Class IB PI3K non-lipid kinase events

No Pathway Network information available for Class IB PI3K non-lipid kinase events

#	Name	Source	Genes
1	Class IB PI3K non-lipid kinase events	PubChem	MAP2K1 MAPK1 PDE3B PIK3CG PIK3R6
2	IL-5 signaling pathway	WikiPathways	PIK3CG

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	2
2	PDE3B	Phosphodiesterase 3B	Protein Coding	1
3	PIK3R6	Phosphoinositide-3-Kinase Regulatory Subunit 6	Protein Coding	1
4	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
5	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	4.13
2	Melorheostosis, isolated	Enrichment	MAP2K1	3.43
3	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	3.43
4	Noonan syndrome 13	Enrichment	MAPK1	3.43
5	Melorheostosis	Enrichment	MAP2K1	3.43
6	Vitamin d hydroxylation-deficient rickets, type 1b	Enrichment	PDE3B	3.13
7	Vitamin d hydroxylation-deficient rickets, type 1a	Enrichment	PDE3B	2.96
8	Langerhans cell histiocytosis	Enrichment	MAP2K1	2.96
9	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1	2.83
10	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.83
11	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1	2.83
12	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	2.59
13	Arteriovenous malformation	Enrichment	MAP2K1	2.48
14	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1	2.43
15	Lung non-small cell carcinoma	Enrichment	MAP2K1	2.39
16	Specific learning disability	Enrichment	MAPK1	2.39
17	Pulmonary disease, chronic obstructive	Enrichment	PDE3B	2.32
18	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1	2.26
19	Heart, malformation of	Enrichment	MAPK1	2.18
20	Noonan syndrome 1	Enrichment	MAP2K1	2.07
21	Rasopathy	Enrichment	MAP2K1	2.02
22	Autism spectrum disorder	Enrichment	MAP2K1	1.40
23	Microcephaly	Enrichment	MAPK1	1.35

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Class IB PI3K non-lipid kinase events