Clathrin-mediated endocytosis

No Pathway Network information available for Clathrin-mediated endocytosis

Pathways in the Clathrin-mediated endocytosis SuperPath

#	Name	Source	Genes
1	Clathrin-mediated endocytosis	Reactome	AAK1 ACTB ACTG1 ACTR2 ACTR3 ADRB2 AGFG1 AGTR1 AMPH AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APOB AREG ARF6 ARFGAP1 ARPC1A ARPC2 ARPC3 ARPC4 ARPC5 ARRB1 ARRB2 AVP AVPR2 BIN1 BTC CBL CD3D CD3G CD4 CFTR CHRM2 CLTA CLTB CLTC CLTCL1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS7B COPS8 CTTN DAB2 DNAJC6 DNM1 DNM2 DNM3 DVL2 EGF EGFR EPGN EPN1 EPN2 EPS15 EPS15L1 EREG FCHO1 FCHO2 FNBP1 FNBP1L FZD4 GAK GAPVD1 GPS1 GRB2 GRK2 GRK3 HBEGF HGS HIP1 HIP1R HSPA8 IGF2R IL7R ITSN1 ITSN2 KIAA0319 LDLR LDLRAP1 LRP2 M6PR NECAP1 NECAP2 NEDD8 OCRL PACSIN1 PACSIN2 PACSIN3 PICALM PIK3C2A PIP5K1C RAB5A RAB5B RAB5C REPS1 REPS2 RPS27A SCARB2 SGIP1 SH3GL1 SH3GL2 SH3GL3 SH3KBP1 SLC18A3 SLC2A8 SNAP91 SNX18 SNX9 STAM STAM2 STON1 STON1-GTF2A1L STON2 SYNJ1 SYNJ2 SYT1 SYT11 SYT2 SYT8 SYT9 TACR1 TF TFRC TGFA TGOLN2 TOR1A TOR1B TRIP10 UBA52 UBB UBC UBQLN1 UBQLN2 VAMP2 VAMP3 VAMP4 VAMP7 VAMP8 WASL WNT5A (see all 146) (see less)
2	Cargo recognition for clathrin-mediated endocytosis	Reactome	AAK1 ADRB2 AGFG1 AGTR1 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APOB AREG ARRB1 ARRB2 AVP AVPR2 BTC CBL CD3D CD3G CD4 CFTR CHRM2 CLTA CLTB CLTC CLTCL1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS7B COPS8 DAB2 DVL2 EGF EGFR EPGN EPN1 EPN2 EPS15 EPS15L1 EREG FCHO1 FCHO2 FZD4 GPS1 GRB2 GRK2 GRK3 HBEGF HGS IGF2R IL7R ITSN1 ITSN2 KIAA0319 LDLR LDLRAP1 LRP2 M6PR NECAP1 NECAP2 NEDD8 PICALM REPS1 REPS2 RPS27A SCARB2 SGIP1 SH3GL1 SH3GL2 SH3GL3 SH3KBP1 SLC18A3 SLC2A8 SNAP91 STAM STAM2 STON1 STON1-GTF2A1L STON2 SYT1 SYT11 SYT2 SYT8 SYT9 TACR1 TF TFRC TGFA TGOLN2 TOR1A TOR1B UBA52 UBB UBC UBQLN1 UBQLN2 VAMP2 VAMP3 VAMP4 VAMP7 VAMP8 WNT5A (see all 106) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	STAM2	Signal Transducing Adaptor Molecule 2	Protein Coding	2
2	TGOLN2	Trans-Golgi Network Protein 2	Protein Coding	2
3	CFTR	CF Transmembrane Conductance Regulator	Protein Coding	2
4	COPS8	COP9 Signalosome Subunit 8	Protein Coding	2
5	COPS6	COP9 Signalosome Subunit 6	Protein Coding	2
6	COPS5	COP9 Signalosome Subunit 5	Protein Coding	2
7	STON1	Stonin 1	Protein Coding	2
8	CHRM2	Cholinergic Receptor Muscarinic 2	Protein Coding	2
9	FCHO2	FCH And Mu Domain Containing Endocytic Adaptor 2	Protein Coding	2
10	AP2M1	Adaptor Related Protein Complex 2 Subunit Mu 1	Protein Coding	2
11	AP2S1	Adaptor Related Protein Complex 2 Subunit Sigma 1	Protein Coding	2
12	CLTA	Clathrin Light Chain A	Protein Coding	2
13	CLTB	Clathrin Light Chain B	Protein Coding	2
14	CLTC	Clathrin Heavy Chain	Protein Coding	2
15	SYT2	Synaptotagmin 2	Protein Coding	2
16	SYT9	Synaptotagmin 9	Protein Coding	2
17	ADRB2	Adrenoceptor Beta 2	Protein Coding	2
18	GRK2	G Protein-Coupled Receptor Kinase 2	Protein Coding	2
19	GRK3	G Protein-Coupled Receptor Kinase 3	Protein Coding	2
20	AP2A1	Adaptor Related Protein Complex 2 Subunit Alpha 1	Protein Coding	2
21	DAB2	DAB Adaptor Protein 2	Protein Coding	2
22	AP2A2	Adaptor Related Protein Complex 2 Subunit Alpha 2	Protein Coding	2
23	AP2B1	Adaptor Related Protein Complex 2 Subunit Beta 1	Protein Coding	2
24	HBEGF	Heparin Binding EGF Like Growth Factor	Protein Coding	2
25	AGTR1	Angiotensin II Receptor Type 1	Protein Coding	2
26	DVL2	Dishevelled Segment Polarity Protein 2	Protein Coding	2
27	TOR1A	Torsin Family 1 Member A	Protein Coding	2
28	EGF	Epidermal Growth Factor	Protein Coding	2
29	EGFR	Epidermal Growth Factor Receptor	Protein Coding	2
30	EPS15	Epidermal Growth Factor Receptor Pathway Substrate 15	Protein Coding	2
31	EREG	Epiregulin	Protein Coding	2
32	AAK1	AP2 Associated Kinase 1	Protein Coding	2
33	EPN2	Epsin 2	Protein Coding	2
34	FCHO1	FCH And Mu Domain Containing Endocytic Adaptor 1	Protein Coding	2
35	SYT11	Synaptotagmin 11	Protein Coding	2
36	EPGN	Epithelial Mitogen	Protein Coding	2
37	NECAP1	NECAP Endocytosis Associated 1	Protein Coding	2
38	LDLRAP1	Low Density Lipoprotein Receptor Adaptor Protein 1	Protein Coding	2
39	TOR1B	Torsin Family 1 Member B	Protein Coding	2
40	STON1-GTF2A1L	STON1-GTF2A1L Readthrough	Protein Coding	2
41	GPS1	G Protein Pathway Suppressor 1	Protein Coding	2
42	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	2
43	EPN1	Epsin 1	Protein Coding	2
44	UBQLN2	Ubiquilin 2	Protein Coding	2
45	UBQLN1	Ubiquilin 1	Protein Coding	2
46	SLC2A8	Solute Carrier Family 2 Member 8	Protein Coding	2
47	SH3KBP1	SH3 Domain Containing Kinase Binding Protein 1	Protein Coding	2
48	AGFG1	ArfGAP With FG Repeats 1	Protein Coding	2
49	APOB	Apolipoprotein B	Protein Coding	2
50	IGF2R	Insulin Like Growth Factor 2 Receptor	Protein Coding	2
51	IL7R	Interleukin 7 Receptor	Protein Coding	2
52	AREG	Amphiregulin	Protein Coding	2
53	LDLR	Low Density Lipoprotein Receptor	Protein Coding	2
54	LRP2	LDL Receptor Related Protein 2	Protein Coding	2
55	M6PR	Mannose-6-Phosphate Receptor, Cation Dependent	Protein Coding	2
56	ARRB1	Arrestin Beta 1	Protein Coding	2
57	ARRB2	Arrestin Beta 2	Protein Coding	2
58	NEDD8	NEDD8 Ubiquitin Like Modifier	Protein Coding	2
59	ITSN2	Intersectin 2	Protein Coding	2
60	COPS7A	COP9 Signalosome Subunit 7A	Protein Coding	2
61	COPS4	COP9 Signalosome Subunit 4	Protein Coding	2
62	AVP	Arginine Vasopressin	Protein Coding	2
63	AVPR2	Arginine Vasopressin Receptor 2	Protein Coding	2
64	NECAP2	NECAP Endocytosis Associated 2	Protein Coding	2
65	EPS15L1	Epidermal Growth Factor Receptor Pathway Substrate 15 Like 1	Protein Coding	2
66	RPS27A	Ribosomal Protein S27a	Protein Coding	2
67	ITSN1	Intersectin 1	Protein Coding	2
68	SH3GL1	SH3 Domain Containing GRB2 Like 1, Endophilin A2	Protein Coding	2
69	SH3GL2	SH3 Domain Containing GRB2 Like 2, Endophilin A1	Protein Coding	2
70	SH3GL3	SH3 Domain Containing GRB2 Like 3, Endophilin A3	Protein Coding	2
71	COPS7B	COP9 Signalosome Subunit 7B	Protein Coding	2
72	SLC18A3	Solute Carrier Family 18 Member A3	Protein Coding	2
73	VAMP2	Vesicle Associated Membrane Protein 2	Protein Coding	2
74	VAMP7	Vesicle Associated Membrane Protein 7	Protein Coding	2
75	BTC	Betacellulin	Protein Coding	2
76	SYT1	Synaptotagmin 1	Protein Coding	2
77	TACR1	Tachykinin Receptor 1	Protein Coding	2
78	TF	Transferrin	Protein Coding	2
79	TFRC	Transferrin Receptor	Protein Coding	2
80	TGFA	Transforming Growth Factor Alpha	Protein Coding	2
81	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	2
82	UBB	Ubiquitin B	Protein Coding	2
83	UBC	Ubiquitin C	Protein Coding	2
84	WNT5A	Wnt Family Member 5A	Protein Coding	2
85	STAM	Signal Transducing Adaptor Molecule	Protein Coding	2
86	CLTCL1	Clathrin Heavy Chain Like 1	Protein Coding	2
87	PICALM	Phosphatidylinositol Binding Clathrin Assembly Protein	Protein Coding	2
88	FZD4	Frizzled Class Receptor 4	Protein Coding	2
89	SGIP1	SH3GL Interacting Endocytic Adaptor 1	Protein Coding	2
90	REPS1	RALBP1 Associated Eps Domain Containing 1	Protein Coding	2
91	COPS3	COP9 Signalosome Subunit 3	Protein Coding	2
92	STON2	Stonin 2	Protein Coding	2
93	CBL	Cbl Proto-Oncogene	Protein Coding	2
94	VAMP8	Vesicle Associated Membrane Protein 8	Protein Coding	2
95	VAMP4	Vesicle Associated Membrane Protein 4	Protein Coding	2
96	SYT8	Synaptotagmin 8	Protein Coding	2
97	HGS	Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate	Protein Coding	2
98	CD3D	CD3 Delta Subunit Of T-Cell Receptor Complex	Protein Coding	2
99	CD3G	CD3 Gamma Subunit Of T-Cell Receptor Complex	Protein Coding	2
100	REPS2	RALBP1 Associated Eps Domain Containing 2	Protein Coding	2
101	CD4	CD4 Molecule	Protein Coding	2
102	COPS2	COP9 Signalosome Subunit 2	Protein Coding	2
103	VAMP3	Vesicle Associated Membrane Protein 3	Protein Coding	2
104	SCARB2	Scavenger Receptor Class B Member 2	Protein Coding	2
105	KIAA0319	KIAA0319	Protein Coding	2
106	SNAP91	Synaptosome Associated Protein 91	Protein Coding	2
107	ARPC5	Actin Related Protein 2/3 Complex Subunit 5	Protein Coding	1
108	ARPC4	Actin Related Protein 2/3 Complex Subunit 4	Protein Coding	1
109	ARPC3	Actin Related Protein 2/3 Complex Subunit 3	Protein Coding	1
110	ACTR3	Actin Related Protein 3	Protein Coding	1
111	ACTR2	Actin Related Protein 2	Protein Coding	1
112	ARPC2	Actin Related Protein 2/3 Complex Subunit 2	Protein Coding	1
113	ARPC1A	Actin Related Protein 2/3 Complex Subunit 1A	Protein Coding	1
114	PACSIN2	Protein Kinase C And Casein Kinase Substrate In Neurons 2	Protein Coding	1
115	SNX18	Sorting Nexin 18	Protein Coding	1
116	DNM1	Dynamin 1	Protein Coding	1
117	DNM2	Dynamin 2	Protein Coding	1
118	CTTN	Cortactin	Protein Coding	1
119	FNBP1	Formin Binding Protein 1	Protein Coding	1
120	PIP5K1C	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Gamma	Protein Coding	1
121	GAK	Cyclin G Associated Kinase	Protein Coding	1
122	DNM3	Dynamin 3	Protein Coding	1
123	GAPVD1	GTPase Activating Protein And VPS9 Domains 1	Protein Coding	1
124	AMPH	Amphiphysin	Protein Coding	1
125	BIN1	Bridging Integrator 1	Protein Coding	1
126	PACSIN3	Protein Kinase C And Casein Kinase Substrate In Neurons 3	Protein Coding	1
127	PACSIN1	Protein Kinase C And Casein Kinase Substrate In Neurons 1	Protein Coding	1
128	HIP1	Huntingtin Interacting Protein 1	Protein Coding	1
129	HSPA8	Heat Shock Protein Family A (Hsp70) Member 8	Protein Coding	1
130	ARF6	ARF GTPase 6	Protein Coding	1
131	OCRL	OCRL Inositol Polyphosphate-5-Phosphatase	Protein Coding	1
132	SNX9	Sorting Nexin 9	Protein Coding	1
133	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	1
134	FNBP1L	Formin Binding Protein 1 Like	Protein Coding	1
135	ARFGAP1	ARF GTPase Activating Protein 1	Protein Coding	1
136	RAB5A	RAB5A, Member RAS Oncogene Family	Protein Coding	1
137	RAB5B	RAB5B, Member RAS Oncogene Family	Protein Coding	1
138	RAB5C	RAB5C, Member RAS Oncogene Family	Protein Coding	1
139	ACTB	Actin Beta	Protein Coding	1
140	ACTG1	Actin Gamma 1	Protein Coding	1
141	SYNJ1	Synaptojanin 1	Protein Coding	1
142	SYNJ2	Synaptojanin 2	Protein Coding	1
143	WASL	WASP Like Actin Nucleation Promoting Factor	Protein Coding	1
144	HIP1R	Huntingtin Interacting Protein 1 Related	Protein Coding	1
145	TRIP10	Thyroid Hormone Receptor Interactor 10	Protein Coding	1
146	DNAJC6	DnaJ Heat Shock Protein Family (Hsp40) Member C6	Protein Coding	1

Disorders associated with Clathrin-mediated endocytosis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Homozygous familial hypercholesterolemia	Enrichment	APOB, LDLR, LDLRAP1	4.60
2	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	3.94
3	Hypercholesterolemia, familial, 2	Enrichment	APOB, LDLR	3.74
4	Hypercholesterolemia, familial, 4	Enrichment	LDLR, LDLRAP1	3.74
5	Familial hypercholesterolemia	Enrichment	APOB, LDLR, LDLRAP1	3.71
6	Atypical juvenile parkinsonism	Enrichment	DNAJC6, SYNJ1	3.47
7	Hyperlipidemia, familial combined, 3	Enrichment	APOB, LDLR	3.22
8	Cowden syndrome 1	Enrichment	EGFR, LDLR	3.05
9	Myopathy, centronuclear, 1	Enrichment	BIN1, DNM2	2.78
10	Coronary heart disease 5	Enrichment	APOB, LDLR	2.68
11	Severe combined immunodeficiency	Enrichment	CD3D, CD3G, IL7R	2.67
12	Undetermined early-onset epileptic encephalopathy	Enrichment	CLTC, DNM1, NECAP1, SYNJ1	2.51
13	Presynaptic congenital myasthenic syndromes	Enrichment	SLC18A3, SYT2	2.50
14	Hypercholesterolemia, familial, 1	Enrichment	APOB, LDLR	2.35
15	Early-onset parkinson's disease	Enrichment	DNAJC6, SYNJ1	2.15
16	Diabetes insipidus, neurohypophyseal	Enrichment	AVP	2.11
17	Hypocalciuric hypercalcemia, familial, type iii	Enrichment	AP2S1	2.11
18	Nephrogenic syndrome of inappropriate antidiuresis	Enrichment	AVPR2	2.11
19	Diabetes insipidus, nephrogenic, 1, x-linked	Enrichment	AVPR2	2.11
20	Immunodeficiency 61	Enrichment	SH3KBP1	2.11
21	Hypomagnesemia 4, renal	Enrichment	EGF	2.11
22	Dystonia 1, torsion, autosomal dominant	Enrichment	TOR1A	2.11
23	Donnai-barrow syndrome	Enrichment	LRP2	2.11
24	Atransferrinemia	Enrichment	TF	2.11
25	Baker-gordon syndrome	Enrichment	SYT1	2.11
26	Okt4 epitope deficiency	Enrichment	CD4	2.11
27	Neurodegeneration with brain iron accumulation 7	Enrichment	REPS1	2.11
28	Amyotrophic lateral sclerosis 15 with or without frontotemporal dementia	Enrichment	UBQLN2	2.11
29	Central diabetes insipidus	Enrichment	AVP	2.11
30	X-linked nephrogenic diabetes insipidus	Enrichment	AVPR2	2.11
31	Immunodeficiency 76	Enrichment	FCHO1	2.11
32	Myasthenic syndrome, congenital, 7a, presynaptic, and distal motor neuropathy, autosomal dominant	Enrichment	SYT2	2.11
33	Neurodevelopmental disorder with hypotonia and autistic features with or without hyperkinetic movements	Enrichment	VAMP2	2.11
34	Immunodeficiency 46	Enrichment	TFRC	2.11
35	Immunodeficiency 79	Enrichment	CD4	2.11
36	Arthrogryposis multiplex congenita 5	Enrichment	TOR1A	2.11
37	Myasthenic syndrome, congenital, 7b, presynaptic, autosomal recessive	Enrichment	SYT2	2.11
38	Immunodeficiency 19, severe combined	Enrichment	CD3D	2.11
39	Prolactin-producing pituitary gland adenoma	Enrichment	LRP2	2.11
40	Congenital myasthenic syndrome 7	Enrichment	SYT2	2.11
41	Congenital insensitivity to pain with severe intellectual disability	Enrichment	CLTCL1	2.11
42	Aquagenic palmoplantar keratoderma	Enrichment	CFTR	2.11
43	Dyt1 early-onset isolated dystonia	Enrichment	TOR1A	2.11
44	Immunodeficiency 19	Enrichment	CD3D	2.11
45	T-b+ severe combined immunodeficiency due to il-7ralpha deficiency	Enrichment	IL7R	2.11
46	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.11
47	Hereditary arginine vasopressin deficiency	Enrichment	AVP	2.11
48	Baraitser-winter syndrome 1	Enrichment	ACTB	1.97
49	Parkinson disease 19a, juvenile-onset	Enrichment	DNAJC6	1.97
50	Charcot-marie-tooth disease, dominant intermediate b	Enrichment	DNM2	1.97
51	Developmental and epileptic encephalopathy 53	Enrichment	SYNJ1	1.97
52	Congenital myopathy 27	Enrichment	PACSIN3	1.97
53	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	1.97
54	Oculoskeletodental syndrome	Enrichment	PIK3C2A	1.97
55	Lowe oculocerebrorenal syndrome	Enrichment	OCRL	1.97
56	Becker nevus syndrome	Enrichment	ACTB	1.97
57	Dystonia-deafness syndrome 1	Enrichment	ACTB	1.97
58	Lethal congenital contracture syndrome 5	Enrichment	DNM2	1.97
59	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	1.97
60	Baraitser-winter syndrome	Enrichment	ACTB	1.97
61	Autosomal dominant charcot-marie-tooth disease type 2m	Enrichment	DNM2	1.97
62	Congenital smooth muscle hamartoma	Enrichment	ACTB	1.97
63	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	1.97
64	Oculocerebrodental syndrome	Enrichment	PIK3C2A	1.97
65	Precocious puberty, male-limited	Enrichment	STON1-GTF2A1L	1.81
66	Leydig cell hypoplasia, type i	Enrichment	STON1-GTF2A1L	1.81
67	Spermatogenic failure, y-linked, 2	Enrichment	CFTR	1.81
68	Ovarian germ cell cancer	Enrichment	CBL	1.81
69	Developmental and epileptic encephalopathy 21	Enrichment	NECAP1	1.81
70	Hypobetalipoproteinemia, familial, 1	Enrichment	APOB	1.81
71	Hyperlipoproteinemia, type iii	Enrichment	LDLR	1.81
72	Immunodeficiency 104, severe combined	Enrichment	IL7R	1.81
73	Multiple sclerosis 3	Enrichment	IL7R	1.81
74	Intellectual developmental disorder, autosomal dominant 60, with seizures	Enrichment	AP2M1	1.81
75	Hypobetalipoproteinemia	Enrichment	APOB	1.81
76	Immunodeficiency 17	Enrichment	CD3G	1.81
77	Myasthenic syndrome, congenital, 21, presynaptic	Enrichment	SLC18A3	1.81
78	Leydig cell hypoplasia type ii	Enrichment	STON1-GTF2A1L	1.81
79	Malignant germ cell tumor of ovary	Enrichment	CBL	1.81
80	Non-syndromic syndactyly	Enrichment	LRP2	1.81
81	Submucosal cleft palate	Enrichment	UBB	1.81
82	Cleft hard palate	Enrichment	UBB	1.81
83	Lethal congenital contracture syndrome 3	Enrichment	PIP5K1C	1.67
84	Dent disease 2	Enrichment	OCRL	1.67
85	Deafness, autosomal dominant 20	Enrichment	ACTG1	1.67
86	Baraitser-winter syndrome 2	Enrichment	ACTG1	1.67
87	Ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus	Enrichment	DNAJC6	1.67
88	Parkinson disease 20, early-onset	Enrichment	SYNJ1	1.67
89	Developmental delay, language impairment, and ocular abnormalities	Enrichment	ARPC4	1.67
90	Immunodeficiency 113 with autoimmunity and autoinflammation	Enrichment	ARPC5	1.67
91	Immunodeficiency 133	Enrichment	ARPC5	1.67
92	Uvula, bifid	Enrichment	UBB	1.63
93	Intellectual developmental disorder with microcephaly and pontine and cerebellar hypoplasia	Enrichment	LDLR	1.63
94	Dyslexia 2	Enrichment	KIAA0319	1.63
95	Nuchal bleb, familial	Enrichment	CFTR	1.63
96	Cleft soft palate	Enrichment	UBB	1.63
97	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.63
98	Intellectual developmental disorder, autosomal dominant 56	Enrichment	CLTC	1.63
99	Torsion dystonia 1	Enrichment	TOR1A	1.63
100	Syndromic x-linked intellectual disability najm type	Enrichment	LDLR	1.63
101	Nephrogenic diabetes insipidus	Enrichment	AVPR2	1.63
102	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.63
103	T-b+ severe combined immunodeficiency due to cd3delta/cd3epsilon/cd3zeta	Enrichment	CD3D	1.63
104	Intellectual developmental disorder, autosomal dominant 1	Enrichment	ITSN1	1.51
105	Acyl-coa dehydrogenase, very long-chain, deficiency of	Enrichment	DVL2	1.51
106	Gaucher disease, type i	Enrichment	SCARB2	1.51
107	Robinow syndrome, autosomal dominant 1	Enrichment	WNT5A	1.51
108	Epilepsy, progressive myoclonic, 4, with or without renal failure	Enrichment	SCARB2	1.51
109	Retinopathy of prematurity	Enrichment	FZD4	1.51
110	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 1	Enrichment	CLTC	1.51
111	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL	1.51
112	Prolactinoma	Enrichment	LRP2	1.51
113	Idiopathic bronchiectasis	Enrichment	CFTR	1.51
114	Diabetes insipidus	Enrichment	AVP	1.51
115	Autosomal dominant robinow syndrome	Enrichment	WNT5A	1.51
116	Myopathy, centronuclear, x-linked	Enrichment	DNM2	1.50
117	Developmental and epileptic encephalopathy 31b	Enrichment	DNM1	1.50
118	Dent disease	Enrichment	OCRL	1.50
119	Exudative vitreoretinopathy 1	Enrichment	FZD4	1.41
120	Robinow syndrome, autosomal recessive 1	Enrichment	WNT5A	1.41
121	Norrie disease	Enrichment	FZD4	1.41
122	Myeloproliferative neoplasm	Enrichment	CBL	1.41
123	Pseudohermaphroditism	Enrichment	STON1-GTF2A1L	1.41
124	Persistent hyperplastic primary vitreous	Enrichment	FZD4	1.41
125	Aggressive systemic mastocytosis	Enrichment	CBL	1.41
126	Leukemia, acute myeloid	Enrichment	PICALM, SH3GL1	1.41
127	Myopathy, centronuclear, 2	Enrichment	BIN1	1.37
128	Aminoacylase 1 deficiency	Enrichment	ACTB	1.37
129	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.37
130	Dystonia 11, myoclonic	Enrichment	TOR1A	1.34
131	Renal tubular dysgenesis	Enrichment	AGTR1	1.34
132	Inflammatory myofibroblastic tumor	Enrichment	CLTC	1.34
133	Autosomal recessive robinow syndrome	Enrichment	WNT5A	1.34
134	Lipid metabolism disorder	Enrichment	LDLR	1.34
135	Lung squamous cell carcinoma	Enrichment	EGFR	1.34
136	Developmental and epileptic encephalopathy 31a	Enrichment	DNM1	1.28
137	Coloboma of choroid and retina	Enrichment	ACTG1	1.28
138	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.27
139	Coats disease	Enrichment	FZD4	1.27
140	Noonan syndrome 3	Enrichment	CLTC	1.27
141	Renal cell carcinoma with mit translocations	Enrichment	CLTC	1.27
142	Autosomal dominant non-syndromic intellectual disability	Enrichment	CLTC, ITSN1	1.24
143	Exudative vitreoretinopathy	Enrichment	FZD4	1.22
144	Severe congenital neutropenia	Enrichment	FCHO1	1.22
145	Isolated split hand-split foot malformation	Enrichment	EPS15L1	1.22
146	Bronchiectasis with or without elevated sweat chloride 1	Enrichment	CFTR	1.17
147	Vas deferens, congenital bilateral aplasia of	Enrichment	CFTR	1.17
148	Myoclonic-atonic epilepsy	Enrichment	AP2M1	1.17
149	Adult hepatocellular carcinoma	Enrichment	EGF	1.17
150	Omenn syndrome	Enrichment	IL7R	1.12
151	Neurodegeneration with brain iron accumulation	Enrichment	REPS1	1.12
152	Progressive myoclonus epilepsy	Enrichment	SCARB2	1.12
153	West syndrome	Enrichment	DNM1, SYNJ1	1.09
154	Combined immunodeficiency	Enrichment	TFRC	1.08
155	Lung non-small cell carcinoma	Enrichment	EGFR	1.08
156	Combined t cell and b cell immunodeficiency	Enrichment	TFRC	1.08
157	Combined t and b cell immunodeficiency	Enrichment	TFRC	1.08
158	Lennox-gastaut syndrome	Enrichment	DNM1	1.08
159	Juvenile myelomonocytic leukemia	Enrichment	CBL	1.05
160	Lip and oral cavity carcinoma	Enrichment	EGFR	1.05
161	Cat eye syndrome	Enrichment	ACTG1	0.99
162	Myoclonic epilepsy of unverricht and lundborg	Enrichment	SCARB2	0.98
163	Lung cancer susceptibility 3	Enrichment	EGFR	0.98
164	Congenital myasthenic syndrome	Enrichment	SYT2	0.98
165	Hereditary chronic pancreatitis	Enrichment	CFTR	0.98
166	46,xy partial gonadal dysgenesis	Enrichment	VAMP7	0.98
167	Lynch syndrome	Enrichment	CFTR	0.95
168	Noonan syndrome and noonan-related syndrome	Enrichment	CBL	0.95
169	Rhabdomyosarcoma	Enrichment	CBL	0.93
170	Gliosarcoma	Enrichment	EGFR	0.93
171	Hypertension, essential	Enrichment	AGTR1	0.90
172	Pancreatitis, hereditary	Enrichment	CFTR	0.90
173	Syndromic intellectual disability	Enrichment	SYT1	0.90
174	Giant cell glioblastoma	Enrichment	EGFR	0.90
175	Stereotypic movement disorder	Enrichment	DNM1	0.88
176	Arteriovenous malformations of the brain	Enrichment	EGFR	0.86
177	Esophageal atresia/tracheoesophageal fistula	Enrichment	ITSN1	0.86
178	Hepatocellular carcinoma	Enrichment	IGF2R	0.80
179	Tooth agenesis	Enrichment	TGFA	0.80
180	Noonan syndrome 1	Enrichment	CBL	0.78
181	Precursor t-cell acute lymphoblastic leukemia	Enrichment	PICALM	0.78
182	Jeune thoracic dystrophy	Enrichment	GRK2	0.75
183	Rasopathy	Enrichment	CBL	0.73
184	Asphyxiating thoracic dystrophy	Enrichment	GRK2	0.70
185	Lissencephaly	Enrichment	ACTG1	0.69
186	Centronuclear myopathy	Enrichment	DNM2	0.69
187	Bladder cancer	Enrichment	EGFR	0.69
188	Lung cancer	Enrichment	EGFR	0.65
189	Cystic fibrosis	Enrichment	CFTR	0.65
190	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	GRK2	0.64
191	Male infertility	Enrichment	CFTR	0.63
192	Developmental and epileptic encephalopathy 1	Enrichment	SYNJ1	0.62
193	Dystonia	Enrichment	TOR1A	0.62
194	Fetal akinesia deformation sequence 1	Enrichment	SLC18A3	0.60
195	Benign epilepsy with centrotemporal spikes	Enrichment	SCARB2	0.56
196	Centralopathic epilepsy	Enrichment	SCARB2	0.54
197	Cakut	Enrichment	ACTG1	0.51
198	Genetic steroid-resistant nephrotic syndrome	Enrichment	GAPVD1	0.51
199	Non-syndromic genetic deafness	Enrichment	ACTG1	0.49
200	Myopathy	Enrichment	DNM2	0.45
201	Myeloma, multiple	Enrichment	IL7R	0.45
202	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	CFTR	0.45
203	Charcot-marie-tooth disease	Enrichment	DNM2	0.45
204	Nonsyndromic hearing loss	Enrichment	ACTG1	0.44
205	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	UBQLN2	0.44
206	Primary ovarian insufficiency	Enrichment	IGF2R	0.43
207	Microcephaly	Enrichment	ACTB, ACTG1	0.42
208	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1	0.37
209	Breast cancer	Enrichment	IL7R	0.35
210	Ovarian cancer	Enrichment	EGFR	0.26
211	Rare genetic deafness	Enrichment	ACTG1	0.24
212	Inherited cancer-predisposing syndrome	Enrichment	EGFR	0.19
213	Hereditary retinal dystrophy	Enrichment	FZD4, LRP2	0.18
214	Fundus dystrophy	Enrichment	FZD4, LRP2	0.18

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Clathrin-mediated endocytosis

Pathway Network for Clathrin-mediated endocytosis

Member Pathways for Clathrin-mediated endocytosis

Pathways in the Clathrin-mediated endocytosis SuperPath

Associated Genes for Clathrin-mediated endocytosis

Associated Disorders for Clathrin-mediated endocytosis

Disorders associated with Clathrin-mediated endocytosis SuperPath

STRING Interaction Network for Clathrin-mediated endocytosis

Sources for Clathrin-mediated endocytosis