CNTF Signaling

Pathway network for the CNTF Signaling SuperPath

Sources:

QIAGEN
GeneGo (Thomson Reuters)
WikiPathways
Reactome

Pathways in the CNTF Signaling SuperPath

#	Name	Source	Genes
1	CNTF Signaling	QIAGEN	AKT1 CNTF CNTFR GRB2 HRAS IL6ST JAK1 JAK2 KRAS LIFR MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAPK1 MAPK3 MRAS NRAS PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 RAF1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA5 RPS6KA6 RRAS RRAS2 SOS1 SOS2 STAT1 STAT2 STAT3 STAT4 STAT5A STAT5B STAT6 TYK2 (see all 44) (see less)
2	FLT3 Signaling	QIAGEN	AKT1 ARAF ATF4 BAD BCL2 BRAF CBL CREB1 CREB3 CREB3L4 EIF4E EIF4EBP1 ELK1 ELK3 ELK4 FLT3 FLT3LG GAB2 GRB2 HRAS KRAS MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MRAS MTOR NRAS PDPK1 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 RAF1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA5 RPS6KA6 RPS6KB1 RPS6KB2 RPS6KC1 RRAS RRAS2 STAT1 STAT2 STAT3 STAT4 STAT5A STAT5B STAT6 (see all 61) (see less)
3	IL-3 Pathway	QIAGEN	AKT1 ARAF BAD BCL2L1 BRAF CHUK CSF2RB FOS GRB2 HRAS IKBKB IKBKE IKBKG IL3 IL3RA JAK2 JUN KRAS MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAPK1 MAPK3 MRAS NFKB1 NFKBIA NFKBIB NFKBIE NRAS PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PRKCD RAF1 RPS6KB1 RRAS RRAS2 SOS1 SOS2 STAT1 STAT2 STAT3 STAT4 STAT5A STAT5B STAT6 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ (see all 57) (see less)
4	Immune response Oncostatin M signaling via MAPK in human cells	GeneGo (Thomson Reuters)	ATF2 CCL2 CEBPB EGR1 FOS FOSB FOSL1 FOSL2 GRB2 HRAS IL6ST JAK1 JUN JUNB JUND LDLR LIFR MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP3K1 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MMP1 MMP13 MMP3 OSM OSMR PPARG PTPN11 RAC1 RAF1 SHC1 SOS1 SOS2 STAT1 TIMP1 (see all 45) (see less)
5	MAPK cascade	WikiPathways	ARAF BRAF ELK1 GRB2 HRAS JUN KRAS LAMTOR3 MAP2 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K12 MAP3K2 MAP3K3 MAPK1 MAPK10 MAPK12 MAPK14 MAPK3 MBP NRAS PLCB3 RAF1 RASA3 RRAS SIPA1 SOS1 SOS2 (see all 33) (see less)
6	G-protein signaling Ras family GTPases in kinase cascades (scheme)	GeneGo (Thomson Reuters)	ATF2 BRAF CDC42 CEBPB ELK1 FOS HRAS JUN KRAS MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP3K1 MAP3K4 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 NRAS PAK1 RAC1 RAF1 RAP1A RRAS (see all 30) (see less)
7	OSM Pathway	QIAGEN	ARAF BRAF ELK1 GRB2 HRAS IL6ST JAK1 JAK2 JAK3 KRAS MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAPK1 MAPK3 MRAS NRAS OSM OSMR RAF1 RRAS RRAS2 SOS1 SOS2 STAT1 STAT3 (see all 29) (see less)
8	Nur77-Induced AICD in Macrophage	QIAGEN	ARAF BRAF ETS1 ETS2 HRAS KRAS MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAPK1 MAPK3 MEF2A MEF2C MEF2D MRAS NR4A1 NRAS RAF1 RRAS RRAS2 SP1 TLR2 TLR4 (see all 26) (see less)
9	Host-pathogen interaction of human coronaviruses - MAPK signaling	WikiPathways	ATF2 BCL2 BST2 DDIT3 EIF4E FOS IFI27 JUNB MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAP3K4 MAPK1 MAPK10 MAPK12 MAPK14 MAPK3 MAPK8 RAF1 RPS6KA1 RPS6KA2 RPS6KA3 (see all 25) (see less)
10	Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells	WikiPathways	ARAF BRAF HGS HNRNPH1 HRAS KRAS MAPK1 MAPK3 MRAS NRAS PDCD6IP RAB27A RAB5A RAB5B RAB5C RAF1 RRAS RRAS2 (see all 18) (see less)
11	Activation of the AP-1 family of transcription factors	Reactome	ATF2 FOS JUN MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 (see all 10) (see less)

Gene overlap in member pathways for CNTF Signaling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	11
2	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	11
3	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	10
4	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	9
5	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	9
6	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	9
7	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	9
8	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	9
9	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	8
10	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	8
11	RRAS	RAS Related	Protein Coding	8
12	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	7
13	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	7
14	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	6
15	MRAS	Muscle RAS Oncogene Homolog	Protein Coding	6
16	RRAS2	RAS Related 2	Protein Coding	6
17	ARAF	A-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	6
18	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	6
19	MAP2K5	Mitogen-Activated Protein Kinase Kinase 5	Protein Coding	5
20	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	5
21	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	5
22	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	5
23	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	5
24	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	5
25	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	5
26	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	5
27	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	4
28	ELK1	ETS Transcription Factor ELK1	Protein Coding	4
29	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	4
30	ATF2	Activating Transcription Factor 2	Protein Coding	4
31	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	4
32	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	3
33	IL6ST	Interleukin 6 Cytokine Family Signal Transducer	Protein Coding	3
34	JAK1	Janus Kinase 1	Protein Coding	3
35	JAK2	Janus Kinase 2	Protein Coding	3
36	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	3
37	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	3
38	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	3
39	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	3
40	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	3
41	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	3
42	RPS6KA2	Ribosomal Protein S6 Kinase A2	Protein Coding	3
43	RPS6KA3	Ribosomal Protein S6 Kinase A3	Protein Coding	3
44	STAT2	Signal Transducer And Activator Of Transcription 2	Protein Coding	3
45	STAT4	Signal Transducer And Activator Of Transcription 4	Protein Coding	3
46	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	3
47	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	3
48	STAT6	Signal Transducer And Activator Of Transcription 6	Protein Coding	3
49	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	3
50	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	3
51	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	3
52	LIFR	LIF Receptor Subunit Alpha	Protein Coding	2
53	RPS6KA4	Ribosomal Protein S6 Kinase A4	Protein Coding	2
54	RPS6KA5	Ribosomal Protein S6 Kinase A5	Protein Coding	2
55	RPS6KA6	Ribosomal Protein S6 Kinase A6	Protein Coding	2
56	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	2
57	BCL2	BCL2 Apoptosis Regulator	Protein Coding	2
58	EIF4E	Eukaryotic Translation Initiation Factor 4E	Protein Coding	2
59	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	2
60	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	2
61	JUNB	JunB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
62	OSM	Oncostatin M	Protein Coding	2
63	RAC1	Rac Family Small GTPase 1	Protein Coding	2
64	OSMR	Oncostatin M Receptor	Protein Coding	2
65	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	2
66	MAP3K4	Mitogen-Activated Protein Kinase Kinase Kinase 4	Protein Coding	2
67	CNTF	Ciliary Neurotrophic Factor	Protein Coding	1
68	CNTFR	Ciliary Neurotrophic Factor Receptor	Protein Coding	1
69	TYK2	Tyrosine Kinase 2	Protein Coding	1
70	ATF4	Activating Transcription Factor 4	Protein Coding	1
71	CBL	Cbl Proto-Oncogene	Protein Coding	1
72	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
73	CREB3	CAMP Responsive Element Binding Protein 3	Protein Coding	1
74	CREB3L4	CAMP Responsive Element Binding Protein 3 Like 4	Protein Coding	1
75	EIF4EBP1	Eukaryotic Translation Initiation Factor 4E Binding Protein 1	Protein Coding	1
76	ELK3	ETS Transcription Factor ELK3	Protein Coding	1
77	ELK4	ETS Transcription Factor ELK4	Protein Coding	1
78	FLT3	Fms Related Receptor Tyrosine Kinase 3	Protein Coding	1
79	FLT3LG	Fms Related Receptor Tyrosine Kinase 3 Ligand	Protein Coding	1
80	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
81	GAB2	GRB2 Associated Binding Protein 2	Protein Coding	1
82	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
83	RPS6KB2	Ribosomal Protein S6 Kinase B2	Protein Coding	1
84	RPS6KC1	Ribosomal Protein S6 Kinase C1	Protein Coding	1
85	BCL2L1	BCL2 Like 1	Protein Coding	1
86	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
87	CSF2RB	Colony Stimulating Factor 2 Receptor Subunit Beta	Protein Coding	1
88	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
89	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	1
90	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	1
91	IL3	Interleukin 3	Protein Coding	1
92	IL3RA	Interleukin 3 Receptor Subunit Alpha	Protein Coding	1
93	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
94	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
95	NFKBIB	NFKB Inhibitor Beta	Protein Coding	1
96	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	1
97	PRKCD	Protein Kinase C Delta	Protein Coding	1
98	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	1
99	YWHAE	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon	Protein Coding	1
100	YWHAG	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma	Protein Coding	1
101	YWHAH	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Eta	Protein Coding	1
102	YWHAQ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Theta	Protein Coding	1
103	YWHAZ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta	Protein Coding	1
104	EGR1	Early Growth Response 1	Protein Coding	1
105	FOSB	FosB Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
106	FOSL2	FOS Like 2, AP-1 Transcription Factor Subunit	Protein Coding	1
107	JUND	JunD Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
108	LDLR	Low Density Lipoprotein Receptor	Protein Coding	1
109	MMP1	Matrix Metallopeptidase 1	Protein Coding	1
110	MMP3	Matrix Metallopeptidase 3	Protein Coding	1
111	MMP13	Matrix Metallopeptidase 13	Protein Coding	1
112	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	1
113	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
114	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	1
115	SHC1	SHC Adaptor Protein 1	Protein Coding	1
116	TIMP1	TIMP Metallopeptidase Inhibitor 1	Protein Coding	1
117	FOSL1	FOS Like 1, AP-1 Transcription Factor Subunit	Protein Coding	1
118	PLCB3	Phospholipase C Beta 3	Protein Coding	1
119	SIPA1	Signal-Induced Proliferation-Associated 1	Protein Coding	1
120	MAP3K3	Mitogen-Activated Protein Kinase Kinase Kinase 3	Protein Coding	1
121	MBP	Myelin Basic Protein	Protein Coding	1
122	MAP2	Microtubule Associated Protein 2	Protein Coding	1
123	LAMTOR3	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 3	Protein Coding	1
124	MAP3K2	Mitogen-Activated Protein Kinase Kinase Kinase 2	Protein Coding	1
125	MAP3K12	Mitogen-Activated Protein Kinase Kinase Kinase 12	Protein Coding	1
126	RASA3	RAS P21 Protein Activator 3	Protein Coding	1
127	CDC42	Cell Division Cycle 42	Protein Coding	1
128	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
129	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	1
130	JAK3	Janus Kinase 3	Protein Coding	1
131	ETS1	ETS Proto-Oncogene 1, Transcription Factor	Protein Coding	1
132	ETS2	ETS Proto-Oncogene 2, Transcription Factor	Protein Coding	1
133	MEF2A	Myocyte Enhancer Factor 2A	Protein Coding	1
134	MEF2C	Myocyte Enhancer Factor 2C	Protein Coding	1
135	MEF2D	Myocyte Enhancer Factor 2D	Protein Coding	1
136	NR4A1	Nuclear Receptor Subfamily 4 Group A Member 1	Protein Coding	1
137	SP1	Sp1 Transcription Factor	Protein Coding	1
138	TLR2	Toll Like Receptor 2	Protein Coding	1
139	TLR4	Toll Like Receptor 4	Protein Coding	1
140	BST2	Bone Marrow Stromal Cell Antigen 2	Protein Coding	1
141	IFI27	Interferon Alpha Inducible Protein 27	Protein Coding	1
142	DDIT3	DNA Damage Inducible Transcript 3	Protein Coding	1
143	RAB5C	RAB5C, Member RAS Oncogene Family	Protein Coding	1
144	RAB5B	RAB5B, Member RAS Oncogene Family	Protein Coding	1
145	RAB27A	RAB27A, Member RAS Oncogene Family	Protein Coding	1
146	RAB5A	RAB5A, Member RAS Oncogene Family	Protein Coding	1
147	HNRNPH1	Heterogeneous Nuclear Ribonucleoprotein H1	Protein Coding	1
148	PDCD6IP	Programmed Cell Death 6 Interacting Protein	Protein Coding	1
149	HGS	Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate	Protein Coding	1

Disorders associated with CNTF Signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, RAF1, RRAS2, SOS1, SOS2	16.00
2	Noonan syndrome 1	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, RAF1, RRAS, RRAS2, SOS1, SOS2	16.00
3	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, CBL, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1	11.66
4	Lung non-small cell carcinoma	Enrichment	BRAF, HRAS, KRAS, MAP2K1, NRAS	11.61
5	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	10.79
6	Cardiofaciocutaneous syndrome	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	10.79
7	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, HRAS, NRAS, RAF1	9.71
8	Noonan syndrome 3	Enrichment	HRAS, KRAS, RAF1, SOS1	9.22
9	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1, NRAS	8.20
10	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	8.11
11	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2, STAT3	8.06
12	Differentiated thyroid carcinoma	Enrichment	BRAF, HRAS, KRAS, NRAS	7.30
13	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS	7.16
14	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF, HRAS, NRAS	7.16
15	Pilomyxoid astrocytoma	Enrichment	BRAF, KRAS, RAF1	7.16
16	Follicular thyroid carcinoma	Enrichment	BRAF, HRAS, NRAS	7.16
17	Juvenile myelomonocytic leukemia	Enrichment	CBL, KRAS, NRAS, RRAS	6.75
18	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	5.78
19	Pulmonic stenosis	Enrichment	BRAF, SOS1	5.36
20	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	5.30
21	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	5.00
22	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	5.00
23	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	4.76
24	Stuve-wiedemann syndrome 1	Enrichment	IL6ST, LIFR	4.51
25	Stüve-wiedemann syndrome	Enrichment	IL6ST, LIFR	4.51
26	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	4.46
27	Gallbladder cancer	Enrichment	BRAF, KRAS	4.46
28	Congenital generalized lipodystrophy	Enrichment	FOS, PPARG	4.19
29	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1	4.13
30	Leukemia, acute myeloid	Enrichment	JAK2, KRAS, NRAS	4.08
31	Histiocytoid hemangioma	Enrichment	FOS, FOSB	3.97
32	Lip and oral cavity carcinoma	Enrichment	BRAF, HRAS	3.96
33	Myeloma, multiple	Enrichment	BRAF, FLT3, KRAS, PIK3R2	3.94
34	Arteriovenous malformation	Enrichment	HRAS, MAP2K1	3.90
35	Lung cancer susceptibility 3	Enrichment	BRAF, KRAS	3.82
36	Breast adenocarcinoma	Enrichment	AKT1, KRAS	3.82
37	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1	3.80
38	Specific learning disability	Enrichment	MAPK1, RPS6KA3	3.75
39	Arteriovenous malformations of the brain	Enrichment	BRAF, KRAS	3.55
40	Overgrowth syndrome	Enrichment	MTOR, PIK3R1	3.39
41	Colorectal cancer	Enrichment	AKT1, BRAF, NRAS, PIK3R1	3.32
42	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1, SOS1	3.29
43	Bladder cancer	Enrichment	HRAS, KRAS	3.18
44	Ventricular septal defect	Enrichment	BRAF, RPS6KA3	3.15
45	Noonan syndrome 13	Enrichment	MAPK1	3.13
46	Diffuse large b-cell lymphoma	Enrichment	BRAF, STAT3	3.13
47	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	3.12
48	Acute promyelocytic leukemia	Enrichment	STAT3, STAT5B	3.11
49	Lung cancer	Enrichment	BRAF, KRAS	3.09
50	Oculoectodermal syndrome	Enrichment	KRAS	2.88
51	Pallister-killian syndrome	Enrichment	ARAF	2.88
52	Griscelli syndrome, type 2	Enrichment	RAB27A	2.88
53	Noonan syndrome 5	Enrichment	RAF1	2.88
54	Noonan syndrome 7	Enrichment	BRAF	2.88
55	Leopard syndrome 3	Enrichment	BRAF	2.88
56	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.88
57	Melanosis, neurocutaneous	Enrichment	NRAS	2.88
58	Noonan syndrome 6	Enrichment	NRAS	2.88
59	Noonan syndrome 11	Enrichment	MRAS	2.88
60	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.88
61	Lymphangioma	Enrichment	BRAF	2.88
62	Phace association	Enrichment	BRAF	2.88
63	Leopard syndrome 2	Enrichment	RAF1	2.88
64	Griscelli syndrome	Enrichment	RAB27A	2.88
65	Trigonitis	Enrichment	RAF1	2.88
66	Microcephaly 29, primary, autosomal recessive	Enrichment	PDCD6IP	2.88
67	Congenital pulmonary airway malformation	Enrichment	KRAS	2.88
68	Syringocystadenoma papilliferum	Enrichment	BRAF	2.88
69	Ganglioglioma	Enrichment	BRAF	2.88
70	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.88
71	Phace syndrome	Enrichment	BRAF	2.88
72	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.88
73	Classic hairy cell leukemia	Enrichment	BRAF	2.88
74	Neurocutaneous melanocytosis	Enrichment	NRAS	2.88
75	Coffin-lowry syndrome	Enrichment	RPS6KA3	2.73
76	Melorheostosis, isolated	Enrichment	MAP2K1	2.73
77	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.73
78	Autism 19	Enrichment	EIF4E	2.73
79	Intellectual developmental disorder, x-linked 19	Enrichment	RPS6KA3	2.73
80	Melorheostosis	Enrichment	MAP2K1	2.73
81	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.73
82	Symptomatic form of coffin-lowry syndrome in female carriers	Enrichment	RPS6KA3	2.73
83	Leprosy 3	Enrichment	TLR2	2.72
84	Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language	Enrichment	MEF2C	2.72
85	Coronary artery disease, autosomal dominant, 1	Enrichment	MEF2A	2.72
86	Macular degeneration, age-related, 10	Enrichment	TLR4	2.72
87	5q14.3 microdeletion syndrome	Enrichment	MEF2C	2.72
88	Complete atrioventricular septal defect without ventricular hypoplasia	Enrichment	MEF2C	2.72
89	Mef2c-related disorder	Enrichment	MEF2C	2.72
90	Amyloidosis, primary localized cutaneous, 1	Enrichment	OSMR	2.67
91	Noonan syndrome 4	Enrichment	SOS1	2.67
92	Noonan syndrome 9	Enrichment	SOS2	2.67
93	Stuve-wiedemann syndrome 2	Enrichment	IL6ST	2.67
94	Hyper-ige syndrome 4a, autosomal dominant, with recurrent infections	Enrichment	IL6ST	2.67
95	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.67
96	Immunodeficiency 31a	Enrichment	STAT1	2.67
97	Immunodeficiency 31b	Enrichment	STAT1	2.67
98	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.67
99	Hyper-ige syndrome 4b, autosomal recessive, with recurrent infections	Enrichment	IL6ST	2.67
100	Immunodeficiency 94 with autoinflammation and dysmorphic facies	Enrichment	IL6ST	2.67
101	T-b+ severe combined immunodeficiency due to jak3 deficiency	Enrichment	JAK3	2.67
102	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.67
103	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.67
104	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	2.67
105	46,xy sex reversal 6	Enrichment	MAP3K1	2.66
106	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.66
107	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.66
108	Nocarh syndrome	Enrichment	CDC42	2.66
109	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.66
110	Rhabdomyosarcoma	Enrichment	CBL, HRAS	2.64
111	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	2.61
112	Cerebral cavernous malformations 5	Enrichment	MAP3K3	2.61
113	Verrucous hemangioma	Enrichment	MAP3K3	2.61
114	Costello syndrome	Enrichment	HRAS	2.58
115	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.58
116	Noonan syndrome 12	Enrichment	RRAS2	2.58
117	Neurodevelopmental disorder with craniofacial dysmorphism and skeletal defects	Enrichment	HNRNPH1	2.58
118	Wooly hair nevus	Enrichment	HRAS	2.58
119	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.53
120	Proteus syndrome	Enrichment	AKT1	2.49
121	Immunodeficiency 35	Enrichment	TYK2	2.49
122	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.49
123	Pseudo-torch syndrome 3	Enrichment	STAT2	2.49
124	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	2.49
125	Hyper-ige syndrome 6, autosomal dominant, with recurrent infections	Enrichment	STAT6	2.49
126	Disabling pansclerotic morphea of childhood	Enrichment	STAT4	2.49
127	Short syndrome	Enrichment	PIK3R1	2.49
128	Systemic lupus erythematosus 11	Enrichment	STAT4	2.49
129	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.49
130	Cowden syndrome 6	Enrichment	AKT1	2.49
131	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.49
132	Metachondromatosis	Enrichment	PTPN11	2.48
133	Leopard syndrome 1	Enrichment	PTPN11	2.48
134	Coronary heart disease 6	Enrichment	MMP3	2.48
135	Pparg-associated congenital generalized lipodystrophy	Enrichment	PPARG	2.48
136	Aplasia cutis-enamel dysplasia syndrome	Enrichment	FOSL2	2.48
137	Malignant astrocytoma	Enrichment	PTPN11	2.48
138	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11	2.48
139	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.43
140	Tafro syndrome	Enrichment	MAP2K2	2.43
141	Breast cancer	Enrichment	AKT1, JUN, KRAS	2.42
142	Ataxia-telangiectasia	Enrichment	BRAF	2.40
143	Tethered spinal cord syndrome	Enrichment	BRAF	2.40
144	Spermatocytoma	Enrichment	HRAS	2.40
145	Incontinentia pigmenti	Enrichment	IKBKG	2.38
146	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.38
147	Fetal encasement syndrome	Enrichment	CHUK	2.38
148	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.38
149	Immunodeficiency 15b	Enrichment	IKBKB	2.38
150	Immunodeficiency 15a	Enrichment	IKBKB	2.38
151	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.38
152	Surfactant metabolism dysfunction, pulmonary, 5	Enrichment	CSF2RB	2.38
153	Developmental and epileptic encephalopathy 56	Enrichment	YWHAG	2.38
154	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.38
155	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.38
156	Distal 17p13.3 microdeletion syndrome	Enrichment	YWHAE	2.38
157	Ovarian cancer	Enrichment	AKT1, KRAS, RRAS2	2.37
158	Fibromatosis, gingival, 1	Enrichment	SOS1	2.37
159	Thrombocythemia 3	Enrichment	JAK2	2.37
160	Immunodeficiency 31c	Enrichment	STAT1	2.37
161	Primary cutaneous amyloidosis	Enrichment	OSMR	2.37
162	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.37
163	Polycythemia	Enrichment	JAK2	2.37
164	Hypereosinophilic syndrome	Enrichment	JAK2	2.37
165	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.35
166	Immune system disease	Enrichment	CDC42	2.35
167	Acute myeloid leukemia with minimal differentiation	Enrichment	FLT3	2.35
168	Immunodeficiency 125	Enrichment	FLT3LG	2.35
169	Autoinflammatory disease, familial, behcet-like 3	Enrichment	SIPA1	2.31
170	Dilated cardiomyopathy	Enrichment	BRAF, RAF1	2.31
171	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.28
172	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF	2.28
173	Intellectual developmental disorder, x-linked, syndromic, bain type	Enrichment	HNRNPH1	2.28
174	Lung sarcomatoid carcinoma	Enrichment	KRAS	2.28
175	Craniopharyngioma	Enrichment	BRAF	2.28
176	Pilocytic astrocytoma	Enrichment	KRAS	2.28
177	Newborn respiratory distress syndrome	Enrichment	BRAF	2.28
178	Epidermolytic nevus	Enrichment	HRAS	2.28
179	Intellectual disability, x-linked, syndromic, bain type	Enrichment	HNRNPH1	2.28
180	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	2.26
181	Myxoid liposarcoma	Enrichment	DDIT3	2.26
182	Jacobsen syndrome	Enrichment	ETS1	2.24
183	Lennox-gastaut syndrome	Enrichment	MAPK10	2.23
184	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	JAK3	2.19
185	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.19
186	Polycythemia vera	Enrichment	JAK2	2.19
187	Nuchal bleb, familial	Enrichment	SOS1	2.19
188	Hyper ige syndrome	Enrichment	STAT3	2.19
189	Hemangiopericytoma, malignant	Enrichment	STAT6	2.19
190	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	2.19
191	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	2.19
192	Lymphomatoid papulosis	Enrichment	TYK2	2.19
193	Laron syndrome with immunodeficiency	Enrichment	STAT5B	2.19
194	Primary cutaneous anaplastic large cell lymphoma	Enrichment	TYK2	2.19
195	Metaphyseal dysplasia, spahr type	Enrichment	MMP13	2.18
196	Spondyloepimetaphyseal dysplasia, missouri type	Enrichment	MMP13	2.18
197	Carotid intimal medial thickness 1	Enrichment	PPARG	2.18
198	Werner syndrome	Enrichment	PTPN11	2.18
199	Hyperlipoproteinemia, type iii	Enrichment	LDLR	2.18
200	Recessive dystrophic epidermolysis bullosa	Enrichment	MMP1	2.18
201	Metaphyseal anadysplasia	Enrichment	MMP13	2.18
202	Familial partial lipodystrophy	Enrichment	PPARG	2.18
203	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	2.13
204	Wilms tumor 5	Enrichment	BRAF	2.10
205	Lung squamous cell carcinoma	Enrichment	KRAS	2.10
206	Immunodeficiency 33	Enrichment	IKBKG	2.08
207	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.08
208	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.08
209	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	2.08
210	Common variable immunodeficiency 12	Enrichment	NFKB1	2.08
211	Erythrocytosis, familial, 1	Enrichment	JAK2	2.07
212	Budd-chiari syndrome	Enrichment	JAK2	2.07
213	Adenosine deaminase deficiency	Enrichment	JAK3	2.07
214	Gingival fibromatosis	Enrichment	SOS1	2.07
215	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	2.07
216	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	2.05
217	Hereditary breast carcinoma	Enrichment	AKT1, KRAS	2.05
218	Ovarian germ cell cancer	Enrichment	CBL	2.05
219	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.05
220	Cebalid syndrome	Enrichment	MTOR	2.05
221	Smith-kingsmore syndrome	Enrichment	MTOR	2.05
222	Acute myeloid leukemia without maturation	Enrichment	FLT3	2.05
223	Malignant germ cell tumor of ovary	Enrichment	CBL	2.05
224	Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2)	Enrichment	FLT3	2.05
225	Follicular lymphoma	Enrichment	BCL2	2.04
226	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	2.01
227	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.01
228	Immunodeficiency 14	Enrichment	PIK3R1	2.01
229	Immunodeficiency 44	Enrichment	STAT2	2.01
230	Hypercholesterolemia, familial, 2	Enrichment	LDLR	2.00
231	Intellectual developmental disorder with microcephaly and pontine and cerebellar hypoplasia	Enrichment	LDLR	2.00
232	Hypercholesterolemia, familial, 4	Enrichment	LDLR	2.00
233	Syndromic x-linked intellectual disability najm type	Enrichment	LDLR	2.00
234	Tricuspid valve insufficiency	Enrichment	PTPN11	2.00
235	Lymphoma, non-hodgkin, familial	Enrichment	BRAF	1.98
236	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	JAK3	1.97
237	Myeloproliferative neoplasm	Enrichment	JAK2	1.97
238	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.93
239	Primary hyperaldosteronism	Enrichment	BRAF	1.93
240	Nasopharyngeal carcinoma	Enrichment	NFKBIA	1.90
241	Miller-dieker lissencephaly syndrome	Enrichment	YWHAE	1.90
242	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	YWHAE	1.90
243	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.89
244	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3R2	1.89
245	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.89
246	Pediatric systemic lupus erythematosus	Enrichment	STAT4	1.89
247	Melanoma	Enrichment	BRAF	1.88
248	Heart, malformation of	Enrichment	MAPK1	1.88
249	Lipodystrophy, familial partial, type 3	Enrichment	PPARG	1.88
250	Leptin deficiency or dysfunction	Enrichment	PPARG	1.88
251	Pseudomyogenic hemangioendothelioma	Enrichment	FOSB	1.88
252	Periventricular leukomalacia	Enrichment	RPS6KC1	1.87
253	Melanoma of soft tissue	Enrichment	CREB1	1.87
254	Mixed phenotype acute leukemia with t	Enrichment	FLT3	1.87
255	Gastroesophageal reflux	Enrichment	RPS6KA3	1.83
256	Orthostatic intolerance	Enrichment	RPS6KA3	1.83
257	Myelofibrosis	Enrichment	JAK2	1.83
258	Essential thrombocythemia	Enrichment	JAK2	1.83
259	Hyperlipidemia, familial combined, 3	Enrichment	LDLR	1.78
260	Lymphoma	Enrichment	PTPN11	1.78
261	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.77
262	Protein-deficiency anemia	Enrichment	NRAS	1.77
263	Focal cortical dysplasia, type ii	Enrichment	MTOR	1.75
264	Chronic myelomonocytic leukemia	Enrichment	FLT3	1.75
265	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	FLT3	1.75
266	Isolated focal cortical dysplasia type ii	Enrichment	MTOR	1.75
267	Autism spectrum disorder	Enrichment	MAP2K1, MEF2C	1.74
268	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.72
269	Wilms tumor 1	Enrichment	BRAF	1.70
270	Lynch syndrome	Enrichment	KRAS	1.70
271	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.70
272	Cowden syndrome 1	Enrichment	LDLR	1.70
273	Lipid metabolism disorder	Enrichment	LDLR	1.70
274	Patent ductus arteriosus	Enrichment	PTPN11	1.70
275	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.68
276	Hereditary pulmonary alveolar proteinosis	Enrichment	CSF2RB	1.68
277	Endometrial stromal sarcoma	Enrichment	YWHAE	1.68
278	Acute myeloid leukemia with maturation	Enrichment	FLT3	1.65
279	Hemimegalencephaly	Enrichment	MTOR	1.65
280	Aggressive systemic mastocytosis	Enrichment	CBL	1.65
281	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	FLT3	1.65
282	Melanoma, cutaneous malignant 1	Enrichment	BRAF	1.65
283	Dandy-walker syndrome	Enrichment	BRAF	1.65
284	Oligoarticular juvenile idiopathic arthritis	Enrichment	STAT4	1.65
285	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	STAT4	1.65
286	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.62
287	Kidney clear cell sarcoma	Enrichment	YWHAE	1.60
288	Homozygous familial hypercholesterolemia	Enrichment	LDLR	1.58
289	Aortic valve disease 1	Enrichment	SOS1	1.56
290	Nk-cell enteropathy	Enrichment	JAK3	1.56
291	Multisystem inflammatory syndrome in children	Enrichment	RAB27A	1.54
292	Cowden syndrome	Enrichment	AKT1	1.54
293	Common variable immunodeficiency	Enrichment	NFKB1	1.54
294	Coronary heart disease 5	Enrichment	LDLR	1.53
295	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.51
296	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	FLT3	1.51
297	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.50
298	Autoinflammatory disease	Enrichment	RAB27A	1.50
299	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.50
300	Pancreatic cancer	Enrichment	KRAS	1.49
301	Behcet syndrome	Enrichment	TLR4	1.45
302	Pectus excavatum	Enrichment	PTPN11	1.44
303	Meningioma	Enrichment	AKT1	1.42
304	Epicanthus	Enrichment	PTPN11	1.41
305	Congenital long qt syndrome	Enrichment	PTPN11	1.41
306	Atypical chronic myeloid leukemia, bcr-abl1 negative	Enrichment	FLT3	1.40
307	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.38
308	Primary autosomal recessive microcephaly	Enrichment	PDCD6IP	1.38
309	Hypercholesterolemia, familial, 1	Enrichment	LDLR	1.37
310	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.37
311	Left ventricular noncompaction	Enrichment	RAF1	1.34
312	Leukemia, acute lymphoblastic	Enrichment	FLT3	1.32
313	Familial hypercholesterolemia	Enrichment	LDLR	1.31
314	Gliosarcoma	Enrichment	PPARG	1.29
315	Giant cell glioblastoma	Enrichment	PPARG	1.26
316	Gastric cancer	Enrichment	KRAS	1.26
317	Human immunodeficiency virus type 1	Enrichment	CCL2	1.24
318	Patent foramen ovale	Enrichment	PTPN11	1.24
319	Severe covid-19	Enrichment	JAK3	1.22
320	Microcephaly	Enrichment	MAPK1, PTPN11	1.20
321	Non-syndromic x-linked intellectual disability	Enrichment	RPS6KA3	1.19
322	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.18
323	Rare genetic intellectual disability	Enrichment	MTOR	1.18
324	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	1.17
325	Severe combined immunodeficiency	Enrichment	JAK3	1.17
326	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	1.15
327	Systemic lupus erythematosus	Enrichment	ETS1	1.14
328	Scoliosis	Enrichment	PTPN11	1.12
329	Strabismus	Enrichment	PTPN11	1.07
330	Hypertelorism	Enrichment	RPS6KA3	1.04
331	Malaria	Enrichment	IKBKG	1.03
332	Long qt syndrome 1	Enrichment	PTPN11	1.02
333	Precursor t-cell acute lymphoblastic leukemia	Enrichment	FLT3	1.01
334	Cakut	Enrichment	LIFR	0.98
335	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MEF2C	0.98
336	Primary ovarian insufficiency	Enrichment	JAK2	0.92
337	Type 2 diabetes mellitus	Enrichment	PPARG	0.88
338	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.88
339	Thrombocytopenia	Enrichment	PTPN11	0.83
340	Body mass index quantitative trait locus 11	Enrichment	PPARG	0.81
341	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.77
342	Autosomal dominant non-syndromic intellectual disability	Enrichment	YWHAZ	0.72
343	Undetermined early-onset epileptic encephalopathy	Enrichment	YWHAG	0.68
344	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.45

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

CNTF Signaling

Pathway Network for CNTF Signaling

Pathway network for the CNTF Signaling SuperPath

Member Pathways for CNTF Signaling

Pathways in the CNTF Signaling SuperPath

Gene overlap in member pathways for CNTF Signaling SuperPath

Associated Genes for CNTF Signaling

Associated Disorders for CNTF Signaling

Disorders associated with CNTF Signaling SuperPath

STRING Interaction Network for CNTF Signaling

Sources for CNTF Signaling