Common pathways underlying drug addiction

No Pathway Network information available for Common pathways underlying drug addiction

Pathways in the Common pathways underlying drug addiction SuperPath

#	Name	Source	Genes
1	Common pathways underlying drug addiction	WikiPathways	ACTB ACTG1 ACTG2 ADCY1 ADCY8 ARAF CALM1 CAMK2A CAMK4 CREB1 DRD1 DRD2 DRD4 GJB1 GNAI1 GNAS GRIA1 GRIA2 GRIA3 GRIA4 GRIN1 GRIN2A GRM1 GRM5 MAP2K1 MAP2K2 MAPK1 MAPK3 PPP1CA PPP1CB PPP1CC PPP1R1A PRKACA PRKACB PRKACG PRKCA PRKCB PRKCG RAF1 RAP1A RAP1B (see all 41) (see less)
2	Hippocampal synaptogenesis and neurogenesis	WikiPathways	CREB1 DRD1

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DRD1	Dopamine Receptor D1	Protein Coding	2
2	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	2
3	RAP1B	RAP1B, Member Of RAS Oncogene Family	Protein Coding	1
4	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	1
5	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	1
6	CAMK4	Calcium/Calmodulin Dependent Protein Kinase IV	Protein Coding	1
7	CALM1	Calmodulin 1	Protein Coding	1
8	ACTG2	Actin Gamma 2, Smooth Muscle	Protein Coding	1
9	ACTG1	Actin Gamma 1	Protein Coding	1
10	ACTB	Actin Beta	Protein Coding	1
11	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
12	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
13	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
14	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
15	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
16	PRKCG	Protein Kinase C Gamma	Protein Coding	1
17	PRKCB	Protein Kinase C Beta	Protein Coding	1
18	PRKCA	Protein Kinase C Alpha	Protein Coding	1
19	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	1
20	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	1
21	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
22	PPP1R1A	Protein Phosphatase 1 Regulatory Inhibitor Subunit 1A	Protein Coding	1
23	PPP1CC	Protein Phosphatase 1 Catalytic Subunit Gamma	Protein Coding	1
24	ARAF	A-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
25	GRM5	Glutamate Metabotropic Receptor 5	Protein Coding	1
26	GRM1	Glutamate Metabotropic Receptor 1	Protein Coding	1
27	GRIN2A	Glutamate Ionotropic Receptor NMDA Type Subunit 2A	Protein Coding	1
28	GRIN1	Glutamate Ionotropic Receptor NMDA Type Subunit 1	Protein Coding	1
29	GRIA4	Glutamate Ionotropic Receptor AMPA Type Subunit 4	Protein Coding	1
30	GRIA3	Glutamate Ionotropic Receptor AMPA Type Subunit 3	Protein Coding	1
31	GRIA2	Glutamate Ionotropic Receptor AMPA Type Subunit 2	Protein Coding	1
32	GRIA1	Glutamate Ionotropic Receptor AMPA Type Subunit 1	Protein Coding	1
33	GNAS	GNAS Complex Locus	Protein Coding	1
34	GNAI1	G Protein Subunit Alpha I1	Protein Coding	1
35	GJB1	Gap Junction Protein Beta 1	Protein Coding	1
36	DRD4	Dopamine Receptor D4	Protein Coding	1
37	DRD2	Dopamine Receptor D2	Protein Coding	1
38	ADCY8	Adenylate Cyclase 8	Protein Coding	1
39	ADCY1	Adenylate Cyclase 1	Protein Coding	1
40	PPP1CB	Protein Phosphatase 1 Catalytic Subunit Beta	Protein Coding	1
41	PPP1CA	Protein Phosphatase 1 Catalytic Subunit Alpha	Protein Coding	1

Disorders associated with Common pathways underlying drug addiction SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome 1	Enrichment	MAP2K1, MAP2K2, PPP1CB, RAF1	6.21
2	Rasopathy	Enrichment	MAP2K1, MAP2K2, PPP1CB, RAF1	5.99
3	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	5.05
4	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1, MAP2K2, RAF1	4.94
5	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1, MAP2K2	4.27
6	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1, MAP2K2	4.27
7	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	3.53
8	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	3.50
9	Melanoma of soft tissue	Enrichment	CREB1	3.35
10	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A, GRIA1, GRIN1	3.34
11	Epilepsy, focal, with speech disorder and with or without impaired intellectual development	Enrichment	GRIN2A	2.52
12	Baraitser-winter syndrome 1	Enrichment	ACTB	2.52
13	Pallister-killian syndrome	Enrichment	ARAF	2.52
14	Noonan syndrome 5	Enrichment	RAF1	2.52
15	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	2.52
16	Melorheostosis, isolated	Enrichment	MAP2K1	2.52
17	Osseous heteroplasia, progressive	Enrichment	GNAS	2.52
18	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.52
19	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.52
20	Deafness, autosomal recessive 44	Enrichment	ADCY1	2.52
21	Spinocerebellar ataxia, autosomal recessive 13	Enrichment	GRM1	2.52
22	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	2.52
23	Megacystis-microcolon-intestinal hypoperistalsis syndrome 5	Enrichment	ACTG2	2.52
24	Noonan syndrome 13	Enrichment	MAPK1	2.52
25	Pituitary adenoma 3, multiple types	Enrichment	GNAS	2.52
26	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	2.52
27	Intellectual developmental disorder, x-linked, syndromic, wu type	Enrichment	GRIA3	2.52
28	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.52
29	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.52
30	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	2.52
31	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive	Enrichment	GRIN1	2.52
32	Spinocerebellar ataxia 14	Enrichment	PRKCG	2.52
33	Becker nevus syndrome	Enrichment	ACTB	2.52
34	Melorheostosis	Enrichment	MAP2K1	2.52
35	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.52
36	Visceral neuropathy, familial, 3, autosomal dominant	Enrichment	ACTG2	2.52
37	Leopard syndrome 2	Enrichment	RAF1	2.52
38	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.52
39	Thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies	Enrichment	RAP1B	2.52
40	Neurodevelopmental disorder with language impairment and behavioral abnormalities	Enrichment	GRIA2	2.52
41	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.52
42	Autosomal dominant familial visceral neuropathy	Enrichment	ACTG2	2.52
43	Developmental and epileptic encephalopathy 101	Enrichment	GRIN1	2.52
44	Disorders of gnas inactivation	Enrichment	GNAS	2.52
45	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant	Enrichment	GRIN1	2.52
46	Neurodevelopmental disorder with or without seizures and gait abnormalities	Enrichment	GRIA4	2.52
47	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.52
48	Intellectual developmental disorder, autosomal dominant 67	Enrichment	GRIA1	2.52
49	Noonan syndrome-like disorder with loose anagen hair 2	Enrichment	PPP1CB	2.52
50	Spinocerebellar ataxia 44	Enrichment	GRM1	2.52
51	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.52
52	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	2.52
53	Intellectual developmental disorder, autosomal recessive 76	Enrichment	GRIA1	2.52
54	Trigonitis	Enrichment	RAF1	2.52
55	Baraitser-winter syndrome	Enrichment	ACTB	2.52
56	Syndromic x-linked intellectual disability 94	Enrichment	GRIA3	2.52
57	Autonomic nervous system disease	Enrichment	DRD4	2.52
58	Landau-kleffner syndrome	Enrichment	GRIN2A	2.52
59	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.52
60	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.52
61	Intellectual disability, autosomal dominant 8	Enrichment	GRIN1	2.52
62	Gria2-related neurodevelopmental disorder	Enrichment	GRIA2	2.52
63	Early-onset epileptic encephalopathy and intellectual disability due to grin2a mutation	Enrichment	GRIN2A	2.52
64	Monostotic fibrous dysplasia	Enrichment	GNAS	2.52
65	Grin2a-related disorders	Enrichment	GRIN2A	2.52
66	Chondromyxoid fibroma	Enrichment	GRM1	2.52
67	Mazabraud syndrome	Enrichment	GNAS	2.52
68	Myopathic intestinal pseudoobstruction	Enrichment	ACTG2	2.52
69	Actg2 visceral myopathy	Enrichment	ACTG2	2.52
70	Microcephaly	Enrichment	ACTB, ACTG1, MAPK1	2.22
71	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	2.22
72	Spinocerebellar ataxia, x-linked 1	Enrichment	GJB1	2.22
73	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS	2.22
74	Pseudopseudohypoparathyroidism	Enrichment	GNAS	2.22
75	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	2.22
76	Deafness, autosomal dominant 20	Enrichment	ACTG1	2.22
77	Baraitser-winter syndrome 2	Enrichment	ACTG1	2.22
78	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	2.22
79	Long qt syndrome 14	Enrichment	CALM1	2.22
80	Noonan syndrome-like disorder with loose anagen hair	Enrichment	PPP1CB	2.22
81	Bilateral generalized polymicrogyria	Enrichment	GRIN1	2.22
82	Intellectual developmental disorder, autosomal dominant 21	Enrichment	GRIN2A	2.22
83	Pseudohypoparathyroidism	Enrichment	GNAS	2.22
84	Fibrolamellar carcinoma	Enrichment	PRKACA	2.22
85	Rolandic epilepsy-speech dyspraxia syndrome	Enrichment	GRIN2A	2.22
86	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	2.22
87	Tafro syndrome	Enrichment	MAP2K2	2.22
88	Intestinal obstruction	Enrichment	ACTG2	2.22
89	Epilepsy-aphasia spectrum	Enrichment	GRIN2A	2.22
90	Benign epilepsy with centrotemporal spikes	Enrichment	GRIN1, GRIN2A	2.17
91	Centralopathic epilepsy	Enrichment	GRIN1, GRIN2A	2.13
92	West syndrome	Enrichment	GRIA3, GRIN1	2.11
93	Mccune-albright syndrome	Enrichment	GNAS	2.04
94	Charcot-marie-tooth disease, x-linked dominant, 1	Enrichment	GJB1	2.04
95	Langerhans cell histiocytosis	Enrichment	MAP2K1	2.04
96	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	2.04
97	Body mass index quantitative trait locus 11	Enrichment	GNAS, GRIA4	2.00
98	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	ACTG2	1.92
99	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	1.92
100	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	1.92
101	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.92
102	Aminoacylase 1 deficiency	Enrichment	ACTB	1.92
103	Hereditary ataxia	Enrichment	PRKCG	1.92
104	Noonan syndrome with multiple lentigines	Enrichment	RAF1	1.92
105	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.92
106	Autosomal recessive non-syndromic intellectual disability	Enrichment	GRIA1, GRIN1	1.88
107	Hypertrophic neuropathy of dejerine-sottas	Enrichment	GJB1	1.82
108	Visceral myopathy 1	Enrichment	ACTG2	1.82
109	Coloboma of choroid and retina	Enrichment	ACTG1	1.82
110	Sensory peripheral neuropathy	Enrichment	GJB1	1.82
111	Dystonia 11, myoclonic	Enrichment	DRD2	1.74
112	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.74
113	Intestinal pseudo-obstruction	Enrichment	ACTG2	1.74
114	Pain disorder	Enrichment	GJB1	1.74
115	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	1.68
116	Noonan syndrome 3	Enrichment	RAF1	1.68
117	Brachydactyly	Enrichment	GNAS	1.68
118	Pilomyxoid astrocytoma	Enrichment	RAF1	1.68
119	Melanocytic nevus syndrome, congenital	Enrichment	RAF1	1.62
120	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	1.62
121	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.62
122	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1	1.62
123	Arteriovenous malformation	Enrichment	MAP2K1	1.57
124	Primary hyperaldosteronism	Enrichment	GNAS	1.57
125	Cat eye syndrome	Enrichment	ACTG1	1.53
126	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1	1.53
127	Lung non-small cell carcinoma	Enrichment	MAP2K1	1.48
128	Specific learning disability	Enrichment	MAPK1	1.48
129	Autism spectrum disorder	Enrichment	GRIA1, MAP2K1	1.37
130	Dandy-walker syndrome	Enrichment	PPP1CB	1.30
131	Heart, malformation of	Enrichment	MAPK1	1.28
132	Early infantile developmental and epileptic encephalopathy	Enrichment	GRIN1	1.28
133	Lissencephaly	Enrichment	ACTG1	1.21
134	Attention deficit-hyperactivity disorder	Enrichment	DRD4	1.19
135	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.15
136	Developmental and epileptic encephalopathy 1	Enrichment	GRIN1	1.14
137	Long qt syndrome 1	Enrichment	CALM1	1.06
138	Long qt syndrome	Enrichment	CALM1	1.05
139	Peripheral nervous system disease	Enrichment	GJB1	1.03
140	Neuropathy	Enrichment	GJB1	1.03
141	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.02
142	Cakut	Enrichment	ACTG1	1.01
143	Left ventricular noncompaction	Enrichment	RAF1	1.00
144	Dystonia	Enrichment	GRIA3	1.00
145	Developmental and epileptic encephalopathy	Enrichment	GRIA3	0.99
146	Non-syndromic genetic deafness	Enrichment	ACTG1	0.99
147	Epilepsy	Enrichment	GRIN2A	0.94
148	Charcot-marie-tooth disease	Enrichment	GJB1	0.93
149	Nonsyndromic hearing loss	Enrichment	ACTG1	0.92
150	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1	0.84
151	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.83
152	Rare genetic deafness	Enrichment	ACTG1	0.67
153	Dilated cardiomyopathy	Enrichment	RAF1	0.67
154	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	ADCY1	0.63
155	Complex neurodevelopmental disorder	Enrichment	GRIA4	0.50

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Common pathways underlying drug addiction

Pathway Network for Common pathways underlying drug addiction

Member Pathways for Common pathways underlying drug addiction

Pathways in the Common pathways underlying drug addiction SuperPath

Associated Genes for Common pathways underlying drug addiction

Associated Disorders for Common pathways underlying drug addiction

Disorders associated with Common pathways underlying drug addiction SuperPath

STRING Interaction Network for Common pathways underlying drug addiction

Sources for Common pathways underlying drug addiction