Colorectal Cancer Metastasis

No Pathway Network information available for Colorectal Cancer Metastasis

Pathways in the Colorectal Cancer Metastasis SuperPath

#	Name	Source	Genes
1	Colorectal Cancer Metastasis	QIAGEN	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 AKT1 APC APPL1 ARRB1 AXIN2 BAX BCL2L1 BIRC5 BRAF CASP3 CASP9 CCND1 CCND2 CDH1 CDKN1A CTNNB1 DCC DVL1 E2F4 EGF EGFR FZD1 FZD10 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 FZD9 GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRB2 GRK1 GRK2 GRK3 GRK4 GRK5 GRK6 GRK7 GSK3B IFNG IFNGR1 IFNGR2 IL6 IL6R JAK1 KRAS LEF1 LEFTY2 LRP5 LRP6 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAPK1 MAPK3 MAPK6 MLC1 MLH1 MMP1 MMP11 MMP12 MMP14 MMP2 MMP7 MMP9 MSH2 MSH3 MSH6 MYC NFKB1 NOS2 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PTGER2 PTGER4 PTGS2 SMAD2 SMAD3 SMAD4 SOS1 SOS2 SRC STAT1 STAT3 TCF3 TCF4 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TLR1 TLR10 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TLR8 TLR9 TNF TNFRSF1A TP53 VEGFA WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B (see all 165) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ADCY1	Adenylate Cyclase 1	Protein Coding	1
2	ADCY2	Adenylate Cyclase 2	Protein Coding	1
3	ADCY3	Adenylate Cyclase 3	Protein Coding	1
4	ADCY4	Adenylate Cyclase 4	Protein Coding	1
5	ADCY5	Adenylate Cyclase 5	Protein Coding	1
6	ADCY6	Adenylate Cyclase 6	Protein Coding	1
7	ADCY7	Adenylate Cyclase 7	Protein Coding	1
8	ADCY8	Adenylate Cyclase 8	Protein Coding	1
9	ADCY9	Adenylate Cyclase 9	Protein Coding	1
10	GRK2	G Protein-Coupled Receptor Kinase 2	Protein Coding	1
11	GRK3	G Protein-Coupled Receptor Kinase 3	Protein Coding	1
12	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
13	APC	APC Regulator Of Wnt Signaling Pathway	Protein Coding	1
14	APPL1	Adaptor Protein, Phosphotyrosine Interacting With PH Domain And Leucine Zipper 1	Protein Coding	1
15	ARRB1	Arrestin Beta 1	Protein Coding	1
16	AXIN2	Axin 2	Protein Coding	1
17	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	1
18	BCL2L1	BCL2 Like 1	Protein Coding	1
19	BIRC5	Baculoviral IAP Repeat Containing 5	Protein Coding	1
20	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
21	CASP3	Caspase 3	Protein Coding	1
22	CASP9	Caspase 9	Protein Coding	1
23	CCND1	Cyclin D1	Protein Coding	1
24	CCND2	Cyclin D2	Protein Coding	1
25	CDH1	Cadherin 1	Protein Coding	1
26	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
27	CTNNB1	Catenin Beta 1	Protein Coding	1
28	DCC	DCC Netrin 1 Receptor	Protein Coding	1
29	DVL1	Dishevelled Segment Polarity Protein 1	Protein Coding	1
30	E2F4	E2F Transcription Factor 4	Protein Coding	1
31	LEFTY2	Left-Right Determination Factor 2	Protein Coding	1
32	EGF	Epidermal Growth Factor	Protein Coding	1
33	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
34	FZD1	Frizzled Class Receptor 1	Protein Coding	1
35	FZD10	Frizzled Class Receptor 10	Protein Coding	1
36	FZD2	Frizzled Class Receptor 2	Protein Coding	1
37	FZD3	Frizzled Class Receptor 3	Protein Coding	1
38	FZD4	Frizzled Class Receptor 4	Protein Coding	1
39	FZD5	Frizzled Class Receptor 5	Protein Coding	1
40	FZD6	Frizzled Class Receptor 6	Protein Coding	1
41	FZD7	Frizzled Class Receptor 7	Protein Coding	1
42	FZD8	Frizzled Class Receptor 8	Protein Coding	1
43	FZD9	Frizzled Class Receptor 9	Protein Coding	1
44	GNAS	GNAS Complex Locus	Protein Coding	1
45	GNB1	G Protein Subunit Beta 1	Protein Coding	1
46	GNB2	G Protein Subunit Beta 2	Protein Coding	1
47	GNB3	G Protein Subunit Beta 3	Protein Coding	1
48	GNB4	G Protein Subunit Beta 4	Protein Coding	1
49	GNB5	G Protein Subunit Beta 5	Protein Coding	1
50	GNG10	G Protein Subunit Gamma 10	Protein Coding	1
51	GNG11	G Protein Subunit Gamma 11	Protein Coding	1
52	GNG12	G Protein Subunit Gamma 12	Protein Coding	1
53	GNG13	G Protein Subunit Gamma 13	Protein Coding	1
54	GNG2	G Protein Subunit Gamma 2	Protein Coding	1
55	GNG3	G Protein Subunit Gamma 3	Protein Coding	1
56	GNG4	G Protein Subunit Gamma 4	Protein Coding	1
57	GNG5	G Protein Subunit Gamma 5	Protein Coding	1
58	GNG7	G Protein Subunit Gamma 7	Protein Coding	1
59	GNG8	G Protein Subunit Gamma 8	Protein Coding	1
60	GNGT1	G Protein Subunit Gamma Transducin 1	Protein Coding	1
61	GNGT2	G Protein Subunit Gamma Transducin 2	Protein Coding	1
62	GRK4	G Protein-Coupled Receptor Kinase 4	Protein Coding	1
63	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
64	GRK5	G Protein-Coupled Receptor Kinase 5	Protein Coding	1
65	GRK6	G Protein-Coupled Receptor Kinase 6	Protein Coding	1
66	GRK7	G Protein-Coupled Receptor Kinase 7	Protein Coding	1
67	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
68	IFNG	Interferon Gamma	Protein Coding	1
69	IFNGR1	Interferon Gamma Receptor 1	Protein Coding	1
70	IFNGR2	Interferon Gamma Receptor 2	Protein Coding	1
71	IL6	Interleukin 6	Protein Coding	1
72	IL6R	Interleukin 6 Receptor	Protein Coding	1
73	JAK1	Janus Kinase 1	Protein Coding	1
74	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
75	LEF1	Lymphoid Enhancer Binding Factor 1	Protein Coding	1
76	LRP5	LDL Receptor Related Protein 5	Protein Coding	1
77	LRP6	LDL Receptor Related Protein 6	Protein Coding	1
78	SMAD2	SMAD Family Member 2	Protein Coding	1
79	SMAD3	SMAD Family Member 3	Protein Coding	1
80	SMAD4	SMAD Family Member 4	Protein Coding	1
81	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
82	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
83	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
84	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
85	MAP2K5	Mitogen-Activated Protein Kinase Kinase 5	Protein Coding	1
86	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
87	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
88	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
89	MAPK6	Mitogen-Activated Protein Kinase 6	Protein Coding	1
90	MLC1	Modulator Of VRAC Current 1	Protein Coding	1
91	MLH1	MutL Homolog 1	Protein Coding	1
92	MMP1	Matrix Metallopeptidase 1	Protein Coding	1
93	MMP11	Matrix Metallopeptidase 11	Protein Coding	1
94	MMP12	Matrix Metallopeptidase 12	Protein Coding	1
95	MMP14	Matrix Metallopeptidase 14	Protein Coding	1
96	MMP2	Matrix Metallopeptidase 2	Protein Coding	1
97	MMP7	Matrix Metallopeptidase 7	Protein Coding	1
98	MMP9	Matrix Metallopeptidase 9	Protein Coding	1
99	MSH2	MutS Homolog 2	Protein Coding	1
100	MSH3	MutS Homolog 3	Protein Coding	1
101	MSH6	MutS Homolog 6	Protein Coding	1
102	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
103	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
104	NOS2	Nitric Oxide Synthase 2	Protein Coding	1
105	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	1
106	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
107	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
108	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
109	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	1
110	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
111	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	1
112	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	1
113	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	1
114	PRKAR1B	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta	Protein Coding	1
115	PRKAR2A	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Alpha	Protein Coding	1
116	PRKAR2B	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Beta	Protein Coding	1
117	PTGER2	Prostaglandin E Receptor 2	Protein Coding	1
118	PTGER4	Prostaglandin E Receptor 4	Protein Coding	1
119	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	1
120	GRK1	G Protein-Coupled Receptor Kinase 1	Protein Coding	1
121	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
122	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	1
123	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
124	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
125	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
126	TCF3	Transcription Factor 3	Protein Coding	1
127	TCF4	Transcription Factor 4	Protein Coding	1
128	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
129	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	1
130	TGFB3	Transforming Growth Factor Beta 3	Protein Coding	1
131	TGFBR1	Transforming Growth Factor Beta Receptor 1	Protein Coding	1
132	TGFBR2	Transforming Growth Factor Beta Receptor 2	Protein Coding	1
133	TLR1	Toll Like Receptor 1	Protein Coding	1
134	TLR10	Toll Like Receptor 10	Protein Coding	1
135	TLR2	Toll Like Receptor 2	Protein Coding	1
136	TLR3	Toll Like Receptor 3	Protein Coding	1
137	TLR4	Toll Like Receptor 4	Protein Coding	1
138	TLR5	Toll Like Receptor 5	Protein Coding	1
139	TLR6	Toll Like Receptor 6	Protein Coding	1
140	TLR7	Toll Like Receptor 7	Protein Coding	1
141	TLR8	Toll Like Receptor 8	Protein Coding	1
142	TLR9	Toll Like Receptor 9	Protein Coding	1
143	TNF	Tumor Necrosis Factor	Protein Coding	1
144	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	1
145	TP53	Tumor Protein P53	Protein Coding	1
146	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1
147	WNT1	Wnt Family Member 1	Protein Coding	1
148	WNT10A	Wnt Family Member 10A	Protein Coding	1
149	WNT10B	Wnt Family Member 10B	Protein Coding	1
150	WNT11	Wnt Family Member 11	Protein Coding	1
151	WNT9A	Wnt Family Member 9A	Protein Coding	1
152	WNT9B	Wnt Family Member 9B	Protein Coding	1
153	WNT16	Wnt Family Member 16	Protein Coding	1
154	WNT2	Wnt Family Member 2	Protein Coding	1
155	WNT2B	Wnt Family Member 2B	Protein Coding	1
156	WNT3	Wnt Family Member 3	Protein Coding	1
157	WNT3A	Wnt Family Member 3A	Protein Coding	1
158	WNT4	Wnt Family Member 4	Protein Coding	1
159	WNT5A	Wnt Family Member 5A	Protein Coding	1
160	WNT5B	Wnt Family Member 5B	Protein Coding	1
161	WNT6	Wnt Family Member 6	Protein Coding	1
162	WNT7A	Wnt Family Member 7A	Protein Coding	1
163	WNT7B	Wnt Family Member 7B	Protein Coding	1
164	WNT8A	Wnt Family Member 8A	Protein Coding	1
165	WNT8B	Wnt Family Member 8B	Protein Coding	1

Disorders associated with Colorectal Cancer Metastasis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Colorectal cancer	Enrichment	AKT1, APC, AXIN2, BAX, BRAF, CCND1, CDH1, CTNNB1, DCC, FZD3, MLH1, MSH2, MSH6, PIK3R1, SMAD4, SRC, TLR2, TP53	10.93
2	Loeys-dietz syndrome	Enrichment	SMAD2, SMAD3, TGFB2, TGFB3, TGFBR1, TGFBR2	9.57
3	Gallbladder cancer	Enrichment	BRAF, CTNNB1, KRAS, SMAD4, TP53	8.29
4	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	7.67
5	Cardiofaciocutaneous syndrome	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	7.67
6	Gastric cancer	Enrichment	APC, CDH1, KRAS, MLH1, MSH2, MSH6, SMAD4, TP53	7.39
7	Hereditary breast carcinoma	Enrichment	AKT1, APC, CDH1, KRAS, MLH1, MSH2, MSH6, TP53	7.31
8	Noonan syndrome 1	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2, SOS1, SOS2	6.60
9	Breast cancer	Enrichment	AKT1, APC, CDH1, GNG3, KRAS, MLH1, MSH2, MSH6, TP53	6.53
10	Ovarian cancer	Enrichment	AKT1, APC, AXIN2, CDH1, CTNNB1, EGFR, KRAS, MSH2, MSH6, TP53	6.40
11	Rasopathy	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2, SOS1, SOS2	6.25
12	Inherited cancer-predisposing syndrome	Enrichment	APC, AXIN2, CDH1, EGFR, MLH1, MSH2, MSH3, MSH6, PRKAR1A, SMAD4, TP53	6.22
13	Lynch syndrome	Enrichment	KRAS, MLH1, MSH2, MSH6, TGFBR2	6.17
14	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2, SOS1	6.17
15	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	SMAD2, SMAD3, SMAD4, TGFB2, TGFB3, TGFBR1, TGFBR2	6.04
16	Loeys-dietz syndrome 1	Enrichment	SMAD2, TGFBR1, TGFBR2	5.75
17	Endometrial cancer	Enrichment	CDH1, MLH1, MSH2, MSH3, MSH6	5.36
18	Lung non-small cell carcinoma	Enrichment	BRAF, EGFR, KRAS, MAP2K1	5.19
19	Robinow syndrome, autosomal dominant 1	Enrichment	DVL1, FZD2, WNT5A	5.15
20	Mismatch repair cancer syndrome 1	Enrichment	MLH1, MSH2, MSH6	5.15
21	Craniopharyngioma	Enrichment	APC, BRAF, CTNNB1	5.15
22	Autosomal dominant robinow syndrome	Enrichment	DVL1, FZD2, WNT5A	5.15
23	Exudative vitreoretinopathy 1	Enrichment	CTNNB1, FZD4, LRP5	4.76
24	Robinow syndrome, autosomal recessive 1	Enrichment	DVL1, FZD2, WNT5A	4.76
25	Lung cancer susceptibility 3	Enrichment	BRAF, EGFR, KRAS, TP53	4.72
26	Bladder cancer	Enrichment	CDKN1A, CTNNB1, EGFR, KRAS, TP53	4.63
27	Autosomal recessive robinow syndrome	Enrichment	DVL1, FZD2, WNT5A	4.46
28	Adrenocortical carcinoma	Enrichment	CTNNB1, PRKAR1A, TP53	4.46
29	Breast adenocarcinoma	Enrichment	AKT1, KRAS, TP53	4.46
30	Myeloma, multiple	Enrichment	BRAF, CCND1, KRAS, PIK3R2, TCF3, TP53	4.24
31	Esophageal cancer	Enrichment	DCC, TGFBR2, TP53	4.22
32	Arteriovenous malformations of the brain	Enrichment	BRAF, EGFR, IL6, KRAS	4.15
33	Exudative vitreoretinopathy	Enrichment	CTNNB1, FZD4, LRP5	4.02
34	Hepatoblastoma	Enrichment	APC, CTNNB1, MSH2, TP53	3.97
35	Tooth agenesis	Enrichment	AXIN2, LRP6, WNT10A, WNT10B	3.89
36	Adult hepatocellular carcinoma	Enrichment	CTNNB1, EGF, TP53	3.85
37	Primary hyperaldosteronism	Enrichment	BRAF, GNAS, TP53	3.85
38	Muir-torre syndrome	Enrichment	MLH1, MSH2	3.83
39	Pulmonic stenosis	Enrichment	BRAF, SOS1	3.83
40	Loeys-dietz syndrome 2	Enrichment	TGFBR1, TGFBR2	3.83
41	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS, PRKAR1A	3.83
42	Loeys-dietz syndrome 4	Enrichment	TGFB2, TGFB3	3.83
43	Lynch syndrome 1	Enrichment	MLH1, MSH2, MSH6	3.70
44	Marfan syndrome	Enrichment	TGFB2, TGFBR1, TGFBR2	3.70
45	Familial colorectal cancer	Enrichment	MLH1, MSH2, TP53	3.70
46	Lip and oral cavity carcinoma	Enrichment	BRAF, EGFR, TP53	3.45
47	Desmoid disease, hereditary	Enrichment	APC, CTNNB1	3.36
48	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	MMP14, MMP2	3.36
49	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1	3.36
50	Osteoporosis, juvenile	Enrichment	WNT1, WNT3A	3.36
51	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, STAT3	3.36
52	Desmoid tumor	Enrichment	APC, CTNNB1	3.36
53	Colon adenocarcinoma	Enrichment	APC, MSH6	3.36
54	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS, MLH1, MSH2, MSH6, TP53	3.27
55	Lung cancer	Enrichment	BRAF, EGFR, KRAS, MLH1	3.24
56	Osteoporosis	Enrichment	LRP5, SRC, WNT1	3.23
57	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CDH1, KRAS	3.06
58	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF, TP53	3.06
59	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	CCND2, PIK3R2	3.06
60	Lynch syndrome 4	Enrichment	MSH2, MSH6	3.06
61	Lung sarcomatoid carcinoma	Enrichment	KRAS, TP53	3.06
62	Retinopathy of prematurity	Enrichment	FZD4, LRP5	3.06
63	Aortic aneurysm	Enrichment	SMAD3, TGFBR1	3.06
64	Rhabdomyosarcoma	Enrichment	MSH2, MSH6, TP53	3.06
65	Gliosarcoma	Enrichment	EGFR, MSH2, TP53	3.06
66	Polycystic liver disease	Enrichment	CTNNB1, LRP5, LRP6	2.97
67	Giant cell glioblastoma	Enrichment	EGFR, MSH2, TP53	2.97
68	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1, LRP5, LRP6	2.97
69	Robinow syndrome, autosomal dominant 2	Enrichment	DVL1, FZD2	2.84
70	Behcet syndrome	Enrichment	IFNGR1, TLR4, TNFRSF1A	2.83
71	Diffuse large b-cell lymphoma	Enrichment	BRAF, STAT3, TP53	2.83
72	Ehlers-danlos syndrome	Enrichment	SMAD3, TGFB2, TGFBR2	2.83
73	Lung squamous cell carcinoma	Enrichment	EGFR, KRAS	2.67
74	Hepatocellular carcinoma	Enrichment	APC, CTNNB1, TP53	2.64
75	Squamous cell carcinoma, head and neck	Enrichment	EGFR, TP53	2.53
76	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1	2.53
77	Noonan syndrome 3	Enrichment	KRAS, SOS1	2.53
78	Pilomyxoid astrocytoma	Enrichment	BRAF, KRAS	2.53
79	Pancreatic cancer	Enrichment	KRAS, SMAD4, TP53	2.48
80	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS, TCF4	2.41
81	Lymphoma, non-hodgkin, familial	Enrichment	BRAF, TP53	2.41
82	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	2.30
83	Colonic benign neoplasm	Enrichment	APC, MLH1	2.30
84	Prostate cancer	Enrichment	CDH1, MSH6, TP53	2.29
85	Leukemia, chronic lymphocytic	Enrichment	CCND1, TP53	2.21
86	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1, TCF3	2.21
87	Myelodysplastic syndrome	Enrichment	GNB1, TP53	2.12
88	Uterine corpus cancer	Enrichment	MSH2, MSH6	2.12
89	Acute promyelocytic leukemia	Enrichment	PRKAR1A, STAT3	1.98
90	Medulloblastoma	Enrichment	APC, CTNNB1	1.92
91	Periodic fever, familial, autosomal dominant	Enrichment	TNFRSF1A	1.91
92	Proteus syndrome	Enrichment	AKT1	1.91
93	Acrodysostosis 1 with or without hormone resistance	Enrichment	PRKAR1A	1.91
94	Endosteal hyperostosis, autosomal dominant	Enrichment	LRP5	1.91
95	Nail disorder, nonsyndromic congenital, 1	Enrichment	FZD6	1.91
96	Mullerian aplasia and hyperandrogenism	Enrichment	WNT4	1.91
97	Leprosy 3	Enrichment	TLR2	1.91
98	Oculoectodermal syndrome	Enrichment	KRAS	1.91
99	Helicobacter pylori infection	Enrichment	IFNGR1	1.91
100	Bone mineral density quantitative trait locus 1	Enrichment	LRP5	1.91
101	Exudative vitreoretinopathy 4	Enrichment	LRP5	1.91
102	Legionnaire disease	Enrichment	TLR5	1.91
103	Oligodontia-colorectal cancer syndrome	Enrichment	AXIN2	1.91
104	Hypomagnesemia 4, renal	Enrichment	EGF	1.91
105	Noonan syndrome 4	Enrichment	SOS1	1.91
106	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	1.91
107	46,xx sex reversal with dysgenesis of kidneys, adrenals, and lungs	Enrichment	WNT4	1.91
108	Carney complex, type 1	Enrichment	PRKAR1A	1.91
109	Melorheostosis, isolated	Enrichment	MAP2K1	1.91
110	Osseous heteroplasia, progressive	Enrichment	GNAS	1.91
111	Omodysplasia 2	Enrichment	FZD2	1.91
112	Noonan syndrome 7	Enrichment	BRAF	1.91
113	Leopard syndrome 3	Enrichment	BRAF	1.91
114	Immunodeficiency 83 viral infections	Enrichment	TLR3	1.91
115	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3	Enrichment	CCND2	1.91
116	Multiple self-healing squamous epithelioma	Enrichment	TGFBR1	1.91
117	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	1.91
118	Split-hand/foot malformation 6	Enrichment	WNT10B	1.91
119	Tooth agenesis, selective, 7	Enrichment	LRP6	1.91
120	Noonan syndrome 9	Enrichment	SOS2	1.91
121	Dyskinesia with orofacial involvement, autosomal dominant	Enrichment	ADCY5	1.91
122	Leprosy 5	Enrichment	TLR1	1.91
123	Tooth agenesis, selective, 8	Enrichment	WNT10B	1.91
124	Deafness, autosomal recessive 44	Enrichment	ADCY1	1.91
125	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	1.91
126	Immunodeficiency 27a	Enrichment	IFNGR1	1.91
127	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	1.91
128	Ectodermal dysplasia 17 with or without limb malformations	Enrichment	LEF1	1.91
129	Exudative vitreoretinopathy 8	Enrichment	LRP6	1.91
130	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Enrichment	GNB2	1.91
131	Immunodeficiency 69	Enrichment	IFNG	1.91
132	Noonan syndrome 13	Enrichment	MAPK1	1.91
133	Neurodevelopmental disorder with hyperkinetic movements and dyskinesia	Enrichment	ADCY5	1.91
134	Pituitary adenoma 3, multiple types	Enrichment	GNAS	1.91
135	Agammaglobulinemia 8b, autosomal recessive	Enrichment	TCF3	1.91
136	Short syndrome	Enrichment	PIK3R1	1.91
137	Immunodeficiency 74, covid19-related, x-linked	Enrichment	TLR7	1.91
138	Bone marrow failure syndrome 5	Enrichment	TP53	1.91
139	Winchester syndrome	Enrichment	MMP14	1.91
140	Systemic lupus erythematosus 1	Enrichment	TLR5	1.91
141	Diarrhea 9	Enrichment	WNT2B	1.91
142	X-linked immunodeficiency 74	Enrichment	TLR7	1.91
143	Papilloma of choroid plexus	Enrichment	TP53	1.91
144	Basal cell carcinoma 7	Enrichment	TP53	1.91
145	Lynch syndrome 2	Enrichment	MLH1	1.91
146	Systemic lupus erythematosus 17	Enrichment	TLR7	1.91
147	Anaplastic thyroid carcinoma	Enrichment	TP53	1.91
148	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	1.91
149	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	1.91
150	Myxoma, intracardiac	Enrichment	PRKAR1A	1.91
151	Osteoporosis-pseudoglioma syndrome	Enrichment	LRP5	1.91
152	Coronary artery disease, autosomal dominant 2	Enrichment	LRP6	1.91
153	Bone mineral density quantitative trait locus 16	Enrichment	WNT1	1.91
154	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	1.91
155	Dyskinesia with orofacial involvement, autosomal recessive	Enrichment	ADCY5	1.91
156	Microvascular complications of diabetes 1	Enrichment	VEGFA	1.91
157	Agammaglobulinemia 8a, autosomal dominant	Enrichment	TCF3	1.91
158	Lymphangioma	Enrichment	BRAF	1.91
159	Immunodeficiency 27b	Enrichment	IFNGR1	1.91
160	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	1.91
161	Camurati-engelmann disease 2	Enrichment	TGFB2	1.91
162	Polycystic liver disease 4 with or without kidney cysts	Enrichment	LRP5	1.91
163	Phace association	Enrichment	BRAF	1.91
164	Santos syndrome	Enrichment	WNT7A	1.91
165	Melorheostosis	Enrichment	MAP2K1	1.91
166	Colorectal cancer, hereditary nonpolyposis, type 6	Enrichment	TGFBR2	1.91
167	Interleukin 6, serum level of, quantitative trait locus	Enrichment	IL6R	1.91
168	Immunodeficiency 31a	Enrichment	STAT1	1.91
169	Soluble interleukin-6 receptor, serum level of, quantitative trait locus	Enrichment	IL6R	1.91
170	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	1.91
171	Multiple sclerosis 5	Enrichment	TNFRSF1A	1.91
172	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	1.91
173	Cowden syndrome 6	Enrichment	AKT1	1.91
174	Hyper-ige syndrome 5, autosomal recessive, with recurrent infections	Enrichment	IL6R	1.91
175	Melioidosis	Enrichment	TLR5	1.91
176	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	1.91
177	Loeys-dietz syndrome 6	Enrichment	SMAD2	1.91
178	Charcot-marie-tooth disease, dominant intermediate f	Enrichment	GNB4	1.91
179	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	1.91
180	Microphthalmia/coloboma 11	Enrichment	FZD5	1.91
181	Macular degeneration, age-related, 10	Enrichment	TLR4	1.91
182	Immunodeficiency 31b	Enrichment	STAT1	1.91
183	Disorders of gnas inactivation	Enrichment	GNAS	1.91
184	Corneal dystrophy, fuchs endothelial, 3	Enrichment	TCF4	1.91
185	Ductal carcinoma in situ	Enrichment	TP53	1.91
186	Loeys-dietz syndrome 5	Enrichment	TGFB3	1.91
187	Mismatch repair cancer syndrome 2	Enrichment	MSH2	1.91
188	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	1.91
189	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	1.91
190	Tnf receptor-associated periodic fever syndrome	Enrichment	TNFRSF1A	1.91
191	Thrombocytopenia 6	Enrichment	SRC	1.91
192	Maturity-onset diabetes of the young, type 14	Enrichment	APPL1	1.91
193	Gaze palsy, familial horizontal, with progressive scoliosis 2, with impaired intellectual development	Enrichment	DCC	1.91
194	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	1.91
195	Sick sinus syndrome 4	Enrichment	GNB2	1.91
196	Rectal benign neoplasm	Enrichment	MSH2	1.91
197	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	1.91
198	Congenital heart defects, multiple types, 8, with or without heterotaxy	Enrichment	SMAD2	1.91
199	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	1.91
200	Adenoid ameloblastoma	Enrichment	CTNNB1	1.91
201	Heritable thoracic aortic disease	Enrichment	SMAD4	1.91
202	Lrp5-related primary osteoporosis	Enrichment	LRP5	1.91
203	Ascending colon cancer	Enrichment	MSH2	1.91
204	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	1.91
205	Prkar1b-related neurodegenerative dementia with intermediate filaments	Enrichment	PRKAR1B	1.91
206	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	1.91
207	Breast lobular carcinoma	Enrichment	CDH1	1.91
208	Congenital pulmonary airway malformation	Enrichment	KRAS	1.91
209	Choroid plexus cancer	Enrichment	TP53	1.91
210	Ovarian cyst	Enrichment	MSH2	1.91
211	Familial adenomatous polyposis	Enrichment	APC	1.91
212	Syringocystadenoma papilliferum	Enrichment	BRAF	1.91
213	Pleomorphic xanthoastrocytoma	Enrichment	TP53	1.91
214	Ganglioglioma	Enrichment	BRAF	1.91
215	Nongerminomatous germ cell tumor	Enrichment	BRAF	1.91
216	Monostotic fibrous dysplasia	Enrichment	GNAS	1.91
217	Phace syndrome	Enrichment	BRAF	1.91
218	Gardner syndrome	Enrichment	APC	1.91
219	Osteosclerosis-developmental delay-craniosynostosis syndrome	Enrichment	LRP5	1.91
220	5q22 microdeletion syndrome	Enrichment	APC	1.91
221	Autosomal dominant mendelian susceptibility to mycobacterial diseases due to partial ifngammar2 deficiency	Enrichment	IFNGR2	1.91
222	Attenuated familial adenomatous polyposis	Enrichment	APC	1.91
223	Classic hairy cell leukemia	Enrichment	BRAF	1.91
224	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	1.91
225	Mazabraud syndrome	Enrichment	GNAS	1.91
226	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	1.91
227	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	1.91
228	Microcystic stromal tumor	Enrichment	CTNNB1	1.91
229	Human immunodeficiency virus type 1	Enrichment	IFNG, TLR3	1.70
230	Ectrodactyly and ectodermal dysplasia without cleft lip/palate	Enrichment	LEF1	1.62
231	Blepharocheilodontic syndrome 1	Enrichment	CDH1	1.62
232	Burkitt lymphoma	Enrichment	MYC	1.62
233	Fibromatosis, gingival, 1	Enrichment	SOS1	1.62
234	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	1.62
235	Myhre syndrome	Enrichment	SMAD4	1.62
236	Tooth agenesis, selective, 4	Enrichment	WNT10A	1.62
237	Adrenocortical carcinoma, hereditary	Enrichment	TP53	1.62
238	Camurati-engelmann disease 1	Enrichment	TGFB1	1.62
239	Van buchem disease	Enrichment	LRP5	1.62
240	Amelogenesis imperfecta, type ig	Enrichment	PRKAR1A	1.62
241	Schopf-schulz-passarge syndrome	Enrichment	WNT10A	1.62
242	Ulna and fibula, absence of, with severe limb deficiency	Enrichment	WNT7A	1.62
243	Bladder exstrophy and epispadias complex	Enrichment	WNT3	1.62
244	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	1.62
245	Cervical cancer	Enrichment	TP53	1.62
246	Odontoonychodermal dysplasia	Enrichment	WNT10A	1.62
247	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	1.62
248	Tetraamelia syndrome 1	Enrichment	WNT3	1.62
249	Pseudopseudohypoparathyroidism	Enrichment	GNAS	1.62
250	Juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome	Enrichment	SMAD4	1.62
251	Microvascular complications of diabetes 5	Enrichment	TGFBR2	1.62
252	Osteogenesis imperfecta, type xv	Enrichment	WNT1	1.62
253	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	1.62
254	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS	1.62
255	Lethal congenital contracture syndrome 8	Enrichment	ADCY6	1.62
256	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	1.62
257	Robinow syndrome, autosomal dominant 3	Enrichment	FZD2	1.62
258	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	1.62
259	Fibular aplasia or hypoplasia, femoral bowing, and poly-, syn-, and oligodactyly	Enrichment	WNT7A	1.62
260	Lymphoma, hodgkin, classic	Enrichment	TP53	1.62
261	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.62
262	Oguchi disease 2	Enrichment	GRK1	1.62
263	Loeys-dietz syndrome 3	Enrichment	SMAD3	1.62
264	Immunodeficiency 31c	Enrichment	STAT1	1.62
265	Marbach-schaaf neurodevelopmental syndrome	Enrichment	PRKAR1B	1.62
266	Usher syndrome, type iv	Enrichment	PRKAR1A	1.62
267	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	1.62
268	Immunodeficiency 127	Enrichment	TNF	1.62
269	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	1.62
270	Recessive dystrophic epidermolysis bullosa	Enrichment	MMP1	1.62
271	Split hand-foot malformation	Enrichment	LEF1	1.62
272	Leprosy 1	Enrichment	TLR6	1.62
273	Acrodysostosis	Enrichment	PRKAR1A	1.62
274	Pseudohypoparathyroidism	Enrichment	GNAS	1.62
275	Camurati-engelmann disease	Enrichment	TGFB1	1.62
276	Congenital fibrosarcoma	Enrichment	TP53	1.62
277	Metaphyseal anadysplasia 2	Enrichment	MMP9	1.62
278	Body mass index quantitative trait locus 19	Enrichment	ADCY3	1.62
279	Li-fraumeni syndrome 1	Enrichment	TP53	1.62
280	Sarcoma	Enrichment	TP53	1.62
281	Fibrolamellar carcinoma	Enrichment	PRKACA	1.62
282	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	1.62
283	Periampullary adenoma	Enrichment	APC	1.62
284	Gastric adenocarcinoma and proximal polyposis of the stomach	Enrichment	APC	1.62
285	Cervix carcinoma	Enrichment	TP53	1.62
286	Hodgkin's lymphoma	Enrichment	TP53	1.62
287	Ciliary dyskinesia, primary, 18	Enrichment	PRKAR1B	1.62
288	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	1.62
289	Mismatch repair cancer syndrome 3	Enrichment	MSH6	1.62
290	Horizontal gaze palsy with progressive scoliosis	Enrichment	DCC	1.62
291	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	1.62
292	Metaphyseal anadysplasia	Enrichment	MMP9	1.62
293	Intermittent hydrarthrosis	Enrichment	TNFRSF1A	1.62
294	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PRKAR1A	1.62
295	B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3)	Enrichment	TCF3	1.62
296	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	1.62
297	Oguchi disease	Enrichment	GRK1	1.62
298	Teratoma	Enrichment	CTNNB1	1.62
299	Osteosclerosis	Enrichment	LRP5	1.62
300	Bladder exstrophy-epispadias-cloacal exstrophy complex	Enrichment	WNT3	1.62
301	B-lymphoblastic leukemia/lymphoma with t(17;19)	Enrichment	TCF3	1.62
302	Common variable immunodeficiency 12	Enrichment	NFKB1	1.62
303	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	1.62
304	Tafro syndrome	Enrichment	MAP2K2	1.62
305	Cerebral visual impairment	Enrichment	GNB1	1.62
306	Multisystem inflammatory syndrome in children	Enrichment	TLR3, TLR6	1.54
307	Brittle bone disorder	Enrichment	LRP5, WNT1	1.50
308	Malaria	Enrichment	NOS2, TNF	1.50
309	Congenital stationary night blindness	Enrichment	GNB3, GRK1	1.50
310	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	1.44
311	Mccune-albright syndrome	Enrichment	GNAS	1.44
312	Ataxia-telangiectasia	Enrichment	BRAF	1.44
313	Juvenile polyposis syndrome	Enrichment	SMAD4	1.44
314	Asthma, nasal polyps, and aspirin intolerance	Enrichment	PTGER2	1.44
315	Tuberous sclerosis 1	Enrichment	IFNG	1.44
316	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	TLR8	1.44
317	Mullerian duct aplasia, unilateral renal agenesis, and cervicothoracic somite anomalies	Enrichment	WNT4	1.44
318	Microphthalmia, syndromic 9	Enrichment	WNT7B	1.44
319	Tooth agenesis, selective, 2	Enrichment	WNT10A	1.44
320	Osteopetrosis, autosomal dominant 1	Enrichment	LRP5	1.44
321	Nuchal bleb, familial	Enrichment	SOS1	1.44
322	Osteogenic sarcoma	Enrichment	TP53	1.44
323	Psoriatic arthritis	Enrichment	TNF	1.44
324	Hepatitis c virus	Enrichment	IFNG	1.44
325	Nasopharyngeal carcinoma	Enrichment	TP53	1.44
326	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3R1	1.44
327	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.44
328	Tuberous sclerosis 2	Enrichment	IFNG	1.44
329	Cenani-lenz syndactyly syndrome	Enrichment	APC	1.44
330	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.44
331	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.44
332	Lynch syndrome 5	Enrichment	MSH6	1.44
333	Immunodeficiency 28	Enrichment	IFNGR2	1.44
334	Anus, imperforate	Enrichment	CTNNB1	1.44
335	Familial adenomatous polyposis 4	Enrichment	MSH3	1.44
336	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.44
337	Tethered spinal cord syndrome	Enrichment	BRAF	1.44
338	Hyper ige syndrome	Enrichment	STAT3	1.44
339	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	1.44
340	Nail disease	Enrichment	FZD6	1.44
341	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.44
342	Anaplastic astrocytoma	Enrichment	TP53	1.44
343	Immunodeficiency 14	Enrichment	PIK3R1	1.44
344	Squamous cell carcinoma	Enrichment	TP53	1.44
345	Cellular ependymoma	Enrichment	MSH2	1.44
346	Tanycytic ependymoma	Enrichment	MSH2	1.44
347	Papillary ependymoma	Enrichment	MSH2	1.44
348	T-cell acute lymphoblastic leukemia	Enrichment	BAX	1.44
349	Adenocarcinoma	Enrichment	TP53	1.44
350	Migraine without aura	Enrichment	TNF	1.44
351	Bone osteosarcoma	Enrichment	TP53	1.44
352	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	1.44
353	Tetraamelia syndrome	Enrichment	WNT3	1.44
354	Intellectual developmental disorder with dysmorphic facies and behavioral abnormalities	Enrichment	MSH6	1.44
355	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.44
356	Clear cell ependymoma	Enrichment	MSH2	1.44
357	Megalencephalic leukoencephalopathy with subcortical cysts	Enrichment	MLC1	1.44
358	Hypomyelination neuropathy-arthrogryposis syndrome	Enrichment	ADCY6	1.44
359	Apc-associated polyposis conditions	Enrichment	APC	1.44
360	Autism spectrum disorder	Enrichment	DCC, GNB1, MAP2K1, TCF4	1.36
361	Kaposi sarcoma	Enrichment	IL6	1.32
362	Mirror movements 1	Enrichment	DCC	1.32
363	Chorea, benign hereditary	Enrichment	ADCY5	1.32
364	Schimmelpenning-feuerstein-mims syndrome	Enrichment	KRAS	1.32
365	Gaucher disease, type i	Enrichment	MSH6	1.32
366	Ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	WNT10A	1.32
367	Small cell cancer of the lung	Enrichment	TP53	1.32
368	Anemia, autoimmune hemolytic	Enrichment	TLR8	1.32
369	Spastic paraplegia 17, autosomal dominant	Enrichment	GNG3	1.32
370	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	1.32
371	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.32
372	Lipodystrophy, congenital generalized, type 2	Enrichment	GNG3	1.32
373	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3R2	1.32
374	Pitt-hopkins syndrome	Enrichment	TCF4	1.32
375	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.32
376	Pilomatrixoma	Enrichment	CTNNB1	1.32
377	Carney complex variant	Enrichment	PRKAR1A	1.32
378	Arrhythmogenic right ventricular dysplasia, familial, 10	Enrichment	PRKAR1A	1.32
379	Alazami syndrome	Enrichment	CTNNB1	1.32
380	Mantle cell lymphoma	Enrichment	CCND1	1.32
381	Orofacial cleft	Enrichment	LRP6	1.32
382	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS	1.32
383	Ectodermal dysplasia	Enrichment	WNT10A	1.32
384	Hepatitis b	Enrichment	IFNGR1	1.32
385	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.32
386	Noonan syndrome with multiple lentigines	Enrichment	BRAF	1.32
387	Pilocytic astrocytoma	Enrichment	KRAS	1.32
388	Newborn respiratory distress syndrome	Enrichment	BRAF	1.32
389	Eyelid coloboma	Enrichment	FZD5	1.32
390	Cerebral malaria	Enrichment	TNF	1.32
391	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.32
392	Vitreoretinopathy	Enrichment	LRP5	1.32
393	Benign ependymoma	Enrichment	MSH2	1.32
394	Orofacial clefting syndrome	Enrichment	LRP6	1.32
395	Gingival fibromatosis	Enrichment	SOS1	1.32
396	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.32
397	Lens coloboma	Enrichment	FZD5	1.32
398	Familial sick sinus syndrome	Enrichment	GNB2	1.32
399	Differentiated thyroid carcinoma	Enrichment	BRAF, KRAS	1.32
400	Non-immune hydrops fetalis	Enrichment	FZD6, KRAS	1.26
401	Connective tissue disease	Enrichment	SMAD3, TGFBR2	1.24
402	Arrhythmogenic right ventricular dysplasia, familial, 1	Enrichment	TGFB3	1.23
403	Von hippel-lindau syndrome	Enrichment	CCND1	1.23
404	Norrie disease	Enrichment	FZD4	1.23
405	Rhabdomyosarcoma 2	Enrichment	TP53	1.23
406	Megalencephalic leukoencephalopathy with subcortical cysts 1	Enrichment	MLC1	1.23
407	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.23
408	Familial adenomatous polyposis 1	Enrichment	APC	1.23
409	Cholangitis, primary sclerosing	Enrichment	TCF4	1.23
410	Fuchs' endothelial dystrophy	Enrichment	TCF4	1.23
411	Lymphoma	Enrichment	TP53	1.23
412	Glioblastoma	Enrichment	MSH2	1.23
413	Arrhythmogenic right ventricular dysplasia 1	Enrichment	TGFB3	1.23
414	Persistent hyperplastic primary vitreous	Enrichment	FZD4	1.23
415	Vascular dementia	Enrichment	TNF	1.23
416	Acute megakaryocytic leukemia	Enrichment	TP53	1.23
417	Autosomal recessive hypohidrotic ectodermal dysplasia syndrome	Enrichment	WNT10A	1.23
418	Herpes simplex virus encephalitis	Enrichment	TLR3	1.23
419	Coloboma of choroid and retina	Enrichment	FZD5	1.23
420	Generalized juvenile polyposis/juvenile polyposis coli	Enrichment	SMAD4	1.23
421	Idiopathic aplastic anemia	Enrichment	IFNG	1.23
422	Microcephaly	Enrichment	CTNNB1, GNB1, MAPK1, TCF4	1.20
423	Atrial septal defect 1	Enrichment	TGFB2	1.15
424	Li-fraumeni syndrome	Enrichment	TP53	1.15
425	Coloboma of optic nerve	Enrichment	FZD5	1.15
426	Cowden syndrome 1	Enrichment	EGFR	1.15
427	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.15
428	Split-hand/foot malformation 1	Enrichment	LEF1	1.15
429	Type 1 diabetes mellitus	Enrichment	IL6	1.15
430	Wilms tumor 5	Enrichment	BRAF	1.15
431	Renal dysplasia, cystic	Enrichment	WNT9B	1.15
432	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.15
433	Renal hypoplasia	Enrichment	WNT9B	1.15
434	Diarrhea	Enrichment	WNT2B	1.15
435	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.15
436	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.15
437	Classic ehlers-danlos syndrome	Enrichment	TGFBR1	1.15
438	Multicystic kidney dysplasia	Enrichment	FZD3	1.15
439	Cleft lip with or without cleft palate	Enrichment	CDH1	1.15
440	Multicystic dysplastic kidney	Enrichment	FZD3	1.15
441	Systemic lupus erythematosus	Enrichment	TLR7, TNF	1.09
442	Nevus, epidermal	Enrichment	KRAS	1.09
443	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A	1.09
444	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF	1.09
445	Myelofibrosis	Enrichment	SRC	1.09
446	Coats disease	Enrichment	FZD4	1.09
447	Leukemia, chronic myeloid	Enrichment	KRAS	1.09
448	Brachydactyly	Enrichment	GNAS	1.09
449	Essential thrombocythemia	Enrichment	TP53	1.09
450	Hereditary hemorrhagic telangiectasia	Enrichment	SMAD4	1.09
451	Common variable immunodeficiency	Enrichment	NFKB1	1.09
452	Follicular thyroid carcinoma	Enrichment	BRAF	1.09
453	Overgrowth syndrome	Enrichment	PIK3R1	1.09
454	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.09
455	Leukemia, acute myeloid	Enrichment	KRAS, TP53	1.07
456	Melanocytic nevus syndrome, congenital	Enrichment	BRAF	1.03
457	Glioma susceptibility 1	Enrichment	TP53	1.03
458	Renal hypodysplasia/aplasia 1	Enrichment	WNT9B	1.03
459	Hypothyroidism	Enrichment	GNB1	1.03
460	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.03
461	Isolated split hand-split foot malformation	Enrichment	WNT10B	1.03
462	Tooth agenesis, selective, 1	Enrichment	AXIN2	0.98
463	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	0.98
464	Rheumatoid arthritis	Enrichment	TLR1	0.98
465	Charge syndrome	Enrichment	TNFRSF1A	0.98
466	Inflammatory bowel disease 1	Enrichment	IL6	0.98
467	Arteriovenous malformation	Enrichment	MAP2K1	0.98
468	Ventricular septal defect	Enrichment	BRAF	0.98
469	Cowden syndrome	Enrichment	AKT1	0.98
470	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	0.98
471	Renal agenesis, bilateral	Enrichment	WNT9B	0.98
472	Cat eye syndrome	Enrichment	FZD5	0.94
473	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1	0.94
474	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	0.94
475	Aplastic anemia	Enrichment	IFNG	0.94
476	Melanoma	Enrichment	BRAF	0.94
477	Thrombocytopenia	Enrichment	SMAD4, SRC	0.94
478	Body mass index quantitative trait locus 11	Enrichment	ADCY3, GNAS	0.91
479	Autosomal dominant non-syndromic intellectual disability	Enrichment	GNB1, TCF4	0.91
480	Pectus excavatum	Enrichment	TGFBR1	0.90
481	Asthma	Enrichment	TNF	0.90
482	Leukemia, acute lymphoblastic	Enrichment	GNB1	0.90
483	Specific learning disability	Enrichment	MAPK1	0.90
484	Epicanthus	Enrichment	TCF4	0.86
485	Juvenile myelomonocytic leukemia	Enrichment	KRAS	0.86
486	Meningioma	Enrichment	AKT1	0.86
487	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	TGFB3	0.86
488	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	TGFB3	0.86
489	Congenital nervous system abnormality	Enrichment	CTNNB1, GNB5, MLC1	0.86
490	Nervous system disease	Enrichment	CTNNB1, GNB5, MLC1	0.86
491	Aortic valve disease 1	Enrichment	SOS1	0.83
492	Microphthalmia/coloboma 12	Enrichment	FZD5	0.83
493	Osteogenesis imperfecta, type iv	Enrichment	WNT1	0.83
494	Breast-ovarian cancer, familial 1	Enrichment	MSH2	0.83
495	Alzheimer's disease	Enrichment	TNF	0.83
496	Stereotypic movement disorder	Enrichment	TCF4	0.83
497	Chronic kidney disease	Enrichment	WNT9B	0.83
498	Multiple sclerosis	Enrichment	TNFRSF1A	0.80
499	Aortic aneurysm, familial thoracic 1	Enrichment	SMAD3	0.80
500	Cleft lip/palate	Enrichment	CDH1	0.80
501	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	TGFB3	0.80
502	46,xy partial gonadal dysgenesis	Enrichment	SOS1	0.80
503	Coloboma of macula	Enrichment	FZD5	0.78
504	Wilms tumor 1	Enrichment	BRAF	0.78
505	Corpus callosum, agenesis of	Enrichment	DCC	0.78
506	Osteogenesis imperfecta, type iii	Enrichment	WNT1	0.78
507	Hydrocephalus	Enrichment	FZD3	0.78
508	Isolated corpus callosum agenesis	Enrichment	DCC	0.78
509	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	DCC	0.78
510	Hypertension, essential	Enrichment	GNB3	0.73
511	Melanoma, cutaneous malignant 1	Enrichment	BRAF	0.73
512	Cleft palate, isolated	Enrichment	GNB1	0.73
513	Dandy-walker syndrome	Enrichment	BRAF	0.73
514	Heart, malformation of	Enrichment	MAPK1	0.70
515	Macs syndrome	Enrichment	WNT7B	0.66
516	Maturity-onset diabetes of the young	Enrichment	APPL1	0.66
517	Attention deficit-hyperactivity disorder	Enrichment	GNB5	0.63
518	Visceral heterotaxy	Enrichment	LEFTY2	0.63
519	Microphthalmia	Enrichment	WNT7B	0.63
520	Diamond-blackfan anemia 1	Enrichment	TP53	0.61
521	Kallmann syndrome	Enrichment	DCC	0.61
522	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	0.61
523	Autoinflammatory disease	Enrichment	TNFRSF1A	0.59
524	Jeune thoracic dystrophy	Enrichment	GRK2	0.58
525	Hydrops fetalis, nonimmune	Enrichment	FZD6	0.56
526	Strabismus	Enrichment	GNB1	0.55
527	Asphyxiating thoracic dystrophy	Enrichment	GRK2	0.54
528	Hirschsprung disease 1	Enrichment	AXIN2	0.52
529	Cystic fibrosis	Enrichment	TGFB1	0.49
530	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	GRK2	0.48
531	Dystonia	Enrichment	GNB1	0.46
532	Diamond-blackfan anemia	Enrichment	TP53	0.45
533	Cerebral palsy	Enrichment	GNB1	0.42
534	Type 2 diabetes mellitus	Enrichment	IL6	0.40
535	Distal arthrogryposis	Enrichment	FZD3	0.40
536	Primary ciliary dyskinesia	Enrichment	PRKAR1B	0.22
537	Dilated cardiomyopathy	Enrichment	BRAF	0.20
538	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	ADCY1	0.18
539	Hereditary retinal dystrophy	Enrichment	FZD4, GRK1, LRP5	0.16
540	Fundus dystrophy	Enrichment	FZD4, GRK1, LRP5	0.16
541	Complex neurodevelopmental disorder	Enrichment	GNB2	0.11

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Colorectal Cancer Metastasis

Pathway Network for Colorectal Cancer Metastasis

Member Pathways for Colorectal Cancer Metastasis

Pathways in the Colorectal Cancer Metastasis SuperPath

Associated Genes for Colorectal Cancer Metastasis

Associated Disorders for Colorectal Cancer Metastasis

Disorders associated with Colorectal Cancer Metastasis SuperPath

STRING Interaction Network for Colorectal Cancer Metastasis

Sources for Colorectal Cancer Metastasis