CKAP4 signaling pathway map

No Pathway Network information available for CKAP4 signaling pathway map

Pathways in the CKAP4 signaling pathway map SuperPath

#	Name	Source	Genes
1	CKAP4 signaling pathway map	WikiPathways	ABCG2 AKT1 ANGPTL2 APAF1 ATM BAX BCL2L11 BIRC5 BMI1 BRCA1 CAND1 CASP1 CASP3 CASP4 CASP5 CASP8 CASP9 CCN2 CCNB1 CCNB2 CCND1 CCNE1 CD44 CD74 CDH1 CDK1 CDK4 CDKN1B CHEK2 CKAP4 COMMD3-BMI1 CTNNB1 DAP3 DKK1 DKK3 DSP DUSP6 E2F1 EGFR ESR1 FAS FBXO3 FBXW7 GLI2 GOLPH3 GSK3B HSPA1A IL6R ITGA5 ITGB1 ITGB4 JUN KDR LEF1 MAP2K1 MAP2K2 MAPK1 MAPK14 MAPKAPK3 MDM2 MIF MIR527 MIR665 MMP1 MMP14 MMP9 MYC MYCN NANOG NFKB1 NGFR OCLN PARD3 PFDN5 PIK3CA PLAU PLVAP POU5F1 PTCH1 PTEN PTGER3 PTK2B RAD9A RELA RPS6KA6 SERPINE1 SHH SMAD3 SMAD4 SNAI1 SOX2 SP1 SRC STAT1 SUSD2 TCF7 TGFB1 TGFB2 TGFBR1 TGFBR2 TJP1 TNF TNFRSF10A TNFRSF10B TNFRSF1A TP53 TRAF1 TWIST1 VIM WASF3 WNT3A ZEB1 (see all 112) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PLVAP	Plasmalemma Vesicle Associated Protein	Protein Coding	1
2	GOLPH3	Golgi Phosphoprotein 3	Protein Coding	1
3	FBXO3	F-Box Protein 3	Protein Coding	1
4	RPS6KA6	Ribosomal Protein S6 Kinase A6	Protein Coding	1
5	WASF3	WASP Family Member 3	Protein Coding	1
6	FBXW7	F-Box And WD Repeat Domain Containing 7	Protein Coding	1
7	DKK1	Dickkopf Wnt Signaling Pathway Inhibitor 1	Protein Coding	1
8	DKK3	Dickkopf Wnt Signaling Pathway Inhibitor 3	Protein Coding	1
9	TCF7	Transcription Factor 7	Protein Coding	1
10	IL6R	Interleukin 6 Receptor	Protein Coding	1
11	CCN2	Cellular Communication Network Factor 2	Protein Coding	1
12	CKAP4	Cytoskeleton Associated Protein 4	Protein Coding	1
13	PFDN5	Prefoldin Subunit 5	Protein Coding	1
14	CCNB2	Cyclin B2	Protein Coding	1
15	CCNE1	Cyclin E1	Protein Coding	1
16	MAPKAPK3	MAPK Activated Protein Kinase 3	Protein Coding	1
17	NGFR	Nerve Growth Factor Receptor	Protein Coding	1
18	BIRC5	Baculoviral IAP Repeat Containing 5	Protein Coding	1
19	BMI1	BMI1 Proto-Oncogene, Polycomb Ring Finger	Protein Coding	1
20	COMMD3-BMI1	COMMD3-BMI1 Readthrough	Protein Coding	1
21	WNT3A	Wnt Family Member 3A	Protein Coding	1
22	PTGER3	Prostaglandin E Receptor 3	Protein Coding	1
23	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	1
24	CHEK2	Checkpoint Kinase 2	Protein Coding	1
25	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
26	PTEN	Phosphatase And Tensin Homolog	Protein Coding	1
27	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	1
28	CD74	CD74 Molecule	Protein Coding	1
29	MIF	Macrophage Migration Inhibitory Factor	Protein Coding	1
30	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
31	MMP1	Matrix Metallopeptidase 1	Protein Coding	1
32	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	1
33	PTK2B	Protein Tyrosine Kinase 2 Beta	Protein Coding	1
34	PARD3	Par-3 Family Cell Polarity Regulator	Protein Coding	1
35	ZEB1	Zinc Finger E-Box Binding Homeobox 1	Protein Coding	1
36	CTNNB1	Catenin Beta 1	Protein Coding	1
37	DSP	Desmoplakin	Protein Coding	1
38	SOX2	SRY-Box Transcription Factor 2	Protein Coding	1
39	NANOG	Nanog Homeobox	Protein Coding	1
40	POU5F1	POU Class 5 Homeobox 1	Protein Coding	1
41	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
42	CDK4	Cyclin Dependent Kinase 4	Protein Coding	1
43	SMAD3	SMAD Family Member 3	Protein Coding	1
44	ITGA5	Integrin Subunit Alpha 5	Protein Coding	1
45	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
46	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
47	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
48	CDK1	Cyclin Dependent Kinase 1	Protein Coding	1
49	CAND1	Cullin Associated And Neddylation Dissociated 1	Protein Coding	1
50	MDM2	MDM2 Proto-Oncogene	Protein Coding	1
51	KDR	Kinase Insert Domain Receptor	Protein Coding	1
52	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
53	CCNB1	Cyclin B1	Protein Coding	1
54	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
55	ATM	ATM Serine/Threonine Kinase	Protein Coding	1
56	TP53	Tumor Protein P53	Protein Coding	1
57	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
58	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
59	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
60	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
61	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	1
62	MMP9	Matrix Metallopeptidase 9	Protein Coding	1
63	ESR1	Estrogen Receptor 1	Protein Coding	1
64	ABCG2	ATP Binding Cassette Subfamily G Member 2 (JR Blood Group)	Protein Coding	1
65	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
66	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
67	CDH1	Cadherin 1	Protein Coding	1
68	CD44	CD44 Molecule (IN Blood Group)	Protein Coding	1
69	TNFRSF10A	TNF Receptor Superfamily Member 10a	Protein Coding	1
70	TNFRSF10B	TNF Receptor Superfamily Member 10b	Protein Coding	1
71	CASP9	Caspase 9	Protein Coding	1
72	CASP8	Caspase 8	Protein Coding	1
73	CASP4	Caspase 4	Protein Coding	1
74	CASP3	Caspase 3	Protein Coding	1
75	CASP1	Caspase 1	Protein Coding	1
76	DAP3	Death Associated Protein 3	Protein Coding	1
77	VIM	Vimentin	Protein Coding	1
78	TWIST1	Twist Family BHLH Transcription Factor 1	Protein Coding	1
79	TRAF1	TNF Receptor Associated Factor 1	Protein Coding	1
80	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	1
81	TNF	Tumor Necrosis Factor	Protein Coding	1
82	TJP1	Tight Junction Protein 1	Protein Coding	1
83	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	1
84	SP1	Sp1 Transcription Factor	Protein Coding	1
85	SNAI1	Snail Family Transcriptional Repressor 1	Protein Coding	1
86	SHH	Sonic Hedgehog Signaling Molecule	Protein Coding	1
87	CCND1	Cyclin D1	Protein Coding	1
88	RAD9A	RAD9 Checkpoint Clamp Component A	Protein Coding	1
89	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	1
90	PTCH1	Patched 1	Protein Coding	1
91	PLAU	Plasminogen Activator, Urokinase	Protein Coding	1
92	LEF1	Lymphoid Enhancer Binding Factor 1	Protein Coding	1
93	SERPINE1	Serpin Family E Member 1	Protein Coding	1
94	MYCN	MYCN Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
95	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
96	MMP14	Matrix Metallopeptidase 14	Protein Coding	1
97	SMAD4	SMAD Family Member 4	Protein Coding	1
98	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
99	ITGB4	Integrin Subunit Beta 4	Protein Coding	1
100	FAS	Fas Cell Surface Death Receptor	Protein Coding	1
101	HSPA1A	Heat Shock Protein Family A (Hsp70) Member 1A	Protein Coding	1
102	APAF1	Apoptotic Peptidase Activating Factor 1	Protein Coding	1
103	GLI2	GLI Family Zinc Finger 2	Protein Coding	1
104	E2F1	E2F Transcription Factor 1	Protein Coding	1
105	DUSP6	Dual Specificity Phosphatase 6	Protein Coding	1
106	OCLN	Occludin	Protein Coding	1
107	BCL2L11	BCL2 Like 11	Protein Coding	1
108	MIR665	MicroRNA 665	RNA Gene	1
109	CASP5	Caspase 5	Protein Coding	1
110	MIR527	MicroRNA 527	RNA Gene	1
111	SUSD2	Sushi Domain Containing 2	Protein Coding	1
112	ANGPTL2	Angiopoietin Like 2	Protein Coding	1

Disorders associated with CKAP4 signaling pathway map SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Colorectal cancer	Enrichment	AKT1, ATM, BAX, BRCA1, CCND1, CDH1, CHEK2, CTNNB1, FBXW7, PIK3CA, SMAD4, SRC, TP53	10.65
2	Breast cancer	Enrichment	AKT1, ATM, BRCA1, CASP8, CDH1, CHEK2, ESR1, JUN, PIK3CA, PTEN, TP53	10.56
3	Ovarian cancer	Enrichment	AKT1, ATM, BRCA1, CDH1, CDKN1B, CHEK2, CTNNB1, EGFR, PIK3CA, PTCH1, PTEN, TP53	10.50
4	Gastric cancer	Enrichment	ATM, BRCA1, CDH1, CDK4, CHEK2, PIK3CA, PTEN, SMAD4, TP53	10.13
5	Hereditary breast carcinoma	Enrichment	AKT1, ATM, BRCA1, CDH1, CHEK2, ESR1, PIK3CA, PTEN, TP53	10.04
6	Bladder cancer	Enrichment	ATM, BRCA1, CTNNB1, EGFR, PIK3CA, PTEN, TP53	8.53
7	Prostate cancer	Enrichment	ATM, BRCA1, CDH1, CHEK2, PIK3CA, PTEN, TP53	8.53
8	Inherited cancer-predisposing syndrome	Enrichment	ATM, BRCA1, CDH1, CDK4, CDKN1B, CHEK2, EGFR, PTCH1, PTEN, SMAD4, TP53	7.95
9	Endometrial cancer	Enrichment	ATM, BRCA1, CDH1, CHEK2, PIK3CA, PTEN	7.87
10	Squamous cell carcinoma, head and neck	Enrichment	EGFR, PTEN, TNFRSF10B, TP53	6.82
11	Gallbladder cancer	Enrichment	CTNNB1, PIK3CA, SMAD4, TP53	6.82
12	Lung cancer	Enrichment	BRCA1, CASP8, CHEK2, EGFR, FAS, PIK3CA	6.68
13	Loeys-dietz syndrome	Enrichment	SMAD3, TGFB2, TGFBR1, TGFBR2	6.27
14	Adult hepatocellular carcinoma	Enrichment	CASP8, CTNNB1, PIK3CA, TP53	6.27
15	Uterine corpus cancer	Enrichment	ATM, BRCA1, CHEK2, PTEN	5.86
16	Pancreatic cancer	Enrichment	ATM, BRCA1, CHEK2, SMAD4, TP53	5.79
17	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, BRCA1, CHEK2, PTCH1, PTEN, TP53	5.24
18	Rhabdomyosarcoma	Enrichment	BRCA1, PTCH1, PTEN, TP53	5.13
19	Li-fraumeni syndrome	Enrichment	CHEK2, MDM2, TP53	4.97
20	Cowden syndrome 1	Enrichment	EGFR, PIK3CA, PTEN	4.97
21	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA, TP53	4.97
22	Hepatocellular carcinoma	Enrichment	CASP8, CTNNB1, PIK3CA, TP53	4.54
23	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD3, SMAD4, TGFB2, TGFBR1, TGFBR2	4.53
24	Cowden syndrome	Enrichment	AKT1, PIK3CA, PTEN	4.35
25	Marfan syndrome	Enrichment	TGFB2, TGFBR1, TGFBR2	4.20
26	Leukemia, chronic lymphocytic	Enrichment	ATM, CCND1, TP53	4.20
27	Loeys-dietz syndrome 2	Enrichment	TGFBR1, TGFBR2	4.17
28	Li-fraumeni syndrome 1	Enrichment	CHEK2, TP53	4.17
29	Sarcoma	Enrichment	CHEK2, TP53	4.17
30	Lung non-small cell carcinoma	Enrichment	EGFR, MAP2K1, PIK3CA	4.06
31	Meningioma	Enrichment	AKT1, PIK3CA, PTEN	3.94
32	Lip and oral cavity carcinoma	Enrichment	EGFR, PIK3CA, TP53	3.94
33	Breast-ovarian cancer, familial 1	Enrichment	ATM, BRCA1, CHEK2	3.83
34	Osteogenic sarcoma	Enrichment	CHEK2, TP53	3.70
35	Osteoporosis, juvenile	Enrichment	DKK1, WNT3A	3.70
36	Dedifferentiated liposarcoma	Enrichment	CDK4, MDM2	3.70
37	Loeys-dietz syndrome 1	Enrichment	TGFBR1, TGFBR2	3.70
38	Adenocarcinoma	Enrichment	ATM, TP53	3.70
39	Migraine without aura	Enrichment	ESR1, TNF	3.70
40	Laryngeal squamous cell carcinoma	Enrichment	PTEN, TNFRSF10B	3.70
41	Bone osteosarcoma	Enrichment	CHEK2, TP53	3.70
42	Well-differentiated liposarcoma	Enrichment	CDK4, MDM2	3.70
43	Lynch syndrome	Enrichment	CHEK2, PIK3CA, TGFBR2	3.63
44	Septopreoptic holoprosencephaly	Enrichment	GLI2, PTCH1, SHH	3.63
45	Midline interhemispheric variant of holoprosencephaly	Enrichment	GLI2, PTCH1, SHH	3.63
46	Gliosarcoma	Enrichment	ATM, EGFR, TP53	3.55
47	Microform holoprosencephaly	Enrichment	GLI2, PTCH1, SHH	3.55
48	Lobar holoprosencephaly	Enrichment	GLI2, PTCH1, SHH	3.55
49	Giant cell glioblastoma	Enrichment	ATM, EGFR, TP53	3.47
50	Alobar holoprosencephaly	Enrichment	GLI2, PTCH1, SHH	3.47
51	Polydactyly, preaxial ii	Enrichment	PTCH1, SHH	3.40
52	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1, MAP2K2	3.40
53	Mantle cell lymphoma	Enrichment	ATM, CCND1	3.40
54	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1, MAP2K2	3.40
55	Aortic aneurysm	Enrichment	SMAD3, TGFBR1	3.40
56	Semilobar holoprosencephaly	Enrichment	GLI2, PTCH1, SHH	3.39
57	Diffuse large b-cell lymphoma	Enrichment	CHEK2, PTEN, TP53	3.32
58	Ehlers-danlos syndrome	Enrichment	SMAD3, TGFB2, TGFBR2	3.32
59	Macs syndrome	Enrichment	PTCH1, SHH, SOX2	3.25
60	Acute megakaryocytic leukemia	Enrichment	PTEN, TP53	3.18
61	Hemimegalencephaly	Enrichment	PIK3CA, PTEN	3.18
62	Adrenocortical carcinoma	Enrichment	CTNNB1, TP53	3.00
63	Lung squamous cell carcinoma	Enrichment	EGFR, PIK3CA	3.00
64	Esophageal cancer	Enrichment	TGFBR2, TP53	2.86
65	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, PIK3CA	2.86
66	Arteriovenous malformation	Enrichment	MAP2K1, PIK3CA	2.63
67	Colonic benign neoplasm	Enrichment	ATM, CHEK2	2.63
68	Lynch syndrome 1	Enrichment	ATM, CHEK2	2.54
69	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1, PIK3CA	2.54
70	Melanoma	Enrichment	CHEK2, PTEN	2.54
71	Familial colorectal cancer type x	Enrichment	ATM, CHEK2	2.45
72	Septooptic dysplasia	Enrichment	SHH, SOX2	2.37
73	Neural tube defects	Enrichment	ITGB1, PARD3	2.30
74	Multiple sclerosis	Enrichment	ITGB4, TNFRSF1A	2.24
75	Medulloblastoma	Enrichment	CTNNB1, PTCH1	2.24
76	Lung cancer susceptibility 3	Enrichment	EGFR, TP53	2.24
77	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1, MAP2K2	2.18
78	Periodic fever, familial, autosomal dominant	Enrichment	TNFRSF1A	2.08
79	Holoprosencephaly 3	Enrichment	SHH	2.08
80	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	2.08
81	Chiari malformation type i	Enrichment	DKK1	2.08
82	Macrodactyly	Enrichment	PIK3CA	2.08
83	Proteus syndrome	Enrichment	AKT1	2.08
84	Pseudo-torch syndrome 1	Enrichment	OCLN	2.08
85	Vacterl association with hydrocephalus	Enrichment	PTEN	2.08
86	Caspase 8 deficiency	Enrichment	CASP8	2.08
87	Melanoma, cutaneous malignant 3	Enrichment	CDK4	2.08
88	Schilbach-rott syndrome	Enrichment	PTCH1	2.08
89	Melorheostosis, isolated	Enrichment	MAP2K1	2.08
90	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.08
91	Microphthalmia/coloboma 5	Enrichment	SHH	2.08
92	Uric acid concentration, serum, quantitative trait locus 1	Enrichment	ABCG2	2.08
93	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	2.08
94	Cowden syndrome 5	Enrichment	PIK3CA	2.08
95	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.08
96	Culler-jones syndrome	Enrichment	GLI2	2.08
97	Accelerated tumor formation	Enrichment	MDM2	2.08
98	Ectodermal dysplasia 17 with or without limb malformations	Enrichment	LEF1	2.08
99	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.08
100	Noonan syndrome 13	Enrichment	MAPK1	2.08
101	Lessel-kubisch syndrome	Enrichment	MDM2	2.08
102	Bone marrow failure syndrome 5	Enrichment	TP53	2.08
103	Winchester syndrome	Enrichment	MMP14	2.08
104	Diarrhea 10, protein-losing enteropathy type	Enrichment	PLVAP	2.08
105	Papilloma of choroid plexus	Enrichment	TP53	2.08
106	Basal cell carcinoma 7	Enrichment	TP53	2.08
107	Anaplastic thyroid carcinoma	Enrichment	TP53	2.08
108	Infant-type hemispheric glioma	Enrichment	BRCA1	2.08
109	Plasminogen activator inhibitor-1 deficiency	Enrichment	SERPINE1	2.08
110	Papillary tumor of the pineal region	Enrichment	PTEN	2.08
111	Tumor predisposition syndrome 4	Enrichment	CHEK2	2.08
112	Camurati-engelmann disease 2	Enrichment	TGFB2	2.08
113	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.08
114	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.08
115	Melorheostosis	Enrichment	MAP2K1	2.08
116	Neuroendocrine tumor	Enrichment	CDKN1B	2.08
117	Holoprosencephaly 9	Enrichment	GLI2	2.08
118	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	2.08
119	Interleukin 6, serum level of, quantitative trait locus	Enrichment	IL6R	2.08
120	Immunodeficiency 31a	Enrichment	STAT1	2.08
121	Soluble interleukin-6 receptor, serum level of, quantitative trait locus	Enrichment	IL6R	2.08
122	Multiple sclerosis 5	Enrichment	TNFRSF1A	2.08
123	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.08
124	Cowden syndrome 6	Enrichment	AKT1	2.08
125	Hyper-ige syndrome 5, autosomal recessive, with recurrent infections	Enrichment	IL6R	2.08
126	Hypogonadotropic hypogonadism 19 with or without anosmia	Enrichment	DUSP6	2.08
127	Endometrial serous adenocarcinoma	Enrichment	ATM	2.08
128	Immunodeficiency 31b	Enrichment	STAT1	2.08
129	Glioma susceptibility 2	Enrichment	PTEN	2.08
130	Macular dystrophy, patterned, 3	Enrichment	MAPKAPK3	2.08
131	Ductal carcinoma in situ	Enrichment	TP53	2.08
132	Blood group, junior system	Enrichment	ABCG2	2.08
133	Tnf receptor-associated periodic fever syndrome	Enrichment	TNFRSF1A	2.08
134	Thrombocytopenia 6	Enrichment	SRC	2.08
135	Leiomyosarcoma	Enrichment	CHEK2	2.08
136	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.08
137	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.08
138	Tufted angioma of skin	Enrichment	KDR	2.08
139	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.08
140	Developmental delay, hypotonia, and impaired language	Enrichment	FBXW7	2.08
141	Adenoid ameloblastoma	Enrichment	CTNNB1	2.08
142	Heritable thoracic aortic disease	Enrichment	SMAD4	2.08
143	Skin fragility-woolly hair-palmoplantar keratoderma syndrome	Enrichment	DSP	2.08
144	Hypospadias	Enrichment	PIK3CA	2.08
145	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.08
146	Perrault syndrome 7	Enrichment	DAP3	2.08
147	Breast lobular carcinoma	Enrichment	CDH1	2.08
148	B-cell non-hodgkin lymphoma	Enrichment	ATM	2.08
149	Choroid plexus cancer	Enrichment	TP53	2.08
150	Rare venous malformation	Enrichment	PIK3CA	2.08
151	Turner syndrome	Enrichment	PTCH1	2.08
152	Diaphragmatic eventration	Enrichment	PIK3CA	2.08
153	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.08
154	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.08
155	Rare combined vascular malformation	Enrichment	PIK3CA	2.08
156	Cavernous lymphangioma	Enrichment	PIK3CA	2.08
157	Congenital plasminogen activator inhibitor type 1 deficiency	Enrichment	SERPINE1	2.08
158	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.08
159	Monosomy 9q22.3	Enrichment	PTCH1	2.08
160	Postaxial polydactyly-anterior pituitary anomalies-facial dysmorphism syndrome	Enrichment	GLI2	2.08
161	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.08
162	Premature aging	Enrichment	VIM	2.08
163	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.08
164	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.08
165	Macrodactyly of toe	Enrichment	PIK3CA	2.08
166	Microcystic stromal tumor	Enrichment	CTNNB1	2.08
167	Primary peritoneal carcinoma	Enrichment	BRCA1	2.08
168	Autosomal dominant preaxial polydactyly-upperback hypertrichosis syndrome	Enrichment	SHH	2.08
169	Polycystic liver disease	Enrichment	CTNNB1, DKK3	2.07
170	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1, DKK3	2.07
171	Behcet syndrome	Enrichment	FAS, TNFRSF1A	1.98
172	Myeloma, multiple	Enrichment	ATM, CCND1, TP53	1.96
173	Hepatoblastoma	Enrichment	CTNNB1, TP53	1.89
174	Microphthalmia	Enrichment	PTCH1, SOX2	1.85
175	Noonan syndrome 1	Enrichment	MAP2K1, MAP2K2	1.82
176	Malaria	Enrichment	MAPKAPK3, TNF	1.82
177	Ectrodactyly and ectodermal dysplasia without cleft lip/palate	Enrichment	LEF1	1.78
178	Blepharocheilodontic syndrome 1	Enrichment	CDH1	1.78
179	Burkitt lymphoma	Enrichment	MYC	1.78
180	Myhre syndrome	Enrichment	SMAD4	1.78
181	Adrenocortical carcinoma, hereditary	Enrichment	TP53	1.78
182	Camurati-engelmann disease 1	Enrichment	TGFB1	1.78
183	Robinow-sorauf syndrome	Enrichment	TWIST1	1.78
184	Kyphomelic dysplasia	Enrichment	CCN2	1.78
185	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	1.78
186	Arrhythmogenic right ventricular dysplasia, familial, 8	Enrichment	DSP	1.78
187	Grange syndrome	Enrichment	DAP3	1.78
188	Quebec platelet disorder	Enrichment	PLAU	1.78
189	Cervical cancer	Enrichment	TP53	1.78
190	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	1.78
191	Microvascular complications of diabetes 5	Enrichment	TGFBR2	1.78
192	Keratosis, seborrheic	Enrichment	PIK3CA	1.78
193	Solitary median maxillary central incisor	Enrichment	SHH	1.78
194	White-sutton syndrome	Enrichment	GLI2	1.78
195	Angioma, tufted	Enrichment	KDR	1.78
196	Noonan syndrome 8	Enrichment	PIK3CA	1.78
197	Lymphoma, hodgkin, classic	Enrichment	TP53	1.78
198	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.78
199	Keratosis palmoplantaris striata ii	Enrichment	DSP	1.78
200	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	1.78
201	Loeys-dietz syndrome 3	Enrichment	SMAD3	1.78
202	Immunodeficiency 31c	Enrichment	STAT1	1.78
203	Congenital heart defects, multiple types, 3	Enrichment	CHEK2	1.78
204	Spondyloepimetaphyseal dysplasia, li-shao-li type	Enrichment	CCN2	1.78
205	Cardiomyopathy, dilated, with woolly hair, keratoderma, and tooth agenesis	Enrichment	DSP	1.78
206	Sweeney-cox syndrome	Enrichment	TWIST1	1.78
207	Epidermolysis bullosa, junctional 5a, intermediate	Enrichment	ITGB4	1.78
208	Fanconi anemia, complementation group s	Enrichment	BRCA1	1.78
209	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	1.78
210	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	1.78
211	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	1.78
212	Pancreatic cancer 4	Enrichment	BRCA1	1.78
213	Immunodeficiency 127	Enrichment	TNF	1.78
214	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	1.78
215	Rela fusion-positive ependymoma	Enrichment	RELA	1.78
216	Recessive dystrophic epidermolysis bullosa	Enrichment	MMP1	1.78
217	Split hand-foot malformation	Enrichment	LEF1	1.78
218	Progressive familial heart block	Enrichment	DSP	1.78
219	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	1.78
220	Cataract 30	Enrichment	VIM	1.78
221	Camurati-engelmann disease	Enrichment	TGFB1	1.78
222	Congenital fibrosarcoma	Enrichment	TP53	1.78
223	Metaphyseal anadysplasia 2	Enrichment	MMP9	1.78
224	High grade glioma	Enrichment	ATM	1.78
225	Cardiomyopathy, dilated, with woolly hair and keratoderma	Enrichment	DSP	1.78
226	Loeys-dietz syndrome 4	Enrichment	TGFB2	1.78
227	Megalencephaly-polydactyly syndrome	Enrichment	MYCN	1.78
228	Cervix carcinoma	Enrichment	TP53	1.78
229	Hodgkin's lymphoma	Enrichment	TP53	1.78
230	T-cell prolymphocytic leukemia	Enrichment	ATM	1.78
231	Inflammatory breast carcinoma	Enrichment	BRCA1	1.78
232	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	1.78
233	Metaphyseal anadysplasia	Enrichment	MMP9	1.78
234	Peritoneum cancer	Enrichment	BRCA1	1.78
235	Intermittent hydrarthrosis	Enrichment	TNFRSF1A	1.78
236	Bilateral breast cancer	Enrichment	BRCA1	1.78
237	Localized junctional epidermolysis bullosa, non-herlitz type	Enrichment	ITGB4	1.78
238	Vacterl with hydrocephalus	Enrichment	PTEN	1.78
239	Teratoma	Enrichment	CTNNB1	1.78
240	Familial retinoblastoma	Enrichment	MYCN	1.78
241	Non-syndromic sagittal craniosynostosis	Enrichment	TWIST1	1.78
242	Common variable immunodeficiency 12	Enrichment	NFKB1	1.78
243	Juvenile polyposis of infancy	Enrichment	PTEN	1.78
244	Isolated radial hemimelia	Enrichment	SHH	1.78
245	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	1.78
246	Tafro syndrome	Enrichment	MAP2K2	1.78
247	Rasopathy	Enrichment	MAP2K1, MAP2K2	1.71
248	Desmoid disease, hereditary	Enrichment	CTNNB1	1.61
249	Craniosynostosis 1	Enrichment	TWIST1	1.61
250	Retinoblastoma	Enrichment	MYCN	1.61
251	Ataxia-telangiectasia	Enrichment	ATM	1.61
252	Juvenile polyposis syndrome	Enrichment	SMAD4	1.61
253	Polycythemia vera	Enrichment	ATM	1.61
254	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.61
255	Syndactyly, type iv	Enrichment	SHH	1.61
256	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	MMP14	1.61
257	Langerhans cell histiocytosis	Enrichment	MAP2K1	1.61
258	Corneal dystrophy, posterior polymorphous, 3	Enrichment	ZEB1	1.61
259	Psoriatic arthritis	Enrichment	TNF	1.61
260	Corneal dystrophy, fuchs endothelial, 6	Enrichment	ZEB1	1.61
261	Nasopharyngeal carcinoma	Enrichment	TP53	1.61
262	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA	1.61
263	Epidermolysis bullosa, lethal acantholytic	Enrichment	DSP	1.61
264	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.61
265	Estrogen resistance	Enrichment	ESR1	1.61
266	Holoprosencephaly 7	Enrichment	PTCH1	1.61
267	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.61
268	Anus, imperforate	Enrichment	CTNNB1	1.61
269	Erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper-ige	Enrichment	DSP	1.61
270	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.61
271	Woolly hair-skin fragility syndrome	Enrichment	DSP	1.61
272	Bacteremia 2	Enrichment	MAPKAPK3	1.61
273	Koolen-de vries syndrome	Enrichment	ATM	1.61
274	Desmoid tumor	Enrichment	CTNNB1	1.61
275	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	1.61
276	Keratosis palmoplantaris striata	Enrichment	DSP	1.61
277	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.61
278	Anaplastic astrocytoma	Enrichment	TP53	1.61
279	Hypoplastic or aplastic tibia with polydactyly	Enrichment	SHH	1.61
280	Squamous cell carcinoma	Enrichment	TP53	1.61
281	T-cell acute lymphoblastic leukemia	Enrichment	BAX	1.61
282	Intraocular pressure quantitative trait locus	Enrichment	ZEB1	1.61
283	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.61
284	Keratoacanthoma	Enrichment	PIK3CA	1.61
285	Vogt-koyanagi-harada disease	Enrichment	FAS	1.61
286	Cystic fibrosis	Enrichment	MIF, TGFB1	1.54
287	Connective tissue disease	Enrichment	SMAD3, TGFBR2	1.54
288	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CDH1	1.49
289	Small cell cancer of the lung	Enrichment	TP53	1.49
290	Microphthalmia, syndromic 3	Enrichment	SOX2	1.49
291	Schizencephaly	Enrichment	SHH	1.49
292	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.49
293	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA1	1.49
294	Autoimmune lymphoproliferative syndrome	Enrichment	FAS	1.49
295	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.49
296	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	1.49
297	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.49
298	Epidermolysis bullosa simplex 5c, with pyloric atresia	Enrichment	ITGB4	1.49
299	Saethre-chotzen syndrome	Enrichment	TWIST1	1.49
300	Pilomatrixoma	Enrichment	CTNNB1	1.49
301	Cholangiocarcinoma	Enrichment	BRCA1	1.49
302	Alazami syndrome	Enrichment	CTNNB1	1.49
303	Arthrogryposis multiplex congenita 3, myogenic type	Enrichment	ESR1	1.49
304	Lung sarcomatoid carcinoma	Enrichment	TP53	1.49
305	Cerebrovascular disease	Enrichment	PIK3CA	1.49
306	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.49
307	Craniopharyngioma	Enrichment	CTNNB1	1.49
308	Tuberculosis	Enrichment	MAPKAPK3	1.49
309	Corneal dystrophy	Enrichment	ZEB1	1.49
310	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.49
311	Hemoglobin c disease	Enrichment	CHEK2	1.49
312	Cerebral malaria	Enrichment	TNF	1.49
313	Non-syndromic bicoronal craniosynostosis	Enrichment	TWIST1	1.49
314	Primary hyperparathyroidism	Enrichment	CDKN1B	1.49
315	Systemic-onset juvenile idiopathic arthritis	Enrichment	MIF	1.49
316	Glioma	Enrichment	PTEN	1.49
317	Oculomotor apraxia	Enrichment	ATM	1.49
318	Pseudomyogenic hemangioendothelioma	Enrichment	SERPINE1	1.49
319	Capillary malformations, congenital	Enrichment	PIK3CA	1.39
320	Alzheimer disease 2	Enrichment	PLAU	1.39
321	Feingold syndrome 1	Enrichment	MYCN	1.39
322	Epidermolysis bullosa simplex 1c, localized	Enrichment	ITGB4	1.39
323	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.39
324	Von hippel-lindau syndrome	Enrichment	CCND1	1.39
325	Rhabdomyosarcoma 2	Enrichment	TP53	1.39
326	Macrocephaly/autism syndrome	Enrichment	PTEN	1.39
327	Rheumatoid arthritis, systemic juvenile	Enrichment	MIF	1.39
328	Breast-ovarian cancer, familial 2	Enrichment	BRCA1	1.39
329	Fuchs' endothelial dystrophy	Enrichment	ZEB1	1.39
330	Pervasive developmental disorder	Enrichment	FBXW7	1.39
331	Lymphoma	Enrichment	TP53	1.39
332	Cardiac arrest	Enrichment	DSP	1.39
333	Congenital diarrhea 7 with exudative enteropathy	Enrichment	PLVAP	1.39
334	Glioblastoma	Enrichment	ATM	1.39
335	Hemangioma	Enrichment	PTEN	1.39
336	Histiocytoid hemangioma	Enrichment	VIM	1.39
337	Aplasia cutis congenita	Enrichment	ITGB4	1.39
338	Vascular dementia	Enrichment	TNF	1.39
339	Diffuse cutaneous systemic sclerosis	Enrichment	CCN2	1.39
340	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	1.39
341	Rare pervasive developmental disorder	Enrichment	FBXW7	1.39
342	Atrial septal defect 1	Enrichment	TGFB2	1.31
343	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.31
344	Corneal dystrophy, posterior polymorphous, 1	Enrichment	ZEB1	1.31
345	Basal cell nevus syndrome 1	Enrichment	PTCH1	1.31
346	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.31
347	Epidermolysis bullosa, junctional 1a, intermediate	Enrichment	ITGB4	1.31
348	Split-hand/foot malformation 1	Enrichment	LEF1	1.31
349	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.31
350	Epidermolysis bullosa, junctional 5b, with pyloric atresia	Enrichment	ITGB4	1.31
351	Wilms tumor 5	Enrichment	CHEK2	1.31
352	Hemangioma, capillary infantile	Enrichment	KDR	1.31
353	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.31
354	Basal cell carcinoma 1	Enrichment	PTCH1	1.31
355	Junctional epidermolysis bullosa non-herlitz type	Enrichment	ITGB4	1.31
356	Clear cell renal cell carcinoma	Enrichment	ATM	1.31
357	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.31
358	Limited scleroderma	Enrichment	CCN2	1.31
359	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.31
360	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	1.31
361	Inherited arrhythmogenic cardiomyopathy	Enrichment	DSP	1.31
362	Cleft lip with or without cleft palate	Enrichment	CDH1	1.31
363	Nevus, epidermal	Enrichment	PIK3CA	1.25
364	Multiple endocrine neoplasia, type i	Enrichment	CDKN1B	1.25
365	Thyroid cancer, nonmedullary, 2	Enrichment	PTEN	1.25
366	Myelofibrosis	Enrichment	SRC	1.25
367	Renal cell carcinoma, papillary, 1	Enrichment	ATM	1.25
368	Essential thrombocythemia	Enrichment	TP53	1.25
369	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.25
370	Common variable immunodeficiency	Enrichment	NFKB1	1.25
371	Follicular thyroid carcinoma	Enrichment	PTEN	1.25
372	Epidermolysis bullosa simplex	Enrichment	ITGB4	1.25
373	Congenital hydrocephalus	Enrichment	PTCH1	1.25
374	Overgrowth syndrome	Enrichment	PTCH1	1.25
375	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.25
376	Thrombocytopenia	Enrichment	SMAD4, SRC	1.22
377	Glioma susceptibility 1	Enrichment	TP53	1.19
378	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.19
379	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.19
380	Neuroblastoma	Enrichment	MYCN	1.19
381	Myocarditis	Enrichment	DSP	1.19
382	Combined pituitary hormone deficiency	Enrichment	GLI2	1.19
383	Charge syndrome	Enrichment	TNFRSF1A	1.14
384	Arrhythmogenic right ventricular dysplasia, familial, 9	Enrichment	DSP	1.14
385	Junctional epidermolysis bullosa	Enrichment	ITGB4	1.14
386	Primary hyperaldosteronism	Enrichment	TP53	1.14
387	Familial isolated arrhythmogenic right ventricular dysplasia	Enrichment	DSP	1.14
388	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	1.14
389	Cataract 30, multiple types	Enrichment	VIM	1.10
390	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.10
391	Familial colorectal cancer	Enrichment	TP53	1.10
392	Primary ovarian insufficiency	Enrichment	CHEK2, KDR	1.07
393	Migraine with or without aura 1	Enrichment	ESR1	1.06
394	Pectus excavatum	Enrichment	TGFBR1	1.06
395	Immune deficiency disease	Enrichment	ATM	1.06
396	Asthma	Enrichment	TNF	1.06
397	Meningioma, familial	Enrichment	PTEN	1.06
398	Myelodysplastic syndrome	Enrichment	TP53	1.06
399	Nanophthalmos	Enrichment	SOX2	1.06
400	Specific learning disability	Enrichment	MAPK1	1.06
401	Cardiac conduction defect	Enrichment	DSP	1.02
402	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	DSP	1.02
403	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	DSP	1.02
404	Aortic valve disease 1	Enrichment	DSP	0.99
405	Alzheimer's disease	Enrichment	TNF	0.99
406	Nk-cell enteropathy	Enrichment	CHEK2	0.99
407	Osteoporosis	Enrichment	SRC	0.96
408	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	0.96
409	Periventricular nodular heterotopia	Enrichment	BRCA1	0.96
410	Cleft lip/palate	Enrichment	CDH1	0.96
411	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	DSP	0.96
412	Renal cell carcinoma, nonpapillary	Enrichment	ATM	0.93
413	Polydactyly, postaxial, type a1	Enrichment	PTCH1	0.93
414	Wilms tumor 1	Enrichment	CHEK2	0.93
415	Perrault syndrome 1	Enrichment	DAP3	0.91
416	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	DSP	0.91
417	Isolated congenital microcephaly	Enrichment	OCLN	0.91
418	Alzheimer disease, familial, 1	Enrichment	PLAU	0.88
419	Melanoma, cutaneous malignant 1	Enrichment	CDK4	0.88
420	Interstitial lung disease 2	Enrichment	DSP	0.88
421	Heart, malformation of	Enrichment	MAPK1	0.86
422	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	DUSP6	0.86
423	Arteriovenous malformations of the brain	Enrichment	EGFR	0.84
424	Craniosynostosis	Enrichment	GLI2	0.82
425	Cardiomyopathy, dilated, 1a	Enrichment	DSP	0.80
426	Cardiomyopathy, dilated, 1g	Enrichment	DSP	0.78
427	Myocardial infarction	Enrichment	ESR1	0.78
428	Skin disease	Enrichment	ITGB4	0.78
429	Diamond-blackfan anemia 1	Enrichment	TP53	0.76
430	Kallmann syndrome	Enrichment	DUSP6	0.76
431	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	0.76
432	Autoinflammatory disease	Enrichment	TNFRSF1A	0.74
433	Tetralogy of fallot	Enrichment	KDR	0.71
434	Congenital nervous system abnormality	Enrichment	CTNNB1, PTEN	0.66
435	Nervous system disease	Enrichment	CTNNB1, PTEN	0.66
436	Long qt syndrome 1	Enrichment	DSP	0.66
437	Long qt syndrome	Enrichment	DSP	0.64
438	Autism spectrum disorder	Enrichment	MAP2K1, PTEN	0.64
439	Fanconi anemia, complementation group a	Enrichment	BRCA1	0.60
440	Left ventricular noncompaction	Enrichment	DSP	0.60
441	Diamond-blackfan anemia	Enrichment	TP53	0.59
442	Microcephaly	Enrichment	CTNNB1, MAPK1	0.57
443	Systemic lupus erythematosus	Enrichment	TNF	0.56
444	Leukemia, acute myeloid	Enrichment	TP53	0.55
445	Hypertelorism	Enrichment	PIK3CA	0.46
446	Familial isolated dilated cardiomyopathy	Enrichment	DSP	0.45
447	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	GLI2	0.43
448	Autism	Enrichment	SHH	0.35
449	Dilated cardiomyopathy	Enrichment	DSP	0.31

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

CKAP4 signaling pathway map

Pathway Network for CKAP4 signaling pathway map

Member Pathways for CKAP4 signaling pathway map

Pathways in the CKAP4 signaling pathway map SuperPath

Associated Genes for CKAP4 signaling pathway map

Associated Disorders for CKAP4 signaling pathway map

Disorders associated with CKAP4 signaling pathway map SuperPath

STRING Interaction Network for CKAP4 signaling pathway map

Sources for CKAP4 signaling pathway map