Complex III assembly

No Pathway Network information available for Complex III assembly

Pathways in the Complex III assembly SuperPath

#	Name	Source	Genes
1	Complex III assembly	Reactome	BCS1L CYC1 FXN HSCB HSPA9 ISCU LETM1 LYRM4 LYRM7 MT-CYB NFS1 TTC19 UQCC1 UQCC2 UQCC3 UQCC5 UQCC6 UQCR10 UQCR11 UQCRB UQCRC1 UQCRC2 UQCRFS1 UQCRH UQCRHL UQCRQ (see all 26) (see less)
2	Mitochondrial complex III assembly	WikiPathways	BCS1L CYC1 LYRM7 TTC19 UQCC1 UQCC2 UQCC3 UQCR10 UQCR11 UQCRB UQCRC1 UQCRC2 UQCRFS1 UQCRH UQCRQ (see all 15) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	UQCR11	Ubiquinol-Cytochrome C Reductase, Complex III Subunit XI	Protein Coding	2
2	CYC1	Cytochrome C1	Protein Coding	2
3	UQCRQ	Ubiquinol-Cytochrome C Reductase Complex III Subunit VII	Protein Coding	2
4	UQCR10	Ubiquinol-Cytochrome C Reductase, Complex III Subunit X	Protein Coding	2
5	TTC19	Tetratricopeptide Repeat Domain 19	Protein Coding	2
6	UQCC1	Ubiquinol-Cytochrome C Reductase Complex Assembly Factor 1	Protein Coding	2
7	BCS1L	BCS1 Ubiquinol-Cytochrome C Reductase Complex Chaperone	Protein Coding	2
8	UQCRB	Ubiquinol-Cytochrome C Reductase Binding Protein	Protein Coding	2
9	UQCRC1	Ubiquinol-Cytochrome C Reductase Core Protein 1	Protein Coding	2
10	UQCRC2	Ubiquinol-Cytochrome C Reductase Core Protein 2	Protein Coding	2
11	UQCRFS1	Ubiquinol-Cytochrome C Reductase, Rieske Iron-Sulfur Polypeptide 1	Protein Coding	2
12	UQCRH	Ubiquinol-Cytochrome C Reductase Hinge Protein	Protein Coding	2
13	UQCC3	Ubiquinol-Cytochrome C Reductase Complex Assembly Factor 3	Protein Coding	2
14	UQCC2	Ubiquinol-Cytochrome C Reductase Complex Assembly Factor 2	Protein Coding	2
15	LYRM7	LYR Motif Containing 7	Protein Coding	2
16	HSCB	HscB Mitochondrial Iron-Sulfur Cluster Cochaperone	Protein Coding	1
17	ISCU	Iron-Sulfur Cluster Assembly Enzyme	Protein Coding	1
18	FXN	Frataxin	Protein Coding	1
19	HSPA9	Heat Shock Protein Family A (Hsp70) Member 9	Protein Coding	1
20	LETM1	Leucine Zipper And EF-Hand Containing Transmembrane Protein 1	Protein Coding	1
21	UQCRHL	Ubiquinol-Cytochrome C Reductase Hinge Protein Like	Protein Coding	1
22	UQCC5	Ubiquinol-Cytochrome C Reductase Complex Assembly Factor 5	Protein Coding	1
23	MT-CYB	Mitochondrially Encoded Cytochrome B	Protein Coding	1
24	LYRM4	LYR Motif Containing 4	Protein Coding	1
25	UQCC6	Ubiquinol-Cytochrome C Reductase Complex Assembly Factor 6	Protein Coding	1
26	NFS1	NFS1 Cysteine Desulfurase	Protein Coding	1

Disorders associated with Complex III assembly SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Isolated complex iii deficiency	Enrichment	BCS1L, CYC1, LYRM7, MT-CYB, TTC19, UQCC2, UQCC3, UQCRB, UQCRC2, UQCRFS1, UQCRQ	16.00
2	Mitochondrial complex iii deficiency, nuclear type 1	Enrichment	BCS1L, LYRM7	5.47
3	Combined oxidative phosphorylation deficiency 19	Enrichment	LYRM4, NFS1	4.98
4	Mitochondrial disease	Enrichment	MT-CYB, TTC19, UQCRC2	3.23
5	Mitochondrial complex iii deficiency, nuclear type 3	Enrichment	UQCRB	2.96
6	Mitochondrial complex iii deficiency, nuclear type 6	Enrichment	CYC1	2.96
7	Mitochondrial complex iii deficiency, nuclear type 7	Enrichment	UQCC2	2.96
8	Bjornstad syndrome	Enrichment	BCS1L	2.96
9	Gracile syndrome	Enrichment	BCS1L	2.96
10	Mitochondrial complex iii deficiency, nuclear type 8	Enrichment	LYRM7	2.96
11	Mitochondrial complex iii deficiency, nuclear type 10	Enrichment	UQCRFS1	2.96
12	Mitochondrial complex iii deficiency, nuclear type 11	Enrichment	UQCRH	2.96
13	Renal tubulopathy-encephalopathy-liver failure syndrome	Enrichment	BCS1L	2.96
14	Myopathy with lactic acidosis, hereditary	Enrichment	ISCU	2.72
15	Even-plus syndrome	Enrichment	HSPA9	2.72
16	Anemia, sideroblastic, 4	Enrichment	HSPA9	2.72
17	Combined oxidative phosphorylation deficiency 52	Enrichment	NFS1	2.72
18	Neurodegeneration, childhood-onset, with multisystem involvement due to mitochondrial dysfunction	Enrichment	LETM1	2.72
19	Anemia, sideroblastic, 5	Enrichment	HSCB	2.72
20	Mitochondrial complex iii deficiency, nuclear type 9	Enrichment	UQCC3	2.66
21	Parkinsonism with polyneuropathy	Enrichment	UQCRC1	2.66
22	Mitochondrial complex iii deficiency, nuclear type 2	Enrichment	TTC19	2.48
23	Autosomal recessive sideroblastic anemia	Enrichment	HSPA9	2.42
24	Propionic acidemia	Enrichment	UQCRFS1	2.35
25	Mitochondrial complex v deficiency, nuclear type 3	Enrichment	UQCRC2	2.35
26	Mitochondrial complex iii deficiency, nuclear type 4	Enrichment	UQCRQ	2.26
27	Friedreich ataxia	Enrichment	FXN	2.24
28	Cardiomyopathy, infantile histiocytoid	Enrichment	MT-CYB	2.12
29	Leigh syndrome, nuclear	Enrichment	BCS1L, MT-CYB	2.12
30	Leigh disease	Enrichment	BCS1L, MT-CYB	2.03
31	Wolf-hirschhorn syndrome	Enrichment	LETM1	1.94
32	Movement disease	Enrichment	BCS1L	1.92
33	Lactic acidosis	Enrichment	UQCRFS1	1.88
34	Mitochondrial myopathy, infantile, transient	Enrichment	MT-CYB	1.77
35	Mitochondrial encephalomyopathy	Enrichment	MT-CYB	1.72
36	Familial colorectal cancer	Enrichment	MT-CYB	1.72
37	Mitochondrial myopathy with reversible cytochrome c oxidase deficiency	Enrichment	MT-CYB	1.72
38	Hypertrophic cardiomyopathy	Enrichment	UQCRC1	1.33
39	Leber hereditary optic neuropathy, modifier of	Enrichment	MT-CYB	1.16
40	Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes	Enrichment	MT-CYB	1.15
41	Epilepsy	Enrichment	MT-CYB	1.13
42	Hereditary breast carcinoma	Enrichment	MT-CYB	1.09
43	Body mass index quantitative trait locus 11	Enrichment	MT-CYB	1.04
44	Microcephaly	Enrichment	BCS1L	0.89
45	Breast cancer	Enrichment	MT-CYB	0.87
46	Leber plus disease	Enrichment	MT-CYB	0.78
47	Ovarian cancer	Enrichment	MT-CYB	0.75

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Complex III assembly

Pathway Network for Complex III assembly

Member Pathways for Complex III assembly

Pathways in the Complex III assembly SuperPath

Associated Genes for Complex III assembly

Associated Disorders for Complex III assembly

Disorders associated with Complex III assembly SuperPath

STRING Interaction Network for Complex III assembly

Sources for Complex III assembly