CLEC7A (Dectin-1) signaling

Pathway network for the CLEC7A (Dectin-1) signaling SuperPath

Sources:

Reactome
PubChem

Pathways in the CLEC7A (Dectin-1) signaling SuperPath

#	Name	Source	Genes
1	CLEC7A (Dectin-1) signaling	Reactome	ADRM1 AHCYL1 BTRC CALM1 CALM2 CALM3 CARD9 CASP8 CDC34 CHUK CLEC7A CUL1 FBXW11 IKBKB IKBKG IL1B ITPR1 ITPR2 ITPR3 MAP3K14 MAP3K7 NFATC1 NFATC2 NFATC3 NFKB1 NFKB2 NFKBIA PDPK1 PLCG2 PPP3CA PPP3CB PPP3R1 PRKCD PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 PYCARD RELA RELB RPS27A SEM1 SKP1 SRC SYK TAB1 TAB2 TAB3 TRAF6 UBA3 UBA52 UBB UBC UBE2D1 UBE2D2 UBE2M UBE2N UBE2V1 (see all 84) (see less)
2	C-type lectin receptors (CLRs)	Reactome	ADRM1 AHCYL1 BTRC CALM1 CALM2 CALM3 CARD9 CASP8 CD209 CDC34 CHUK CLEC10A CLEC4A CLEC4C CLEC4D CLEC4E CLEC6A CLEC7A CREBBP CUL1 EP300 FBXW11 FCER1G FYN HRAS ICAM2 ICAM3 IKBKB IKBKG IL1B ITPR1 ITPR2 ITPR3 KRAS LYN MAP3K14 MAP3K7 MUC1 MUC12 MUC13 MUC15 MUC16 MUC17 MUC19 MUC2 MUC20 MUC21 MUC3A MUC4 MUC5AC MUC5B MUC6 MUC7 MUCL1 NFATC1 NFATC2 NFATC3 NFKB1 NFKB2 NFKBIA NRAS PAK1 PAK2 PAK3 PDPK1 PLCG2 PPP3CA PPP3CB PPP3R1 PRKACA PRKACB PRKACG PRKCD PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 PYCARD RAF1 RELA RELB RPS27A RPS6KA5 SEM1 SKP1 SRC SYK TAB1 TAB2 TAB3 TRAF6 UBA3 UBA52 UBB UBC UBE2D1 UBE2D2 UBE2M UBE2N UBE2V1 (see all 126) (see less)
3	Fc epsilon receptor (FCERI) signaling	Reactome	ADRM1 AHCYL1 BTK BTRC CALM1 CALM2 CALM3 CDC34 CHUK CUL1 FBXW11 FCER1A FCER1G FOS FYN GAB2 GRAP2 GRB2 HRAS IKBKB IKBKG ITK ITPR1 ITPR2 ITPR3 JUN KRAS LAT LCP2 LYN MAP2K4 MAP2K7 MAP3K1 MAP3K7 MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 MS4A2 NFATC1 NFATC2 NFATC3 NFKB1 NFKBIA NRAS PAK1 PAK2 PDPK1 PIK3CA PIK3CB PIK3R1 PIK3R2 PLCG1 PLCG2 PPP3CA PPP3CB PPP3R1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 RAC1 RASGRP1 RASGRP2 RASGRP4 RELA RPS27A SEM1 SHC1 SKP1 SOS1 SYK TAB1 TAB2 TAB3 TRAF6 UBA52 UBB UBC UBE2D1 UBE2D2 UBE2N UBE2V1 VAV1 VAV2 VAV3 (see all 113) (see less)
4	Role of LAT2/NTAL/LAB on calcium mobilization	Reactome	FCER1A FCER1G FYN GAB2 GRB2 LYN MS4A2 PDPK1 PIK3CA PIK3CB PIK3R1 PIK3R2 SHC1 SOS1 SYK (see all 15) (see less)
5	Alternative NF-kappaB pathway	PubChem	BTRC CHUK MAP3K14 NFKB1 NFKB2 RELB (see all 6) (see less)

Gene overlap in member pathways for CLEC7A (Dectin-1) signaling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	4
2	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	4
3	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	4
4	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	4
5	BTRC	Beta-Transducin Repeat Containing E3 Ubiquitin Protein Ligase	Protein Coding	4
6	PSMD14	Proteasome 26S Subunit, Non-ATPase 14	Protein Coding	3
7	TAB1	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1	Protein Coding	3
8	AHCYL1	Adenosylhomocysteinase Like 1	Protein Coding	3
9	ADRM1	ADRM1 26S Proteasome Ubiquitin Receptor	Protein Coding	3
10	TAB2	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 2	Protein Coding	3
11	FBXW11	F-Box And WD Repeat Domain Containing 11	Protein Coding	3
12	TAB3	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 3	Protein Coding	3
13	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	3
14	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	3
15	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	3
16	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	3
17	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	3
18	NFATC2	Nuclear Factor Of Activated T Cells 2	Protein Coding	3
19	NFATC3	Nuclear Factor Of Activated T Cells 3	Protein Coding	3
20	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	3
21	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	3
22	PLCG2	Phospholipase C Gamma 2	Protein Coding	3
23	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	3
24	PPP3CB	Protein Phosphatase 3 Catalytic Subunit Beta	Protein Coding	3
25	PPP3R1	Protein Phosphatase 3 Regulatory Subunit B, Alpha	Protein Coding	3
26	PSMA1	Proteasome 20S Subunit Alpha 1	Protein Coding	3
27	PSMA2	Proteasome 20S Subunit Alpha 2	Protein Coding	3
28	PSMA3	Proteasome 20S Subunit Alpha 3	Protein Coding	3
29	PSMA4	Proteasome 20S Subunit Alpha 4	Protein Coding	3
30	PSMA5	Proteasome 20S Subunit Alpha 5	Protein Coding	3
31	PSMA6	Proteasome 20S Subunit Alpha 6	Protein Coding	3
32	PSMA7	Proteasome 20S Subunit Alpha 7	Protein Coding	3
33	PSMB1	Proteasome 20S Subunit Beta 1	Protein Coding	3
34	PSMB2	Proteasome 20S Subunit Beta 2	Protein Coding	3
35	PSMB3	Proteasome 20S Subunit Beta 3	Protein Coding	3
36	PSMB4	Proteasome 20S Subunit Beta 4	Protein Coding	3
37	PSMB5	Proteasome 20S Subunit Beta 5	Protein Coding	3
38	PSMB6	Proteasome 20S Subunit Beta 6	Protein Coding	3
39	PSMB7	Proteasome 20S Subunit Beta 7	Protein Coding	3
40	PSMC1	Proteasome 26S Subunit, ATPase 1	Protein Coding	3
41	PSMC2	Proteasome 26S Subunit, ATPase 2	Protein Coding	3
42	PSMC3	Proteasome 26S Subunit, ATPase 3	Protein Coding	3
43	PSMC4	Proteasome 26S Subunit, ATPase 4	Protein Coding	3
44	PSMC5	Proteasome 26S Subunit, ATPase 5	Protein Coding	3
45	PSMC6	Proteasome 26S Subunit, ATPase 6	Protein Coding	3
46	PSMD1	Proteasome 26S Subunit, Non-ATPase 1	Protein Coding	3
47	PSMD2	Proteasome 26S Subunit Ubiquitin Receptor, Non-ATPase 2	Protein Coding	3
48	PSMD3	Proteasome 26S Subunit, Non-ATPase 3	Protein Coding	3
49	PSMD7	Proteasome 26S Subunit, Non-ATPase 7	Protein Coding	3
50	PSMD8	Proteasome 26S Subunit, Non-ATPase 8	Protein Coding	3
51	PSMD11	Proteasome 26S Subunit, Non-ATPase 11	Protein Coding	3
52	PSMD12	Proteasome 26S Subunit, Non-ATPase 12	Protein Coding	3
53	PSMD13	Proteasome 26S Subunit, Non-ATPase 13	Protein Coding	3
54	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	3
55	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	3
56	RPS27A	Ribosomal Protein S27a	Protein Coding	3
57	SKP1	S-Phase Kinase Associated Protein 1	Protein Coding	3
58	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	3
59	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	3
60	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	3
61	UBB	Ubiquitin B	Protein Coding	3
62	UBC	Ubiquitin C	Protein Coding	3
63	UBE2D1	Ubiquitin Conjugating Enzyme E2 D1	Protein Coding	3
64	UBE2D2	Ubiquitin Conjugating Enzyme E2 D2	Protein Coding	3
65	UBE2N	Ubiquitin Conjugating Enzyme E2 N	Protein Coding	3
66	UBE2V1	Ubiquitin Conjugating Enzyme E2 V1	Protein Coding	3
67	SEM1	SEM1 26S Proteasome Subunit	Protein Coding	3
68	CALM1	Calmodulin 1	Protein Coding	3
69	CALM2	Calmodulin 2	Protein Coding	3
70	CALM3	Calmodulin 3	Protein Coding	3
71	CUL1	Cullin 1	Protein Coding	3
72	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	3
73	MAP3K14	Mitogen-Activated Protein Kinase Kinase Kinase 14	Protein Coding	3
74	PSMD6	Proteasome 26S Subunit, Non-ATPase 6	Protein Coding	3
75	CDC34	Cell Division Cycle 34, Ubiquitin Conjugating Enzyme	Protein Coding	3
76	FCER1G	Fc Epsilon Receptor Ig	Protein Coding	3
77	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	3
78	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	3
79	PYCARD	PYD And CARD Domain Containing	Protein Coding	2
80	IL1B	Interleukin 1 Beta	Protein Coding	2
81	PRKCD	Protein Kinase C Delta	Protein Coding	2
82	CARD9	Caspase Recruitment Domain Family Member 9	Protein Coding	2
83	CLEC7A	C-Type Lectin Domain Containing 7A	Protein Coding	2
84	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	2
85	CASP8	Caspase 8	Protein Coding	2
86	UBA3	Ubiquitin Like Modifier Activating Enzyme 3	Protein Coding	2
87	UBE2M	Ubiquitin Conjugating Enzyme E2 M	Protein Coding	2
88	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	2
89	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	2
90	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	2
91	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	2
92	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	2
93	FCER1A	Fc Epsilon Receptor Ia	Protein Coding	2
94	MS4A2	Membrane Spanning 4-Domains A2	Protein Coding	2
95	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	2
96	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	2
97	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	2
98	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	2
99	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	2
100	SHC1	SHC Adaptor Protein 1	Protein Coding	2
101	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	2
102	GAB2	GRB2 Associated Binding Protein 2	Protein Coding	2
103	MUC12	Mucin 12, Cell Surface Associated	Protein Coding	1
104	CLEC10A	C-Type Lectin Domain Containing 10A	Protein Coding	1
105	MUCL1	Mucin Like 1	Protein Coding	1
106	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	1
107	MUC17	Mucin 17, Cell Surface Associated	Protein Coding	1
108	MUC15	Mucin 15, Cell Surface Associated	Protein Coding	1
109	CLEC4C	C-Type Lectin Domain Family 4 Member C	Protein Coding	1
110	MUC20	Mucin 20, Cell Surface Associated	Protein Coding	1
111	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
112	CLEC4E	C-Type Lectin Domain Family 4 Member E	Protein Coding	1
113	MUC19	Mucin 19, Oligomeric (Gene/Pseudogene)	Protein Coding	1
114	CD209	CD209 Molecule	Protein Coding	1
115	CLEC4D	C-Type Lectin Domain Family 4 Member D	Protein Coding	1
116	ICAM2	Intercellular Adhesion Molecule 2	Protein Coding	1
117	ICAM3	Intercellular Adhesion Molecule 3	Protein Coding	1
118	MUC21	Mucin 21, Cell Surface Associated	Protein Coding	1
119	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	1
120	MUC2	Mucin 2, Oligomeric Mucus/Gel-Forming	Protein Coding	1
121	MUC3A	Mucin 3A, Cell Surface Associated	Protein Coding	1
122	MUC4	Mucin 4, Cell Surface Associated	Protein Coding	1
123	MUC5AC	Mucin 5AC, Oligomeric Mucus/Gel-Forming	Protein Coding	1
124	MUC6	Mucin 6, Oligomeric Mucus/Gel-Forming (Gene/Pseudogene)	Protein Coding	1
125	MUC7	Mucin 7, Secreted	Protein Coding	1
126	PAK3	P21 (RAC1) Activated Kinase 3	Protein Coding	1
127	CLEC4A	C-Type Lectin Domain Family 4 Member A	Protein Coding	1
128	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
129	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	1
130	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	1
131	MUC13	Mucin 13, Cell Surface Associated	Protein Coding	1
132	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
133	MUC5B	Mucin 5B, Oligomeric Mucus/Gel-Forming	Protein Coding	1
134	RPS6KA5	Ribosomal Protein S6 Kinase A5	Protein Coding	1
135	CLEC6A	C-Type Lectin Domain Containing 6A	Protein Coding	1
136	MUC16	Mucin 16, Cell Surface Associated	Protein Coding	1
137	RASGRP1	RAS Guanyl Releasing Protein 1	Protein Coding	1
138	RASGRP2	RAS Guanyl Releasing Protein 2	Protein Coding	1
139	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	1
140	RASGRP4	RAS Guanyl Releasing Protein 4	Protein Coding	1
141	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
142	LAT	Linker For Activation Of T Cells	Protein Coding	1
143	ITK	IL2 Inducible T Cell Kinase	Protein Coding	1
144	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
145	LCP2	Lymphocyte Cytosolic Protein 2	Protein Coding	1
146	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
147	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
148	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
149	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
150	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
151	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
152	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
153	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	1
154	RAC1	Rac Family Small GTPase 1	Protein Coding	1
155	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
156	BTK	Bruton Tyrosine Kinase	Protein Coding	1
157	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	1
158	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	1
159	GRAP2	GRB2 Related Adaptor Protein 2	Protein Coding	1

Disorders associated with CLEC7A (Dectin-1) signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS, PIK3CA	6.80
2	Lung non-small cell carcinoma	Enrichment	HRAS, KRAS, NRAS, PIK3CA	5.84
3	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	5.65
4	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	5.47
5	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	5.47
6	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, NRAS, SOS1	5.24
7	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	5.16
8	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	4.90
9	Noonan syndrome 3	Enrichment	HRAS, KRAS, SOS1	4.72
10	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3, ITPR3	4.48
11	Noonan syndrome 1	Enrichment	HRAS, KRAS, NRAS, SOS1	4.45
12	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	4.42
13	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS, RAF1	4.37
14	Rasopathy	Enrichment	HRAS, KRAS, NRAS, SOS1	4.23
15	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	4.16
16	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	3.69
17	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	3.39
18	Fetal encasement syndrome	Enrichment	CHUK	3.35
19	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	3.35
20	Immunodeficiency 53	Enrichment	RELB	3.35
21	Bartsocas-papas syndrome 2	Enrichment	CHUK	3.35
22	Immunodeficiency 112	Enrichment	MAP3K14	3.35
23	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	3.35
24	Nik deficiency	Enrichment	MAP3K14	3.35
25	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	3.05
26	Immunodeficiency, common variable, 10	Enrichment	NFKB2	3.05
27	Common variable immunodeficiency 12	Enrichment	NFKB1	3.05
28	Breast adenocarcinoma	Enrichment	KRAS, PIK3CA	3.00
29	Lung squamous cell carcinoma	Enrichment	KRAS, PIK3CA	3.00
30	Isolated split hand-split foot malformation	Enrichment	BTRC, SEM1	2.98
31	Macrodactyly	Enrichment	PIK3CA	2.96
32	Noonan syndrome 4	Enrichment	SOS1	2.96
33	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.96
34	Cowden syndrome 5	Enrichment	PIK3CA	2.96
35	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.96
36	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	2.96
37	Short syndrome	Enrichment	PIK3R1	2.96
38	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.96
39	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.96
40	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.96
41	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.96
42	Autoinflammatory disease, systemic, with vasculitis	Enrichment	LYN	2.96
43	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.96
44	Hypospadias	Enrichment	PIK3CA	2.96
45	Colitis	Enrichment	SYK	2.96
46	Rare venous malformation	Enrichment	PIK3CA	2.96
47	Diaphragmatic eventration	Enrichment	PIK3CA	2.96
48	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.96
49	Rare combined vascular malformation	Enrichment	PIK3CA	2.96
50	Cavernous lymphangioma	Enrichment	PIK3CA	2.96
51	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.96
52	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.96
53	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.96
54	Macrodactyly of toe	Enrichment	PIK3CA	2.96
55	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	2.90
56	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	2.90
57	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	2.85
58	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, PIK3CA	2.85
59	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	2.85
60	Gallbladder cancer	Enrichment	KRAS, PIK3CA	2.85
61	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	2.85
62	Pilomyxoid astrocytoma	Enrichment	KRAS, RAF1	2.76
63	Bladder cancer	Enrichment	HRAS, KRAS, PIK3CA	2.76
64	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	2.76
65	Immunodeficiency, common variable, 1	Enrichment	NFKB2	2.75
66	Fibromatosis, gingival, 1	Enrichment	SOS1	2.66
67	Pulmonic stenosis	Enrichment	SOS1	2.66
68	Keratosis, seborrheic	Enrichment	PIK3CA	2.66
69	Noonan syndrome 8	Enrichment	PIK3CA	2.66
70	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.66
71	Arthritis	Enrichment	SYK	2.66
72	Arteriovenous malformation	Enrichment	HRAS, PIK3CA	2.62
73	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	2.53
74	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, PIK3CA	2.53
75	Breast cancer	Enrichment	PIK3CA, SHC1	2.52
76	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.48
77	Nuchal bleb, familial	Enrichment	SOS1	2.48
78	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.48
79	Immunodeficiency 14	Enrichment	PIK3R1	2.48
80	Keratoacanthoma	Enrichment	PIK3CA	2.48
81	Colorectal cancer	Enrichment	PIK3CA, PIK3R1	2.39
82	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	2.37
83	Lip and oral cavity carcinoma	Enrichment	HRAS, PIK3CA	2.37
84	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	2.35
85	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	2.35
86	Cerebrovascular disease	Enrichment	PIK3CA	2.35
87	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.35
88	Gingival fibromatosis	Enrichment	SOS1	2.35
89	Aortic valve disease 1	Enrichment	SOS1, TAB2	2.30
90	Patent foramen ovale	Enrichment	PSMC3, TAB2	2.26
91	Capillary malformations, congenital	Enrichment	PIK3CA	2.26
92	Hemimegalencephaly	Enrichment	PIK3CA	2.26
93	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1, SOS1	2.23
94	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	2.21
95	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.21
96	Immunodeficiency 103 fungal infections	Enrichment	CARD9	2.21
97	Incontinentia pigmenti	Enrichment	IKBKG	2.21
98	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.21
99	Caspase 8 deficiency	Enrichment	CASP8	2.21
100	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.21
101	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.21
102	Immunodeficiency 15b	Enrichment	IKBKB	2.21
103	Neurodevelopmental disorder with microcephaly, hypotonia, and absent language	Enrichment	PSMB1	2.21
104	Immunodeficiency 15a	Enrichment	IKBKB	2.21
105	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	2.21
106	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	2.21
107	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	2.21
108	Neurodevelopmental, jaw, eye, and digital syndrome	Enrichment	FBXW11	2.21
109	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.21
110	Stankiewicz-isidor syndrome	Enrichment	PSMD12	2.21
111	Candidiasis, familial, 4	Enrichment	CLEC7A	2.21
112	Deafness, cataract, impaired intellectual development, and polyneuropathy	Enrichment	PSMC3	2.21
113	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.21
114	Long qt syndrome 16	Enrichment	CALM3	2.21
115	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.21
116	Thrombocytopenia 6	Enrichment	SRC	2.21
117	Long qt syndrome 15	Enrichment	CALM2	2.21
118	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	2.21
119	Polyvalvular heart disease syndrome	Enrichment	TAB2	2.21
120	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	2.18
121	Cowden syndrome 1	Enrichment	PIK3CA	2.18
122	Hemihyperplasia, isolated	Enrichment	PIK3CA	2.18
123	Lynch syndrome	Enrichment	KRAS, PIK3CA	2.17
124	Overgrowth syndrome	Enrichment	PIK3R1	2.11
125	Rare genetic intellectual disability	Enrichment	CREBBP, EP300	2.08
126	Oculoectodermal syndrome	Enrichment	KRAS	2.08
127	Melanosis, neurocutaneous	Enrichment	NRAS	2.08
128	Bleeding disorder, platelet-type, 18	Enrichment	RASGRP2	2.08
129	Noonan syndrome 6	Enrichment	NRAS	2.08
130	46,xy sex reversal 6	Enrichment	MAP3K1	2.08
131	Immunodeficiency 64 with lymphoproliferation	Enrichment	RASGRP1	2.08
132	Noonan syndrome 13	Enrichment	MAPK1	2.08
133	Immunodeficiency 81	Enrichment	LCP2	2.08
134	Knobloch syndrome 2	Enrichment	PAK2	2.08
135	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.08
136	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.08
137	Isolated growth hormone deficiency type iii	Enrichment	BTK	2.08
138	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.08
139	Lymphoproliferative syndrome 1	Enrichment	ITK	2.08
140	Congenital pulmonary airway malformation	Enrichment	KRAS	2.08
141	Immunodeficiency 64	Enrichment	RASGRP1	2.08
142	Ebv-induced lymphoproliferative disease due to rasgrp1 deficiency	Enrichment	RASGRP1	2.08
143	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.08
144	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.08
145	Neurocutaneous melanocytosis	Enrichment	NRAS	2.08
146	Intellectual developmental disorder, x-linked 30	Enrichment	PAK3	2.03
147	Noonan syndrome 5	Enrichment	RAF1	2.03
148	Tubulointerstitial kidney disease, autosomal dominant 2	Enrichment	MUC1	2.03
149	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.03
150	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.03
151	Leopard syndrome 2	Enrichment	RAF1	2.03
152	Dengue virus	Enrichment	CD209	2.03
153	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.03
154	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.03
155	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.03
156	Trigonitis	Enrichment	RAF1	2.03
157	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.03
158	Menke-hennekam syndrome	Enrichment	CREBBP	2.03
159	Extrinsic allergic alveolitis	Enrichment	MUC5B	2.03
160	Adult hepatocellular carcinoma	Enrichment	PIK3CA	2.00
161	Cowden syndrome	Enrichment	PIK3CA	2.00
162	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.96
163	Immune deficiency disease	Enrichment	SYK	1.92
164	Spinocerebellar ataxia 29	Enrichment	ITPR1	1.91
165	Immunodeficiency 33	Enrichment	IKBKG	1.91
166	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	1.91
167	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	1.91
168	Aspergillosis	Enrichment	CLEC7A	1.91
169	Long qt syndrome 14	Enrichment	CALM1	1.91
170	Birk-aharoni syndrome	Enrichment	PSMC1	1.91
171	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	1.91
172	Proteasome-associated autoinflammatory syndrome 3	Enrichment	PSMB4	1.91
173	Rela fusion-positive ependymoma	Enrichment	RELA	1.91
174	Congenital heart defects, multiple types, 2	Enrichment	TAB2	1.91
175	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	1.91
176	17q24.2 microdeletion syndrome	Enrichment	PSMD12	1.91
177	Joint contractures, osteochondromas, and b-cell lymphoma	Enrichment	NFATC2	1.91
178	Cardiac anomalies-short stature-joint hypermobility-facial dysmorphism syndrome	Enrichment	TAB2	1.91
179	Submucosal cleft palate	Enrichment	UBB	1.91
180	Cleft hard palate	Enrichment	UBB	1.91
181	Meningioma	Enrichment	PIK3CA	1.88
182	Nk-cell enteropathy	Enrichment	PIK3CB	1.85
183	Long qt syndrome	Enrichment	CALM1, CALM2	1.80
184	Costello syndrome	Enrichment	HRAS	1.78
185	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	1.78
186	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	1.78
187	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.78
188	Agammaglobulinemia, x-linked	Enrichment	BTK	1.78
189	Lymphoproliferative syndrome	Enrichment	ITK	1.78
190	Immunodeficiency 52	Enrichment	LAT	1.78
191	Wooly hair nevus	Enrichment	HRAS	1.78
192	Pelvic organ prolapse	Enrichment	TAB2	1.73
193	Proteasome-associated autoinflammatory syndrome 1	Enrichment	PSMB4	1.73
194	Gillespie syndrome	Enrichment	ITPR1	1.73
195	Uvula, bifid	Enrichment	UBB	1.73
196	Cleft soft palate	Enrichment	UBB	1.73
197	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.73
198	Proteosome-associated autoinflammatory syndrome	Enrichment	PSMB4	1.73
199	Frontometaphyseal dysplasia	Enrichment	MAP3K7	1.73
200	Thyroid hemiagenesis	Enrichment	PSMD3	1.73
201	Thumb deformity	Enrichment	CREBBP	1.73
202	Panbronchiolitis, diffuse	Enrichment	MUC5B	1.73
203	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	1.73
204	Menke-hennekam syndrome 2	Enrichment	EP300	1.73
205	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	1.73
206	Fibrolamellar carcinoma	Enrichment	PRKACA	1.73
207	Endometrial cancer	Enrichment	PIK3CA	1.64
208	Hepatocellular carcinoma	Enrichment	PIK3CA	1.62
209	Spinocerebellar ataxia 15	Enrichment	ITPR1	1.61
210	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK	1.61
211	Langerhans cell histiocytosis	Enrichment	NRAS	1.61
212	Agammaglobulinemia 1	Enrichment	BTK	1.61
213	Spermatocytoma	Enrichment	HRAS	1.61
214	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	1.56
215	Tethered spinal cord syndrome	Enrichment	CREBBP	1.56
216	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	1.56
217	Lung cancer	Enrichment	KRAS, PIK3CA	1.54
218	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.51
219	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.51
220	Prostate cancer	Enrichment	PIK3CA	1.50
221	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	1.48
222	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.48
223	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.48
224	Congenital generalized lipodystrophy	Enrichment	FOS	1.48
225	Cardiofaciocutaneous syndrome	Enrichment	KRAS	1.48
226	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.48
227	Pilocytic astrocytoma	Enrichment	KRAS	1.48
228	Epidermolytic nevus	Enrichment	HRAS	1.48
229	Knobloch syndrome	Enrichment	PAK2	1.48
230	Developmental dysplasia of the hip 1	Enrichment	PSMC3	1.44
231	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.44
232	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.44
233	Patent ductus arteriosus	Enrichment	PSMC3	1.44
234	Chronic mucocutaneous candidiasis	Enrichment	CLEC7A	1.44
235	Noonan syndrome with multiple lentigines	Enrichment	RAF1	1.44
236	Knobloch syndrome 1	Enrichment	PAK2	1.39
237	Histiocytoid hemangioma	Enrichment	FOS	1.39
238	Myelofibrosis	Enrichment	SRC	1.37
239	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	1.36
240	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.34
241	Gastric cancer	Enrichment	PIK3CA	1.33
242	Hereditary breast carcinoma	Enrichment	PIK3CA	1.32
243	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.31
244	Ovarian cancer	Enrichment	KRAS, MAP3K1, PIK3CA	1.28
245	Coronary heart disease 5	Enrichment	IKBKG	1.26
246	Pulmonary fibrosis	Enrichment	MUC5B	1.26
247	Hypertrichosis	Enrichment	CREBBP	1.26
248	Hypertelorism	Enrichment	PIK3CA	1.25
249	Myeloma, multiple	Enrichment	PIK3R2	1.22
250	Polymicrogyria	Enrichment	PSMC3	1.22
251	Lennox-gastaut syndrome	Enrichment	MAPK10	1.19
252	Migraine with or without aura 1	Enrichment	TAB2	1.18
253	Congenital long qt syndrome	Enrichment	ITPR3	1.14
254	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.14
255	Charge syndrome	Enrichment	EP300	1.09
256	Multiple sclerosis	Enrichment	ITPR1	1.08
257	Osteoporosis	Enrichment	SRC	1.08
258	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.06
259	Specific learning disability	Enrichment	MAPK1	1.06
260	Anterior segment dysgenesis	Enrichment	ITPR1	1.05
261	Gliosarcoma	Enrichment	NFKBIA	1.02
262	Asthma	Enrichment	MUC7	1.01
263	Sudden infant death syndrome	Enrichment	CALM2	1.00
264	Giant cell glioblastoma	Enrichment	NFKBIA	1.00
265	Protein-deficiency anemia	Enrichment	NRAS	0.99
266	Microcephaly	Enrichment	EP300, PAK3, PSMC3	0.97
267	Complex neurodevelopmental disorder	Enrichment	FBXW11, PAK3, PSMD12	0.96
268	Lung cancer susceptibility 3	Enrichment	KRAS	0.96
269	Cardiomyopathy, dilated, 1a	Enrichment	NFATC2	0.91
270	Heart disease	Enrichment	CREBBP	0.91
271	Rhabdomyosarcoma	Enrichment	HRAS	0.90
272	Myocardial infarction	Enrichment	PSMA6	0.89
273	Polydactyly, postaxial, type a1	Enrichment	EP300	0.88
274	Corpus callosum, agenesis of	Enrichment	CREBBP	0.88
275	Isolated corpus callosum agenesis	Enrichment	CREBBP	0.88
276	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	0.88
277	Malaria	Enrichment	IKBKG	0.88
278	Heart, malformation of	Enrichment	MAPK1	0.85
279	Interstitial lung disease 2	Enrichment	MUC5B	0.83
280	Arteriovenous malformations of the brain	Enrichment	KRAS	0.83
281	Diffuse large b-cell lymphoma	Enrichment	BTK	0.83
282	Human immunodeficiency virus type 1	Enrichment	CD209	0.81
283	Dilated cardiomyopathy	Enrichment	RAF1, TAB2	0.77
284	Severe combined immunodeficiency	Enrichment	IKBKB	0.73
285	Pancreatic cancer	Enrichment	KRAS	0.72
286	Hydrops fetalis, nonimmune	Enrichment	HRAS	0.71
287	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	0.70
288	Scoliosis	Enrichment	CREBBP	0.70
289	Severe covid-19	Enrichment	MUC5B	0.62
290	Thrombocytopenia	Enrichment	SRC	0.59
291	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.58
292	Autosomal dominant non-syndromic intellectual disability	Enrichment	PPP3CA	0.57
293	Left ventricular noncompaction	Enrichment	RAF1	0.55
294	Spastic ataxia	Enrichment	ITPR1	0.55
295	Undetermined early-onset epileptic encephalopathy	Enrichment	PPP3CA	0.53
296	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	0.43
297	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.41
298	Autism	Enrichment	CREBBP	0.31
299	Congenital nervous system abnormality	Enrichment	CREBBP	0.20
300	Nervous system disease	Enrichment	CREBBP	0.20

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

CLEC7A (Dectin-1) signaling

Pathway Network for CLEC7A (Dectin-1) signaling

Pathway network for the CLEC7A (Dectin-1) signaling SuperPath

Member Pathways for CLEC7A (Dectin-1) signaling

Pathways in the CLEC7A (Dectin-1) signaling SuperPath

Gene overlap in member pathways for CLEC7A (Dectin-1) signaling SuperPath

Associated Genes for CLEC7A (Dectin-1) signaling

Associated Disorders for CLEC7A (Dectin-1) signaling

Disorders associated with CLEC7A (Dectin-1) signaling SuperPath

STRING Interaction Network for CLEC7A (Dectin-1) signaling

Sources for CLEC7A (Dectin-1) signaling