Clock-controlled autophagy in bone metabolism

No Pathway Network information available for Clock-controlled autophagy in bone metabolism

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

Disorders associated with Clock-controlled autophagy in bone metabolism SuperPath

according to GeneCards Suite gene sharing
#DisorderTypeGenesScore
1Van buchem diseaseEnrichmentLRP5, SOST4.46
2Craniodiaphyseal dysplasiaEnrichmentSOST, SP74.46
3Paget disease of bone 5, juvenile-onsetEnrichmentTNFRSF11A, TNFRSF11B4.46
4Spastic paraplegia-paget disease of bone syndromeEnrichmentSQSTM1, VCP4.46
5Pulmonary arterial hypertension associated with congenital heart diseaseEnrichmentBMPR2, SMAD93.99
6Paget disease of bone 2, early-onsetEnrichmentSQSTM1, TNFRSF11A3.69
7Paget's disease of bone 2EnrichmentSQSTM1, TNFRSF11A3.69
8Atrioventricular septal defectEnrichmentBMP5, NR1D23.47
9Breast adenocarcinomaEnrichmentAKT1, RB1CC13.29
10Hemochromatosis, type 1EnrichmentBMP2, BMP63.03
11Behavioral variant of frontotemporal dementiaEnrichmentSQSTM1, VCP2.92
12Frontotemporal dementia and/or amyotrophic lateral sclerosis 1EnrichmentSQSTM1, VCP2.82
13Heritable pulmonary arterial hypertensionEnrichmentBMPR2, SMAD92.74
14Osteogenesis imperfecta, type ivEnrichmentSERPINF1, SP72.59
15Chiari malformation type iEnrichmentDKK12.23
16Proteus syndromeEnrichmentAKT12.23
17Endosteal hyperostosis, autosomal dominantEnrichmentLRP52.23
18Craniodiaphyseal dysplasia, autosomal dominantEnrichmentSOST2.23
19Paget disease of bone 3EnrichmentSQSTM12.23
20Bone mineral density quantitative trait locus 1EnrichmentLRP52.23
21Exudative vitreoretinopathy 4EnrichmentLRP52.23
22Sclerosteosis 1EnrichmentSOST2.23
23PycnodysostosisEnrichmentCTSK2.23
24Osteopetrosis, autosomal recessive 7EnrichmentTNFRSF11A2.23
25Brachyphalangy, polydactyly, and tibial aplasia/hypoplasiaEnrichmentHMGB12.23
26Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 1EnrichmentVCP2.23
27Short sleep, familial natural, 1EnrichmentBHLHE412.23
28Split-hand/foot malformation 6EnrichmentWNT10B2.23
29Tooth agenesis, selective, 8EnrichmentWNT10B2.23
30Myopathy, distal, with rimmed vacuolesEnrichmentSQSTM12.23
31Spinocerebellar ataxia, autosomal recessive 25EnrichmentATG52.23
32Frontotemporal dementia and/or amyotrophic lateral sclerosis 3EnrichmentSQSTM12.23
33Epilepsy, idiopathic generalized 15EnrichmentRORB2.23
34Osteopetrosis, autosomal dominant 3EnrichmentPLEKHM12.23
35Microphthalmia, syndromic 6EnrichmentBMP42.23
36Danon diseaseEnrichmentLAMP22.23
37Orofacial cleft 11EnrichmentBMP42.23
38Osteoporosis-pseudoglioma syndromeEnrichmentLRP52.23
39Cataract 18EnrichmentFYCO12.23
40Cone-rod dystrophy 21EnrichmentDRAM22.23
41Polycystic liver disease 4 with or without kidney cystsEnrichmentLRP52.23
42Inflammatory bowel disease 10EnrichmentATG16L12.23
43Iron overloadEnrichmentBMP62.23
44Hypogonadotropic hypogonadism 16 with or without anosmiaEnrichmentSEMA3A2.23
45Cowden syndrome 6EnrichmentAKT12.23
46Pulmonary hypertension, primary, 2EnrichmentSMAD92.23
47Delayed sleep phase disorderEnrichmentCRY12.23
48Frontotemporal dementia and/or amyotrophic lateral sclerosis 6EnrichmentVCP2.23
4920p12.3 microdeletion syndromeEnrichmentBMP22.23
50Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1EnrichmentBMP22.23
51Multisystem proteinopathyEnrichmentVCP2.23
52Heritable thoracic aortic diseaseEnrichmentSMAD42.23
53Adult-onset distal myopathy due to vcp mutationEnrichmentVCP2.23
54Lrp5-related primary osteoporosisEnrichmentLRP52.23
55Primary pulmonary hypertensionEnrichmentBMPR22.23
56Pulmonary hypertensionEnrichmentBMPR22.23
57Drug- or toxin-induced pulmonary arterial hypertensionEnrichmentBMPR22.23
58Osteosclerosis-developmental delay-craniosynostosis syndromeEnrichmentLRP52.23
59Brittle bone disorderEnrichmentLRP5, SERPINF12.10
60Familial expansile osteolysisEnrichmentTNFRSF11A1.93
61Hypoparathyroidism, familial isolated, 1EnrichmentPTH1.93
62Metaphyseal dysplasia with maxillary hypoplasia with or without brachydactylyEnrichmentRUNX21.93
63Myhre syndromeEnrichmentSMAD41.93
64Camurati-engelmann disease 1EnrichmentTGFB11.93
65Pulmonary venoocclusive disease 1, autosomal dominantEnrichmentBMPR21.93
66Amyotrophic lateral sclerosis 6 with or without frontotemporal dementiaEnrichmentVCP1.93
67Juvenile polyposis/hereditary hemorrhagic telangiectasia syndromeEnrichmentSMAD41.93
68Welander distal myopathyEnrichmentSQSTM11.93
69Osteogenesis imperfecta, type xiiEnrichmentSP71.93
70Fibrodysplasia ossificans progressivaEnrichmentBMPR21.93
71Adams-oliver syndrome 5EnrichmentNOTCH11.93
72Fatty liver disease 1EnrichmentATG71.93
73Thrombocythemia 3EnrichmentJAK21.93
74Osteopetrosis, autosomal recessive 2EnrichmentTNFSF111.93
75Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onsetEnrichmentSQSTM11.93
76Cebalid syndromeEnrichmentMTOR1.93
77Inflammatory bowel disease, immunodeficiency, and encephalopathyEnrichmentTGFB11.93
78Pulmonary venoocclusive disease 1EnrichmentBMPR21.93
79Intravascular large b-cell lymphomaEnrichmentBCL21.93
80SclerosteosisEnrichmentSOST1.93
81Spinocerebellar ataxia, autosomal recessive 31EnrichmentATG71.93
82Camurati-engelmann diseaseEnrichmentTGFB11.93
83Paget's disease of boneEnrichmentSQSTM11.93
84Smith-kingsmore syndromeEnrichmentMTOR1.93
85PolycythemiaEnrichmentJAK21.93
86Craniosynostosis 7EnrichmentBMP21.93
87Growth delay due to insulin-like growth factor type 1 deficiencyEnrichmentIGF11.93
88Hypereosinophilic syndromeEnrichmentJAK21.93
89Pulmonary venoocclusive diseaseEnrichmentBMPR21.93
90OsteosclerosisEnrichmentLRP51.93
91Idiopathic/heritable pulmonary arterial hypertensionEnrichmentBMPR21.93
92Cleidocranial dysplasia 1EnrichmentRUNX21.75
93Juvenile polyposis syndromeEnrichmentSMAD41.75
94DysosteosclerosisEnrichmentTNFRSF11A1.75
95Polycythemia veraEnrichmentJAK21.75
96Osteopetrosis, autosomal dominant 1EnrichmentLRP51.75
97Osteoporosis, juvenileEnrichmentDKK11.75
98Transposition of the great arteries, dextro-loopedEnrichmentBMP21.75
99Osteogenesis imperfecta, type viEnrichmentSERPINF11.75
100Nail disorder, nonsyndromic congenital, 9EnrichmentCTSK1.75
101Inclusion body myopathy with paget disease of bone and frontotemporal dementiaEnrichmentVCP1.75
102Breast implant-associated anaplastic large cell lymphomaEnrichmentJAK21.75
103Osteopetrosis, autosomal recessive 6EnrichmentPLEKHM11.75
104High-grade b-cell lymphoma double-hit/triple-hitEnrichmentBCL21.75
105Familial isolated hypoparathyroidismEnrichmentPTH1.75
106Cleidocranial dysplasiaEnrichmentRUNX21.75
107Adult-onset myasthenia gravisEnrichmentTNFRSF11A1.75
108KeratoacanthomaEnrichmentNOTCH11.75
109Kaposi sarcomaEnrichmentIL61.63
110Erythrocytosis, familial, 1EnrichmentJAK21.63
111Brachydactyly, type a2EnrichmentBMP21.63
112Robinow syndrome, autosomal dominant 1EnrichmentWNT5A1.63
113Budd-chiari syndromeEnrichmentJAK21.63
114Microtia-anotiaEnrichmentBMP51.63
115Focal cortical dysplasia, type iiEnrichmentMTOR1.63
116Chondrocalcinosis 2EnrichmentTNFRSF11B1.63
117Barrett esophagusEnrichmentCTHRC11.63
118Cone-rod dystrophy 16EnrichmentDRAM21.63
119Leptin deficiency or dysfunctionEnrichmentLEP1.63
120Retinopathy of prematurityEnrichmentLRP51.63
121Autosomal dominant robinow syndromeEnrichmentWNT5A1.63
122Autosomal recessive osteopetrosisEnrichmentTNFSF111.63
123Primary hyperparathyroidismEnrichmentPTH1.63
124Systemic-onset juvenile idiopathic arthritisEnrichmentIL61.63
125Isolated focal cortical dysplasia type iiEnrichmentMTOR1.63
126VitreoretinopathyEnrichmentLRP51.63
127Familial thoracic aortic aneurysm and aortic dissectionEnrichmentNOTCH1, SMAD41.56
128Hereditary breast carcinomaEnrichmentAKT1, RB1CC11.56
129Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominantEnrichmentTRAF61.54
130Dementia, lewy bodyEnrichmentVCP1.54
131Exudative vitreoretinopathy 1EnrichmentLRP51.54
132Robinow syndrome, autosomal recessive 1EnrichmentWNT5A1.54
133Rheumatoid arthritis, systemic juvenileEnrichmentIL61.54
134Insulin-like growth factor iEnrichmentIGF11.54
135Charcot-marie-tooth disease, axonal, type 2eEnrichmentVCP1.54
136Ventricular septal defect 1EnrichmentBMP21.54
137Cholangitis, primary sclerosingEnrichmentSEMA4D1.54
138Follicular lymphomaEnrichmentBCL21.54
139Myeloproliferative neoplasmEnrichmentJAK21.54
140HemimegalencephalyEnrichmentMTOR1.54
141Generalized juvenile polyposis/juvenile polyposis coliEnrichmentSMAD41.54
142Atrial septal defect 1EnrichmentBMP21.46
143Type 1 diabetes mellitusEnrichmentIL61.46
144Epilepsy, childhood absence 1EnrichmentRORB1.46
145Anterior segment dysgenesis 5EnrichmentBMP41.46
146Congenital anomalies of kidney and urinary tract 1EnrichmentTRAP11.46
147Inflammatory bowel disease 25, autosomal recessiveEnrichmentTGFB11.46
148Autosomal recessive robinow syndromeEnrichmentWNT5A1.46
149Il10-related early-onset inflammatory bowel diseaseEnrichmentTGFB11.46
150MyelofibrosisEnrichmentJAK21.39
151Renal cell carcinoma, papillary, 1EnrichmentMTOR1.39
152Adams-oliver syndromeEnrichmentNOTCH11.39
153Essential thrombocythemiaEnrichmentJAK21.39
154Gallbladder cancerEnrichmentSMAD41.39
155Hereditary hemorrhagic telangiectasiaEnrichmentSMAD41.39
156Overgrowth syndromeEnrichmentMTOR1.39
157Frontotemporal dementia and/or amyotrophic lateral sclerosis 7EnrichmentSQSTM1, VCP1.34
158Exudative vitreoretinopathyEnrichmentLRP51.34
159Hypoplastic left heart syndromeEnrichmentNOTCH11.34
160Isolated split hand-split foot malformationEnrichmentWNT10B1.34
161Primary ovarian insufficiencyEnrichmentBMP6, JAK21.32
162Tooth agenesis, selective, 1EnrichmentBMPR21.29
163Inflammatory bowel disease 1EnrichmentIL61.29
164Leukemia, acute lymphoblastic 3EnrichmentJAK21.29
165Progressive non-fluent aphasiaEnrichmentVCP1.29
166Cowden syndromeEnrichmentAKT11.29
167Peters-plus syndromeEnrichmentBMP41.24
168Stickler syndromeEnrichmentBMP41.24
169Primary bone dysplasiaEnrichmentCTSK1.24
170Epilepsy, idiopathic generalizedEnrichmentRORB1.20
171OsteochondrodysplasiaEnrichmentCTSK1.20
172Renal hypodysplasia/aplasia 3EnrichmentBMP41.16
173MeningiomaEnrichmentAKT11.16
174Breast cancerEnrichmentAKT1, RB1CC11.14
175Aortic valve disease 1EnrichmentNOTCH11.13
176Pulmonary hypertension, primary, 1EnrichmentBMPR21.13
177Alzheimer's diseaseEnrichmentVCP1.13
178OsteoporosisEnrichmentLRP51.10
179Aortic aneurysm, familial thoracic 1EnrichmentNOTCH11.10
180Cleft lip/palateEnrichmentBMP41.10
181Renal cell carcinoma, nonpapillaryEnrichmentMTOR1.07
182Osteogenesis imperfecta, type iiiEnrichmentSERPINF11.07
183Rare genetic intellectual disabilityEnrichmentMTOR1.07
184Colorectal cancerEnrichmentAKT1, SMAD41.03
185Alzheimer disease, familial, 1EnrichmentVCP1.02
186Cataract 44EnrichmentFYCO11.02
187Polycystic liver diseaseEnrichmentLRP51.02
188Autosomal dominant polycystic liver diseaseEnrichmentLRP51.02
189Early-onset nuclear cataractEnrichmentFYCO11.00
190Arteriovenous malformations of the brainEnrichmentIL60.97
191Neuropathy, hereditary motor and sensory, okinawa typeEnrichmentVCP0.97
192Tooth agenesisEnrichmentWNT10B0.91
193Kallmann syndromeEnrichmentSEMA3A0.90
194ScoliosisEnrichmentCTSK0.88
195Pancreatic cancerEnrichmentSMAD40.86
196Tetralogy of fallotEnrichmentNOTCH10.85
197Brugada syndromeEnrichmentSEMA3A0.85
198Severe covid-19EnrichmentFYCO10.80
199Cystic fibrosisEnrichmentTGFB10.76
200Connective tissue diseaseEnrichmentNOTCH10.76
201Familial hypertrophic cardiomyopathyEnrichmentLAMP20.75
202CakutEnrichmentTRAP10.74
203Left ventricular noncompactionEnrichmentLAMP20.73
204Eye diseaseEnrichmentFYCO10.73
205Leukemia, acute myeloidEnrichmentJAK20.68
206EpilepsyEnrichmentRORB0.68
207Type 2 diabetes mellitusEnrichmentIL60.66
208Gastric cancerEnrichmentSMAD40.65
209Nephrotic syndromeEnrichmentRUNX20.65
210Hypertrophic cardiomyopathyEnrichmentLAMP20.65
211ThrombocytopeniaEnrichmentSMAD40.61
212Cone-rod dystrophy 2EnrichmentDRAM20.48
213Dilated cardiomyopathyEnrichmentLAMP20.42
214Ovarian cancerEnrichmentAKT10.35
215Hereditary retinal dystrophyEnrichmentDRAM2, LRP50.29
216Fundus dystrophyEnrichmentDRAM2, LRP50.29
217Inherited cancer-predisposing syndromeEnrichmentSMAD40.26

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