Class I PI3K signaling events

No Pathway Network information available for Class I PI3K signaling events

Pathways in the Class I PI3K signaling events SuperPath

#	Name	Source	Genes
1	Class I PI3K signaling events	PubChem	ADAP1 AKT1 ARAP3 ARF1 ARF5 ARF6 BLNK BTK CYTH2 CYTH3 DAPP1 FOXO3 HSP90AA1 LCK PDPK1 PIK3CA PIK3CB PIK3CG PIK3R1 PIK3R6 PLCG1 PLEKHA2 PTEN RAC1 RAP1A RHOA SGK1 SRC SYK (see all 29) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ARF5	ARF GTPase 5	Protein Coding	1
2	CYTH3	Cytohesin 3	Protein Coding	1
3	ARAP3	ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 3	Protein Coding	1
4	CYTH2	Cytohesin 2	Protein Coding	1
5	DAPP1	Dual Adaptor Of Phosphotyrosine And 3-Phosphoinositides 1	Protein Coding	1
6	BLNK	B Cell Linker	Protein Coding	1
7	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
8	SGK1	Serum/Glucocorticoid Regulated Kinase 1	Protein Coding	1
9	BTK	Bruton Tyrosine Kinase	Protein Coding	1
10	ADAP1	ArfGAP With Dual PH Domains 1	Protein Coding	1
11	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
12	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	1
13	PLEKHA2	Pleckstrin Homology Domain Containing A2	Protein Coding	1
14	PIK3R6	Phosphoinositide-3-Kinase Regulatory Subunit 6	Protein Coding	1
15	PTEN	Phosphatase And Tensin Homolog	Protein Coding	1
16	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	1
17	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	1
18	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
19	FOXO3	Forkhead Box O3	Protein Coding	1
20	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
21	RHOA	Ras Homolog Family Member A	Protein Coding	1
22	HSP90AA1	Heat Shock Protein 90 Alpha Family Class A Member 1	Protein Coding	1
23	RAC1	Rac Family Small GTPase 1	Protein Coding	1
24	ARF6	ARF GTPase 6	Protein Coding	1
25	ARF1	ARF GTPase 1	Protein Coding	1
26	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
27	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
28	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
29	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1

Disorders associated with Class I PI3K signaling events SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Cowden syndrome	Enrichment	AKT1, PIK3CA, PTEN	6.14
2	Meningioma	Enrichment	AKT1, PIK3CA, PTEN	5.72
3	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.88
4	Colorectal cancer	Enrichment	AKT1, PIK3CA, PIK3R1, SRC	4.48
5	Hemimegalencephaly	Enrichment	PIK3CA, PTEN	4.36
6	Cowden syndrome 1	Enrichment	PIK3CA, PTEN	4.18
7	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	4.18
8	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	4.18
9	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA, PTEN	3.96
10	Autosomal non-syndromic agammaglobulinemia	Enrichment	BLNK, PIK3R1	3.71
11	Breast cancer	Enrichment	AKT1, PIK3CA, PTEN	3.27
12	Diffuse large b-cell lymphoma	Enrichment	BTK, PTEN	3.13
13	Endometrial cancer	Enrichment	PIK3CA, PTEN	3.04
14	Ovarian cancer	Enrichment	AKT1, PIK3CA, PTEN	2.90
15	Bladder cancer	Enrichment	PIK3CA, PTEN	2.76
16	Prostate cancer	Enrichment	PIK3CA, PTEN	2.76
17	Macrodactyly	Enrichment	PIK3CA	2.67
18	Proteus syndrome	Enrichment	AKT1	2.67
19	Vacterl association with hydrocephalus	Enrichment	PTEN	2.67
20	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.67
21	Cowden syndrome 5	Enrichment	PIK3CA	2.67
22	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.67
23	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	2.67
24	Short syndrome	Enrichment	PIK3R1	2.67
25	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.67
26	Isolated growth hormone deficiency type iii	Enrichment	BTK	2.67
27	Papillary tumor of the pineal region	Enrichment	PTEN	2.67
28	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.67
29	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.67
30	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.67
31	Cowden syndrome 6	Enrichment	AKT1	2.67
32	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.67
33	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.67
34	Glioma susceptibility 2	Enrichment	PTEN	2.67
35	Immunodeficiency 22	Enrichment	LCK	2.67
36	Thrombocytopenia 6	Enrichment	SRC	2.67
37	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.67
38	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.67
39	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.67
40	Hypospadias	Enrichment	PIK3CA	2.67
41	Colitis	Enrichment	SYK	2.67
42	Rare venous malformation	Enrichment	PIK3CA	2.67
43	Diaphragmatic eventration	Enrichment	PIK3CA	2.67
44	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.67
45	Rare combined vascular malformation	Enrichment	PIK3CA	2.67
46	Cavernous lymphangioma	Enrichment	PIK3CA	2.67
47	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.67
48	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.67
49	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.67
50	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.67
51	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.67
52	Macrodactyly of toe	Enrichment	PIK3CA	2.67
53	Gastric cancer	Enrichment	PIK3CA, PTEN	2.42
54	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	2.37
55	Agammaglobulinemia 4, autosomal recessive	Enrichment	BLNK	2.37
56	Keratosis, seborrheic	Enrichment	PIK3CA	2.37
57	Noonan syndrome 8	Enrichment	PIK3CA	2.37
58	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.37
59	Agammaglobulinemia, x-linked	Enrichment	BTK	2.37
60	Periventricular nodular heterotopia 8	Enrichment	ARF1	2.37
61	Agammaglobulinemia 4	Enrichment	BLNK	2.37
62	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.37
63	Vacterl with hydrocephalus	Enrichment	PTEN	2.37
64	Arthritis	Enrichment	SYK	2.37
65	Juvenile polyposis of infancy	Enrichment	PTEN	2.37
66	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.19
67	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK	2.19
68	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.19
69	Agammaglobulinemia 1	Enrichment	BTK	2.19
70	Immunodeficiency 14	Enrichment	PIK3R1	2.19
71	Laryngeal squamous cell carcinoma	Enrichment	PTEN	2.19
72	Keratoacanthoma	Enrichment	PIK3CA	2.19
73	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.07
74	Cerebrovascular disease	Enrichment	PIK3CA	2.07
75	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.07
76	Glioma	Enrichment	PTEN	2.07
77	Capillary malformations, congenital	Enrichment	PIK3CA	1.97
78	Macrocephaly/autism syndrome	Enrichment	PTEN	1.97
79	Hemangioma	Enrichment	PTEN	1.97
80	Acute megakaryocytic leukemia	Enrichment	PTEN	1.97
81	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.89
82	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.89
83	Nevus, epidermal	Enrichment	PIK3CA	1.83
84	Thyroid cancer, nonmedullary, 2	Enrichment	PTEN	1.83
85	Myelofibrosis	Enrichment	SRC	1.83
86	Squamous cell carcinoma, head and neck	Enrichment	PTEN	1.83
87	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.83
88	Gallbladder cancer	Enrichment	PIK3CA	1.83
89	Follicular thyroid carcinoma	Enrichment	PTEN	1.83
90	Overgrowth syndrome	Enrichment	PIK3R1	1.83
91	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.72
92	Arteriovenous malformation	Enrichment	PIK3CA	1.72
93	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.72
94	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.67
95	Melanoma	Enrichment	PTEN	1.67
96	Immune deficiency disease	Enrichment	SYK	1.63
97	Meningioma, familial	Enrichment	PTEN	1.63
98	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.63
99	Uterine corpus cancer	Enrichment	PTEN	1.63
100	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.60
101	Nk-cell enteropathy	Enrichment	PIK3CB	1.56
102	Osteoporosis	Enrichment	SRC	1.53
103	Periventricular nodular heterotopia	Enrichment	ARF1	1.53
104	Lynch syndrome	Enrichment	PIK3CA	1.50
105	Rhabdomyosarcoma	Enrichment	PTEN	1.47
106	Hepatocellular carcinoma	Enrichment	PIK3CA	1.34
107	Lung cancer	Enrichment	PIK3CA	1.18
108	Severe combined immunodeficiency	Enrichment	LCK	1.17
109	Thrombocytopenia	Enrichment	SRC	1.01
110	Hypertelorism	Enrichment	PIK3CA	0.98
111	Hereditary breast ovarian cancer syndrome	Enrichment	PTEN	0.95
112	Myeloma, multiple	Enrichment	SGK1	0.95
113	Congenital nervous system abnormality	Enrichment	PTEN	0.69
114	Nervous system disease	Enrichment	PTEN	0.69
115	Autism spectrum disorder	Enrichment	PTEN	0.68
116	Inherited cancer-predisposing syndrome	Enrichment	PTEN	0.61

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Class I PI3K signaling events

Pathway Network for Class I PI3K signaling events

Member Pathways for Class I PI3K signaling events

Pathways in the Class I PI3K signaling events SuperPath

Associated Genes for Class I PI3K signaling events

Associated Disorders for Class I PI3K signaling events

Disorders associated with Class I PI3K signaling events SuperPath

STRING Interaction Network for Class I PI3K signaling events

Sources for Class I PI3K signaling events