Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism

Pathway network for the Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism SuperPath

Sources:

WikiPathways
PubChem
Reactome

Pathways in the Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism SuperPath

#	Name	Source	Genes
1	Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism	WikiPathways	CYP11A1 CYP11B2 HSD3B1 HSD3B2 POR
2	progesterone biosynthesis	PubChem	HSD3B1 HSD3B2
3	Defective CYP11B2 causes CMO-1 deficiency	Reactome	CYP11B2

Gene overlap in member pathways for Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HSD3B2	Hydroxy-Delta-5-Steroid Dehydrogenase, 3 Beta- And Steroid Delta-Isomerase 2	Protein Coding	2
2	HSD3B1	Hydroxy-Delta-5-Steroid Dehydrogenase, 3 Beta- And Steroid Delta-Isomerase 1	Protein Coding	2
3	CYP11B2	Cytochrome P450 Family 11 Subfamily B Member 2	Protein Coding	2
4	POR	Cytochrome P450 Oxidoreductase	Protein Coding	1
5	CYP11A1	Cytochrome P450 Family 11 Subfamily A Member 1	Protein Coding	1

Disorders associated with Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Steroid inherited metabolic disorder	Direct
2	Lipoid congenital adrenal hyperplasia	Enrichment	CYP11A1, HSD3B2, POR	8.06
3	Adrenal hyperplasia, congenital, due to 3-beta-hydroxysteroid dehydrogenase 2 deficiency	Enrichment	HSD3B2	3.53
4	Hypospadias 1, x-linked	Enrichment	HSD3B2	3.53
5	3 beta-hydroxysteroid dehydrogenase deficiency	Enrichment	HSD3B2	3.53
6	Adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete	Enrichment	CYP11A1	3.43
7	Brachycephaly, deafness, cataract, microstomia, and impaired intellectual development	Enrichment	POR	3.43
8	Inherited isolated adrenal insufficiency due to partial cyp11a1 deficiency	Enrichment	CYP11A1	3.43
9	Corticosterone methyloxidase type i deficiency	Enrichment	CYP11B2	3.13
10	Antley-bixler syndrome with genital anomalies and disordered steroidogenesis	Enrichment	POR	3.13
11	Corticosterone methyloxidase type ii deficiency	Enrichment	CYP11B2	3.13
12	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	POR	3.13
13	Disordered steroidogenesis due to cytochrome p450 oxidoreductase deficiency	Enrichment	POR	3.13
14	Cytochrome p450 oxidoreductase deficiency	Enrichment	POR	3.13
15	Familial hypoaldosteronism	Enrichment	CYP11B2	3.13
16	Early-onset familial hypoaldosteronism	Enrichment	CYP11B2	3.13
17	Hyperaldosteronism, familial, type i	Enrichment	CYP11B2	2.66
18	Adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency	Enrichment	CYP11A1	2.66
19	21-hydroxylase-deficient congenital adrenal hyperplasia	Enrichment	CYP11A1	2.66
20	Primary ovarian insufficiency	Enrichment	POR	1.67

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism

Pathway Network for Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism

Pathway network for the Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism SuperPath

Member Pathways for Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism

Pathways in the Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism SuperPath

Gene overlap in member pathways for Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism SuperPath

Associated Genes for Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism

Associated Disorders for Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism

Disorders associated with Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism SuperPath

STRING Interaction Network for Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism

Sources for Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism