.68
328	Combined t cell and b cell immunodeficiency	Enrichment	BCL11B	0.68
329	Combined t and b cell immunodeficiency	Enrichment	BCL11B	0.68
330	Septooptic dysplasia	Enrichment	ARID1A	0.67
331	Hypercholesterolemia, familial, 1	Enrichment	SMARCA4	0.64
332	Neural tube defects	Enrichment	KMT5B	0.64
333	Acute promyelocytic leukemia	Enrichment	TBL1XR1	0.64
334	Chromosome 1p36 deletion syndrome	Enrichment	PRDM16	0.64
335	Protein-deficiency anemia	Enrichment	NSD2	0.64
336	Nk-cell enteropathy	Enrichment	SMARCB1	0.64
337	Pituitary stalk interruption syndrome	Enrichment	SMARCA2	0.61
338	Thrombocytopenia	Enrichment	MECOM, NSD2	0.60
339	Colorectal cancer	Enrichment	ARID1A, CCND1, EP300	0.60
340	Wilms tumor 1	Enrichment	REST	0.58
341	Familial hypercholesterolemia	Enrichment	SMARCA4	0.58
342	Male infertility with spermatogenesis disorder	Enrichment	KMT2D	0.58
343	Body mass index quantitative trait locus 11	Enrichment	DNMT3A, PRMT7	0.58
344	Hydrocephalus, congenital, 1	Enrichment	SETD2	0.56
345	Gliosarcoma	Enrichment	DNMT3A	0.56
346	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	REST, TRRAP	0.55
347	Melanoma, cutaneous malignant 1	Enrichment	CDK4	0.54
348	Cleft palate, isolated	Enrichment	SMARCA4	0.54
349	Giant cell glioblastoma	Enrichment	DNMT3A	0.54
350	Cakut	Enrichment	KAT6B	0.52
351	Beckwith-wiedemann syndrome	Enrichment	NSD1	0.52
352	Polycystic kidney disease	Enrichment	HDAC8	0.52
353	Non-syndromic x-linked intellectual disability	Enrichment	HCFC1	0.50
354	Schizophrenia	Enrichment	EHMT1, SETD1A	0.48
355	Congenital nervous system abnormality	Enrichment	CREBBP, DNMT3A, KMT2D	0.45
356	Nervous system disease	Enrichment	CREBBP, DNMT3A, KMT2D	0.45
357	Strabismus	Enrichment	KMT2D	0.38
358	Visceral heterotaxy 5	Enrichment	BRWD1	0.33
359	Lung cancer	Enrichment	KMT2D	0.32
360	Male infertility	Enrichment	BRWD1	0.30
361	Left ventricular noncompaction	Enrichment	PRDM16	0.30
362	Dystonia	Enrichment	KMT2B	0.30
363	Cerebral palsy	Enrichment	SMARCA4	0.26
364	Epilepsy	Enrichment	SETD1B	0.26
365	Rare genetic deafness	Enrichment	PAX3	0.25
366	Type 2 diabetes mellitus	Enrichment	PRMT7	0.24
367	Gastric cancer	Enrichment	CDK4	0.24
368	Hypertrophic cardiomyopathy	Enrichment	NSD2	0.24
369	West syndrome	Enrichment	KDM2B	0.23
370	Joubert syndrome 1	Enrichment	RCOR1	0.20
371	Familial isolated dilated cardiomyopathy	Enrichment	PRDM16	0.18
372	Undetermined early-onset epileptic encephalopathy	Enrichment	ACTL6B	0.17
373	Autosomal recessive non-syndromic intellectual disability	Enrichment	KDM5B	0.16
374	Ovarian cancer	Enrichment	SMARCB1	0.06

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Chromatin modifying enzymes

Pathway Network for Chromatin modifying enzymes

Pathway network for the Chromatin modifying enzymes SuperPath

Member Pathways for Chromatin modifying enzymes

Pathways in the Chromatin modifying enzymes SuperPath

Gene overlap in member pathways for Chromatin modifying enzymes SuperPath

Associated Genes for Chromatin modifying enzymes

Associated Disorders for Chromatin modifying enzymes

Disorders associated with Chromatin modifying enzymes SuperPath

STRING Interaction Network for Chromatin modifying enzymes

Sources for Chromatin modifying enzymes