Complement cascade

Pathway network for the Complement cascade SuperPath

Sources:

Reactome
WikiPathways
QIAGEN

Pathways in the Complement cascade SuperPath

#	Name	Source	Genes
1	Complement cascade	Reactome	C1QA C1QB C1QC C1R C1S C2 C3 C3AR1 C4A C4B C4B_2 C4BPA C4BPB C5 C5AR1 C5AR2 C6 C7 C8A C8B C8G C9 CD19 CD46 CD55 CD59 CD81 CFB CFD CFH CFHR1 CFHR2 CFHR3 CFHR4 CFHR5 CFI CFP CLU COLEC10 COLEC11 CPB2 CPN1 CPN2 CR1 CR2 CRP ELANE F2 FCN1 FCN2 FCN3 GZMM MASP1 MASP2 MBL2 PROS1 SERPING1 VTN (see all 58) (see less)
2	Complement system in neuronal development and plasticity	WikiPathways	APAF1 ATP10A ATP11A ATP11C ATP8B1 ATP8B2 ATP8B3 AXL BAK1 BAX BID C1QA C1QB C1QC C1R C1S C2 C3 C3AR1 C4A C4B C4BPA C4BPB C5 C5AR1 C5AR2 C6 C7 C8A C8B C8G C9 CAP1 CASP10 CASP3 CASP7 CASP8 CASP9 CD46 CD55 CD59 CFB CFD CFH CFI CFP CLU COLEC10 COLEC11 COLEC12 CR1 CR2 CRB1 CRB2 CSMD1 CX3CL1 CX3CR1 CYCS DEDD DIABLO DLGAP5 FAS FASLG FCN1 FCN2 FCN3 GAS6 HTRA2 IFNG ITGAM ITGAV ITGAX ITGB2 ITGB3 LLGL2 MARK1 MARK2 MARK3 MASP1 MASP2 MBL1P MBL2 MBP MERTK MFGE8 PALS1 PARD3 PARD6A PARD6B PARD6G PATJ PLSCR1 PLSCR3 PLSCR4 PRKCI PRKCZ PROS1 SCRIB SERPING1 SUSD4 TGFB1 TGFB2 TGFB3 TYRO3 VTN XIAP (see all 106) (see less)
3	Complement system	WikiPathways	A2M ADIPOQ ADM ALB APCS APOA1 ARRB2 C1QBP C1S C2 C3 C3AR1 C4A C4BPA C5 C5AR1 C5AR2 C6 C7 C8A C9 CALR CD19 CD40 CD46 CD55 CD59 CD93 CFB CFD CFH CFHR2 CFHR4 CFI CFP CLEC4M CPN1 CR1 CR2 CRP CSNK1A1 DCN ELANE F10 F13A1 FCER2 FCGR3A FCN1 FCN2 FGA FGB FGG FKBP2 FPR1 GNA15 GNAI2 GNAI3 IBSP ICAM1 ICAM2 ITGA2 ITGA2B ITGB3 KLKB1 LAMA5 LAMB1 LAMC1 LRP2 MASP1 MASP2 MBL2 PLAUR PLG PRKACA PRKCA PRNP PROS1 PTX3 RPS19 SELE SELL SELP SELPLG SERPING1 SFTPA1 SFTPA2 SPP1 THBS1 TLR2 TXN VSIG4 VTN WAS (see all 93) (see less)
4	Regulation of Complement cascade	Reactome	C1QA C1QB C1QC C1R C1S C2 C3 C3AR1 C4A C4B C4B_2 C4BPA C4BPB C5 C5AR1 C5AR2 C6 C7 C8A C8B C8G C9 CD19 CD46 CD55 CD59 CD81 CFB CFH CFHR1 CFHR2 CFHR3 CFHR4 CFHR5 CFI CFP CLU CPB2 CPN1 CPN2 CR1 CR2 ELANE F2 PROS1 SERPING1 VTN (see all 47) (see less)
5	Complement Pathway	QIAGEN	C1QA C1QB C1QC C1R C1S C2 C3 C4A C5 C6 C7 C8A C8B C8G C9 CFB CFD MASP1 MASP2 MBL2 (see all 20) (see less)
6	Classical Complement Pathway	QIAGEN	C1QA C1QB C1QC C1R C1S C2 C3 C4A C5 C6 C7 C8A C8B C8G C9 (see all 15) (see less)
7	Lectin Induced Complement Pathway	QIAGEN	C2 C3 C4A C5 C6 C7 C8A C8B C8G C9 MASP1 MASP2 MBL2 (see all 13) (see less)
8	Activation of C3 and C5	Reactome	C2 C3 C4A C4B C4B_2 C5 CFB CFP (see all 8) (see less)

Gene overlap in member pathways for Complement cascade SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	C2	Complement C2	Protein Coding	8
2	C3	Complement C3	Protein Coding	8
3	C4A	Complement C4A (Chido/Rodgers Blood Group)	Protein Coding	8
4	C5	Complement C5	Protein Coding	8
5	C6	Complement C6	Protein Coding	7
6	C7	Complement C7	Protein Coding	7
7	C8A	Complement C8 Alpha Chain	Protein Coding	7
8	C9	Complement C9	Protein Coding	7
9	CFB	Complement Factor B	Protein Coding	6
10	C1S	Complement C1s	Protein Coding	6
11	C8B	Complement C8 Beta Chain	Protein Coding	6
12	C8G	Complement C8 Gamma Chain	Protein Coding	6
13	MASP2	MBL Associated Serine Protease 2	Protein Coding	5
14	MBL2	Mannose Binding Lectin 2	Protein Coding	5
15	CFP	Complement Factor Properdin	Protein Coding	5
16	MASP1	MBL Associated Serine Protease 1	Protein Coding	5
17	C1QA	Complement C1q A Chain	Protein Coding	5
18	C1QB	Complement C1q B Chain	Protein Coding	5
19	C1QC	Complement C1q C Chain	Protein Coding	5
20	C1R	Complement C1r	Protein Coding	5
21	CR1	Complement C3b/C4b Receptor 1 (Knops Blood Group)	Protein Coding	4
22	CR2	Complement C3d Receptor 2	Protein Coding	4
23	CD55	CD55 Molecule (Cromer Blood Group)	Protein Coding	4
24	CFD	Complement Factor D	Protein Coding	4
25	C5AR2	Complement C5a Receptor 2	Protein Coding	4
26	CFH	Complement Factor H	Protein Coding	4
27	CFI	Complement Factor I	Protein Coding	4
28	CD46	CD46 Molecule	Protein Coding	4
29	PROS1	Protein S	Protein Coding	4
30	SERPING1	Serpin Family G Member 1	Protein Coding	4
31	C3AR1	Complement C3a Receptor 1	Protein Coding	4
32	C4B	Complement C4B (Chido/Rodgers Blood Group)	Protein Coding	4
33	C4BPA	Complement Component 4 Binding Protein Alpha	Protein Coding	4
34	C5AR1	Complement C5a Receptor 1	Protein Coding	4
35	VTN	Vitronectin	Protein Coding	4
36	CD59	CD59 Molecule (CD59 Blood Group)	Protein Coding	4
37	C4B_2	Complement Component 4B (Chido/Rodgers Blood Group), Copy 2	Protein Coding	3
38	CFHR4	Complement Factor H Related 4	Protein Coding	3
39	CLU	Clusterin	Protein Coding	3
40	CPN1	Carboxypeptidase N Subunit 1	Protein Coding	3
41	ELANE	Elastase, Neutrophil Expressed	Protein Coding	3
42	FCN1	Ficolin 1	Protein Coding	3
43	FCN2	Ficolin 2	Protein Coding	3
44	CFHR2	Complement Factor H Related 2	Protein Coding	3
45	C4BPB	Complement Component 4 Binding Protein Beta	Protein Coding	3
46	CD19	CD19 Molecule	Protein Coding	3
47	COLEC10	Collectin Subfamily Member 10	Protein Coding	2
48	CFHR3	Complement Factor H Related 3	Protein Coding	2
49	CPB2	Carboxypeptidase B2	Protein Coding	2
50	CPN2	Carboxypeptidase N Subunit 2	Protein Coding	2
51	CRP	C-Reactive Protein	Protein Coding	2
52	F2	Coagulation Factor II, Thrombin	Protein Coding	2
53	CFHR1	Complement Factor H Related 1	Protein Coding	2
54	COLEC11	Collectin Subfamily Member 11	Protein Coding	2
55	CFHR5	Complement Factor H Related 5	Protein Coding	2
56	FCN3	Ficolin 3	Protein Coding	2
57	CD81	CD81 Molecule	Protein Coding	2
58	ITGB3	Integrin Subunit Beta 3	Protein Coding	2
59	GZMM	Granzyme M	Protein Coding	1
60	DLGAP5	DLG Associated Protein 5	Protein Coding	1
61	PARD6B	Par-6 Family Cell Polarity Regulator Beta	Protein Coding	1
62	CASP10	Caspase 10	Protein Coding	1
63	CASP9	Caspase 9	Protein Coding	1
64	CASP8	Caspase 8	Protein Coding	1
65	CASP7	Caspase 7	Protein Coding	1
66	CASP3	Caspase 3	Protein Coding	1
67	COLEC12	Collectin Subfamily Member 12	Protein Coding	1
68	TYRO3	TYRO3 Protein Tyrosine Kinase	Protein Coding	1
69	TGFB3	Transforming Growth Factor Beta 3	Protein Coding	1
70	TGFB2	Transforming Growth Factor Beta 2	Protein Coding	1
71	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
72	CSMD1	CUB And Sushi Multiple Domains 1	Protein Coding	1
73	CX3CL1	C-X3-C Motif Chemokine Ligand 1	Protein Coding	1
74	BID	BH3 Interacting Domain Death Agonist	Protein Coding	1
75	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	1
76	BAK1	BCL2 Antagonist/Killer 1	Protein Coding	1
77	ATP10A	ATPase Phospholipid Transporting 10A (Putative)	Protein Coding	1
78	PLSCR4	Phospholipid Scramblase 4	Protein Coding	1
79	DIABLO	Diablo IAP-Binding Mitochondrial Protein	Protein Coding	1
80	PARD3	Par-3 Family Cell Polarity Regulator	Protein Coding	1
81	PRKCZ	Protein Kinase C Zeta	Protein Coding	1
82	PRKCI	Protein Kinase C Iota	Protein Coding	1
83	AXL	AXL Receptor Tyrosine Kinase	Protein Coding	1
84	CYCS	Cytochrome C, Somatic	Protein Coding	1
85	PLSCR1	Phospholipid Scramblase 1	Protein Coding	1
86	ATP8B1	ATPase Phospholipid Transporting 8B1	Protein Coding	1
87	MFGE8	Milk Fat Globule EGF And Factor V/VIII Domain Containing	Protein Coding	1
88	MBP	Myelin Basic Protein	Protein Coding	1
89	MARK1	Microtubule Affinity Regulating Kinase 1	Protein Coding	1
90	LLGL2	LLGL Scribble Cell Polarity Complex Component 2	Protein Coding	1
91	ITGB2	Integrin Subunit Beta 2	Protein Coding	1
92	ITGAX	Integrin Subunit Alpha X	Protein Coding	1
93	ITGAV	Integrin Subunit Alpha V	Protein Coding	1
94	ITGAM	Integrin Subunit Alpha M	Protein Coding	1
95	FASLG	Fas Ligand	Protein Coding	1
96	FAS	Fas Cell Surface Death Receptor	Protein Coding	1
97	IFNG	Interferon Gamma	Protein Coding	1
98	XIAP	X-Linked Inhibitor Of Apoptosis	Protein Coding	1
99	APAF1	Apoptotic Peptidase Activating Factor 1	Protein Coding	1
100	CRB2	Crumbs Cell Polarity Complex Component 2	Protein Coding	1
101	HTRA2	HtrA Serine Peptidase 2	Protein Coding	1
102	GAS6	Growth Arrest Specific 6	Protein Coding	1
103	CRB1	Crumbs Cell Polarity Complex Component 1	Protein Coding	1
104	ATP11A	ATPase Phospholipid Transporting 11A	Protein Coding	1
105	MARK2	Microtubule Affinity Regulating Kinase 2	Protein Coding	1
106	CX3CR1	C-X3-C Motif Chemokine Receptor 1	Protein Coding	1
107	CAP1	Cyclase Associated Actin Cytoskeleton Regulatory Protein 1	Protein Coding	1
108	MERTK	MER Proto-Oncogene, Tyrosine Kinase	Protein Coding	1
109	PATJ	PATJ Crumbs Cell Polarity Complex Component	Protein Coding	1
110	ATP8B3	ATPase Phospholipid Transporting 8B3	Protein Coding	1
111	DEDD	Death Effector Domain Containing	Protein Coding	1
112	MBL1P	Mannose Binding Lectin 1, Pseudogene	Pseudogene	1
113	PARD6G	Par-6 Family Cell Polarity Regulator Gamma	Protein Coding	1
114	PALS1	Protein Associated With LIN7 1, MAGUK P55 Family Member	Protein Coding	1
115	ATP8B2	ATPase Phospholipid Transporting 8B2	Protein Coding	1
116	PLSCR3	Phospholipid Scramblase 3	Protein Coding	1
117	SUSD4	Sushi Domain Containing 4	Protein Coding	1
118	PARD6A	Par-6 Family Cell Polarity Regulator Alpha	Protein Coding	1
119	MARK3	Microtubule Affinity Regulating Kinase 3	Protein Coding	1
120	ATP11C	ATPase Phospholipid Transporting 11C (ATP11C Blood Group)	Protein Coding	1
121	SCRIB	Scribble Planar Cell Polarity Protein	Protein Coding	1
122	SFTPA1	Surfactant Protein A1	Protein Coding	1
123	CD93	CD93 Molecule	Protein Coding	1
124	CD40	CD40 Molecule	Protein Coding	1
125	ADIPOQ	Adiponectin, C1Q And Collagen Domain Containing	Protein Coding	1
126	CALR	Calreticulin	Protein Coding	1
127	WAS	WASP Actin Nucleation Promoting Factor	Protein Coding	1
128	TXN	Thioredoxin	Protein Coding	1
129	SFTPA2	Surfactant Protein A2	Protein Coding	1
130	TLR2	Toll Like Receptor 2	Protein Coding	1
131	C1QBP	Complement C1q Binding Protein	Protein Coding	1
132	THBS1	Thrombospondin 1	Protein Coding	1
133	SPP1	Secreted Phosphoprotein 1	Protein Coding	1
134	SELPLG	Selectin P Ligand	Protein Coding	1
135	SELP	Selectin P	Protein Coding	1
136	SELL	Selectin L	Protein Coding	1
137	SELE	Selectin E	Protein Coding	1
138	RPS19	Ribosomal Protein S19	Protein Coding	1
139	PTX3	Pentraxin 3	Protein Coding	1
140	PRNP	Prion Protein (Kanno Blood Group)	Protein Coding	1
141	PRKCA	Protein Kinase C Alpha	Protein Coding	1
142	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
143	PLG	Plasminogen	Protein Coding	1
144	PLAUR	Plasminogen Activator, Urokinase Receptor	Protein Coding	1
145	ARRB2	Arrestin Beta 2	Protein Coding	1
146	LRP2	LDL Receptor Related Protein 2	Protein Coding	1
147	LAMC1	Laminin Subunit Gamma 1	Protein Coding	1
148	LAMB1	Laminin Subunit Beta 1	Protein Coding	1
149	KLKB1	Kallikrein B1	Protein Coding	1
150	ITGA2B	Integrin Subunit Alpha 2b	Protein Coding	1
151	ITGA2	Integrin Subunit Alpha 2	Protein Coding	1
152	ICAM2	Intercellular Adhesion Molecule 2	Protein Coding	1
153	ICAM1	Intercellular Adhesion Molecule 1	Protein Coding	1
154	IBSP	Integrin Binding Sialoprotein	Protein Coding	1
155	APOA1	Apolipoprotein A1	Protein Coding	1
156	APCS	Amyloid P Component, Serum	Protein Coding	1
157	GNAI3	G Protein Subunit Alpha I3	Protein Coding	1
158	GNAI2	G Protein Subunit Alpha I2	Protein Coding	1
159	FKBP2	FKBP Prolyl Isomerase 2	Protein Coding	1
160	FGG	Fibrinogen Gamma Chain	Protein Coding	1
161	FGB	Fibrinogen Beta Chain	Protein Coding	1
162	FGA	Fibrinogen Alpha Chain	Protein Coding	1
163	FCGR3A	Fc Gamma Receptor IIIa	Protein Coding	1
164	FCER2	Fc Epsilon Receptor II	Protein Coding	1
165	F13A1	Coagulation Factor XIII A Chain	Protein Coding	1
166	F10	Coagulation Factor X	Protein Coding	1
167	ALB	Albumin	Protein Coding	1
168	A2M	Alpha-2-Macroglobulin	Protein Coding	1
169	DCN	Decorin	Protein Coding	1
170	CSNK1A1	Casein Kinase 1 Alpha 1	Protein Coding	1
171	ADM	Adrenomedullin	Protein Coding	1
172	VSIG4	V-Set And Immunoglobulin Domain Containing 4	Protein Coding	1
173	CLEC4M	C-Type Lectin Domain Family 4 Member M	Protein Coding	1
174	LAMA5	Laminin Subunit Alpha 5	Protein Coding	1
175	GNA15	G Protein Subunit Alpha 15	Protein Coding	1
176	FPR1	Formyl Peptide Receptor 1	Protein Coding	1

Disorders associated with Complement cascade SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	C3 glomerulopathy	Enrichment	CFH, CFHR1, CFHR2, CFHR3, CFHR5	16.00
2	Immunodeficiency due to a late component of complement deficiency	Enrichment	C5, C6, C7, C8A, C8B, C8G, C9	16.00
3	Immunodeficiency due to a classical component pathway complement deficiency	Enrichment	C1QA, C1QB, C1QC, C1R, C1S, C2, C4A, C4B	11.15
4	Atypical hemolytic uremic syndrome with complement gene abnormality	Enrichment	C3, CD46, CFB, CFH, CFI	11.12
5	Hemolytic uremic syndrome, atypical 1	Enrichment	C3AR1, CFH, CFHR1, CFHR3	9.20
6	C1q deficiency 1	Enrichment	C1QA, C1QB, C1QC	8.96
7	Atypical hemolytic-uremic syndrome	Enrichment	C3, CD46, CFH, CFHR5, CFI	8.93
8	Afibrinogenemia, congenital	Enrichment	CFI, FGA, FGB, FGG	8.68
9	Systemic lupus erythematosus 16	Enrichment	C1QA, C1R, C4A	7.96
10	Genetic atypical hemolytic-uremic syndrome	Enrichment	C3, CD46, CFH	7.41
11	Hellp syndrome	Enrichment	CD46, CFH, CFI	6.81
12	Macular degeneration, age-related, 14	Enrichment	C2, CFB	6.52
13	Dysfibrinogenemia, congenital	Enrichment	FGA, FGB, FGG	6.51
14	Familial dysfibrinogenemia	Enrichment	FGA, FGB, FGG	6.51
15	Familial hypofibrinogenemia	Enrichment	FGA, FGB, FGG	6.51
16	Complement component 6 deficiency	Enrichment	C6, C8B	6.07
17	Thrombocytopenia	Enrichment	F10, FGG, ITGA2B, ITGB3, PROS1, WAS	6.07
18	Periodontal ehlers-danlos syndrome	Enrichment	C1R, C1S	5.94
19	3mc syndrome	Enrichment	COLEC10, COLEC11, MASP1	5.83
20	Autoimmune lymphoproliferative syndrome	Enrichment	CASP10, FAS, FASLG	5.73
21	Ehlers-danlos syndrome, periodontal type, 1	Enrichment	C1R, C1S	5.47
22	Ehlers-danlos syndrome, periodontal type, 2	Enrichment	C1R, C1S	5.47
23	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGA2, ITGA2B, ITGB3	5.21
24	Common variable immunodeficiency phenotype due to cd19/cd81 deficiency	Enrichment	CD19, CD81	4.93
25	De novo thrombotic microangiopathy after kidney transplantation	Enrichment	CFH, CFI	4.93
26	Cyclic neutropenia	Enrichment	CFD, ELANE	4.75
27	Familial drusen	Enrichment	CFH, CFI	4.45
28	Neutropenia, severe congenital, x-linked	Enrichment	ELANE, WAS	4.33
29	Neutropenia, severe congenital, 1, autosomal dominant	Enrichment	CFD, ELANE	4.27
30	Loeys-dietz syndrome 4	Enrichment	TGFB2, TGFB3	4.22
31	Macular degeneration, age-related, 1	Enrichment	CFHR1, CFHR3	4.15
32	Angioedema, hereditary, 1	Enrichment	PLG, SERPING1	3.86
33	Bleeding disorder, platelet-type, 16	Enrichment	ITGA2B, ITGB3	3.86
34	Systemic lupus erythematosus	Enrichment	C4A, C4B	3.65
35	Amyloidosis, hereditary systemic 2	Enrichment	APOA1, FGA	3.34
36	Complement component 2 deficiency	Enrichment	C2	3.23
37	Complement component 5 deficiency	Enrichment	C5	3.23
38	Hemolytic uremic syndrome, atypical 4	Enrichment	CFB	3.23
39	Hemolytic uremic syndrome, atypical 5	Enrichment	C3	3.23
40	Eculizumab, poor response to	Enrichment	C5	3.23
41	Properdin deficiency, x-linked	Enrichment	CFP	3.23
42	Complement component 4a deficiency	Enrichment	C4A	3.23
43	Blood group, chido/rodgers system	Enrichment	C4A	3.23
44	Complement component 4b deficiency	Enrichment	C4B	3.23
45	Macular degeneration, age-related, 9	Enrichment	C3	3.23
46	Complement component 3 deficiency, autosomal recessive	Enrichment	C3	3.23
47	Complement factor b deficiency	Enrichment	CFB	3.23
48	Complement component 3 deficiency	Enrichment	C3	3.23
49	Membranoproliferative glomerulonephritis	Enrichment	C3	3.23
50	Primary membranoproliferative glomerulonephritis	Enrichment	C3	3.23
51	Thrombophilia due to thrombin defect	Enrichment	F13A1, FGA	3.02
52	Glanzmann thrombasthenia 1	Enrichment	ITGA2B, ITGB3	3.02
53	3mc syndrome 1	Enrichment	MASP1	3.02
54	Complement component 7 deficiency	Enrichment	C7	3.02
55	Complement component 8 deficiency, type i	Enrichment	C8A	3.02
56	Macular degeneration, age-related, 15	Enrichment	C9	3.02
57	Masp2 deficiency	Enrichment	MASP2	3.02
58	Mannose-binding lectin deficiency	Enrichment	MBL2	3.02
59	Complement component 9 deficiency	Enrichment	C9	3.02
60	Complement component 8 deficiency, type ii	Enrichment	C8B	3.02
61	Immunodeficiency due to masp-2 deficiency	Enrichment	MASP2	3.02
62	C1q deficiency 3	Enrichment	C1QC	2.96
63	C1q deficiency 2	Enrichment	C1QB	2.96
64	Lathosterolosis	Enrichment	C5	2.93
65	Severe covid-19	Enrichment	CASP10, FCN2, ITGAV	2.84
66	Complement factor d deficiency	Enrichment	CFD	2.83
67	Recurrent neisseria infections due to factor d deficiency	Enrichment	CFD	2.83
68	Lung cancer	Enrichment	CASP8, FAS, FASLG	2.71
69	Autosomal dominant macrothrombocytopenia	Enrichment	ITGA2B, ITGB3	2.69
70	Loeys-dietz syndrome	Enrichment	TGFB2, TGFB3	2.68
71	Complement component c1s deficiency	Enrichment	C1S	2.66
72	Complement component 4, partial deficiency of	Enrichment	SERPING1	2.46
73	Carboxypeptidase n deficiency	Enrichment	CPN1	2.46
74	Basal laminar drusen	Enrichment	CFH	2.46
75	Prothrombin deficiency, congenital	Enrichment	F2	2.46
76	Macular degeneration, age-related, 4	Enrichment	CFH	2.46
77	Thrombophilia due to protein s deficiency, autosomal dominant	Enrichment	PROS1	2.46
78	Complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy	Enrichment	CD55	2.46
79	Blood group, cromer system	Enrichment	CD55	2.46
80	Immunodeficiency, common variable, 6	Enrichment	CD81	2.46
81	Thrombophilia due to protein s deficiency, autosomal recessive	Enrichment	PROS1	2.46
82	Hemolytic uremic syndrome, atypical 3	Enrichment	CFI	2.46
83	Macular degeneration, age-related, 13	Enrichment	CFI	2.46
84	Complement factor h deficiency	Enrichment	CFH	2.46
85	Complement factor i deficiency	Enrichment	CFI	2.46
86	Hemolytic uremic syndrome, atypical 2	Enrichment	CD46	2.46
87	Immunodeficiency, common variable, 3	Enrichment	CD19	2.46
88	Hemolytic anemia, cd59-mediated, with or without immune-mediated polyneuropathy	Enrichment	CD59	2.46
89	Pregnancy loss, recurrent 2	Enrichment	F2	2.46
90	C3 glomerulopathy 3	Enrichment	CFHR5	2.46
91	Protein s deficiency	Enrichment	PROS1	2.46
92	C1 inhibitor deficiency	Enrichment	SERPING1	2.46
93	Prothrombin deficiency	Enrichment	F2	2.46
94	Protein-losing enteropathy	Enrichment	CD55	2.46
95	Genetic hemolytic uremic syndrome	Enrichment	CFH	2.46
96	Hereditary angioedema with c1inh deficiency	Enrichment	SERPING1	2.46
97	Hereditary thrombophilia due to congenital protein s deficiency	Enrichment	PROS1	2.46
98	Immunodeficiency with factor h anomaly	Enrichment	CFH	2.46
99	Multiple sclerosis	Enrichment	LAMA5, LAMB1	2.40
100	Ficolin 3 deficiency	Enrichment	FCN3	2.37
101	Rheumatic heart disease	Enrichment	FCN3	2.37
102	Immunodeficiency due to ficolin3 deficiency	Enrichment	FCN3	2.37
103	Neural tube defects	Enrichment	PARD3, SCRIB	2.35
104	Amyotrophic lateral sclerosis 10 with or without frontotemporal dementia	Enrichment	MASP2	2.32
105	Interstitial lung disease 2	Enrichment	SFTPA1, SFTPA2	2.23
106	Leprosy 3	Enrichment	TLR2	2.16
107	Thrombocytopenia 1	Enrichment	WAS	2.16
108	Fatal familial insomnia	Enrichment	PRNP	2.16
109	Prekallikrein deficiency	Enrichment	KLKB1	2.16
110	Gerstmann-straussler disease	Enrichment	PRNP	2.16
111	Donnai-barrow syndrome	Enrichment	LRP2	2.16
112	Lissencephaly 5	Enrichment	LAMB1	2.16
113	Kuru	Enrichment	PRNP	2.16
114	Immunodeficiency 20	Enrichment	FCGR3A	2.16
115	Hyperthyroxinemia, familial dysalbuminemic	Enrichment	ALB	2.16
116	Ventricular tachycardia, familial	Enrichment	GNAI2	2.16
117	Angioedema, hereditary, 4	Enrichment	PLG	2.16
118	Interstitial lung disease 1	Enrichment	SFTPA1	2.16
119	Nephrotic syndrome, type 26	Enrichment	LAMA5	2.16
120	Combined oxidative phosphorylation deficiency 33	Enrichment	C1QBP	2.16
121	Fetomaternal alloimmune thrombocytopenia 2	Enrichment	ITGA2B	2.16
122	Spongiform encephalopathy with neuropsychiatric features	Enrichment	PRNP	2.16
123	Huntington disease-like 1	Enrichment	PRNP	2.16
124	Immunodeficiency with hyper-igm, type 3	Enrichment	CD40	2.16
125	Familial alzheimer-like prion disease	Enrichment	PRNP	2.16
126	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.16
127	Factor xiii, a subunit, deficiency of	Enrichment	F13A1	2.16
128	Prion disease	Enrichment	PRNP	2.16
129	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.16
130	Was-related disorders	Enrichment	WAS	2.16
131	Congenital analbuminemia	Enrichment	ALB	2.16
132	Bent bone dysplasia syndrome 2	Enrichment	LAMA5	2.16
133	Prolactin-producing pituitary gland adenoma	Enrichment	LRP2	2.16
134	Analbuminemia	Enrichment	ALB	2.16
135	Congenital fibrinogen deficiency	Enrichment	FGG	2.16
136	Prp systemic amyloidosis	Enrichment	PRNP	2.16
137	Fetomaternal alloimmune thrombocytopenia 3	Enrichment	ITGA2	2.16
138	Inherited human prion disease	Enrichment	PRNP	2.16
139	Lama5-related multisystemic syndrome	Enrichment	LAMA5	2.16
140	Inherited creutzfeldt-jakob disease	Enrichment	PRNP	2.16
141	Inherited prekallikrein deficiency	Enrichment	KLKB1	2.16
142	Immunodeficiency, common variable, 2	Enrichment	CR2	2.16
143	Immunodeficiency, common variable, 7	Enrichment	CR2	2.16
144	Nephrotic syndrome, type 7	Enrichment	CFH	2.16
145	Angioedema	Enrichment	SERPING1	2.16
146	Pigmented paravenous chorioretinal atrophy	Enrichment	CRB1	2.11
147	Lymphoproliferative syndrome, x-linked, 2	Enrichment	XIAP	2.11
148	Systemic lupus erythematosus 6	Enrichment	ITGAM	2.11
149	Parkinson disease 13, autosomal dominant	Enrichment	HTRA2	2.11
150	Caspase 8 deficiency	Enrichment	CASP8	2.11
151	Ventriculomegaly with cystic kidney disease	Enrichment	CRB2	2.11
152	Immunodeficiency 69	Enrichment	IFNG	2.11
153	Hemolytic anemia, congenital, x-linked	Enrichment	ATP11C	2.11
154	Retinitis pigmentosa 12	Enrichment	CRB1	2.11
155	Deafness, autosomal dominant 33	Enrichment	ATP11A	2.11
156	Intellectual developmental disorder, autosomal dominant 76	Enrichment	MARK2	2.11
157	Leukodystrophy, hypomyelinating, 24	Enrichment	ATP11A	2.11
158	Thrombocytopenia 4	Enrichment	CYCS	2.11
159	Camurati-engelmann disease 2	Enrichment	TGFB2	2.11
160	Focal segmental glomerulosclerosis 9	Enrichment	CRB2	2.11
161	Autoimmune lymphoproliferative syndrome, type iia	Enrichment	CASP10	2.11
162	Macular degeneration, age-related, 12	Enrichment	CX3CR1	2.11
163	Leber congenital amaurosis 8	Enrichment	CRB1	2.11
164	Loeys-dietz syndrome 5	Enrichment	TGFB3	2.11
165	Visual impairment and progressive phthisis bulbi	Enrichment	MARK3	2.11
166	Auditory neuropathy, autosomal dominant 2	Enrichment	ATP11A	2.11
167	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	2.11
168	Pigmented paravenous retinochoroidal atrophy	Enrichment	CRB1	2.11
169	Human immunodeficiency virus type 1	Enrichment	CX3CR1, IFNG	2.07
170	3mc syndrome 2	Enrichment	COLEC11	2.07
171	Behcet syndrome	Enrichment	C4A, FAS	2.02
172	Ehlers-danlos syndrome	Enrichment	C1R, TGFB2	2.02
173	Myocardial infarction	Enrichment	F13A1, ITGB3	2.01
174	Systemic lupus erythematosus 9	Enrichment	CR2	1.98
175	Cerebral sinovenous thrombosis	Enrichment	F2	1.98
176	Malaria	Enrichment	CR1, ICAM1	1.97
177	3mc syndrome 3	Enrichment	COLEC10	1.89
178	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	1.86
179	Plasminogen deficiency, type i	Enrichment	PLG	1.86
180	Wiskott-aldrich syndrome	Enrichment	WAS	1.86
181	Corneal dystrophy, congenital stromal	Enrichment	DCN	1.86
182	Lissencephaly 1	Enrichment	LAMB1	1.86
183	Creutzfeldt-jakob disease	Enrichment	PRNP	1.86
184	Fibrolamellar carcinoma	Enrichment	PRKACA	1.86
185	Hereditary angioedema	Enrichment	PLG	1.86
186	Hypopituitarism	Enrichment	GNAI2	1.86
187	Hypoalphalipoproteinemia, primary, 2, intermediate	Enrichment	APOA1	1.86
188	Amyloidosis, hereditary systemic 3	Enrichment	APOA1	1.86
189	Factor xiii deficiency	Enrichment	F13A1	1.86
190	Non-syndromic syndactyly	Enrichment	LRP2	1.86
191	Thrombotic microangiopathy	Enrichment	CD46	1.86
192	Leukocyte adhesion deficiency, type i	Enrichment	ITGB2	1.81
193	Camurati-engelmann disease 1	Enrichment	TGFB1	1.81
194	Retinitis pigmentosa 13	Enrichment	CRB1	1.81
195	Leukocyte adhesion deficiency, type iii	Enrichment	ITGB2	1.81
196	Deafness, autosomal dominant 64	Enrichment	DIABLO	1.81
197	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	1.81
198	Retinitis pigmentosa-deafness syndrome	Enrichment	CRB1	1.81
199	Camurati-engelmann disease	Enrichment	TGFB1	1.81
200	Deafness, autosomal dominant 84	Enrichment	ATP11A	1.81
201	Retinitis pigmentosa 38	Enrichment	MERTK	1.81
202	Autosomal dominant severe congenital neutropenia	Enrichment	ELANE	1.76
203	Cystic fibrosis	Enrichment	MBL2, PLG	1.70
204	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	1.69
205	Thrombocythemia 1	Enrichment	CALR	1.69
206	Factor x deficiency	Enrichment	F10	1.69
207	Adiponectin deficiency	Enrichment	ADIPOQ	1.69
208	Hypoalphalipoproteinemia, primary, 2	Enrichment	APOA1	1.69
209	Spastic paraplegia 50, autosomal recessive	Enrichment	APOA1	1.69
210	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	1.69
211	Aggressive periodontitis	Enrichment	FPR1	1.69
212	Congenital factor x deficiency	Enrichment	F10	1.69
213	Cholestasis, intrahepatic, of pregnancy, 1	Enrichment	ATP8B1	1.63
214	Cholestasis, benign recurrent intrahepatic, 1	Enrichment	ATP8B1	1.63
215	Tuberous sclerosis 1	Enrichment	IFNG	1.63
216	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	FASLG	1.63
217	Hepatitis c virus	Enrichment	IFNG	1.63
218	Tuberous sclerosis 2	Enrichment	IFNG	1.63
219	T-cell acute lymphoblastic leukemia	Enrichment	BAX	1.63
220	Arachnoid cyst	Enrichment	PALS1	1.63
221	Angelman syndrome due to imprinting defect in 15q11-q13	Enrichment	ATP10A	1.63
222	Vogt-koyanagi-harada disease	Enrichment	FAS	1.63
223	Neutropenia	Enrichment	ELANE	1.62
224	Ehlers-danlos syndrome, arthrochalasia type, 1	Enrichment	ALB	1.57
225	Budd-chiari syndrome	Enrichment	CALR	1.57
226	Auriculocondylar syndrome 1	Enrichment	GNAI3	1.57
227	Frontotemporal dementia 2	Enrichment	PRNP	1.57
228	Hypoalphalipoproteinemia, primary, 1	Enrichment	APOA1	1.57
229	Achromatopsia 4	Enrichment	GNAI3	1.57
230	Prolactinoma	Enrichment	LRP2	1.57
231	Cerebral malaria	Enrichment	ICAM1	1.57
232	Pediatric systemic lupus erythematosus	Enrichment	SPP1	1.57
233	Bestrophinopathy, autosomal recessive	Enrichment	CRB1	1.51
234	Lymphoproliferative syndrome 2	Enrichment	XIAP	1.51
235	Intrahepatic cholestasis of pregnancy	Enrichment	ATP8B1	1.51
236	3-methylglutaconic aciduria, type viii	Enrichment	HTRA2	1.51
237	Glanzmann thrombasthenia 2	Enrichment	ITGB3	1.47
238	Stroke, ischemic	Enrichment	F2	1.47
239	Arrhythmogenic right ventricular dysplasia, familial, 1	Enrichment	TGFB3	1.41
240	Arrhythmogenic right ventricular dysplasia 1	Enrichment	TGFB3	1.41
241	Autosomal thrombocytopenia with normal platelets	Enrichment	CYCS	1.41
242	Idiopathic aplastic anemia	Enrichment	IFNG	1.41
243	Chronic kidney disease	Enrichment	CFH	1.36
244	Atrial septal defect 1	Enrichment	TGFB2	1.34
245	Cholestasis, progressive familial intrahepatic, 1	Enrichment	ATP8B1	1.34
246	Anxiety	Enrichment	PALS1	1.34
247	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.34
248	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.34
249	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	TGFB2, TGFB3	1.33
250	Myelofibrosis	Enrichment	CALR	1.33
251	Essential thrombocythemia	Enrichment	CALR	1.33
252	Progressive familial intrahepatic cholestasis	Enrichment	ATP8B1	1.27
253	Spastic paraplegia 4, autosomal dominant	Enrichment	FGG	1.27
254	Ellis-van creveld syndrome	Enrichment	PRKACA	1.22
255	Leber congenital amaurosis 1	Enrichment	CRB1	1.22
256	Lymphoma, non-hodgkin, familial	Enrichment	CASP10	1.22
257	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ATP11A, DIABLO	1.21
258	Adult hepatocellular carcinoma	Enrichment	CASP8	1.17
259	Presynaptic congenital myasthenic syndromes	Enrichment	LAMA5	1.14
260	Marfan syndrome	Enrichment	TGFB2	1.12
261	Aplastic anemia	Enrichment	IFNG	1.12
262	Autoinflammatory disease	Enrichment	ELANE	1.10
263	Nanophthalmos	Enrichment	CRB1	1.08
264	Early-onset parkinson's disease	Enrichment	HTRA2	1.05
265	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	TGFB3	1.05
266	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	TGFB3	1.05
267	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.01
268	Nk-cell enteropathy	Enrichment	AXL	1.01
269	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	TGFB3	0.98
270	Cerebral palsy	Enrichment	F2	0.90
271	Diamond-blackfan anemia 1	Enrichment	RPS19	0.83
272	Hepatocellular carcinoma	Enrichment	CASP8	0.80
273	Cone dystrophy	Enrichment	CRB1	0.77
274	Genetic steroid-resistant nephrotic syndrome	Enrichment	LAMA5	0.68
275	Stargardt disease 1	Enrichment	CRB1	0.68
276	Diamond-blackfan anemia	Enrichment	RPS19	0.66
277	Usher syndrome	Enrichment	CRB1	0.64
278	Eye disease	Enrichment	CRB1	0.62
279	Nephrotic syndrome	Enrichment	LAMA5	0.59
280	Gastric cancer	Enrichment	CASP10	0.54
281	Optic atrophy plus syndrome	Enrichment	CRB1	0.53
282	Primary ovarian insufficiency	Enrichment	THBS1	0.48
283	Schizophrenia	Enrichment	CSMD1	0.43
284	Hereditary retinal dystrophy	Enrichment	CFH, CRB1, MERTK	0.40
285	Fundus dystrophy	Enrichment	CFH, CRB1, MERTK	0.40
286	Cone-rod dystrophy 2	Enrichment	CRB1	0.38
287	Autism	Enrichment	CSMD1	0.36
288	Breast cancer	Enrichment	CASP8	0.35
289	Colorectal cancer	Enrichment	TLR2	0.35
290	Mitochondrial disease	Enrichment	C1QBP	0.35
291	Retinitis pigmentosa	Enrichment	CRB1, MERTK	0.30
292	Leber plus disease	Enrichment	CRB1	0.28
293	Autism spectrum disorder	Enrichment	MARK2	0.24
294	Complex neurodevelopmental disorder	Enrichment	PALS1	0.21

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Complement cascade

Pathway Network for Complement cascade

Pathway network for the Complement cascade SuperPath

Member Pathways for Complement cascade

Pathways in the Complement cascade SuperPath

Gene overlap in member pathways for Complement cascade SuperPath

Associated Genes for Complement cascade

Associated Disorders for Complement cascade

Disorders associated with Complement cascade SuperPath

STRING Interaction Network for Complement cascade

Sources for Complement cascade